Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of met-enkephalin cas 58569-55-4 in China. Welcome to wholesale bulk high quality met-enkephalin cas 58569-55-4 for sale here from our factory. Good service and reasonable price are available.
Met-enkephalin, as the earliest discovered opioid-like neuropeptide in the human body, has a relatively small molecular structure - consisting of only five amino acids in the precise sequence of "tyrosine - glycine - glycine - phenylalanine - methionine". Despite its small size, it plays a crucial role as a "natural analgesic" and "emotional regulator" in the nervous system.
It is mainly distributed in the central nervous system (such as the striatum and limbic system of the brain) and the adrenal glands, etc. By selectively activating δ-type and μ-type opioid receptors, it directly inhibits the transmission of pain signals in the spinal cord and brain, thereby generating rapid and effective endogenous analgesic effects.
|
Customized Bottle Caps And Corks:
|
|
|
Chemical Formula |
C27H35N5O7S |
|
Exact Mass |
573 |
|
Molecular Weight |
574 |
|
m/z |
573 (100.0%), 574 (29.2%), 575 (4.5%), 575 (4.1%), 574 (1.8%), 575 (1.4%), 576 (1.3%) |
|
Elemental Analysis |
C, 56.53; H, 6.15; N, 12.21; O, 19.52; S, 5.59 |
Its mechanism of action is similar to that of exogenous opioid drugs such as morphine, but as a body's own messenger, the risks of respiratory depression and addiction it causes are much lower than those of the latter. In addition to its outstanding analgesic function, methionine enkephalin is deeply involved in regulating emotions, reward circuits, and stress responses, and can induce feelings of pleasure and satisfaction. It is a key substance for the body to cope with stress and maintain internal environmental stability. It also plays an important modulatory role in learning and memory, endocrine regulation, and immune system functions.
However, its instability - being easily degraded by peptide enzymes in the body, resulting in a very short biological half-life - greatly limits its direct clinical application potential. Nevertheless, it remains a key template and research direction for developing new, highly efficient, and low-dependency analgesic drugs, and profoundly reveals the precise chemical mechanism by which the brain manages pain and emotions.
MET5 enkephalin, as a bioactive neuropeptide, has broad application value in various fields such as medicine, biology, drug development, and biochemistry.
By synthesizing and modifying the molecular structure of MET5 enkephalin, candidate drugs and research tools with different activities and selectivity can be developed, providing strong support for a deeper understanding of the essence of life activities, revealing the pathogenesis of diseases, and developing new therapeutic drugs.Meanwhile, with the continuous development of science and technology and the continuous innovation of research methods, the chemical uses of MET5 enkephalin will become more extensive and in-depth.Met-enkephalin, as a bioactive neuropeptide, has a wide range of chemical applications. It plays an important role in multiple fields such as medicine, biology, drug development, and biochemistry.
Applications in the medical field
(1) Pain management:MET5 enkephalin is an endogenous analgesic substance that can regulate the transmission of pain signals by binding to specific receptors on the cell membrane. Therefore, in the medical field, MET5 enkephalin or its analogues are used as the basis for the development of analgesic drugs. By synthesizing and modifying the molecular structure of MET5 enkephalin, more efficient and low side effect analgesic drugs can be developed to alleviate various pain symptoms, such as postoperative pain and chronic pain.
(2) Antidepressant and anti anxiety effects:MET5 enkephalin also has antidepressant and anti anxiety effects, which can regulate the release and reuptake of neurotransmitters, and improve emotional states. Therefore, in the field of psychiatry, MET5 enkephalin or its analogues are also used as the basis for the development of antidepressant and anti anxiety drugs. The development of these drugs can help alleviate symptoms in patients with mental illness and improve their quality of life.
(3) Neuroprotective effect:MET5 enkephalin also has neuroprotective effects, which can reduce neuronal damage and death, and promote nerve regeneration. Therefore, in the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc., MET5 enkephalin or its analogues are used as potential therapeutic drugs. Through in-depth research on the neuroprotective mechanism of MET5 enkephalin, it is expected to provide new ideas and methods for the treatment of these diseases.
