Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of chlortetracycline tablet in China. Welcome to wholesale bulk high quality chlortetracycline tablet for sale here from our factory. Good service and reasonable price are available.
Chlortetracycline tablets belong to the tetracycline class of broad-spectrum antibiotics. By binding to the 30S subunit of bacterial ribosomes, it inhibits the binding of aminoacyl tRNA to the mRNA‑ribosome complex, blocks bacterial protein synthesis, and thus exerts potent bacteriostatic effects. It is effective against a wide range of pathogens, including Gram‑positive bacteria (such as Staphylococcus aureus and Streptococcus species), Gram‑negative bacteria (such as Brucella and Vibrio cholerae), and atypical pathogens (such as Mycoplasma and Chlamydia). Due to its broad antimicrobial activity, it has been widely used in both human and veterinary medicine for the treatment of various infectious diseases.
Additional information of chemical compound:
| Product Name | Chlortetracycline Powder | Chlortetracycline Tablets | Chlortetracycline Injection | Chlortetracycline hydrochloride |
| Product Type | Powder | Tablet | Injection | Powder |
| Product Purity | ≥99% | ≥99% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable | Customizable |
Our Products
Chlortetracycline +. COA
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Certificate of Analysis |
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Compound name |
Chlortetracycline | |
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CAS No. |
57-62-5 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
202601090062 | |
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MFG |
Jan 9th 2026 | |
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EXP |
Jan 8th 2029 | |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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This drug was initially used to treat systemic infections caused by sensitive bacteria (such as pneumonia, urinary tract infections, typhoid fever), but due to drug resistance and adverse reactions (such as tooth discoloration, hepatotoxicity), oral formulations have gradually been phased out. Only local formulations (such as eye ointment, eye drops) are still used for ophthalmic infections (such as bacterial conjunctivitis, stye) and skin and soft tissue infections. Adults should take local medication 2-3 times a day, and children (over 8 years old) should undergo strict risk assessment before use.
Chlortetracycline tablets (trade name: aureomycin tablets), as representative drugs of tetracycline antibiotics, have become important tools in the fields of medicine and veterinary medicine since their discovery in the mid-20th century due to their broad-spectrum antibacterial activity and multi domain application value.
Human Medical Field: From Eye Infections to Systemic Treatment
1. Treatment of Eye Infections: Core Indications and Clinical Practice
Chlortetracycline is made into eye ointment or eye drops in the form of hydrochloride salt, and is one of the preferred drugs for treating superficial eye infections:Bacterial conjunctivitis (conjunctivitis): caused by Gram positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes, as well as Gram negative bacteria such as Haemophilus influenzae. Chlorotetracycline alleviates symptoms such as conjunctival congestion and increased secretion by inhibiting bacterial protein synthesis. The usage is 3 times a day, apply once before bedtime, and use continuously for 3-5 days.
Smegma (needle stealing eye): When no abscess has formed, applying chlortetracycline eye ointment after hot compress can promote inflammation absorption and avoid surgical drainage. Its antibacterial spectrum covers the Staphylococcus genus, reducing the risk of secondary infections.
Trachoma: As a specific anti chlamydia drug, chlorotetracycline can block the reproduction of chlamydia and reduce the risk of scar formation. The World Health Organization (WHO) recommends topical medication twice a day for six consecutive weeks.
Bacterial blepharitis: Chlortetracycline eye ointment can quickly control inflammation and prevent corneal involvement for Gram positive bacterial infections at the edge of the eyelids.
2. Skin and soft tissue infections: diversity of local applications
Although the systemic use of chlortetracycline has been reduced due to drug resistance issues, their topical formulations still have value in skin infections:
Oral erosion: Combined with vitamin B ₂ treatment, chlorotetracycline accelerates mucosal healing by inhibiting secondary bacterial infections. It usually takes three days to improve.
Swelling: Apply to the inflamed area of the nasal mucosa or skin, which can inhibit pathogenic bacteria such as Staphylococcus aureus, reduce pain and swelling.
Hand and foot dry cracking: After application, cover with adhesive tape to fix and accelerate wound healing through antibacterial and epidermal repair effects, especially suitable for winter cracking.
4. Special infection scenarios: from anaerobic bacteria to meningitis
Anaerobic bacterial infection: Effective against fragile anaerobic bacteria such as Bacteroidetes, often used in combination with aminoglycosides to treat mixed infections in the abdominal or pelvic cavity.
Meningitis: Suitable for Streptococcus pneumoniae and Neisseria meningitidis in patients with ampicillin resistant Haemophilus influenzae type B meningitis or penicillin allergy. Attention should be paid to the limited penetration of the blood-brain barrier and the need for high-dose administration.
3. Treatment of systemic bacterial infections: historical status and modern limitations
Chlortetracycline tablets were once widely used for systemic infections caused by sensitive bacteria, but due to resistance issues and toxicity risks, they are now limited to specific scenarios:
Rickettsia disease: including epidemic typhus, endemic typhus, Q fever, etc. Chlorotetracycline exerts bactericidal effects by inhibiting protein synthesis in rickettsia, and the treatment course is usually 7-14 days.
