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Myricetin powder, also known as Yangmei bark extract, has a molecular formula of C15H10O8 and a CAS of 529-44-2. It is one of the active ingredients extracted from the stems and leaves of Tengcha or Yangmei bark and leaves, and is a flavonoid alcohol compound. It has the effects of protecting the liver, reducing enzymes and yellowing, and improving immune function. Modern pharmacological research has shown that myricetin has a wide range of pharmacological activities, as well as multiple effects such as anti-inflammatory, analgesic, anti-tumor, hypoglycemic, and hepatoprotective effects, especially in the prevention and treatment of cardiovascular diseases. Due to its antioxidant function and cholesterol lowering effects, myricetin has been marketed as a health food in Europe, especially in some Mediterranean countries, but there is still no related drug on the market, so it has great potential for development and application. In addition to pharmacological activity, there have been many beneficial explorations and achievements in the research of myricetin in other fields, such as the mature extraction, separation, and purification process of myricetin, and the successful application of high-performance liquid chromatography, mass spectrometry, cyclic voltammetry, and multiple methods in the analysis of myricetin; Progress has also been made in the research of Yangmei Su's drop pills, dispersible tablets, cyclodextrin inclusion complexes, and nanoliposomes.
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Chemical Formula |
C26H44O9 |
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Exact Mass |
500.30 |
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Molecular Weight |
500.63 |
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m/z |
500.30 (100.0%), 501.30 (28.1%), 502.31 (2.7%), 502.30 (1.8%), 502.31 (1.1%) |
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Elemental Analysis |
C, 62.38; H, 8.86; O, 28.76 |
Safety and Toxicity
Acute toxicity: Animal experiments have shown a relatively high LD50 value, indicating a lower acute toxicity
Chronic toxicity: Long-term high-dose intake may affect liver and kidney functions (dosage needs to be controlled)
Special groups: Pregnant women, lactating women and children should use with caution
Drug interactions: It may have a synergistic effect with anticoagulants, hypoglycemic drugs, etc., and should be used under the guidance of a doctor
Myricetin powder, also known as yangmei bark extract or yangmei flavonoids, is a flavonol compound extracted from the bark of yangmei, a plant in the Myriaceae family. Its molecular formula is C15H10O8 and its molecular weight is 318.24. Yangmei extract has various pharmacological activities and biological functions, and is widely used in fields such as medicine, food, health products, and cosmetics.
The Application Of Myricetin In The Field Of Medicine
(1) Antioxidant effect
Yangmei extract has strong antioxidant properties, which can eliminate free radicals in the body and protect cells from oxidative damage. This characteristic makes it potentially valuable for the prevention and treatment of diseases related to oxidative stress. For example, myricetin can slow down the aging process, protect the cardiovascular system and reduce the risk of atherosclerosis.
(2) Anti inflammatory effect
Yangmei extract has significant anti-inflammatory effects, which can inhibit inflammatory reactions and alleviate inflammatory symptoms. This characteristic makes it potentially valuable in the treatment of inflammatory diseases such as arthritis and rheumatoid arthritis. In addition, myricetin can also be used to treat oral inflammation such as oral ulcers and gingivitis.
(3) Antitumor effect
Yangmei extract has anti-tumor effects, which can inhibit the growth and proliferation of tumor cells and induce tumor cell apoptosis. This characteristic makes it potentially valuable in the treatment of cancer. Studies have shown that myricetin can inhibit the growth of many tumor cells, such as breast cancer, lung cancer, liver cancer, etc.
(4) Hepatoprotective effect
Yangmei extract has a hepatoprotective effect, which can alleviate liver damage, promote liver cell repair and regeneration. This characteristic makes it potentially valuable in the treatment of liver diseases such as hepatitis and cirrhosis. In addition, myricetin can also reduce the damage of alcohol to the liver and prevent the occurrence of alcoholic liver disease and fatty liver disease.
