6-Bromo-1-hexanol CAS 4286-55-9
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6-Bromo-1-hexanol CAS 4286-55-9

6-Bromo-1-hexanol CAS 4286-55-9

Product Code: BM-2-1-515
CAS number:4286-55-9
Molecular formula: C6H13BrO
Molecular weight: 181.07
EINECS number:610-072-0
MDL No.: MFCD00002983
Hs code: 29055900
Analysis items: HPLC>99.0%, LC-MS
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Changzhou Factory
Technology service: R&D Dept.-4

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 6-bromo-1-hexanol cas 4286-55-9 in China. Welcome to wholesale bulk high quality 6-bromo-1-hexanol cas 4286-55-9 for sale here from our factory. Good service and reasonable price are available.

 

6-Bromo-1-hexanol, also known as 6-bromo-1-hexanol or 6-bromohexanol, is an organic compound. At room temperature and atmospheric pressure, it appears as a colorless to pale yellow liquid, easily soluble in chloroform and alcohol organic solvents, but has poor solubility in water. There are also applications in the pharmaceutical field, but the specific use may vary depending on the purity and preparation process of the product. This compound is irritating and can irritate the skin and mucous membranes. Proper protective equipment should be worn during operation to avoid direct contact with eyes and skin. If accidentally touched, please rinse immediately with plenty of water and seek medical attention. It should also be stored at a temperature of 2-8 ℃ and sealed in a dark, ventilated, and dry place.

Produnct Introduction

Additional information of chemical compound:

 

Chemical Formula

C6H13BrO

Exact Mass

180.01

Molecular Weight

181.07

m/z

180.01(100.0%),182.01(97.3%),181.02(6.5%),183.02(6.3%)

Elemental Analysis

C, 39.80; H, 7.24; Br, 44.13; O, 8.84

Boiling point

105-106℃ 5 mm Hg(lit.)

Density

1.384 g/mL at 25℃(lit.)

Storage conditions

2-8℃

6-Bromo-1-hexanol CAS 4286-55-9 | Shaanxi BLOOM Tech Co., Ltd

6-Bromo-1-hexanol | Shaanxi BLOOM Tech Co., Ltd

Applications

6-Bromo-1-hexanol is an important organic compound with a wide range of applications, particularly in the fields of organic synthesis and pharmaceutical production. The following is a detailed explanation of its purpose:

Application In The Field Of Pharmaceutical Production

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Application in drug synthesis

6-bromohexanol is often used as a starting material or intermediate in drug synthesis. By introducing bromine atoms, further functional group conversion can be carried out to synthesize compounds with specific pharmacological activities. For example, 6-bromohexanol can be converted into drug molecules with antibacterial, anti-inflammatory, or anti-tumor activity through a series of chemical reactions. Its carbon chain structure makes it suitable as a part of the drug backbone. By modifying and expanding functional groups based on it, drug molecules with complex structures and specific activities can be constructed.

This skeleton construction strategy is of great significance in drug development, helping to discover new drugs and optimize existing ones. Due to its hydrophilic hydroxyl functional group, 6-bromohexanol can form drug precursors with better solubility and bioavailability by binding with other hydrophobic drug molecules. This strategy is of great significance in improving the oral absorption and efficacy of drugs.

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6-Bromo-1-hexanol For Sale | Shaanxi BLOOM Tech Co., Ltd

Application in drug modification

The introduction of 6-bromohexanol can stabilize certain sensory groups in drug molecules, thereby improving the stability of the drug. For example, in drug molecules containing ester or amide bonds, the hydroxyl group of 6-bromohexanol can form hydrogen bonds with these functional groups, thereby protecting them from hydrolysis or enzymatic degradation. Its introduction can also regulate the release rate of drugs. By controlling the interaction between 6-bromo-n-hexanol and other components, drug formulations with different release rates can be designed. This strategy is of great significance in controlling the distribution and metabolism of drugs in the body. The bromine atom of 6-bromohexanol can bind with other molecules or groups to form drug precursors with specific targeting properties. This targeted enhancement strategy helps to increase the concentration of drugs in target tissues or organs, thereby improving therapeutic efficacy and reducing side effects.

Application in the preparation of pharmaceutical intermediates

6-Bromo-1-hexanol can be converted into an intermediate with specific pharmacological activity through a series of chemical reactions. These intermediates play an important role in drug synthesis and can serve as key steps in synthesizing complex drug molecules. The introduction of 6-bromohexanol can optimize the synthesis routes of certain drugs.

