Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 4-methoxyphenylacetone cas 122-84-9 in China. Welcome to wholesale bulk high quality 4-methoxyphenylacetone cas 122-84-9 for sale here from our factory. Good service and reasonable price are available.
4-methoxyphenylacetone, an organic chemical with the molecular formula: C10H12O2, The molecular weight is 164.201, and the CAS accession number is 122-84-9. Its boiling point is 268 ℃, melting point is -15 ℃, and refractive index is 1.5251. At room temperature and pressure, it is a light yellow liquid that is insoluble in water but soluble in common organi solvents such as ethyl acetate, dichloromethane, and chloroform. This compound exhibits rich electron cloud density and significant fluorescence luminescence properties due to its unique chemical structure, making it of significant application value in organic synthesis and preparation of organi functional materials.
|
Chemical Formula |
C10H12O2 |
|
Exact Mass |
164 |
|
Molecular Weight |
164 |
|
m/z |
164 (100.0%), 165 (10.8%) |
|
Elemental Analysis |
C, 73.15; H, 7.37; O, 19.49 |
|
|
|
This structure contains an alkyl substituted carbonyl unit, which has good chemical conversion properties. It can undergo nucleophilic addition reactions with nucleophilic reagents such as formate reagents, and can also undergo condensation reactions with amine compounds to obtain imine derivatives. In addition, methoxy, as a strong electron donating functional group, can greatly increase the electron cloud density of molecules, enabling the compound to exhibit rich reactivity and diversity in organi synthesis. For example, it can be modified through a series of functionalization conversion reactions, such as methoxy being oxidized to carboxyl or reduced to hydroxyl, thus synthesizing different types of phenylacetone compounds.
4-Methoxyphenylacetone is a light yellow liquid at room temperature and pressure, insoluble in water but soluble in common organi solvents such as ethyl acetate, dichloromethane, and chloroform. Due to the strong electron donating properties of its methoxy group, methoxyphenylacetone has abundant electron cloud density and significant fluorescence luminescence properties, and has a wide range of applications in the basic research of organi synthess chemistry and the preparation of organi functional materials.
Methoxyphenylacetone has a wide range of applications, mainly in the fields of medicine, pesticides, dyes, fragrances, etc.
Pharmaceutical intermediates:
Methoxyphenylacetone is an important intermediat for the synthess of various drugs. For example, the drug formoterol, which can be used to synthesize and treat respiratory distress caused by bronchial asthma, chronic bronchitis, and other conditions, as well as the drug Prenylamine Lactate, which can be used to treat angina pectoris. Its unique chemical structure and properties make para methoxyphenylacetone an indispensable part of pharmaceutical synthess.
Organic synthesis:
The carbonyl unit substituted with an alkyl group in the structure of methoxyphenylacetone has good chemical conversion properties and can undergo various chemical conversion reactions. For example, its carbonyl unit can undergo nucleophilic addition reactions with nucleophilic reagents such as formate reagents, and can also undergo condensation reactions with amine compounds to obtain imine derivatives.
In addition, methoxyphenylacetone can also be modified through a series of functionalization conversion reactions, such as methoxy being oxidized to carboxyl or reduced to hydroxyl. These reactions can be used to synthesize different phenylacetone compounds, expanding their applications in organi synthess and organi functional materials.
Spices and food additives:
Methoxyphenylacetone, due to its unique aroma and flavor, can be used in spices and food additives to provide special aroma and taste for food, beverages, and other products. Its safe and low toxicity characteristics make para methoxyphenyl acetone have broad application prospects in the food industry.
1. Pharmaceutical field
The synthesis of formoterol:
Methoxyphenylacetone is an important intermediat for the synthess of formoterol. Fumatrol is a long-acting β ₂ receptor agonist used to treat respiratory distress caused by bronchial asthma, chronic bronchitis, and other conditions. By a series of chemical modifications and transformations of methoxyphenylacetone, the important drug formoterol can be obtained. The specific synthess route includes the alkylation, condensation, and other reactions of p-methoxyphenylacetone to ultimately obtain formoterol.
Synthesis of Lactic Acid Cyclidine:
Methoxyphenylacetone is also a key intermediat for the synthess of lactoferrin. Lactic acid angina is a calcium channel blocker used to treat angina pectoris. During its synthess process, methoxyphenylacetone reacts with other chemical reagents, such as acylation and reduction, to ultimately obtain the drug lactate cardiodine.
2. Organic synthesis field
Synthesis of imine derivatives:
The carbonyl unit of methoxyphenylacetone can be condensed with amine compounds to obtain imine derivatives. These derivatives have important applications in organi synthess, such as serving as catalysts, ligands, etc. Specific examples include reacting p-methoxyphenylacetone with different amine compounds to obtain various imine derivatives, which can be used in subsequent organi synthess reactions.
Synthesis of chiral alcohols and chiral amine compounds:
By utilizing the diverse chemical conversion properties of carbonyl groups, methoxyphenylacetone can be used to prepare chiral alcohols and chiral amine compounds. These compounds have a wide range of applications in the fields of medicine, pesticides, etc., such as as as chiral drugs, chiral catalysts, etc. Specific examples include asymmetric synthess reactions of p-methoxyphenylacetone to obtain alcohols or amine compounds with specific chirality.
