Phenacetin crystal is a white crystalline solid at room temperature, insoluble in water, slightly soluble in ether, slightly soluble in boiling water, soluble in ethanol and chloroform. When dissolved in concentrated sulfuric acid, it did not show color, and it was orange after dropping nitric acid into the solution. Odorless, bitter taste. Sometimes used for hair dyes. In addition, phenacetin is typically present in solution, and its appearance and color may vary depending on the solvent used. It is a relatively insoluble substance, but it can be completely or partially dissolved in many other solvents. In water, the solubility of Phenacetin is relatively low, only 0.076 g/L at 20 ° C. However, when Phenacetin is mixed with some organic solvents (such as alcohol, ether, chloroform, etc.), its solubility significantly increases. In addition, phenacetin can also improve its solubility through crystallization or through the conversion of another compound. We are phenacetin suppliers and produce our own chemical experiments, so we have phenacetin powder for sale and can provide online sales services for phenacetin. If you want to buy a phenacetin powder, please send us an email and we will provide you with the most reasonable phenacetin price.
|
CF |
C10H13NO2 |
|
EM |
179.09 |
|
MW |
179.22 |
|
m/z |
179.09 (100.0%), 180.10 (10.8%) |
|
EA |
C, 67.02; H, 7.31; N, 7.82; O, 17.85 |
| Melting Point | 133-136 °C (lit.) |
| Boiling Point | 132 °C / 4mmHg |
| Density | 1.1248 (rough estimate) |
| Refractive Index | 1.5710 |
| Flash Point | 2℃ |
| Storage Conditions | Sealed in dry,Room Temperature |
| Solubility | Soluble in chloroform (a little), methanol (a little) |
| Acidity Coefficient (pKa) | pKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain) |
| Water Solubility | 0.076 g/100 mL |
| Stability | Stable. Incompatible with strong oxidants and acids. |
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Synthesis methods
Phenacetin Crystal can be synthesized by vortex hydrochloric acid method. The method obtains cumene chloride by reacting cumene with hydrochloric acid, and then reacts cumene with methyl-p-phenylenediamine to obtain N-isopropyl-N-(4-methylaminophenyl) formamide, Finally Phenacetin is obtained by heating and adding base. The following are the specific steps:
- Step 1: Reaction of cumene and hydrochloric acid: cumene and hydrochloric acid react in the presence of sulfuric acid to produce cumene chloride.
C6H5CH(CH3)2 + HCl → ClC6H4CH(CH3)2
- Step 2: Reaction of cumene and methyl-p-phenylenediamine: reaction of cumene and methyl-p-phenylenediamine in tetrahydrofuran to generate N-isopropyl-N-(4-methylaminophenyl) Formamide.
ClC6H4CH(CH3)2 + C6H4(NHCH3)2 → HCl + C6H4(CONH(CH3)C6H4NH2)
- Step 3: Heating and base treatment: N-isopropyl-N-(4-methylaminophenyl)formamide is heated and base is added to obtain Phenacetin.
C6H4(CONH(CH3)C6H4NH2)+ NaOH → C6H4(CONH(CH3)C6H4NH2)Na + H2O
C6H4(CONH(CH3)C6H4NH2)Na + CH3CO2H → C6H4(CONH(CH3)C6H4NH2)H + NaOAc
C6H4(CONH(CH3)C6H4NH2)H → C6H4(O)NH(C2H5) + CH3CO2HC2H5
The reaction injection method is a simple and efficient method for the synthesis of Phenacetin. It uses phenol and N-acetylacetonolamine as raw materials to prepare Phenacetin Crystal by reaction injection. The following are the specific steps:
- Step 1: Amidation reaction: N-acetylacetonolamine and phenol undergo amidation reaction in tetrahydrofuran to generate N-(4-hydroxyphenylacetyl)acetonolamine.
C6H5OH + CH3COCH2NHC2H5 → C6H5OC(CH3)NH(C2H5)CH2CH3 + H2O
- Step 2: Cyclization reaction: N-(4-hydroxyphenylacetyl)acetonolamine undergoes a cyclization reaction by heating to generate Phenacetin.
C6H5OC(CH3)NH(C2H5)CH2CH3 → C6H5OC2H5 + H2NCH2CH2COCH3
H2NCH2CH2COCH3 → C6H5OC2H5 + C2H5CONHCH2CH2NH2
C6H5OC2H5 + C2H5CONHCH2CH2NH2 → C6H5OC2H4NHCONHC2H5 + CH3CH2OH
C6H5OC2H4NHCONHC2H5→ C6H4(O)
Pain Relief
Phenacetin exhibits analgesic properties by inhibiting the synthesis of prostaglandins, chemical messengers that contribute to pain and inflammation. By reducing the production of prostaglandins, Phenacetin is able to relieve mild to moderate pain, including headaches, toothaches, menstrual cramps, and muscle pain.
Fever Reduction
In addition to its analgesic properties, Phenacetin also possesses antipyretic effects. It acts on the hypothalamic thermoregulatory center, inhibiting the synthesis and release of neurotransmitters like serotonin that regulate body temperature. This allows the body's temperature set-point to be lowered, resulting in fever reduction.
Anti-Inflammatory (Limited)
While Phenacetin is not a potent anti-inflammatory agent, it can exhibit mild anti-inflammatory properties by reducing the synthesis of prostaglandin E2, a mediator of inflammation. However, its anti-inflammatory effect is relatively weak compared to other drugs.
