Aicar powder is a chemical substance that typically appears as a white or light brown powder and is an activator of adenosine monophosphate protein kinase (AMPK). AMPK is a heterodimeric protein serine/threonine kinase that is a key protein in metabolic regulation. When the energy supply is insufficient, the ratio of AMP/ATP is upregulated, and AMPK is activated, thereby inhibiting the process of synthetic metabolism. Aicar can activate AMPK, simulate exercise effects, and trigger insulin independent skeletal muscle glucose uptake. Icar can regulate lipid and glucose metabolism, and has a significant impact on cellular energy balance. Research has shown that Aicar can inhibit the synthesis of certain inflammatory factors, such as TNF α, IL-1 β, and IL-6, demonstrating a certain anti-inflammatory effect. As a pharmaceutical raw material, Aicar has potential therapeutic value, such as improving pathological conditions such as ischemia or reperfusion injury and renal fibrosis. It should be stored in a cool, dry, and dark environment, with a recommended storage temperature of -20 ° C. Because it is a flammable solid, appropriate personal protective equipment such as N95 masks, goggles, and gloves should be worn during operation.The potential applications of AICAR in metabolic disorders, cardiovascular disease, neurodegenerative diseases, cancer, and exercise performance enhancement highlight its versatility and promise as a therapeutic agent
Customized Bottle Caps & Corks
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Additional information of chemical compound:
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Chemical Formula |
C9H15N4O8P |
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Exact Mass |
338.06 |
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Molecular Weight |
338.21 |
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m/z |
338.06 (100.0%), 339.07 (9.7%), 340.07 (1.6%), 339.06 (1.5%) |
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Elemental Analysis |
C, 31.96; H, 4.47; N, 16.57; O, 37.84; P, 9.16 |
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Melting point |
214-215℃ |
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Boiling point |
726.3±60.0℃(Predicted) |
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Density |
2.06±0.1 g/cm3(Predicted) |
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Storage conditions |
-20℃ |
Aicar Powder COA
Aicar powder is an important chemical substance with a wide range of applications in multiple fields. The following is a detailed explanation of the purpose of Aicar:
1.Scientific research field
Aicar plays a crucial role in metabolic research as an activator of AMP activated protein kinase (AMPK). AMPK is a key sensor of cellular energy status. When cellular energy levels decrease, the AMP/ATP ratio increases, activating AMPK and regulating a series of metabolic processes. Aicar is able to simulate this energy stress state, thereby activating AMPK, providing a powerful tool for studying the role of AMPK in metabolic regulation. Aicar has been widely used in cell experiments to study the effects of AMPK activation on cellular metabolism. For example, by adding Aicar to cells, the uptake and utilization of glucose and fatty acids by AMPK activated cells can be observed, as well as changes in cell growth and proliferation. In animal experiments, Aicar has also been used to study the effect of AMPK activation on overall metabolism. By injecting Aicar into animals, the effects on metabolic indicators such as body weight, blood glucose, and blood lipids can be observed, as well as the role of AMPK activation in improving metabolic diseases.
Research on anti-inflammatory effects
Aicar also has anti-inflammatory effects, which can inhibit the synthesis and release of certain inflammatory factors. This characteristic makes it potentially valuable in the study of anti-inflammatory effects. In vitro experiments, Aicar was used to study its effects on the release of inflammatory cytokines from immune cells such as macrophages and astrocytes. The results indicate that Aicar can dose dependently inhibit the synthesis and release of inflammatory cytokines in these cells. In in vivo experiments, Aicar has also been used to study its improvement effect on inflammatory diseases. For example, in animal models, by injecting Aicar into animals, the improvement effect on inflammatory diseases such as arthritis and enteritis can be observed.
2.Medical and clinical fields
Due to its ability to activate AMPK and regulate lipid and glucose metabolism, Aicar has the potential to treat metabolic diseases. Aicar can promote the uptake and utilization of glucose in skeletal muscles by activating AMPK, thereby reducing blood sugar levels. This is of great significance for patients with diabetes. Aicar can regulate fat metabolism, reduce fat accumulation, and thus help reduce weight and improve obesity. Aicar has therapeutic effects on cardiovascular diseases by improving myocardial energy metabolism and reducing myocardial ischemia-reperfusion injury. Aicar also has a protective effect on the kidneys. By activating AMPK, Aicar can alleviate renal fibrosis and improve renal function. This is of great significance for patients with chronic kidney disease.