Applications in the field of biology
(1) Neurobiological research
Met-enkephalin, as a neuropeptide, has a wide range of applications in the field of neurobiology. By synthesizing and labeling MET5 enkephalin or its analogues, techniques such as autoradiography and fluorescence microscopy can be used to study its distribution, transportation, and receptor binding in the nervous system. This is of great significance for a deeper understanding of the structure and function of the nervous system, and for revealing the mechanism of action of neuropeptides in neural signal transmission.
(2) Molecular Biology Research
MET5 enkephalin can also bind to specific receptors on the cell membrane, activating a series of signal transduction pathways. Therefore, in the field of molecular biology, MET5 enkephalin or its analogues are used as research tools to investigate the mechanisms and functions of related signal transduction pathways. By synthesizing and modifying the molecular structure of MET5 enkephalin, specific and sensitive probes can be developed for detecting the expression and distribution of intracellular signaling molecules, revealing the regulatory mechanisms and biological functions of signal transduction pathways.
Applications in the field of drug research and development
(1) Drug screening and optimization
MET5 enkephalin or its analogues have a wide range of applications in drug development. By synthesizing and modifying the molecular structure of MET5 enkephalin, candidate drugs with different activities and selectivity can be developed. These candidate drugs can be used in drug screening and optimization processes to search for drug molecules with excellent efficacy and low side effects. Meanwhile, by utilizing the interaction mechanism between MET5 enkephalin or its analogues and receptors, more targeted drug molecules can be designed to improve the therapeutic effect and safety of drugs.
(2) Research on the Mechanism of Drug Action
MET5 enkephalin or its analogues also play an important role in the study of drug action mechanisms. By synthesizing and labeling these molecules, biochemical and molecular biology techniques can be utilized to study the binding kinetics, structure-activity relationships, and signal transduction pathways between drugs and receptors. These studies contribute to a deeper understanding of the mechanisms of action and efficacy of drugs, providing theoretical basis for drug development and optimization.
Applications in the field of biochemistry
(1) Peptide library construction and screening
MET5 enkephalin, as a peptide molecule with specific biological activity, has important application value in the construction and screening of peptide libraries in the field of biochemistry. By synthesizing a series of MET5 enkephalin analogues, a diverse and complex peptide library can be constructed. These peptide libraries can be used for high-throughput screening and identification of peptide molecules that interact with specific receptors or biomolecules, providing abundant candidate molecular resources for drug development and basic research.
(2) Research on protein-protein interactions
MET5 enkephalin or its analogues can also be used to study protein-protein interactions. By synthesizing and labeling these molecules, techniques such as affinity chromatography and mass spectrometry can be used to study the binding kinetics, binding sites, and interaction mechanisms of MET5 enkephalin or its analogues with specific proteins. These studies help to reveal the interaction networks and regulatory mechanisms between proteins, providing important clues for a deeper understanding of the essence of life activities.
Met-enkephalin, also known as methionine enkephalin, is a five peptide neurotransmitter composed of five amino acids: methionine, phenylalanine, alanine, glycine, and leucine. It has multiple pharmacological properties, mainly including analgesic, sedative, antidepressant, and anti anxiety effects.
1. Analgesic effect: MET5 enkephalin is an endogenous analgesic substance that can regulate the release of neurotransmitters by binding to opioid receptors, thereby producing analgesic effects. This effect is similar to opioid drugs such as morphine, but does not produce side effects such as drug dependence and addiction.
2. Sedative effect: MET5 enkephalin can also exert a sedative effect by regulating the release of neurotransmitters, helping to alleviate negative emotions such as anxiety and stress.
3. Antidepressant effect: MET5 enkephalin has a certain antidepressant effect in the central nervous system, which can improve emotional state and enhance quality of life. This effect may be related to regulating the levels of neurotransmitters such as serotonin and dopamine.
4. Participate in regulating physiological functions such as appetite, sleep, and mood: MET5 enkephalin can also participate in regulating physiological functions such as appetite, sleep, and mood, playing an important role in maintaining physical health and psychological balance.