Antiplatelet Aggregation
Phenacetin has been shown to inhibit the biological activity of platelet-activating factors, thereby preventing platelet adhesion and aggregation. This antiplatelet aggregation effect can be beneficial in reducing the risk of thrombosis and cardiovascular events.
Uric Acid-Lowering
Phenacetin may also reduce uric acid levels in the blood by inhibiting the activity of xanthine oxidase, an enzyme involved in uric acid synthesis. However, this effect is not its primary pharmacological action.
Pharmacological Actions: Nonacetin possesses antipyretic and analgesic properties, though it does not have anti-inflammatory or anti-rheumatic effects. It is metabolized in the liver primarily into acetaminophen (paracetamol) and, to a lesser extent, into p-aminophenol ether. In large doses, it can oxidize hemoglobin into methemoglobin, leading to cyanosis and severe oxygen deficiency, particularly in children.
Indications and Contraindications: Nonacetin is primarily used for fever reduction and pain relief. However, due to its relatively high toxicity, it has been largely replaced by acetaminophen and is now only found in certain compound formulations. It is contraindicated in individuals with hypersensitivity to the drug, pregnant or lactating women, those with liver or kidney dysfunction, and those with a history of hemolytic or other blood disorders. Elderly individuals and children should use it with caution.
Adverse Effects: Long-term or excessive use of Nonacetin can lead to adverse reactions such as hemolytic anemia, methemoglobinemia, renal papillary necrosis, and renal pelvic transitional cell carcinoma. Other adverse effects include dizziness, cyanosis, respiratory distress, and occasional allergic reactions.
The research and application of Phenacetin crystal in the field of medicine focuses on its pharmacological effects, clinical applications, and new discoveries in recent years.
1. Pharmacological effects
Phenacetin crystal is an organic compound with antipyretic and analgesic pharmacological effects. It acts mainly by inhibiting the synthesis of prostaglandins in the body, which is a substance closely related to physiological processes such as pain, fever and inflammation. Therefore, they are used clinically to treat mild to moderate pain and fever symptoms.
2. Clinical Applications
Antipyretic and analgesic: Phenacetin crystals have been widely used as antipyretic and analgesic in clinical practice. However, due to its possible side effects (e.g. nephrotoxicity, hematologic toxicity, etc.), its use has now been restricted or banned in some countries and regions. However, Phenacetin crystals may still be used as an antipyretic and analgesic ingredient under certain specific circumstances, such as in certain compound preparations.
Hepatocellular carcinoma risk group detection: Recent studies have found that Phenacetin crystals have potential application in the preparation of drugs for detecting hepatocellular carcinoma risk groups. By detecting the metabolism of finasteride crystals in the human body, the susceptibility of individuals to liver cancer can be assessed. This finding opens up a new direction for the application of finasteride crystals in the medical field.
3. New Discoveries and Research Progress
Metabolism and toxicity study:
With the in-depth study of it, people have gained a more comprehensive understanding of its metabolic process and toxicity mechanism. This helps to guide the clinical use of drugs and reduce the occurrence of side effects.
Drug interaction:
the interaction between finasteride crystals and other drugs is also one of the hot spots of current research. Understanding drug-drug interactions can help avoid the occurrence of adverse reactions and improve the safety and effectiveness of drug therapy.
Novel formulation development:
In order to improve the bioavailability of finasteride crystals and reduce side effects, researchers are developing novel formulations, such as extended-release formulations and targeted formulations. These new formulations are expected to achieve better efficacy in clinical application.
4. Precautions and safety
Although Phenacetin crystals have certain application value in the field of medicine, its potential side effects and safety issues should not be ignored. When using Phenacetin crystals, it should strictly follow the doctor's instructions, pay attention to the dosage and time of administration, and avoid adverse reactions with other drugs. At the same time, pregnant women, lactating women, liver and kidney insufficiency and other special groups should be cautious to use or avoid the use of Phenacetin crystals.
To summarize, the research and application of Phenacetin crystals in the field of medicine has a broad prospect and potential. However, its safety and efficacy still need further research and verification. In the future, with the continuous progress of science and technology and in-depth clinical practice, Phenacetin crystals are expected to play an important role in more fields.
What are the sales channels for this compound?
Research reagent supplier
Many suppliers specializing in scientific reagents offer sales of Phenacetin. These suppliers typically have a well-established sales network and channels, capable of providing high-quality Phenacetin to research institutions, universities, laboratories, and others worldwide. For example, well-known brands such as Klamar reagents are sold through their official websites, e-commerce platforms, and other channels.
Chemical raw material market
Phenacetin, as a chemical raw material, is also traded in some chemical raw material markets. These markets typically gather numerous chemical suppliers and purchasers, providing a rich selection of chemicals. In these markets, Phenacetin may be sold in different specifications and purities to meet the needs of different customers.
International Trade and Export
Due to its extensive application value in scientific research, pharmaceutical manufacturing, and other fields, Phenacetin is also involved in international trade and exports. Some Chinese chemical producers and suppliers will export Phenacetin to other countries to meet the demand of the international market. These export channels usually include international trade companies, freight forwarders, etc.
Online sales platform
With the development of the Internet, online sales platform has become one of the important sales channels of Phenacetin. Some e-commerce platforms and chemical professional websites have sales information for Phenacetin. These platforms provide a convenient shopping experience and rich product information, allowing customers to easily find and purchase the Phenacetin they need.
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