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October 28, 2025
4-Fluorotropacocaine (3-pseudotropyl-4fluorobenzoate), molecular formula C15H18FNO2, CAS 172883-97-5. From the appearance, it usually appears as a white or almost white crystalline solid. This color is due to the presence of fluorine atoms in its molecules, which causes the compound to have no strong absorption in the visible light region, resulting in a nearly colorless state. Meanwhile, its crystallinity indicates that the compound has a regular molecular arrangement in its solid state, which is also a manifestation of its intermolecular interactions. It has a higher solubility in polar solvents such as ethanol and acetone, while its solubility is lower in non-polar solvents such as petroleum ether and benzene. This is because polar solvents can better interact with the polar part of the compound, thereby increasing its solubility. In addition, as the temperature increases, the solubility of compounds usually increases because high temperatures can reduce the viscosity of solvents, increase the frequency of intermolecular collisions, and facilitate the dissolution process. This compound is flammable and can burn in the air, producing carbon dioxide and water. It can serve as a key intermediate for the synthesis of certain drugs. By further modifying and transforming its functional groups, a series of compounds with specific pharmacological activities can be synthesized, providing an important material basis for the development of new drugs. Due to its unique molecular structure and biological activity, it is widely used in drug development and pharmaceutical processes.
|
Chemical Formula |
C15H18FNO2 |
|
Exact Mass |
263.13 |
|
Molecular Weight |
263.31 |
|
m/z |
263.13 (100.0%), 264.14 (16.2%), 265.14 (1.2%) |
|
Elemental Analysis |
C, 68.42; H, 6.89; F, 7.22; N, 5.32; O, 12.15 |
|
Morphological |
powder |
|
Color |
white to pale yellow powder |
|
Melting point |
50.0 to 55.0 ° C |
|
Boiling point |
166 ° C / 7mmhg (lit.) |
|
Density |
1.092 ± 0.06 g / cm3 (predicted) |
|
Storage conditions |
insert atmosphere |
|
solubility alcohol |
room temperature |
|
Acidity coefficient ( pKa ) |
9.95 ± 0.18 (predicted) |
4-Fluorotropacocaine, named 3-pseudotropyl-4fluorobenzoate in English, mainly acts as antioxidant in cosmetics and skin care products. Which is relatively safe and can be used safely. It has no effect on pregnant women, and 4-Butylresorcinol has no acne.
Before melanin synthesis
It interferes with the synthesis and glycosylation of tyrosinase to prevent the enzyme from being absorbed by melanin.
During melanin synthesis
Inhibition of enzyme activity, as a competitive inhibitor of tyrosinase and trp1 enzyme, reduces the formation of promelanogenic byproducts.
After melanin synthesis
Tyrosinase degradation was increased, the transfer of melanin to keratinocytes was inhibited, and the photostripping effect was due to the effect of fatty acids. This function is enhanced by the presence of fatty acids and regulates the degradation of tyrosinase.
In the field of materials science, 3- (p-fluorobenzoyloxy) tropine can be used as a component of functional materials, providing possibilities for improving and enhancing material properties.
Polymer material modifiers
3-(p-Fluorobenzoyloxy) Tropane can react with polymer materials to improve their physical and chemical properties. By introducing it into polymer chains, the thermal stability, mechanical strength, and other properties of materials can be improved, expanding their application areas.
Optoelectronic materials
Due to the certain optoelectronic properties of 3-(p-fluorobenzoyloxy) tropine, it can be used as a component of optoelectronic materials for the preparation of optoelectronic devices and devices. It has potential application value in fields such as solar cells and displays.
Functional coating
In addition, 3-(p-fluorobenzoyloxy) tropine can also be used to prepare functional coating materials. By coating it on the surface of the substrate, it can endow the substrate with specific properties such as waterproofing, anti fouling, wear resistance, etc., improving the performance and lifespan of the substrate.
In the field of chemical analysis, 3- (p-fluorobenzoyloxy) tropine can be used as an analytical reagent or indicator for the detection and analysis of other compounds.
Analytical reagents
Due to its unique chemical properties, 3- (p-fluorobenzoyloxy) tropine can undergo specific reactions with certain compounds, producing products that are easy to observe and detect. Therefore, it can be used as an analytical reagent for qualitative and quantitative analysis of other compounds.
Indicator
In addition, 3- (p-fluorobenzoyloxy) Tropane can also serve as an indicator for detecting the progress and endpoint of chemical reactions. By observing changes in color or other physical properties of the reaction system, the degree of completion of the reaction can be determined, providing a convenient and accurate method for chemical analysis.
4-Fluorotropacocaine powder supplier BLOOM TECH
Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us.
The laboratory synthesis of 3- (p-Fluorobenzoyloxy) Tropane typically involves multiple steps. The following is a possible synthesis route, including detailed steps and corresponding chemical equations:
Fluorobenzoyl chloride is a key intermediate in the preparation of 3- (p-fluorobenzoyloxy) tropine.
