Tianeptine Hemisulfate Monohydrate Powder, also known as Daryl, is a salt derivative of Tianeptine that typically presents as a white or off-white crystalline powder and dissolves readily in water or selected organic solvents. Its primary application is in pharmaceutical research and analytical development, where its stable crystalline form and reliable solubility support laboratory studies and formulation evaluation. Bloomtechz supplies this material with consistent quality and verified specifications, helping researchers and procurement teams source the compound with confidence for their specialized projects.
It is a tricyclic antidepressant that improves depressive symptoms by regulating the reuptake of neurotransmitters such as serotonin and dopamine. Research has shown that tianeptin may have neuroprotective effects, promoting neuronal growth and repair. It also has a certain alleviating effect on anxiety symptoms and is mainly used to treat depression (mild, moderate, or severe). It is also effective in treating depressive neurosis, chronic alcoholism, and depression that occurs after quitting alcohol.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
Additional information of chemical compound:
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Product Name |
Tianeptine Hemisulfate Monohydrate |
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Product Type |
Powder |
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Product Purity |
100g/1kg/etc. |
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Product Form |
Organic synthesis |
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Tianeptine COA
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| Certificate of Analysis | ||
| Compound name | Tianeptine | |
| Grade | Pharmaceutical grade | |
| CAS No. | 66981-73-5 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090087 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.69% |
| Loss on drying | ≤1.0% | 0.88% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.69% |
| Single impurity | <0.8% | 0.35% |
| Total microbial count | ≤750cfu/g | 274 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 757ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Tianeptine Hemisulfate Monohydrate Powder plays an important role in the field of psychiatry. It is a drug with a unique pharmacological mechanism that differs from traditional antidepressants. With the deepening of research on mental illness, the application of Tianeptine in clinical treatment has gradually received attention. The following is a detailed description of its purpose:
The use in the treatment of mental illnesses
Tianeptine is suitable for treating various degrees of depression, including mild, moderate, and severe depression. It not only has therapeutic effects on depression itself, but also has good therapeutic effects on depressive neurosis. In addition, Tianeptine can also have a therapeutic effect on chronic alcohol poisoning and depression symptoms that occur after quitting drinking. In real life, many chronic alcohol poisoning patients may experience depression symptoms such as low mood and anxiety during the process of quitting alcohol. Tianeptine can help them alleviate these symptoms and improve the success rate of quitting alcohol. Compared with traditional tricyclic antidepressants (TCAs), Tianeptine has similar antidepressant efficacy, but better safety and tolerability.
TCA is often accompanied by adverse reactions such as anticholinergic and cardiovascular effects, such as dry mouth, constipation, and tachycardia, while Tianeptine has significantly fewer adverse reactions in these areas. This makes Tianeptine more suitable for long-term use and can improve patients' treatment compliance. Long term use of Tianeptine can prevent the recurrence of depression. Depression is a disease that is prone to recurrence, and patients still need long-term treatment and prevention after symptoms have improved. Tianeptine can fundamentally improve patients' condition and reduce the risk of recurrence by regulating neurotransmitters and promoting neural plasticity.Elderly patients with depression often have multiple physical illnesses and poor tolerance to medication.
Tianeptine has no significant effects on the cardiovascular and cholinergic systems, no drug addiction, and high safety. However, for patients over the age of 70, the dosage should be limited to two tablets per day or as directed by a doctor. This is because the liver and kidney function of elderly people declines, and their drug metabolism and excretion abilities weaken, which can easily lead to drug accumulation in the body and increase the risk of adverse reactions. Tianeptine has a certain effect on personality and behavioral disorders that occur in patients with alcohol poisoning during their abstinence period.Research has shown that even when chronic alcohol poisoning causes cirrhosis, pharmacokinetic parameters remain unchanged in patients, so there is no need to change the dosage.
Tianeptine can help alcohol poisoning patients alleviate emotional problems during the process of quitting, increase the success rate of quitting, and improve the quality of life of patients.
Tianeptine Hemisulfate Monohydrate Powder has good therapeutic effects on anxiety disorders related to depression. It can improve mood disorders and have a significant effect on physical discomfort, especially gastrointestinal discomfort related to anxiety and mood disorders. Many patients with depression often have anxiety symptoms, and Tianeptine can alleviate both symptoms simultaneously, improving the overall treatment effectiveness of patients. For example, some patients with depression may experience gastrointestinal discomfort symptoms such as loss of appetite, abdominal pain, and diarrhea, which are often related to anxiety.
Tianeptine can help patients alleviate anxiety symptoms and improve their quality of life by improving mood disorders and relieving gastrointestinal discomfort. The effective time to improve anxiety symptoms. Studies have shown that Tianeptine's anti anxiety effect is significant in the first weekend. Compared with some traditional anti anxiety drugs, Tianeptine has a faster onset of action, which can alleviate patients' anxiety symptoms more quickly and reduce their pain.