Veterinary medicine field: from disease treatment to growth promotion
1. Treatment of bacterial diseases in livestock and poultry: core application scenarios
Chlorotetracycline is widely used in veterinary medicine and can treat various livestock and poultry infections
Pig diseases: Control reproductive disorders in sows (such as uterine inflammation, mastitis), commercial pig diarrhea and typhoid fever, white dysentery, etc. Its antibacterial spectrum covers intestinal pathogens such as Escherichia coli and Salmonella, reducing mortality rates and improving feed conversion rates.
Poultry diseases: Treatment of Salmonella infection, Escherichia coli disease, etc. in broiler chickens under 10 weeks of age. The dosage is 20-50g/t of feed, with a 7-day drug withdrawal period. It is necessary to strictly follow the drug withdrawal period regulations to avoid drug residue.
2. Promoting Growth and Feed Additives: Historical Status and Modern Transformation
Chlorotetracycline, as a growth promoter, has a historical position in animal husbandry, but faces strict regulation due to drug resistance issues
Pig feed: Adding 25-75g/t chlortetracycline to feed for pigs under 2 months old can increase daily weight gain by 5% -10% and improve feed conversion rate. The mechanism may be related to inhibiting harmful bacteria in the intestine and reducing nutritional competition.
Broiler feed: Adding 20-50g/t to feed for broiler chickens under 10 weeks of age can reduce mortality and promote weight uniformity. But the European Union has banned the use of antibiotics as growth promoters, and China is gradually restricting their application.
3. Aquaculture application: Control bacterial diseases in fish
Chlortetracycline is used to control bacterial diseases in fish-
Vibrio disease: By inhibiting pathogenic bacteria such as Vibrio parahaemolyticus, it reduces symptoms such as gill rot and surface ulcers in fish. Attention should be paid to the impact of water pH on drug efficacy.
Column disease: To treat fish column shaped yellow rod bacteria infection, it is necessary to combine it with water quality improvement agents to enhance the efficacy.
Research Value: From Basic Research to Application Development
Chlorotetracycline has multiple values in the field of scientific research, and its derivative modification and special mechanism of action provide theoretical basis for the development of new drugs.
1. Fluorescent probe
Chlortetracycline can label mouse sperm acrosome reaction for reproductive biology research. After binding with calcium ions, it emits fluorescence and can monitor the progress of acrosome reaction in real time, providing a technical means for the diagnosis of male infertility.
2. Methanogenic bacteria inhibitor
In anaerobic digestion systems, 10-200mg/L chlorotetracycline can inhibit biogas production and is metabolized through microbial degradation. Research has shown that 200mg/L chlorotetracycline can reduce methane production by 60%, providing a new strategy for regulating biogas engineering.
Special Purpose and Historical Status
1. Antibiotic resistance research model
Chlorotetracycline, as the first tetracycline antibiotic produced industrially, provides a reference for subsequent drug development through the study of its resistance mechanism. Research has shown that bacteria develop drug resistance through the expression of efflux pump genes or mutations in ribosome protective proteins.
2. Drug testing standards
Chlorotetracycline and its epimers (such as 4-epitetracycline), as impurity control indicators, need to be analyzed by liquid chromatography electrospray ionization mass spectrometry. Its detection limit can reach 0.1 μ g/g, providing technical support for drug quality control.
Research and Development History and Background
Discovery and Industrial Production
Discovery time: In 1945, chlortetracycline tablets was isolated from the metabolites of Streptomyces aureofaciens by Lederle Laboratories in the United States.
Industrial significance: As the first tetracycline antibiotics produced industrially, it has promoted the development of antibiotic treatment and is known as a milestone drug in the "golden age of antibiotics".
Evolution of clinical applications
Early application: Widely used in the 1950s and 1960s to treat bacterial infections such as pneumonia, urinary tract infections, and skin infections.
Formulation adjustment: Due to the instability of aqueous solutions (easily decomposed under neutral/alkaline conditions), tablets and injections were phased out after 1982 and are now mainly used as raw materials for external preparations (such as eye ointment).
Challenges of drug resistance
Drug resistance mechanism: Bacteria develop drug resistance by producing inactivating enzymes (such as acetyltransferases), altering target sites, or overexpressing efflux pumps.
Current situation: The resistance rate to Gram positive bacteria (such as Staphylococcus aureus) has significantly increased, but it is still effective against certain atypical pathogens (such as Mycoplasma and Chlamydia).
FAQ
- What is chlortetracycline used for?
It is used for routine infections and intracellular pathogens. However, chlortetracycline is poorly absorbed orally and other tetracyclines are preferred for systemic treatment of infections. The most common use for chlortetracycline is as a feed additive to control respiratory and enteric infections in livestock.
- Why is tetracycline no longer used?
The presence of tetracycline-resistant pathogens limits the use of these agents in treatment of disease. Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines or for a protein that protects bacterial ribosomes from the action of tetracyclines.
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