Improve ischemia or reperfusion injury
Aicar also has the effect of improving ischemia or reperfusion injury. During ischemia or reperfusion, cells undergo severe energy crisis and oxidative stress damage. Aicar can protect cells from these damages by activating AMPK. Cardiac ischemia-reperfusion injury: During the process of cardiac ischemia-reperfusion, Aicar can reduce myocardial cell damage and apoptosis, and improve cardiac function. Cerebral ischemia-reperfusion injury: During cerebral ischemia-reperfusion, Aicar can also protect neurons from damage and improve neurological function.
3.In the field of fitness and nutritional supplementation
Aicar can activate AMPK, promote muscle uptake and utilization of glucose, thereby providing energy support for muscle growth and recovery. This is of great significance for athletes and fitness enthusiasts. By supplementing Aicar, they can better train and accelerate the muscle recovery process.
Aicar can also improve the body's endurance level and enhance athletic performance. By activating AMPK, Aicar can promote the oxidative utilization of fatty acids, providing sustained energy supply for exercise. This is particularly important for projects that require long-term aerobic exercise such as long-distance running, swimming, etc. Aicar has a certain fat reducing effect. By activating AMPK, it can promote the breakdown and metabolism of fat, thereby reducing fat accumulation in the body. This is a good choice for people who want to lose weight and shape themselves. However, it should be noted that the effect of weight loss may vary from person to person, and it should be combined with a reasonable diet and exercise plan to achieve the best results.
Other application areas
The anti-inflammatory and antioxidant effects of Aicar make it have potential application prospects in the cosmetics industry. By adding it to cosmetics, it can exert anti-inflammatory, antioxidant, moisturizing and other effects, thereby improving skin condition and delaying the aging process of the skin. In the field of agriculture, Aicar is also used to study its effects on plant growth and development. By regulating metabolic processes within plants, Aicar has the potential to increase crop yield and quality. However, research in this field is still in its infancy and requires further exploration and study.
Aicar(Acadesine),Akadixin is an activator of membrane permeable AMP activated protein kinase (AMPK). AMPK is a heterodimeric protein serine/threonine kinase that is a key protein in metabolic regulation. When energy supply is insufficient, the ratio of AMP/ATP is upregulated, and AMPK is activated, thereby inhibiting synthetic metabolism. AICAR can activate AMPK, but does not affect the levels of ATP, ADP, and AMP. As a white powder with specific biological activity, Aicar powder has shown broad development prospects in multiple fields. The following is a detailed discussion on its development prospects:
Technological Innovation and R&D Trends
Optimization and improvement of synthesis process
At present, the synthesis process of Aicar is relatively mature, but there are still some problems, such as high raw material costs, cumbersome synthesis steps, and low yield. In the future, with the continuous advancement and innovation of chemical synthesis technology, the synthesis process of Aicar will be further optimized and improved. This will help reduce production costs, improve productivity, and meet market demand.
Development and application of new drug delivery systems
In order to improve the bioavailability and targeting of Aicar, new drug delivery systems such as nanocarriers, liposomes, microspheres, etc. may be developed in the future. These drug delivery systems can encapsulate Aicars internally or adsorb them onto surfaces, entering the body through specific pathways such as oral administration, injection, etc., to achieve slow drug release and targeted delivery. This will help improve the efficacy and safety of drugs, and reduce side effects.
Research on AMPK signaling pathway and development of new drugs
With the continuous deepening of research on the AMPK signaling pathway, more disease targets and signaling pathways related to AMPK may be discovered in the future. This will provide new research directions and candidate drugs for new drug development. Aicar and its analogues may become new drug candidates targeting these new targets, providing new solutions for the treatment of chronic diseases such as metabolic disorders and cardiovascular diseases.
The impact of policies, regulations, and regulatory environment on the development of Aicar
Legal and regulatory restrictions and regulatory requirements
Due to Aicar being considered a genotype banned drug, its use is prohibited in sports competitions. In addition, Aicar may also be subject to legal and regulatory restrictions in multiple fields such as drug management and food safety. Therefore, the production, sales, and use of Aicar must strictly comply with relevant laws, regulations, and regulatory requirements. In the future, with the continuous improvement of laws and regulations and the strengthening of supervision, the supervision of Aicar powder will be more stringent. This will help safeguard the rights and safety of consumers, and prevent the occurrence of illegal production and sales activities. At the same time, it will also promote the healthy development of the Aicar industry, drive technological innovation and industrial upgrading.
