Clascoterone powder is a chemical substance with the chemical name 17- (1-oxopropyl) -17-hydroxyandrost-4-, 16-en-3-one. White or off white crystalline powder, molecular formula C24H34O5, CAS 19608-29-8. Very low solubility in water, but good solubility in organic solvents such as methanol, chloroform, ethanol, ether, etc. It is an important organic compound with various biological activities. It is an artificially synthesized adrenergic β 2 receptor agonist used as a synthetic drug for the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other respiratory diseases. It can dilate bronchial smooth muscle, reduce bronchial spasms, and alleviate asthma symptoms. It should be noted that currently used for treating skin diseases such as acne, it can only be used under the guidance of a doctor. But the products provided by the laboratory are primary chemical products and are only for laboratory use.
It usually exists in the form of white or off white crystals or crystalline powders. This appearance feature indicates that its molecular structure has high orderliness and stability. A white or off white color usually means that the compound does not contain any obvious impurities or chromophores. Crystallinity indicates that clavulane molecules can form a regular lattice structure in the solid state, which is closely related to their intermolecular interactions.
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Chemical Formula |
C24H34O5 |
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Exact Mass |
402 |
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Molecular Weight |
403 |
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m/z |
402 (100.0%), 403 (26.0%), 404 (2.7%), 404 (1.0%) |
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Elemental Analysis |
C, 71.61; H, 8.51; O, 19.87 |
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As a compound with multiple biological activities, clascoterone powder has shown broad application prospects in multiple fields.
Medical field
1. Treatment of acne vulgaris
Acne vulgaris is a chronic skin disease characterized by excessive sebum secretion, hyperkeratosis, colonization of acne bacteria, and inflammation. As a novel local androgen receptor inhibitor, it has a steroid structure similar to dihydrotestosterone and can inhibit the binding of dihydrotestosterone to androgen receptors in vitro. This inhibitory effect makes it significantly effective in treating acne vulgaris. Research has shown that 1% of it exhibits good safety and efficacy in the treatment of moderate to severe acne patients. This cream can reduce the number and severity of acne lesions and improve the skin condition of patients. Therefore, it is expected to become a new option for treating acne vulgaris.
2. Treatment of respiratory system diseases
It also demonstrates therapeutic potential for respiratory system diseases. It can be used as an adrenergic β 2 receptor agonist to dilate bronchial smooth muscle, reduce bronchial spasms, and alleviate asthma symptoms. Klaustone binds to the adrenergic β 2 receptor on the membrane of bronchial smooth muscle cells, activating adenylate cyclase in the cells, increasing cAMP levels, and subsequently activating protein kinase A to reduce Ca2+concentration in bronchial smooth muscle cells, achieving the effect of relaxing the bronchi. In addition, it can inhibit inflammatory and allergic reactions, reduce edema and inflammation of airway mucosa, and further improve asthma symptoms. This makes it have broad application prospects in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
3. Other medicinal purposes
In addition to the main uses mentioned above, it may also have other pharmaceutical applications. For example, it can serve as a pharmaceutical intermediate and participate in the synthesis of other biologically active compounds. In addition, it may also have biological activities such as antibacterial, anti-inflammatory, and antioxidant properties, which make it potentially valuable in the field of drug development. However, these potential uses still require further research and validation.
Aquaculture field
In the aquaculture industry, it has also demonstrated its unique bioactive uses. It has the function of promoting the growth of aquatic organisms and saving feed, while also preventing aquatic diseases. This use demonstrates its potential in promoting biological health and improving production efficiency.
1. Promote growth
It can promote the growth and development of aquatic organisms by regulating their physiological functions. It may increase the growth rate and survival rate of aquatic organisms by affecting their endocrine system, metabolic pathways, or immune system. This makes it have a wide range of application prospects in aquaculture, which helps to improve the efficiency and economic benefits of aquaculture.
2. Save feed
It can also reduce feed waste by increasing the utilization rate of aquatic organisms for feed. It may improve the digestion and absorption function of aquatic organisms or regulate their appetite, enabling them to more effectively utilize the nutrients in feed. This not only helps to reduce breeding costs, but also reduces environmental pollution.
3. Prevention of diseases and pests
It also has the function of preventing aquatic diseases. It may reduce the occurrence and spread of diseases by enhancing the immunity of aquatic organisms or inhibiting the growth and reproduction of pathogens. This is of great significance for ensuring the healthy development of aquaculture and improving the quality of aquatic products.
Clascoterone powder is a new type of oral and topical acne treatment drug with the following pharmacological effects:
1. Inhibition of the secretion of sebaceous glands: Clascoterone, as a local androgen receptor antagonist, can inhibit the secretion of sebum by sebaceous glands, thus reducing the condition of acne.
2. Inflammatory effect: Clascoterone can inhibit the inflammatory reaction and alleviate the symptoms of acne inflammation.
