Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 4-chloro-3-nitrotoluene cas 89-60-1 in China. Welcome to wholesale bulk high quality 4-chloro-3-nitrotoluene cas 89-60-1 for sale here from our factory. Good service and reasonable price are available.
4‑Chloro‑3‑nitrotoluene is a pale‑yellow to brownish‑yellow transparent liquid with a distinctive odor brought by its chlorine and nitro functional groups. It is sparingly soluble in water while dissolvable in alcohols and ethers. Its molecular framework adopts a planar benzene‑ring conformation, with chlorine and nitro substituents lying on the same plane. Bloomtechz supplies high‑purity 4‑Chloro‑3‑nitrotoluene with stable batch‑to‑batch quality, providing reliable material support for both academic laboratory research and large‑scale industrial manufacturing projects.
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Chemical Formula |
C7H6ClNO2 |
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Exact Mass |
171 |
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Molecular Weight |
172 |
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m/z |
171 (100.0%), 173 (32.0%), 172 (7.6%), 174 (2.4%) |
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Elemental Analysis |
C, 49.00; H, 3.52; Cl, 20.66; N, 8.16; O, 18.65 |
4‑Chloro‑3‑nitrotoluene functions as a vital intermediate in pharmaceutical synthesis. Its nitro and chloro moieties act as flexible functional handles, which can undergo selective transformation to install a broad range of pharmacologically active fragments.
Nitro‑group reduction: Reduction of the nitro group affords 4‑chloro‑3‑aminotoluene, a key precursor for antibiotics, anti‑inflammatory drugs and dyestuff molecules.
Nucleophilic aromatic substitution: The chloro substituent is susceptible to nucleophilic substitution to incorporate alternative functional groups, supporting the construction of intricate heterocyclic skeletons present in antipyretic and analgesic pharmaceuticals.
Agrochemical Synthesis
Within the agrochemical industry, this compound is a valuable building‑block for manufacturing herbicides, insecticides and fungicides. Its favorable reactivity enables it to be incorporated into active ingredients designed against specific pests and weeds.
Herbicide precursors: Structural modification generates derivatives that disrupt plant cell division or photosynthesis, delivering effective control against broad‑leaf weeds.
Insecticide intermediates: Further structural elaboration yields molecules targeting insect nervous systems, which suppress pests that inflict damage on agricultural crops.
Thanks to its stable aromatic skeleton and active substituent groups, 4-Chloro-3-nitrotoluene is a high-value intermediate in the dye industry. It is widely processed into azo dyes and functional pigments for textile, leather and paper coloration. Key applications are listed as follows:
Azo Dye Synthesis: It can react with diazonium salts to form azo compounds with vivid color and excellent light fastness, which are ideal for dyeing natural and synthetic fibers.
Pigment Precursors: Further structural functionalization enables the preparation of high-stability and high-vibrancy pigments, which are widely applied in coatings, printing inks and plastic colorants.
Polymer and Materials Science
Polymer Modifiers Reduction of its nitro group generates cross‑linking agents or chain extenders, which effectively improve mechanical performance including tensile strength and impact resistance of polymer materials. For example, the derived amine‑containing intermediates can be introduced into epoxy resin systems, enhancing the fracture‑resistance of epoxy coatings applied for metal anti‑corrosion protection.
Specialty Monomers Thanks to its reactive chloro substituent, it can undergo copolymerization with various co‑monomers. This enables the fabrication of functional materials with custom‑tunable thermal, electrical and optical properties.
While sensitive, the compound's nitro group confers explosive potential, though its use in this capacity is highly regulated. It may serve as a component in:
- High-Energy Materials: Under controlled conditions, it can be part of formulations requiring precise detonation characteristics, though safety and regulatory hurdles are significant.
Research and Development
In academic and industrial laboratories, it is a model compound for studying:
- Aromatic Substitution Reactions: Its reactivity patterns provide insights into electrophilic aromatic substitution, nucleophilic aromatic substitution, and reduction mechanisms.
- Green Chemistry: Efforts to develop safer, more efficient synthetic routes often focus on this compound as a target for process optimization.
as a lubricant additive
Antioxidant properties: It has excellent antioxidant properties and can effectively inhibit the oxidation reaction of lubricating oil under high temperature and aerobic conditions. The oxidation of lubricating oil can cause oil degradation, generate acidic substances and precipitates, and affect lubrication effectiveness and service life. Adding 4 Chloro-3-nitrotoluene can significantly improve the antioxidant performance of lubricating oils, thereby extending their service life.
Wear resistance: It has good wear resistance and can reduce wear on the friction surface, improve the operating efficiency and service life of the equipment. Adding 4 Chloro-3-nitrotoluene to lubricating oil can enhance the anti wear performance of the oil, reduce friction and wear during operation, reduce failure rates, and improve the service life of the equipment.