Trends and opportunities in international cooperation and exchange
With the continuous advancement of globalization and the strengthening of international cooperation, Aicar's research and development, production, and sales will gradually move towards internationalization. In the future, domestic and foreign enterprises will jointly promote the innovation and development of Aicar technology through cooperation and exchange. This will help enhance the international competitiveness of China's Aicar industry and expand the international market. Meanwhile, international cooperation and exchange will also provide new ideas and methods for the research and development of Aicar. By drawing on international advanced experience and technological achievements, we can accelerate the technological innovation and industrial upgrading process of China's Aicar industry.
Prediction of Future Development Trends in the Aicar Industry
The market size continues to expand: With the increasing emphasis on health and fitness, as well as the continuous development of pharmaceutical and biochemical research fields, the market demand for Aicar will continue to grow. It is expected that the Aicar market will continue to expand in the coming years, and market competition will become more intense. In order to seize market share and maintain a competitive advantage, enterprises need to continuously strengthen technology research and innovation, optimize production processes, expand application areas and market channels.
Technological innovation drives industrial upgrading: Technological innovation is an important driving force for the development of Aicar industry. In the future, with the continuous progress and innovation in chemical synthesis technology, drug delivery system technology, AMPK signaling pathway research, etc., the Aicar industry will usher in more opportunities for technological innovation and industrial upgrading. This will help improve product quality and performance, reduce production costs, and enhance market competitiveness. At the same time, it will inject new vitality and momentum into the sustainable development of the Aicar industry.
Acceleration of internationalization process: With the continuous advancement of globalization and the strengthening of international cooperation, the internationalization process of the Aicar industry will accelerate. In the future, domestic and foreign enterprises will jointly promote the innovation and development of Aicar technology through cooperation and exchange. This will help enhance the international competitiveness of China's Aicar industry and expand the international market. At the same time, it will also provide more opportunities and challenges for the sustainable development of the Aicar industry.
Environmental protection and sustainable development have become important issues: With the continuous improvement of environmental awareness and the deepening of sustainable development concepts, the environmental and sustainable development issues of the Aicar industry will receive increasing attention. In the future, enterprises need to strengthen the research and innovation of environmental protection technologies, optimize resource utilization and waste disposal processes, and reduce resource consumption and waste emissions. At the same time, it is also necessary to actively participate in environmental public welfare activities and social responsibility projects to establish a good corporate image and brand image. This will help enhance the corporate social responsibility and public recognition, and lay a solid foundation for the sustainable development of the enterprise.
Quality control
Purity control
The purity of AICAR powder is a core indicator for quality control, and it is usually required that the purity be greater than or equal to 98%.
The content of AICAR can be precisely determined through modern analytical techniques such as high performance liquid chromatography (HPLC), ensuring the accuracy and consistency of its purity.
Impurity control
The impurity content in AICAR powder must be strictly controlled, and the total impurity content usually should not exceed 0.5%.
Any uncontrolled impurities may affect the safety of drugs, so it is necessary to ensure that the impurity levels meet the standards through technical means such as chromatographic analysis.
Heavy metal control
The heavy metal content in AICAR powder must comply with the requirements of the national pharmacopoeia. The content of common heavy metals such as lead, arsenic and cadmium needs to be strictly controlled.
For instance, the content of lead must not exceed 2ppm, and the content of arsenic must not exceed 2ppm to ensure the safety of drug use for human beings and prevent the risk of heavy metal poisoning.
Microbial control
The microbial content of AICAR powder must comply with the relevant pharmacopoeia requirements, including the absence of pathogenic bacteria (such as Salmonella, Escherichia coli, etc.) and the total colony count and mold/yeast content should be within a safe range.
During the production and packaging processes, it is essential to strictly control microbial contamination to ensure the stable quality of the drugs.
Storage and transportation control
AICAR powder should have good stability during storage and transportation.
It is usually required to be stored in a cool and dry place, avoiding direct sunlight and high-temperature environments.
During transportation, appropriate measures should be taken to prevent the powder from getting damp or deteriorating.
Detection method control
Standardized detection methods are adopted to control the quality of AICAR powder, such as laser diffraction, spectral analysis and other technical means.
Strictly follow international and domestic standards such as ASTM, ISO and GB/T to ensure the accuracy and reliability of the test results.
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