Benzodiazepines have certain therapeutic effects in treating anxiety disorders, but there are adverse reactions such as excessive sedation, memory impairment, and psychomotor impairment. They are also prone to tolerance, abuse, and dependence, and withdrawal symptoms may occur after discontinuation.
Compared with benzodiazepines, Tianeptine does not have these adverse reactions, is less likely to cause traffic accidents, is less prone to tolerance or abuse, dependence, and is less likely to experience withdrawal symptoms after discontinuation.Therefore, Tianeptine has certain advantages in terms of efficacy and safety, and is more suitable for long-term use. Although benzodiazepines can be used as first-line drugs in some cases, they are usually not recommended as the first choice due to their high incidence of adverse reactions. Tianeptine's advantages in efficacy and safety make it have greater potential in the treatment of anxiety disorders and may become one of the first-line drugs for anxiety disorder treatment in the future.Tianeptine has neuroprotective effects and can promote neuronal growth and repair.
It can regulate the remodeling of dendrites in hippocampal and amygdala cells, enhance the spontaneous activity of pyramidal cells in the hippocampus, and accelerate their recovery after functional inhibition. These effects help protect brain neurons and reduce nerve damage. For example, in some neurodegenerative diseases, neurons gradually die and atrophy, and Tianeptine's neuroprotective effect may help slow down the progression of the disease. Based on its neuroprotective effect, Tianeptine has potential application value in the treatment of neurological diseases.For example, in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, neuronal damage and death are important causes of disease progression.Tianeptine may protect neurons, delay disease progression, and improve patients' symptoms.
However, current research in this area is still in its early stages and further clinical trials are needed to verify its efficacy and safety.
Post traumatic stress disorder (PTSD) is a common mental illness, in which patients experience a range of psychological and physiological symptoms after experiencing traumatic events. Tianeptine may be helpful in the treatment of PTSD by regulating neurotransmitters and promoting neural plasticity. It can improve the emotional state of patients, alleviate anxiety and depression symptoms, and enhance their quality of life. Corticosteroids are a commonly used medication, but long-term use may lead to cognitive impairment. The neuroprotective effect of Tianeptine may help alleviate the impact of corticosteroids on cognitive function and improve patients' cognitive abilities. However, further research is needed in this area to determine the specific efficacy and safety of Tianeptine.
The impact on childhood asthma
Related research on improving childhood asthma
Researchers explain that the level of free serotonin in plasma is positively correlated with the severity of symptoms in asthma patients. Tianeptine increases the uptake of 5-hydroxytryptamine by platelets and 5-hydroxytryptamine neurons while reducing the level of free 5-hydroxytryptamine. By regulating the balance of 5-hydroxytryptamine, Tianeptine may improve the neural regulation function of the respiratory tract, alleviate airway inflammation and spasms, and thus alleviate asthma symptoms.
Comparison with other medications for treating childhood asthma
Traditional bronchodilators mainly relieve asthma symptoms by relaxing bronchial smooth muscle,
which takes effect quickly but has a relatively short duration of action.The mechanism of action of Tianeptine is different from traditional bronchodilators. It improves asthma symptoms by regulating neurotransmitters and the immune system. Its onset may be relatively slow, but its duration of action may be longer, and it has potential neuroprotective effects. In addition, traditional bronchodilators may have some adverse reactions, such as palpitations and hand tremors, while Tianeptine has relatively fewer adverse reactions. Corticosteroids are commonly used drugs for treating childhood asthma and have strong anti-inflammatory effects. However, long-term use of glucocorticoids may bring some adverse reactions, such as affecting children's growth and development, increasing the risk of infection, etc. Tianeptine improves asthma symptoms with relatively few adverse reactions and may have neuroprotective effects.
For some pediatric patients who have poor response to glucocorticoid therapy or cannot tolerate glucocorticoid adverse reactions, Tianeptine Hemisulfate Monohydrate Powder may be a feasible alternative treatment option.
Precautions and Drug Interactions
Prohibited Groups: Specific groups that are strictly prohibited from using
Allergic individuals: Those who are allergic to thienopitant or its excipients (such as sulfates, crystalline water components) should not use it. Otherwise, they may experience allergic reactions such as rash, breathing difficulties, and laryngeal edema.
Severely impaired liver and kidney function: The liver and kidneys are the main organs for metabolizing and excreting drugs. When liver and kidney functions are severely compromised, the drug may not be metabolized properly, leading to accumulation and poisoning in the body, and causing liver failure or kidney failure.
Pregnant and lactating women: Animal experiments have shown that thienopitant may affect fetal or infant development through the placenta or breast milk, increasing the risk of malformations or neurological damage.
Substance abusers: Thienopitant has a μ-opioid receptor agonistic effect and may cause euphoria when used in combination. Long-term use may lead to tolerance and dependence, and those with a history of drug or alcohol abuse have a higher risk.
Drug Interactions: High-risk combinations to avoid
Alcohol: Alcohol inhibits the activity of liver metabolic enzymes, slows down the decomposition of thienopitant, leads to an increase in blood drug concentration, enhances sedative effects, and may cause respiratory depression, coma, and even death. For example, those who drink alcohol and use thienopitant simultaneously have a more than threefold increase in the risk of respiratory depression.
