Liposomal Vitamin C Tablets

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of liposomal vitamin c tablets in China. Welcome to wholesale bulk high quality liposomal vitamin c tablets for sale here from our factory. Good service and reasonable price are available.

Liposome Vitamin C Tablets is an innovative product that redefines the efficiency of nutritional supplementation through advanced delivery technology. It encapsulates high-dose Vitamin C within micro-spheres formed by a phospholipid bilayer, ingeniously mimicking the structure of cell membranes, thereby achieving precise protection and efficient delivery within the digestive tract. This design not only significantly resists gastric acid erosion but also, thanks to the affinity of phospholipids to intestinal wall cells, promotes the direct entry of Vitamin C into the circulatory system, enabling its bioavailability to exceed the limitations of traditional tablets or powders, potentially reaching over 90%. This means less gastrointestinal irritation, more nutrients being absorbed and utilized by the body, achieving a "direct cell delivery" level of effect. It perfectly combines the concept of nano-pharmaceuticals with daily nutritional needs, especially suitable for those who seek efficient absorption, have sensitive stomachs, or have specific health support goals. It represents a paradigm shift in nutritional science from "what to supplement" to "how to supplement".

Vitamin C COA

The importance of particle size

The particle size of liposomes has a significant impact on their distribution, absorption, and therapeutic efficacy in vivo. Appropriate particle size can enable liposomes to better penetrate biological barriers such as cell membranes and gastrointestinal mucosa, thereby improving the absorption efficiency of vitamin C. Smaller particle sizes typically have larger specific surface areas, which can increase the contact area between liposomes and cell membranes, promoting fusion and endocytosis processes. In addition, particle size can also affect the circulation time and targeting of liposomes in vivo. Generally speaking, nanoscale liposomes (particle size less than 100 nanometers) have a longer blood circulation time and can be passively targeted and enriched in tumor tissues and other lesions.

Particle size control method

1

 

ultrasonication

The ultrasonic method utilizes the cavitation and mechanical effects of ultrasound to reduce the particle size of liposomes. When ultrasound propagates in liquid, it produces alternating changes in high and low pressure, resulting in the formation of tiny bubbles. These bubbles form in low-pressure areas and rapidly rupture in high-pressure areas, producing local high temperatures and pressures, as well as strong shock waves and microjets. These physical effects can disrupt the large particles of liposomes and disperse them into smaller particles. The ultrasonic method is relatively simple to operate and has low equipment costs, making it suitable for small-scale laboratory preparation. However, this method has some limitations. For example, uneven energy distribution of ultrasound may lead to significant differences in particle size in different parts of the sample. In addition, prolonged ultrasonic treatment may cause oxidation and degradation of liposomes, affecting the quality of the product.

2

 

High pressure homogenization

The high-pressure homogenization method is to transport the liposome suspension to the homogenization valve through a high-pressure pump. Under high pressure, the suspension passes through narrow gaps, generating extremely high shear forces, turbulence, and cavitation effects. These forces can disrupt liposome particles and reduce their particle size. The high-pressure homogenization method can effectively reduce the particle size of liposomes and obtain a narrower particle size distribution. This method is suitable for large-scale production with stable product quality. However, the high-pressure homogenization method requires specialized equipment, which is costly, and during the operation, it is necessary to control parameters such as pressure and temperature to avoid damage and oxidation of liposomes.

3

 

Extrusion method

Extrusion method is to pass a liposome suspension through a filter membrane with a specific pore size under a certain pressure. Liposome particles are subjected to shear and extrusion forces when passing through a filter membrane, resulting in a decrease in particle size. By selecting filter membranes with different pore sizes, the final particle size of liposomes can be controlled. The extrusion method is simple to operate and can obtain liposomes with uniform particle size distribution. This method causes minimal structural damage to liposomes and can effectively maintain their integrity. However, the processing speed of extrusion method is relatively slow, which may require longer processing time for large-scale production.

4

 

Microfluidic method

Microfluidics is the use of microscale channels to control the flow and mixing of fluids. In microfluidic chips, liposome precursor solutions and buffer solutions can be mixed in microchannels at specific ratios and flow rates to form liposomes. By precisely controlling the geometric shape, flow rate, and other parameters of microchannels, precise regulation of liposome particle size can be achieved. Microfluidic method has high controllability and accuracy, and can prepare liposomes with uniform particle size and good monodispersity. In addition, microfluidic methods can also achieve continuous production of liposomes with high production efficiency. However, the manufacturing and maintenance costs of microfluidic devices are high, requiring professional technicians to operate them.

Core ingredient: Vitamin C

Vitamin C (L-ascorbic acid) is an important water-soluble vitamin with multiple physiological functions in the human body. It is a potent antioxidant that can eliminate free radicals in the body and protect cells from oxidative damage. Free radicals are harmful substances produced during human metabolism, which can attack biological macromolecules such as cell membranes, proteins, and DNA, leading to cell damage and the occurrence of diseases. Vitamin C exerts antioxidant effects by donating electrons to free radicals, converting them into stable substances.

• Particle size regulation and component engineering are interrelated and influence each other in the preparation of Liposomal Vitamin C Tablets. The selection and ratio of ingredients can affect the physical and chemical properties of liposomes, thereby affecting the effectiveness of particle size regulation. For example, different types and ratios of phospholipids can lead to varying fluidity and flexibility of liposome membranes, thereby affecting the deformation and rupture behavior of liposomes during particle size regulation.
• Meanwhile, particle size regulation can also affect the release and absorption of components in the body. Appropriate particle size can facilitate better interaction between liposomes and cells, promoting the release and absorption of vitamin C. For example, nanoscale liposomes can more easily penetrate cell membranes and deliver vitamin C directly into cells, improving bioavailability.
• Therefore, in the development and production process of liposome vitamin C tablets, it is necessary to comprehensively consider both particle size regulation and component engineering. By optimizing the composition and particle size of the components, products with high absorption, good stability, and safety can be prepared.

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