(5) Hypoglycemic effect
Yangmei extract has a hypoglycemic effect, which can regulate blood sugar levels and improve insulin resistance. This characteristic makes it have potential application value in the treatment of diabetes and its complications. Studies have shown that myricetin can reduce blood glucose levels, improve insulin sensitivity, and reduce the risk of complications in patients with diabetes.
(6) Antagonistic effect of antiplatelet activating factor (PAF)
Yangmei extract can antagonize platelet activating factor (PAF), thereby inhibiting platelet aggregation and activation, and reducing the risk of thrombosis. This characteristic makes it potentially valuable for the treatment of cardiovascular diseases.
(7) Other pharmacological effects
In addition, myricetin also has various pharmacological activities such as anti mutation, prevention of dental caries, and elimination of free radicals in the body. These characteristics make it widely applicable in the prevention and treatment of various diseases.
The application of myricetin in the food industry
(1) Food additives
Yangmei extract can be used as a food additive to increase the antioxidant and stability of food. For example, adding myricetin to foods such as fats, meat products, dairy products, etc. can extend their shelf life and prevent oxidation and spoilage.
(2) Functional food
Yangmei extract can also be used as a raw material for functional foods to develop foods with antioxidant, anti-inflammatory, anti-tumor and other functions. These functional foods can meet the health needs of specific populations, such as the elderly and chronic disease patients.
(3) Natural pigments
Yangmei extract has a certain staining effect and is not easily faded. Therefore, it can be used as a natural pigment for coloring in fields such as food, beverages, cosmetics, etc.
Application Of Yangmei Extract In The Field Of Health Products
(1) Antioxidant health products
Myricetin powder, as an antioxidant, can be added to health products to enhance the body's antioxidant capacity and prevent oxidative stress-related diseases. These health products are suitable for the elderly, people who have long-term exposure to radiation or chemicals, etc.
(2) Anti inflammatory health products
Yangmei extract has anti-inflammatory effects and can be added to health products to alleviate inflammation symptoms and promote inflammation recovery. These health products are suitable for patients with inflammatory diseases such as arthritis and rheumatoid arthritis.
(3) Anti tumor health products
Yangmei extract has anti-tumor effects and can be added to health products to assist in the treatment of cancer and improve the quality of life of patients. These health products are suitable for cancer patients and their families.
(4) Liver Protection and Health Products
Yangmei extract has hepatoprotective effects and can be added to health products to protect liver health and prevent liver diseases such as hepatitis and cirrhosis. These health products are suitable for people who drink alcohol for a long time and take hepatotoxic drugs.
(5) Other health products
In addition, myricetin can also be added to other types of health products, such as hypoglycemic health products, antiplatelet health products, etc., to meet the health needs of different populations.
The Application Of Myricetin In The Field Of Cosmetics
(1) Whitening effect
Yangmei extract has a whitening effect on the skin and can be added to cosmetics to improve uneven skin tone, pigmentation, and other issues. These cosmetics are suitable for people with dark skin and more pigmentation.
(2) Antioxidant effect
Yangmei extract, as an antioxidant, can be added to cosmetics to protect the skin from oxidative damage and delay skin aging. These cosmetics are suitable for people who are exposed to sunlight for a long time and have severe environmental pollution.
(3) Anti inflammatory effect
Yangmei extract has anti-inflammatory effects and can be added to cosmetics to alleviate skin inflammation and promote skin recovery. These cosmetics are suitable for people with skin inflammations such as acne and eczema.
(4) Other functions
In addition, myricetin can also be added to other types of cosmetics, such as moisturizing cosmetics, anti wrinkle cosmetics, etc., to meet the beauty needs of different groups of people.
The extraction and purification of myricetin powder is a complex process involving multiple steps and techniques. The following is a detailed introduction to the extraction and purification of myricetin:
1. Extraction method of myricetin
The water extraction method is a low-cost and safe extraction method, which is very suitable for industrial production. However, this method has low extraction efficiency, high impurities, and is prone to mold growth. Therefore, after extraction, it usually needs to be treated with ethanol precipitation before proceeding to the next step of separation and purification.