Central Nervous System Inhibitors (CNS Depressants):
Benzodiazepines (such as alprazolam, diazepam): Combined use may enhance the sedative effect, leading to confusion, impaired motor coordination, and an increased risk of falls or traffic accidents.
Opioids (such as morphine, fentanyl): Combined use may cause severe respiratory depression, even respiratory arrest, especially at high doses or long-term use, with a higher risk.
Antidepressants:
Monoamine oxidase inhibitors (MAOIs) (such as phenelzine, selegiline): Combined use may trigger serotonin syndrome, characterized by high fever, muscle rigidity, and confusion. Severe cases may require emergency medical intervention.
Selective Serotonin Reuptake Inhibitors (SSRIs) (such as fluoxetine, sertraline): Although the risk is low, combined use may still increase serotonin levels, leading to side effects such as nausea, tremors, and insomnia.
Aspirin: Long-term combined use may inhibit the metabolism of thienopitant, leading to an increase in blood drug concentration, and increasing the risk of side effects such as nausea, vomiting, and headache.
Special Precautions: Scenarios requiring cautious assessment
Driving or operating machinery
Thienopitant may cause drowsiness, dizziness, or impaired concentration, and during use, one should avoid driving or operating precision machinery to prevent accidents.
Long-term use
Long-term use may lead to dependence, and when discontinuing the medication, it is necessary to gradually reduce the dosage to avoid sudden discontinuation, which may trigger withdrawal reactions (such as anxiety, insomnia, tremors).
Legal risks
In regions such as the United States, thienopitant has not been approved for clinical use and is only sold as a dietary supplement. However, some states (such as Tennessee) have classified it as a controlled substance, and illegal possession or sale may face criminal charges.
Reference
[1]Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
[2]O'Neil, M. J. (Ed.). (2013). The Merck index: An encyclopedia of chemicals, drugs, and biologicals (15th ed.). Royal Society of Chemistry.
[3]Moffat, A. C., Osselton, M. D., Widdop, B., & Watts, J. (Eds.). (2011). Clarke's analysis of drugs and poisons (4th ed.). Pharmaceutical Press.
[4]Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (Eds.). (2009). Handbook of pharmaceutical excipients (6th ed.). Pharmaceutical Press.
[5]United States Pharmacopeial Convention. (2023). USP-NF general notices and requirements. United States Pharmacopeia.
Frequently Asked Questions
1. What makes Tianeptine Hemisulfate Monohydrate different from regular Tianeptine powder?
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Tianeptine Hemisulfate Monohydrate is the more stable, higher-purity, and better-soluble pharmaceutical-grade form compared to standard tianeptine base powder. The hemisulfate monohydrate crystal structure delivers improved water solubility, longer shelf life, and stronger batch consistency. For research formulation and compounding use, this grade shows fewer impurities, no easy degradation, and more stable efficacy performance, making it the preferred version for long-term bulk procurement and lab research projects.
2. What are the main applications of Tianeptine Hemisulfate Monohydrate Powder?
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This powder is widely used in neuroscience research, pharmaceutical formulation development, behavioral pharmacology studies, and lab compounding. Researchers mainly utilize it to study mood regulation, neural adaptation, stress response mechanisms, and related neuropharmacological pathways. With its high purity and stable crystal properties, it is ideal for precision experiments, repeated trials, and pre-clinical research, which is why most bulk buyers choose this monohydrate salt form over ordinary tianeptine powder.
3. How pure is your Tianeptine Hemisulfate Monohydrate Powder, and can you provide quality documents?
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Our Tianeptine Hemisulfate Monohydrate Powder reaches high pharmaceutical-grade purity with strict HPLC testing, featuring low moisture, low heavy metals, and zero abnormal impurities. We provide complete supporting documents including COA, HPLC report, MSDS, and production batch records. Every batch is fully tested before delivery to ensure stable quality, consistent solubility, and reliable experimental repeatability-critical for research labs and bulk resale clients.
4. What are your packaging and shipping options for bulk orders?
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We support flexible packaging from small sample sizes to large bulk industrial packages, including 10g, 100g, 1kg, and 25kg specifications. All products are sealed, moisture-proof, light-shielded, and professionally packed for long-distance transportation. We provide global stable shipping, fast delivery, and complete customs documents. For clients with long-term procurement plans, we offer stable batch supply, customized packaging, and exclusive wholesale pricing to reduce your overall costs.
5. Can I get a free sample of Tianeptine Hemisulfate Monohydrate Powder before bulk purchase?
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Yes, we support sample testing orders for clients who need to verify purity, solubility and quality before large-scale cooperation. Samples are delivered with complete test reports so you can validate the product quality for your experiments or market sales. After sample confirmation, we can arrange bulk production and delivery quickly, and provide long-term stable supply solutions to support your continuous research and business development.
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