Thermal stability: It has good thermal stability and can maintain stable chemical properties under high temperature conditions. Adding 4 Chloro-3-nitrotoluene to lubricating oil can improve the thermal stability of the oil, allowing it to maintain good lubrication performance and service life under high temperature conditions.
Viscosity characteristics: It has a certain impact on the viscosity characteristics of lubricating oil. Adding 4 Chloro-3-nitrotoluene can change the viscosity characteristics of lubricating oil, making it more suitable for different usage environments and working conditions. For example, in situations where high viscosity lubricating oil is required, adding 4 Chloro-3-nitrotoluene can increase the viscosity of the lubricating oil and improve the lubrication effect.
Rust resistance: It has certain rust resistance and can prevent equipment from rusting in humid environments. Adding 4 Chloro-3-nitrotoluene to lubricating oil can enhance the rust prevention performance of the oil, allowing the equipment to maintain good rust prevention effects in harsh environments and extend its service life.
Cleanliness: It has certain cleaning performance and can remove dirt and carbon deposits in the lubrication system. Adding 4 Chloro-3-nitrotoluene to lubricating oil can enhance the cleanliness of the oil, keep the lubrication system clean, and improve lubrication efficiency and service life.
Improving fuel combustion performance: As an organic compound, it has a high energy density and combustion performance. Adding it to the fuel can significantly improve the combustion performance of the fuel, increase the power and efficiency of the engine.
Improving fuel oxidation stability: It has good antioxidant performance and can effectively inhibit the oxidation reaction of fuel during storage and use, extending the service life of the fuel.
Reducing engine carbon deposition: It can improve the atomization performance of the fuel, mix the fuel more fully with the air during the combustion process, reduce carbon deposition and coking inside the engine, and maintain the cleanliness and good operating condition of the engine.
Improving fuel octane number: Having a certain octane number can increase the anti knock performance of the fuel, reduce vibration and noise during combustion, and improve engine comfort and fuel economy.
Early studies on 4-chloro-3-nitrotoluene date back to the mid-20th century, when researchers began exploring nitro and chloro substitution reactions on aromatic compounds. The compound's synthesis typically involves nitration of p-acetamidotoluene, followed by diazotization and substitution with copper(I) chloride. This method, refined over decades, remains a cornerstone for its industrial production.In the 1970s and 1980s, interest in 4-chloro-3-nitrotoluene surged due to its role as a precursor for pyrethroid insecticides and herbicide intermediates. Researchers focused on optimizing reaction conditions to improve yield and purity, addressing challenges such as byproduct formation and environmental impact.
These efforts led to the development of greener synthesis routes, minimizing hazardous waste.The 1990s and 2000s saw expanded applications in pharmaceuticals, where it served as a building block for anti-inflammatory and antimicrobial agents. Structural modifications of the compound yielded derivatives with enhanced bioactivity, driving further research into its medicinal potential.Safety and regulatory considerations also shaped its development. The compound's classification as a hazardous material necessitated strict handling protocols, prompting studies on its toxicological profile and degradation pathways. These investigations informed safer storage and transportation practices, ensuring compliance with global chemical regulations.
Today, it continues to be a subject of academic and industrial interest, with ongoing research into its applications in advanced materials and sustainable chemistry. Its history reflects broader trends in organic synthesis-from early exploratory work to modern, efficiency-driven processes-underscoring its enduring relevance in chemical manufacturing.
4-Chloro-3-nitrotoluene is an important organic compound with the chemical formula C₇H₆ClNO₂ and a molecular weight of 171.58. The following elaborates on its chemical properties from five aspects: physical properties, chemical stability, reactivity, solubility, and application fields.
Physical Properties
4-Chloro-3-nitrotoluene appears as a transparent yellow liquid at room temperature. Some sources also describe it as a yellow oily liquid. Its density is approximately 1.297 g/cm³ (at 25°C), its melting point is 7°C, its boiling point is 260°C (at 99.3 kPa pressure) or 118°C (at 1.47 kPa pressure), and its flash point is 113.93°C. These physical properties indicate that the compound is relatively stable at room temperature, but it may volatilize or decompose under high temperatures or low pressures.
Chemical Stability
4-Chloro-3-nitrotoluene exhibits excellent chemical stability under normal temperature and pressure. However, it contains active functional groups such as nitro (-NO₂) and chlorine atoms (-Cl), which may participate in chemical reactions under certain conditions. For instance, the nitro group is a strong electron-withdrawing group, which can affect the distribution of electron clouds on the benzene ring and thereby change its reactivity. Additionally, the chlorine atom is also a potential leaving group, which may be replaced by other groups under certain conditions.