The organic solvent extraction method uses organic solvents (such as ethanol, methanol, etc.) to extract myricetin. This method has high extraction efficiency, but the cost is also relatively high, and attention needs to be paid to solvent recovery and environmental protection issues.
Ultrasonic extraction method utilizes the cavitation, acceleration, and direct flow effects of ultrasonic waves to create disturbance effects on the liquid and solid-liquid interface, allowing the extracted substance to enter the solvent and thereby increase extraction efficiency. This method has the advantages of high extraction efficiency and easy operation.
Microwave extraction method utilizes the penetrability and selective heating characteristics of microwaves to rapidly heat up and break down cell walls in the microwave field, thereby accelerating the extraction process. This method has the advantages of fast extraction speed and low energy consumption.
Supercritical fluid extraction method uses supercritical fluid (such as supercritical carbon dioxide) as a solvent to extract myricetin. This method has the advantages of high extraction efficiency, no pollution, and easy recycling, but the equipment cost is relatively high.
2. Purification method of myricetin
The solvent extraction method utilizes different solvents to separate myricetin and other impurities based on their solubility differences. This method is easy to operate, but attention should be paid to the selection and recovery of solvents.
The silica gel column chromatography method uses silica gel as an adsorbent to separate myricetin and other impurities based on the difference in adsorption capacity on the silica gel. This method has good separation effect, but the operation is more complicated.
Polyamide column chromatography uses polyamide as an adsorbent to separate myricetin and other impurities based on the difference in adsorption capacity on polyamide. This method has the advantages of good separation effect and easy operation.
Sephadex gel column chromatography uses Sephadex gel as adsorbent to separate myricetin and other impurities according to the molecular sieve effect on Sephadex gel. This method is suitable for separating compounds with significant differences in molecular weight.
HPLC is a highly sensitive separation and analysis method that can separate myricetin powder and other impurities based on the difference in distribution coefficients between the stationary and mobile phases. This method has good separation effect, but the equipment cost is relatively high.
Yangmei extract, also known as Yangmei bark extract or Yangmei flavonoids, is a 3,5,7,3 ', 4', 5 '- hexahydroxyflavone widely found in natural plants such as Yangmei, Vitaceae, and Leguminosae. It is soluble in methanol, acetone, and ethanol, but insoluble in chloroform and petroleum ether. A large number of studies have shown that myricetin has a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, anti-cancer, analgesic, liver protective and bacteriostatic activities. At the same time, myricetin can also reduce postprandial blood glucose levels and prevent diabetes.
Effect and Function:
Yangmei extract is a common naturally occurring flavonoid compound found in vegetables, tea, fruits, and wine. In both in vivo and in vitro studies, it has been proven to have various pharmacological activities, including anti-inflammatory, anti-tumor, antibacterial, antiviral, anti obesity, cardiovascular protection, prevention of nerve damage, and liver protection biological functions. Yangmei extract has been approved as a natural health product ingredient in Canada, and health promoting products mainly composed of Yangmei extract are circulating in the European and American markets.
Yangmei extract is generally believed to be more involved in anti osteoporosis and bone health compared to other flavonoids such as resveratrol or quercetin.
The US FDA has widely applied myricetin in pharmaceuticals, food, health products, and cosmetics. Foreign health products and American health products FYI have used myricetin as an additive to treat and prevent arthritis and various inflammations, especially suitable for pregnant and lactating women and infants. Heaven high-purity myricetin has been widely used in the fields of food, medicine, and daily chemical products.
Yangmei extract is a naturally occurring flavonoid compound that has a chemopreventive effect on chronic colitis and inflammation driven colon cancer. Yangmei extract can prevent the occurrence of ulcerative colitis and colon tumors without any side effects.
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