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Benzophenone powder is white and shiny prismatic crystal. Soluble in ethanol, ether and chloroform, insoluble in water. It has sweet taste and rose fragrance. The alcohol solution of benzophenone is not stable under light, and it can form Pinot alcohol compounds. The product mainly has two crystal states, α Type A is a prismatic crystal, β- Type A is an unstable monoclinic crystal, β Type can be changed into α Type. Benzophenone is an intermediate of ultraviolet absorber (absorbing ultraviolet wavelength 290-360 nm) and initiator, organic pigment, medicine, fragrance and insecticide.

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Chemical Formula |
C13H10O |
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Exact Mass |
153 |
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Molecular Weight |
154 |
|
m/z |
182 (100.0%), 183 (14.1%) |
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Elemental Analysis |
C, 85.69; H, 5.53; O, 8.78 |
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Benzophenone, with the chemical formula C13H10O and CAS number 119-61-9, is an important organic compound. It has various unique chemical properties and has a wide and important range of applications in many fields.

Application in the field of photopolymerization
(1) Free radical UV curable varnish system
It is a free radical (II) photoinitiator that plays a crucial role in the free radical UV curable varnish system. In terms of UV wood paint, when exposed to ultraviolet light, it can trigger free radical reactions in the system, causing the wood paint to quickly cure and form a hard and wear-resistant film, effectively protecting the surface of the wood and improving its aesthetics and service life.
In UV paper varnish, it can quickly cure the varnish, enhance the glossiness and waterproofness of the paper, and improve the quality of printed materials. In UV coatings, UV inks, and UV adhesives, light curing reactions are also induced to quickly dry the coatings and inks, cure the adhesives quickly, improve production efficiency, and endow the products with good performance.
(2) Preparation of photosensitive materials
Can be used to prepare photosensitive materials, such as photosensitive resins. In printing and lithography technology, photosensitive resin has important applications.


For example, in the preparation of circuit boards, the light curing reaction triggered by it can accurately transfer circuit patterns onto the substrate, forming high-precision circuits. In the manufacturing of image sensors, photosensitive resins undergo photopolymerization treatment induced by benzophenone to form thin films with specific optical properties, meeting the strict optical performance requirements of image sensors.
Application in the field of medicine
(1) Pharmaceutical intermediates
Benzophenone powder is an important intermediate in many pharmaceuticals. In the production of bicyclic piperidine, a series of chemical reactions are involved in its synthesis process, and bicyclic piperidine has certain pharmacological activity and can be used to treat certain neurological diseases. The synthesis of benzotropin hydrobromide also relies on this substance, which has applications in ophthalmology and other fields, and can be used for treatments such as mydriasis.


Diphenhydramine hydrochloride is also synthesized using this substance as an intermediate. Diphenhydramine is a commonly used antihistamine that can be used to alleviate allergic symptoms such as skin itching, urticaria, etc.
(2) Raw materials for drug synthesis
May be used for synthesizing antibacterial drugs, antiviral drugs, etc. In the synthesis of antibacterial drugs, it can be used as a starting material or intermediate tointroduce specific functional groups through chemical reactions, endowing the drug with antibacterial activity.
In the development of antiviral drugs, it is also possible to participate in the construction of the core structure of the drug, providing a foundation for the development of new antiviral drugs. For example, some highly effective anti-inflammatory and analgesic drugs such as ketoprofen are made from a series of reactions such as bromination, cyanation, hydrolysis, methylation, etc. of m-methylbenzophenone, providing an effective drug choice for treating inflammation and pain.


Application in the field of spices
(1) Fragrance fixative
It is a styrene polymerization inhibitor and flavoring agent. In perfume and soap essence, it can give essence a sweet flavor, and make essence fragrance more durable and stable. In the preparation of perfume, benzophenone can interact with other perfume components to adjust the volatilization speed of the fragrance, so that the head, middle and tail fragrance of perfume are more coordinated and the quality of perfume is improved. In soap essence, it can make essence slowly release fragrance during the use of soap, so that users can continue to feel pleasant fragrance when washing hands or bathing.
(2) Preparation of edible essence
It can be used to mix almond, peach, cream, coconut and other edible essence. In the food industry, edible essence plays an important role in improving food flavor. By reasonably combining with other spice ingredients, it is possible to simulate the aroma of various fruits, dairy products, etc., adding rich taste to food. The recommended dosage in the final flavored food is 0.5-2.4mg/kg, which can ensure that the food has a strong aroma without causing adverse effects on human health.


Application in the field of cosmetics
(1) UV absorber
It is commonly used as a UV absorber in cosmetics, especially in sunscreen products. It can absorb ultraviolet light at 290-360 nanometers, effectively preventing UV damage to the skin. In sunscreen/cream, it can work synergistically with other sunscreen ingredients to form a protective film that blocks the invasion of ultraviolet rays, reducing the risk of skin sunburn, tanning, and photoaging. At the same time, it is non irritating to human skin and safe and reliable to use.
(2) Other cosmetic applications
It may also be used in the production of perfume, lipstick and other products. In perfume, in addition to being a fixative, it may also create a unique fragrance together with other spice ingredients. In lipstick, it may play a certain stabilizing role, preventing pigments and other components in lipstick from decomposing under light, and prolonging the service life of lipstick.