C6H5FO2H + SOCl2 → C6H4FClCOCl + HCl
C6H4FClCOCl + KCl → C6H4FClCOCl + KCl + H2SO4
C6H4FClCOCl + H2O → C6H4FClCOOH + HCl
Material:
-Para fluorobenzoic acid
-Sulfonyl chloride (SOCl2)
-Anhydrous potassium chloride (KCl)
Steps:
In a dry round bottomed flask, add para fluorobenzoic acid (which can be dried in sulfuric acid) and add sufficient amount of thiol chloride.
01
Stir the mixture at room temperature for approximately 1-2 hours.
02
After the reaction is complete, add a small amount of anhydrous potassium chloride to neutralize any remaining sulfuric acid.
03
Dry the product with anhydrous potassium chloride and wash it with an alkaline aqueous solution.
04
Separate the organic phase, dry it with anhydrous sodium sulfate, and then remove the solvent with a rotary evaporator to obtain p-fluorobenzoyl chloride.
05
P-Fluorobenzoyl oxide is another key intermediate in the preparation of 3- (p-Fluorobenzoyloxy) tropine.
C6H4FClCOCl + NaOH → C6H4FClCOONa + HCl
C6H4FClCOONa + CHCl3 → C6H4FClCOOCHCl3 + NaCl
Material:
-P-Fluorobenzoyl chloride
-Sodium hydroxide (NaOH)
-Chloroform (CHCl3)
Steps:
1. In a dry round bottomed flask, add p-fluorobenzoyl chloride and sodium hydroxide.
01
2. Slowly add chloroform while stirring the mixture.
02
After the reaction is completed, separate the organic phase and dry it with anhydrous sodium sulfate.
03
4. Use a rotary evaporator to remove the solvent and obtain p-fluorobenzoyl oxide.
04
The final step is to react p-fluorobenzoyl oxide with Tropane to obtain the target product.
C6H4FClCOOCHCl3 + C7H15 + 3TEA → C6H4FCOOC(CH3)3 + C7H15N3 + 3NaCl
Material:
-P-Fluorobenzoyl oxide
-Tropane
-Triethylamine (TEA)
Steps:
In a dry round bottomed flask, add p-fluorobenzoyl oxide and Tropane.
01
Slowly add triethylamine and stir the reaction mixture at room temperature.
02
After the reaction is completed, transfer the mixture to a separating funnel and acidify the organic phase with a dilute hydrochloric acid solution.
03
Separate the organic phase and dry it with anhydrous sodium sulfate.
04
Use a rotary evaporator to remove the solvent and obtain 3-(p-fluorobenzoyloxy) tropine.
05
Through these steps, organic compounds such as 3- (p-fluorobenzoyloxy) tropine can be synthesized. In laboratory operations, it is necessary to pay attention to the use of appropriate safety measures and ensure that the operation is carried out in a well ventilated environment.
What are the side effects of this compound?
Central nervous system impact
Similar to cocaine, this substance may have a central excitatory effect, causing physiological reactions such as increased heart rate, elevated blood pressure, and rapid breathing in users. Long term use or excessive intake may lead to overexcitement of the central nervous system, which in turn can cause psychological symptoms such as anxiety, tension, and restlessness. This substance may interfere with normal cognitive function, leading to problems such as scattered attention, decreased memory, and confused thinking. In terms of emotions, users may experience abnormal symptoms such as emotional fluctuations, irritability, depression, or mania. At the same time, it may have a high degree of addiction, making it difficult for users to break free from their dependence on it. After addiction, users may experience strong cravings, withdrawal symptoms (such as anxiety, irritability, insomnia, etc.), and resort to any means necessary to obtain medication.
Effects on the cardiovascular system
Long term use or excessive intake of this substance may cause damage to the cardiovascular system, increasing the risk of cardiovascular events such as heart disease and stroke. This substance may cause serious cardiovascular problems such as arrhythmia and myocardial ischemia. It may cause an increase in blood pressure, and long-term hypertension can damage blood vessel walls, increase the risk of arteriosclerosis, vascular rupture, and other conditions. Vascular injury may lead to poor blood circulation, which in turn affects the blood supply to various organs throughout the body.
Effects on the digestive and respiratory systems
In extreme cases, it may lead to inhibition of the respiratory center, causing difficulty breathing or even respiratory failure. Long term use or excessive intake may also lead to lung damage and affect respiratory function. After use, users may experience digestive discomfort symptoms such as nausea and vomiting. These symptoms may be related to the stimulation of the gastrointestinal mucosa by medication. This substance may suppress appetite and cause weight loss for users. Long term loss of appetite and weight loss may lead to health problems such as malnutrition and weakened immunity.
The impact on the urinary system and immune system
This substance may be metabolized and excreted through the kidneys, and long-term use or excessive intake may cause damage to the kidneys. Kidney injury may lead to serious health problems such as renal dysfunction and uremia. Long term use may lead to a decrease in the user's immune system and an increased risk of contracting diseases. Immune decline may also lead to autoimmune diseases and other issues.
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