AHK Tripeptide-3

Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of ahk tripeptide-3 in China. Welcome to wholesale bulk high quality ahk tripeptide-3 for sale here from our factory. Good service and reasonable price are available.

AHK Tripeptide-3 is a high-end active peptide ingredient specifically for skincare and scalp care. In its free form, it appears as a white to off-white lyophilized powder, and its aqueous solution is clear and colorless. Bloomtechz, as a factory with over ten years of experience in the beauty ingredient field, focuses on the research and production of high-quality active peptides, with a mature production system and strict quality control processes. The factory has extensive experience in overseas trade and is familiar with cosmetic ingredient regulations in various countries, providing global customers with stable and compliant ingredients.

We rigorously control the purity, color, and activity of our ingredients, preventing degradation, discoloration, and loss of activity, ensuring strong batch-to-batch consistency. With our own production capacity and mature supply chain, we can offer customized formulations, stable supply, and one-stop ingredient solutions to help clients create high-quality, effective skincare and haircare products. 

 

Certificate of Analysis
Compound name	AHK Tripeptide-3
Grade	Pharmaceutical grade
CAS No.	N/A
Quantity	18g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090055
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.58%
Loss on drying	≤1.0%	0.65%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.68%
Single impurity	<0.8%	0.74%
Total microbial count	≤750cfu/g	188
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	500ppm
Storage	Store in a sealed, dark, and dry place below 2-8°C

Bloomtechz's AHK Tripeptide-3 doesn't chelate copper ions and won't cause a blue reaction. It's suitable for skincare formulas that can't have coloring ingredients, mainly focusing on anti-aging and fibroblast activation.

Keratinocyte migration regulation, accelerating epidermal reepithelialization

Bloomtechz's self-developed in vitro human keratinocyte HaCaT scratch model validated: Bloomtechz AHK Tripeptide-3 at nanomolar concentration upregulates laminin-5 and integrin β4 expression. Laminin-5 is a key anchoring protein for the basement membrane. Integrin mediates the adhesion of keratinocytes to the basement membrane and temporary extracellular matrix, enabling keratinocytes to move directionally along the edge of the wound toward the notch, shortening epidermal closure time. Scratch experiments showed that the AHK Tripeptide-3 treatment group had significantly higher keratinocyte closure rates than the blank control group;

Unlike GHK-Cu's strong activation of fibroblasts, AHK Tripeptide-3 preferentially drives epithelial cell migration, with gentler activation for dermal fibroblast proliferation, suitable for superficial epidermal injury scenarios. 

AHK Tripeptide-3 peptide chain serves as a carrier, precisely delivering chelated divalent copper into cells rather than releasing copper ions freely. Copper ions are coenzymes for multiple repair enzymes, including lysamiyl oxidase (LOX) and SOD superoxide dismutase. The chelation system is key: free copper ions indiscriminately oxidize cell membranes, causing cytotoxicity; Bloomtechz's controlled chelation process ensures copper ions are stably bound to the tripeptide coordination structure, released only after entering the cell under the intracellular microenvironment, reducing extracellular oxidative stimulation. This is a key quality control point for barrier repair to ensure safe effectiveness.

Upregulate the structural proteins of the stratum corneum and tightly bond them, repairing the skin barrier and brick wall structure

Many repair ingredients only supplement exogenous lipids, which is considered "external patching slurry"; Bloomtechz AHK Tripeptide-3 can stimulate endogenous synthesis of barrier core proteins in keratinocytes, rebuilding the brick wall at the cellular level. In 3D artificial epidermal model tests, after Bloomtechz AHK Tripeptide-3 treatment, the expression of genes in keratinocytes FLG filament polymerin, LOR captoprotein, and IVL endoptin was upregulated; At the same time, tight junction proteins ZO-1 and Occludins were upregulated to strengthen tight junctions between granular cells and reduce transdermal water loss (TEWL).

Silk polymer protein breaks down to form natural moisturizing factor NMF, which maintains keratim hydration; Methamin and endopinate protein form the keratinocyte capsule, enhancing the mechanical toughness of keratinocytes; ZO-1/Occludin tightening protein controls intercellular space penetration, reducing external irritants and reducing skin sensitivity and tingling.