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6-Bromo-1-hexanol Product| Shaanxi BLOOM Tech Co., Ltd

By selecting appropriate reaction conditions and catalysts, a more efficient and environmentally friendly synthesis process can be achieved. This optimization strategy helps to reduce production costs and increase drug yield. When 6-bromohexanol is used as an intermediate, its purity is crucial for subsequent drug synthesis and quality control. By strictly controlling the synthesis conditions and purification process, high-purity 6-bromo-n-hexanol intermediate can be obtained, providing reliable guarantees for subsequent drug synthesis.

Other applications in the field of medicine

6-Bromohexanol can be used as a solvent or co solvent in certain situations. Due to its good solubility and chemical stability, it can be used to dissolve or disperse other drug components, thereby improving the preparation and processing of drugs. It can also be used as a component of drug carriers. By combining with other materials, drug carriers with specific structures and functions can be formed to improve drug delivery efficiency and therapeutic efficacy. 6-bromohexanol can also be used as an internal standard or reference in pharmaceutical analysis. By measuring the relative content or proportion relationship between 6-bromo-n-hexanol and other drug components, the quality of the drug can be accurately evaluated and controlled.

6-Bromo-1-hexanol Drug | Shaanxi BLOOM Tech Co., Ltd

Application in the field of dyes and fragrances

6-Bromo-1-hexanol Drugs | Shaanxi BLOOM Tech Co., Ltd

Application in the field of dyes

6-Bromohexanol is often used as an important intermediate in dye synthesis. By introducing bromine atoms, further functional group conversion can be carried out to synthesize dye molecules with specific colors and properties. For example, 6-bromohexanol can react with aromatic amines or other compounds containing active functional groups to form dyes with excellent dyeing properties. These dyes can be applied in various fields such as textiles, leather, paper, etc., endowing products with rich colors and long-lasting dyeing effects. Its introduction can improve the stability and weather resistance of dyes. The presence of bromine atoms can stabilize certain sensory groups in dye molecules, thereby enhancing the dye's resistance to environmental factors such as light, heat, acidity, and alkalinity. This improvement in stability helps to extend the service life of dyes and reduce possible fading or discoloration during the dyeing process.

Application in the field of dyes

The hydroxyl functional group of this substance can regulate the solubility and dispersibility of dyes. By adjusting the ratio and interaction of 6-bromo-n-hexanol with other components, dye formulations with different solubility and dispersibility can be designed. This adjustment strategy helps optimize the dyeing process of dyes, improve dyeing efficiency and uniformity. 6-Bromohexanol can also participate in the synthesis of functional dyes. By introducing other functional groups or structural units on its basis, dyes with special properties can be synthesized, such as fluorescent dyes, thermosensitive dyes, photosensitive dyes, etc. These functional dyes have broad application prospects in anti-counterfeiting, information recording, environmental monitoring and other fields.

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6-Bromo-1-hexanol Spices | Shaanxi BLOOM Tech Co., Ltd

Application in the field of spices

6-bromohexanol can be used as an important raw material in spice synthesis. By reacting chemically with other spice components, compounds with specific aromas and fragrances can be synthesized. These compounds can be used in food, cosmetics, perfume and other fields to provide consumers with a pleasant sensory experience. Its introduction can enhance the durability and stability of spices. The presence of bromine atoms can enhance the resistance of spice molecules to environmental factors such as light, heat, and oxygen, thereby reducing the loss and deterioration of spices during storage and use. This improvement in stability helps to extend the lifespan of spices and maintain their original aroma and fragrance.

Custom Notebook Solutions

The hydroxyl functional group of 6-bromohexanol can regulate the volatility and sensory properties of fragrances. By adjusting the ratio and interaction of 6-bromo-n-hexanol with other flavoring components, the volatilization rate and aroma intensity of the flavoring can be controlled. This adjustment strategy helps optimize the sensory effects of spices, making them more in line with consumers' needs and preferences. It can also participate in the synthesis of complex spices. By introducing other spice components or structural units on its basis, compounds with complex aromas and fragrances can be synthesized. These complex perfumes have broad application prospects in the fields of advanced perfume and cosmetics, and can provide consumers with more delicate and rich sensory experience.