3. Antimicrobial effect: Clascoterone can also inhibit the growth and reproduction of acne bacteria, thus reducing the condition of acne.
4. Protect hair follicle cells: Clascoterone can protect hair follicle cells and reduce the damage of acne to hair follicle cells.
In general, the pharmacological action of Clascoterone is mainly to improve the condition of acne by inhibiting the secretion of sebaceous glands, reducing inflammatory reaction, inhibiting the growth of acne bacteria and protecting hair follicle cells.
Clascoterone is a drug for oral and external treatment of acne. Its pharmacokinetic characteristics are as follows:
1. Absorption: Clascoterone can be rapidly absorbed after oral administration, and the time to reach the peak concentration is 2.5 hours. After external use, Clascoterone can be absorbed through the skin, but its absorption rate is slow.
2. Distribution: Clascoterone can be distributed throughout the body and can enter the skin and sebaceous gland tissue.
3. Metabolism: Clascoterone is mainly metabolized in the liver to form a variety of metabolites, of which 3-OH-Classcoterone is the most important active metabolite.
4. Excretion: Clascoterone and its metabolites are mainly excreted through liver and kidney.
5. Dose dependence: The blood concentration of Clascoterone is positively correlated with its dose. Within the safe range, the higher the dose of Clascoterone, the more obvious its inhibition of sebaceous gland secretion and anti-inflammatory effect.
In general, Clascoterone has good absorption, distribution and metabolism, and has a certain dose dependence in vivo. These characteristics have an important impact on the effect of its treatment of acne.
Clascoterone powder (17-(1-oxopropyl)-17-hydroxyandro-4,16-en-3-one) is a synthetic compound. Its synthetic route is as follows:
1. 3-hydroxy-1-propenol was synthesized from propenol by hydroxylation.
2. 1,3-dimethoxy-5-hydroxy-7,8-dihydro-4H-2-benzopyran-4-one was synthesized from 3-hydroxy-1-propanol through multi-step reaction.
3. Clascoterone was synthesized from 1,3-dimethoxy-5-hydroxy-7,8-dihydro-4H-2-benzopyran-4-one through multi-step reaction.
The synthetic route of Clascoterone is relatively complex, requiring superb chemical technology and strict control of reaction conditions. In addition, cost, yield, purity and other factors need to be considered in industrial production.
Clascoterone is a synthetic compound, and its laboratory synthesis route is as follows:
1. 4-en-3,17-dione and vinyl methyl ether were reduced and alcoholized in the presence of sodium acetate to produce 17-hydroxy-4-enone.
2. 17-(1-bromopropyloxy)-4-enone was synthesized by reacting 17-hydroxy-4-enone with 3-bromopropylic acid.
3. The 17-(1-bromopropyloxy)-4-enone and benzyltrimethylammonium salt are subject to the bromination reaction under the catalysis of alkali to generate 17-(1-oxopropyl)-4-enone.
4. The partial hydrolysis of 17-(1-oxopropyl)-4-enone under the catalysis of sodium hydroxide and the esterification reaction of acetic anhydride were carried out to produce Clascoterone.
It should be noted that when these chemical reactions are carried out in the laboratory, the reaction conditions and operation safety need to be strictly controlled to ensure the high yield and purity of the reaction.
Clascoterone powder is a synthetic compound with certain reaction properties. The following are some reaction properties of Clascoterone:
Oxidation reaction:
Clascoterone is easy to be oxidized, and can be oxidized to corresponding carboxylic acid or keto acid by various oxidants (such as hydrogen peroxide, benzoyl peroxide, etc.).
Reduction reaction:
Clascoterone can be reduced to its corresponding alcohol by a variety of reducing agents (such as sodium sulfite, hydrogen, aluminum, etc.).
Thermal decomposition reaction:
Clascoterone undergoes decomposition reaction at high temperature (about 200 ℃) to produce a variety of different products.
Other reactions:
Clascoterone can also be converted by heating, alkali treatment, acid treatment and other reactions.
It should be noted that in the laboratory or industry, the reaction of Clascoterone requires strict control and safe operation to avoid safety accidents. In addition, Clascoterone is currently used to treat skin diseases such as acne, and can only be used under the guidance of a doctor.
Frequently Asked Questions
Is clascoterone the same as spironolactone?
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Spironolactone has long been the only androgen receptor inhibitor used for acne treatment. The main difference between clascoterone and spironolactone is that spironolactone is an oral agent, and this can cause more systemic side effects.
Is clascoterone cream a steroid?
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Clascoterone is a steroidal antiandrogen, or antagonist of the androgen receptor (AR), the biological target of androgens such as testosterone and dihydrotestosterone (DHT).
What should I avoid while using clascoterone cream?
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Avoid applying WINLEVI Cream to damaged skin (such as cuts, abrasions), eczematous areas, and sunburned skin. Avoid concomitant use of other potentially irritating topical products (medicated or not). Important Information: WIN LEVI cream is for use on the skin only (topical).
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