3. Spices and food additives field
Spice formula:
Because of its unique fragrance, p-methoxyphenylacetone can be used in perfume formulations to provide special fragrance for perfume, essence, etc. Its safe and low toxicity characteristics make para methoxyphenylacetone widely applicable in the fragrance industry.
Food additives:
Methoxyphenylacetone can also be used as a food additive in beverages, candies, baked goods, etc., providing a special taste and flavor. Its unique aroma and flavor make para methoxyphenyl acetone widely used in the food industry.
Synthesis method of 4-Methoxyphenylacetone:
It is an important pharmaceutical intermediate used in the production of the respiratory system drug formoterol and β- Phenylethylamine, amphetamine, cardio-cerebral system drug, and cardionidine lactate, as well as phenylisopropylamine, a hormone drug, are also used to synthesize agricultural pesticides.
At present, the product has not been mass produced in China, and its purity is only 95%, which cannot meet the market demand. According to the references, we have studied the synthess method suitable for industrial production, and changed the distillation and distillation process to treat with sodium bisulfite first, remove the unreacted raw material p-methoxybenzaldehyde, and then conduct simple distillation to obtain qualified products. The process is simplified, the product quality is improved (the purity is more than 98%), and the yield is more than 80%. With p-methoxybenzaldehyde as raw material, sodium methoxide or sodium carbonate catalyzes the condensation to form a ring, and the intermediat is directly hydrolyzed without separation to obtain the target product.
An out-of-tank electrochemical synthesis method of p-methoxyphenylacetone:
It belongs to the field of electrochemical technology. In a two-chamber electrolytic cell, platinum wire is used as the anode, stainless steel sheet as the cathode, acetic acid-acetic anhydride as the solvent, potassium acetate as the supporting electrolyte, and lead acetate is used as the reactant at a certain temperature, and constant current density electrolysis is used to obtain lead tetraacetate.
After electrolysis is stopped, the lead tetraacetate obtained is added to anethole.
After reaction, the organi product is obtained, which is hydrolyzed by sulfuric acid and extracted by ether to obtain the product, P-methoxyphenylacetone. The lead acetate obtained after treatment can be recycled and reused.
The yield of the synthess method is 52~62%. The invention has the advantages of simple and easy access to reaction raw materials, cheap price, green reaction process, simple and safe operation, high yield and low cost. It is a high value-added process route.
An in-tank electrochemical synthesis method of 4-Methoxyphenylacetone:
It belongs to the field of electrochemical technology. In a two-chamber electrolytic cell, platinum wire is used as the anode, stainless steel sheet as the cathode, acetic acid-acetic anhydride as the solvent, and potassium acetate as the supporting electrolyte.
At a certain temperature, in the anode chamber of the electrolytic cell, anethole and lead acetate are simultaneously used as the electrolytic reaction substrate, and the constant current density electrolysis, during which the direct electrolytic oxidation reaction of anethole on the anode and the indirect oxidation reaction with lead tetraacetate as the medium are carried out simultaneously.
After stopping electrolysis, the obtained organi product is hydrolyzed by sulfuric acid and further treated to obtain the product, p-methoxyphenylacetone.
The invention has the advantages of simple and easy access to reaction raw materials, cheap price, green reaction process, simple and safe operation, high yield and low cost, and is a high value-added process route.
synthetic method
There are two main methods for synthesizing methoxyphenylacetone: traditional industrial preparation methods and green synthesis methods.
Traditional industrial preparation methods:
Usually, 3-hydroxyphenylacetone is reacted with dimethyl sulfate. However, this method has disadvantages such as high cost, multiple by-products, low yield, and high toxicity of dimethyl sulfate, which limits its industrial production.
Green synthesis method:
To address the shortcomings of traditional methods, researchers have proposed a green synthesis approach. This method involves adding magnesium powder and anhydrous aluminum trichloride to a reactor equipped with a reflux condenser and a dropping funnel.
By slowly adding a mixed solution of m-methoxybromobenzene and tetrahydrofuran (THF), the temperature of the reaction solution is controlled between 30-80 ℃ to maintain a slight boiling state.
After dropwise addition, heat and reflux for 0.5-1.0 hour to ensure complete reaction of magnesium and obtain Grignard reagent.
Subsequently, slowly add acetonitrile dropwise to the Grignard reagent while stirring, and continue the reaction for 1.0-2.0 hours.
After the reaction is complete, 3mol/L hydrochloric acid is slowly added dropwise under a cold water bath to decompose the added product.
After distillation and other steps, p-methoxyphenylacetone is finally obtained. This method has the advantages of low cost, high yield, and environmental friendliness, and is suitable for industrial production.
Hot Tags: 4-methoxyphenylacetone cas 122-84-9, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, 5 Fluoro 2 Nitroaniline CAS 2369 11 1, 2 Phenylacetamide CAS 103 81 1, 5 Chloroindole 2 carboxylic Acid CAS 10517 21 2, 4 Aminoacetanilide CAS 122 80 5, 2 3 Dichloropyridine CAS 2402 77 9, Tetrabutylammonium Bromide Powder CAS 1643 19 2