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6-Bromo-1-hexanol Field | Shaanxi BLOOM Tech Co., Ltd

Application cases in the field of dyes and fragrances

6-Bromohexanol can react with specific aromatic amines to form dyes with a bright red color. This dye can be applied to the dyeing of textiles, giving them a long-lasting red hue. Introducing 6-bromohexanol into dye molecules can significantly improve the light resistance of the dye. This dye has broad application prospects in outdoor products, automotive interiors, and other fields. By adjusting the ratio of 6-bromo-n-hexanol to other components, dye formulations with different solubilities can be designed. This dye has unique advantages in fields such as printing and pigment printing.

Application cases in the field of dyes and fragrances

6-Bromo-1-hexanol can react with specific aldehyde compounds to form compounds with fruity aroma. This compound can be applied in fields such as food and beverages, providing consumers with a pleasant taste experience. Introducing 6-bromohexanol into spice molecules can significantly improve the persistence of the spice. This perfume has a wide application prospect in the fields of advanced perfume, cosmetics, etc. By adjusting the ratio of 6-bromohexanol to other flavoring components, the volatilization rate and aroma intensity of the flavoring can be controlled. This spice has unique advantages in areas such as air fresheners and indoor fragrances.

6-Bromo-1-hexanol Application | Shaanxi BLOOM Tech Co., Ltd

Safety and Handling

 

 

● Toxicological Profile

Skin and Eye Irritation: 6-Bromo-1-hexanol is a skin and eye irritant. Prolonged or repeated exposure may cause dermatitis or conjunctivitis.

Inhalation Hazards: Inhalation of vapors may cause respiratory irritation.

● Safety Precautions

Personal Protective Equipment (PPE): Use gloves, safety goggles, and a lab coat when handling the compound.

Ventilation: Work in a fume hood to minimize inhalation exposure.

Storage: Store at 2–8°C in a cool, dry, and well-ventilated area. Keep containers tightly sealed to prevent moisture ingress.

● Emergency Response

Skin Contact: Wash affected areas with soap and water.

Eye Contact: Rinse thoroughly with water for at least 15 minutes, removing contact lenses if present.

Inhalation: Move to fresh air and seek medical attention if symptoms persist.

6-Bromo-1-hexanol is a versatile intermediate with significant applications in organic synthesis and pharmaceutical development. Its dual functionality, coupled with advancements in synthetic methodologies, positions it as a key compound in modern chemical research. By adhering to safety protocols and embracing sustainable practices, the chemical industry can harness the full potential of 6-bromo-1-hexanol while minimizing environmental impact. As research progresses, this compound will undoubtedly continue to play a pivotal role in the development of innovative materials and therapeutics.

Frequently Asked Questions
 
 

Why did its synthesis process cause "laboratory accidents"? --The "hot temper" of BMS complex

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In the classical synthesis route, the dropwise addition of borane dimethyl sulfide (BMS) may cause violent reactions or even splashing if the temperature is not strictly controlled.

Synthesis step requirements: Slowly add BMS (15 mmol) dropwise to a THF solution of ω - bromic acid at 0 ° C, then raise the temperature to 45 ° C and stir for 3 hours. Finally, add methanol at 0 ° C to quench.

BMS is a strong reducing agent that decomposes violently when in contact with water or alcohol, producing hydrogen gas. If the temperature control is improper or the feeding is too fast during the quenching stage, the reaction system may produce a large amount of gas and splash.

What other "hidden identities" does it have besides "ordinary intermediates"? --Molecular Welders on Metal Surfaces

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It can serve as a substrate for thiol ene click chemistry, constructing functional molecular layers on metal or polymer surfaces.
Its molecular structure has "personalities" at both ends: the bromine end is the "attacking hand" (which can participate in the SN2 reaction to connect other molecules), and the hydroxyl end is the "bridge builder" (which can form hydrogen bonds or ester bonds to anchor the surface).
Gold nanoparticle modification: hydroxyl groups are converted into thiols through thiolation reaction, and then self-assembled on the gold surface to form a monolayer
Polymer brush preparation: The hydroxyl end can be connected by atom transfer radical polymerization (ATRP) initiator to grow polymer brushes on the surface of silicon wafers
Anti fouling coating design: Utilizing its excellent hydrophobicity (LogP about 2.17, solubility in water about 2.5 g/L), it can be used to prepare functional coatings with controllable surface energy

 

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