P-Toluenesulfonamide Powder CAS 70-55-3

The most fundamental and widespread use lies in organic synthesis, which is a key precursor or intermediate for multiple important chemicals.
1.1 Synthesis of Chloramine-T
Chloramine-T, also known as the sodium salt of N-chloro-p-toluene sulfonamide (CH3C6H4SO2NClNa), is soluble in water and is a widely used disinfectant. It is usually supplied externally in a 0.2% dilute solution. Chloramine-T can be obtained through chlorination reaction, which is the most consumed single use of p-toluenesulfonic acid amide in industry.

On this basis, dichloroamine-T (N, N-dichloro-p-toluene sulfonamide, CH3C6H4SO2 NCl2) can be further synthesized, which is insoluble in water but soluble in organic solvents (such as chlorinated paraffin) and can be used for spray disinfection; And N, N-dichloro-p-carboxylbenzenesulfonamide (HOOCC6H4SO2NCl2), commonly used as a disinfectant for drinking water. These three types of chloramine disinfectants form a complete family of disinfection products, and their sources all point to p-toluenesulfonic acid amide.

1.2 Synthesis of Chloramphenicol Aminosulfonamide (Tevenel)
It is an important raw material for the synthesis of chloramphenicol sulfonamide.

Sulfamethoxacin is a sulfonamide antibiotic that is synthesized through a specific organic route. P-toluenesulfonamide is converted by sulfonamide groups and coupled with the chloramphenicol core to form this pharmaceutical intermediate.
1.3 Synthesis of Fluorescent Dyes
Can be used as one of the raw materials for the synthesis of fluorescent dyes. Its sulfonamide group can participate in coupling, diazotization and other reactions under specific reaction conditions, generating organic compounds with fluorescent properties, which are widely used in fields such as fluorescent labeling and detection reagents.

1.4 Synthetic Saccharin
It can also be used for the synthesis of saccharin. In the classic process of saccharin synthesis, o-toluenesulfonylamide undergoes oxidation, cyclization and other steps to produce saccharin, while p-toluenesulfonylamide can also be used as a starting material or intermediate in some process routes to participate in the reaction.
1.5 Synthetic detergent
It also plays a role in the production of synthetic detergents and can be used as a functional additive in detergent formulations to enhance the cleaning performance of products.

It is a high-quality plasticizer for various polymer materials, and its plasticizing effect varies depending on the resin system.
2.1 PVC Plasticizers and Stabilizers
It is a plasticizer and stabilizer for PVC, with outstanding characteristics of excellent thermal stability and weather resistance, good compatibility with PVC, and fast plasticization speed. Its plasticizing temperature is lower than that of diisooctyl phthalate (DOP) and epoxy fatty acid octyl ester, and it is mainly used for PVC film, artificial leather and other products.

As a solid plasticizer, it has low volatility and can endow PVC products with excellent weather resistance, mechanical properties, and electrical insulation. It is suitable for products such as artificial leather, film, wire and cable materials, shoe soles, etc. However, it tends to turn slightly yellow when exposed to strong light and has lower cold resistance than DOP. Therefore, it is often used in combination with phthalate plasticizers, with a dosage of generally 10-30 parts. In addition, it can also be used as a plasticizer for natural rubber and synthetic rubber to improve the low-temperature flexibility and resilience of rubber products.

2.2 Thermosetting Plastic Solid Plasticizer
It is an excellent solid plasticizer for thermosetting plastics, suitable for resin systems such as phenolic resin, melamine resin, urea formaldehyde resin, and polyamide. A small amount of coordination can improve processability, make curing uniform, and give the product a good luster. It is worth noting that it is incompatible with polyvinyl chloride and vinyl chloride copolymers, and partially compatible with cellulose acetate and nitrocellulose.
2.3 Polyamide specific plasticizers
It is one of the most suitable plasticizers for polyamide. Its low melting point helps improve the processability of the resin, and the flexibility of the product is good.

At the same time, toluene sulfonamide has excellent thermal stability (heat-resistant temperature>150 ℃) and photostability, which can improve the heat resistance of polyamide.

2.4 Cellulose paint plasticizer
Used for nitrocellulose paint, it can obtain a relatively obvious softening point, and when combined with dibutyl phthalate, it can improve softness. The compatibility in ethyl cellulose is slightly lower than 50 parts, which can endow the product with suitable softness, hardness, and photostability; Although the compatibility in cellulose acetate is low (<25 parts), its water resistance can still be improved.

Mainly used as a toughening agent for synthesizing water-soluble melamine formaldehyde resin. By introducing p-toluenesulfonylamide into the resin molecular chain, the toughness and processability of the resin can be significantly improved, making it perform better in applications such as coatings and adhesives. This use is particularly common in the fields of wood panel processing and industrial coatings.

P-toluenesulfonamide is an anti mold and antibacterial agent for resins and coatings. Adding p-toluenesulfonylamide to the coating formula can effectively inhibit the deterioration of the coating caused by mold growth during storage and use, and extend the shelf life of the coating. Its bactericidal mechanism is related to the interference of sulfonamide groups on microbial metabolism, and it is widely used in industrial coatings due to its low toxicity and high safety.