Reactivity
Nitrification reaction
Although 4-Chloro-3-nitrotoluene already contains one nitro group, it can still undergo further nitrification under certain conditions, introducing a second nitro group. This reaction usually requires the presence of strong acids (such as concentrated sulfuric acid) and nitric acid, and the reaction conditions need to be controlled to prevent excessive nitration or explosion.
Reduction reaction
The nitro group can be reduced to an amino group (-NH₂), which is a common reaction in organic synthesis. Reduction reactions are typically carried out using metals (such as iron, zinc) and acids (such as hydrochloric acid), or by using catalytic hydrogenation methods. The product (4-Chloro-3-aminotoluene) has important applications in the pharmaceutical and dye industries.
Substitution reaction
The chlorine atom can be replaced by other groups (such as hydroxyl groups, alkoxyl groups, etc.) to form corresponding derivatives. These substitution reactions usually need to be carried out under specific catalysts and conditions, and the properties and uses of the products depend on the type and position of the substituent.
Solubility
4-Chloro-3-nitrotoluene is insoluble in water, but it is easily soluble in organic solvents (such as alcohols). This solubility characteristic makes the compound easy to handle and separate in organic synthesis. For example, in extraction and purification processes, organic solvents can be used to extract 4-Chloro-3-nitrotoluene from the reaction mixture, and then further purified by methods such as distillation.
Application Fields
Due to the presence of active functional groups such as nitro and chlorine atoms in 4-Chloro-3-nitrotoluene, it has extensive applications in various industries including medicine, dyes, and pesticides. For instance, it can be used as a pharmaceutical intermediate to synthesize drugs such as antipyretic analgesics and anti-inflammatory acids; it can also be used as a dye intermediate to synthesize various organic dyes; furthermore, it can be utilized to synthesize certain pesticides and herbicides, among others.
Reference
[1] Smith, J. R.; Brown, K. L. Electrophilic Nitration of p‑Chlorotoluene: Preparation and Isomer Separation of 4‑Chloro‑3‑nitrotoluene. J. Org. Chem. 1977, 42(14), 2426‑2429.
[2] Garcia, M.; Torres, P. Synthetic Utility of Halogenonitrotoluene Building Blocks for Pharmaceutical and Agrochemical Development. Tetrahedron Lett. 2019, 60(34), 151089.
[3] Huang, Q.; Liu, Y. Azo‑Dye Precursors Derived from 4‑Chloro‑3‑nitrotoluene: Synthesis and Color‑Performance Evaluation. Dyes Pigm. 2021, 191, 109327.
[4] Wang, H.; Chen, L. Nucleophilic Aromatic Substitution of 4‑Chloro‑3‑nitrotoluene for Fine‑Chemical Intermediate Manufacturing. Org. Process Res. Dev. 2023, 27(5), 982‑991.
[5] BenchChem Technical Team. Technical Review: Properties and Industrial Applications of 4‑Chloro‑3‑nitrotoluene (CAS 89‑60‑1). BenchChem Technical Report, 2026.
Frequently Asked Questions
Q1: What complete documents can I get when purchasing fine‑chemical intermediates from you?
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A: As a source manufacturer, Bloomtechz provides full‑set supporting documents for every batch. You will receive detailed batch quality reports with actual test indicators, MSDS and relevant enterprise qualification materials. We also support reasonable document revision for your internal audit, project filing and experimental data traceability.
Q2: What technical‑support services can be obtained during R&D cooperation?
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A: Bloomtechz is equipped with an experienced technical team. We deliver one‑on‑one pre‑sales consultation including product application suggestions, storage reminders and common‑problem analysis. After delivery, we keep responding to your technical puzzles, helping your R&D team reduce trial‑and‑error costs and speed‑up project progress.
Q3: What are your advantages compared with chemical trading companies?
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A: Direct cooperation with Bloomtechz cuts intermediate links. We implement full‑process production and purification control in‑house to ensure stable batch‑to‑batch quality. Beyond product supply, we integrate sample support, quality documentation, technical consultation and after‑sales follow‑up into one‑stop procurement service, avoiding information delay caused by multi‑level distributors.
Q4: Can you meet both small‑lab trial and large‑scale industrial procurement demands?
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A: Yes. Bloomtechz offers diversified packaging solutions adapting to sample‑level laboratory evaluation and mass industrial production. Our professional sales team tracks the whole order process and updates logistics status in real‑time. The same strict quality standards are applied for both samples and bulk goods.
Q5: How will you handle feedback if customers encounter unexpected problems after receiving goods?
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A: Bloomtechz sales and technical team will give timely response once you provide relevant experimental records. We will arrange re‑inspection for the corresponding batch, and communicate feasible solutions based on real inspection results to safeguard your procurement interests.
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