This pathway addresses long-standing problems in sensitive skin with damaged barriers: insufficient filament polymerin expression, immature keratinocyte differentiation, intercellular space leakage, and persistently high TEWL (Therapeutic Weight). It is worth noting that this mechanism is rarely mentioned in the industry's conventional marketing for AHK Tripeptide-3, making it a niche but commercially valuable efficacy dimension of the raw material.

Temporal regulation of inflammation and oxidative stress to prevent chronic inflammation blocking wound repair

Excessive ROS accumulation on surface wounds and damaged skin barriers is a major hindrance to healing.

ROS continuously attacks cell membranes, degrades FLGs, amplifying pro-inflammatory factors such as TNF-α and IL-6, causing wounds to remain in the inflammatory phase and delaying proliferation and repair. Bloomtechz AHK Tripeptide-3 activates endogenous SOD and catalase expression, scavenges reactive oxygen species, and reduces oxidative damage; At the same time, it bidirectionally regulates cytokines, downregulating TNF-α and IL-6 pro-inflammatory factors, moderately maintaining the underlying inflammatory signals needed for repair, upregulating anti-inflammatory factor IL-10, and promoting a smooth transition from acute inflammation to proliferation and repair without completely inhibiting inflammation or blocking cell migration.

TGF-β signal regulation is another key point. AHK Tripeptide-3 selectively downregulates TGF-β1. Sustained high TGF-β1 expression can induce excessive myofibroblast proliferation and disordered collagen deposition, increasing scar risk. Superficial epidermal wounds do not require high TGF-β1. Bloomtechz in vitro raw material models show that AHK Tripeptide-3 can moderately inhibit excessive TGF-β1 secretion, accelerating epidermal healing while reducing the likelihood of post-hyperpigmentation and abnormal fibrosis after superficial wound healing, making it very suitable for post-medical aesthetic and minimally invasive repair scenarios.

Mobilization of Follicular Epithelial Stem Cells: A Supplementary Reserve for Epidermal Repair

In addition to the migration of keratinocytes at the wound edge, the extrafollicular root sheath epithelial stem cells are an important reserve for epidermal cells. AHK Tripeptide-3's targeting affinity for hair follicle epithelial cells is not limited to hair growth; When the epidermis is damaged, it can mobilize follicle epithelial stem cells to migrate to the epidermal wound, replenishing the keratinocyte pool and further accelerating epidermal coverage. This is the unique mechanism that sets AHK Tripeptide apart from many simple keratinocyte active agents. Its advantages are even more pronounced in large-area superficial abrasions and multi-micropore microneedle wounds, making it a cross-mechanism rarely explored in the industry.

AHK Tripeptide-3 is a popular active peptide ingredient in the beauty and scalp care fields, mainly known for promoting collagen production, repairing the dermal matrix, improving the follicle microenvironment, and providing antioxidant and anti-aging effects. Currently, the global peptide ingredient market is quite mixed, with huge differences among manufacturers in solid-phase synthesis processes, impurity control (TFA trifluoroacetic acid, missing peptides, heavy metals), batch consistency, long-term solution stability, compliance documentation, and custom formula development capabilities. Many low-cost competitors only meet HPLC nominal purity standards, but their impurities exceed safe levels, large-scale batches fluctuate, and the finished products tend to have issues like discoloration, reduced activity, irritation, and difficulties with overseas registration. Bloomtechz leverages its solid-phase peptide synthesis platform to optimize deprotection, purification, and chelation processes, strictly controlling key risks like TFA residue, heavy metals, and missing peptides. The table below compares the core differences from various perspectives. The data in the table is for reference only, to help cosmetics brands, formulation developers, and sourcing engineers evaluate and select materials.

1. CosIng Database, European Commission; FDA Cosmetic Ingredient Review (CIR) monographs for copper peptides
2. Industrial peptide raw material benchmark data from global peptide manufacturers public technical datasheets
3. CosIng / FDA cosmetic raw material safety guideline, preservative & heavy metal limit requirements
4. Peptide formulation stability literature, compatibility research of copper peptide with common cosmetic actives

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