Application in the field of plastics and packaging
(1) UV blocking agent
Can be added as a UV blocking agent to plastic packaging. In plastic packaging, ultraviolet radiation can cause photodegradation of the packaging polymer or its contents, affecting the quality of the packaging and the stability of the contents. After adding benzophenone, it can absorb ultraviolet rays, prevent UV damage to plastics, and thus extend the service life of plastic packaging. For example, by adding this substance to plastic packaging such as PET water bottles, manufacturers can use transparent glass or plastic to package their products without the need for opaque or dark packaging.
Which ensures the display effect of the product and improves the protective performance of the packaging.
(2) Plastic additives
It can also be used as other additives for rubber and plastic. It can improve the processing performance of plastics, such as increasing their flowability, making them easier to form during the processing. At the same time, it can also enhance certain physical properties of plastics, such as improving their heat resistance, weather resistance, etc., so that plastic products can maintain good performance in various environments.
Application in the field of organic synthesis
(1) Important intermediates
Benzophenone powder is an important intermediate in organic synthesis, widely used in the manufacturing of organic coatings, dyes, pesticides, etc. In the synthesis of organic coatings, it can be used as a starting material or intermediate to introduce specific functional groups through chemical reactions, construct the core structure of the coating, and endow the coating with good adhesion, weather resistance and other properties. In dye synthesis, participating in the construction of dye molecules gives dyes bright colors and good dyeing properties, which are widely used in the textile and printing industries.
In pesticide synthesis, it may also be used to synthesize compounds with specific insecticidal, bactericidal, or herbicidal activities, providing effective control measures for agricultural production.
(2) Anhydrous indicator
It is commonly used as an anhydrous indicator in organic synthesis. Sodium can reduce benzophenone to dark colored free radical anions, while carbonyl radicals can form non-volatile products with water and oxygen.
When purifying hydrocarbon solvents, if the solution color becomes bluer after adding benzophenone, it indicates that there is less oxygen and water in the solution. Before drying a large amount of aqueous solvent, treat it with a common desiccant (such as sodium sulfate) to shorten the drying time. If sodium is used as a desiccant, its solubility in organic solvents is relatively low, forming a heterogeneous mixture with the solvent, and the drying rate is relatively slow. However, as an anhydrous indicator, it can help determine the dryness of the solvent and ensure that organic synthesis reactions proceed under anhydrous conditions.

Synthesis of benzophenone powder:

1. The electric mixer, thermometer, dropper, and condenser are installed on a 250ml four necked bottle.
2. Install a calcium chloride drying tube at the upper end of the condenser tube and connect it to the upper end of the drying tube through a rubber tube. The latter is placed in a beaker containing water, keeping the circular mouth of the funnel away from the surface of the beaker to absorb the hydrogen chloride gas produced during the reaction process.
2. Place 39 grams (0.5 moles) of anhydrous benzene and 14 grams (0.1 moles) of fully ground anhydrous aluminum chloride into a four necked bottle.
3. Put 14 grams (0.1 moles) of benzoyl chloride into the dropper funnel.
4. Slowly drip benzoyl chloride and stir evenly to avoid excessive reaction. After dripping benzoyl chloride, heat it in a water bath to 50 ° C until there is no hydrogen chloride leakage.
5. Then the reactants are poured into water. Dissolve the precipitate in 100ml of ice water by adding 10ml of concentrated hydrochloric acid. After separating the benzene layer, wash it with 30ml of water, 30ml of 5% sodium hydroxide, and 30ml of water.
6. After separating the benzene layer, dry it with anhydrous magnesium sulfate, recover benzene by atmospheric distillation, and collect the fractionation at 170-175 ° C/2KPa by vacuum distillation to obtain benzophenone.
FAQ
Is benzophenone the same as oxybenzone?
Benzophenone is a chemical with a sweet floral smell. Benzophenone is a different chemical than benzophenone-3 (also called oxybenzone) and benzophenone-4 (also called sulisobenzone).
What are the hazards of benzophenone?
Benzophenone is a chemical compound widely used as a UV-blocking agent in cosmetics, sunscreens, and plastics, as well as a flavoring in foods. Its primary hazards are its potential classification as a carcinogen, risk of endocrine disruption, and toxicity to the environment.
What is benzophenone used for?
Benzophenone is primarily used as an ultraviolet (UV) absorber and stabilizer to protect products from sun damage. It is widely used in the manufacturing of sunscreens, plastics, cosmetics, and inks, while also serving as a fragrant agent and a photoinitiator in industrial UV-curing processes.
Is benzophenone harmful to humans?
Yes, benzophenone is considered potentially harmful to humans. Health organizations classify it as a possible carcinogen, and research links it to endocrine disruption and allergic reactions. Because it easily absorbs into the skin and bioaccumulates, monitoring your exposure is highly recommended.
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