In addition, MET5 enkephalin also has various biological activities, including the ability to bind specifically to opioid receptors. This combination can produce effects similar to enkephalin, such as regulating the release of neurotransmitters and producing analgesic effects.
Preparation instructions for drug characteristics
Met Enkephalin is an endogenous neuropeptide composed of five amino acids, with the molecular formula C ₂₇ H ∝₅ N ₅ O ₇ S and a molecular weight of 573.66 g/mol. Its structure is Tyr Gly Gly Phe Met, which binds with high affinity to the δ - OR and μ - OR opioid receptors through tyrosine residues, activating downstream signaling pathways and producing analgesic, immune regulatory, and neuroprotective effects.
Injection related reactions
Local irritation: When injected intravenously or subcutaneously, high concentration solutions may cause pain, swelling, or hardening at the injection site. Animal experiments have shown that after injecting a dose of 10 mg/kg into the tail vein of rats, local vascular permeability increases for about 2 hours.
Allergic reactions: A very small number of patients (<1%) may experience immediate allergic reactions, manifested as rash, itching, hypotension, or bronchospasm.
The mechanism is related to IgE mediated type I hypersensitivity reaction, which requires immediate discontinuation of medication and treatment with adrenaline.
Cardiovascular system response
Hypotension: Activation of opioid receptors can inhibit sympathetic nervous tension, leading to vasodilation and a decrease in blood pressure. After intravenous injection of 0.1 mg/kg Met Enkephalin in healthy volunteers, the average systolic blood pressure decreased by 15-20 mmHg for about 30 minutes.
Bradycardia: Activation of μ - OR can inhibit sinus node autonomy and slow down heart rate by 5-10 beats per minute. Elderly patients or those with sinus node dysfunction should use it with caution.
Neurological response
Dizziness and drowsiness: About 20% of patients report mild dizziness, which may be related to central nervous system suppression. In the volunteer study, the 0.05 mg/kg dose group showed decreased attention within 1 hour after administration, but did not affect the execution of complex tasks.
Chronic and subchronic toxicity
Repeated dose toxicity study
Rat model: After oral administration of 50 mg/kg/d for 90 consecutive days, vacuolar degeneration of liver cells, granular degeneration of renal tubular epithelial cells, and decreased splenic lymphocytes were observed. Pathological scoring shows that the degree of liver damage is positively correlated with dosage.Non human primates: After subcutaneous injection of a dose of 10 mg/kg/d for 6 consecutive months.no significant organ toxicity was observed in rhesus monkeys, but serum ALT levels slightly increased (<2-fold upper limit) and returned to normal within 2 weeks after discontinuation.
Reproductive and developmental toxicity
Embryotoxicity: After oral administration of a dose of 100 mg/kg/d during organ formation (GD6-18) in pregnant rabbits, the fetal weight decreased by 15% and the rib deformity rate increased to 8% (control group 2%). The mechanism may be related to the interference of zinc ions on the activity of zinc dependent enzymes during embryonic development.Fertility effects: After subcutaneous injection of a dose of 20 mg/kg/d for 60 consecutive days in male rats, the epididymal sperm count decreased by 30%, but no abnormalities were observed in testicular histology.
FAQ
What does metenkephalin do?
Comment: MENK is an endogenous opioid peptide. It exhibits agonist activity at the δ- and μ-opioid receptors. MENK produces immunomodulatory, neuromodulatory, antinociceptive/analgesic, antidepressant, and gastrointestinal motility modulating activities.
Is MENK excitatory or inhibitory?
We found a concentration-dependent effect on modulation; moderate concentrations of enkephalin primarily inhibited inhibitory signaling, leading to ACC disinhibition, while higher concentrations of enkephalin inhibited both excitation and inhibition.
What is the met enkephalin peptide sequence?
This present the amino acid sequence Tyr-Gly-Gly-Phe-Met. The leu-enkephalins present the amino acid sequence Tyr-Gly-Gly-Phe-Leu.
What is the chemical structure of met enkephalin?
Structural features:Both Metenkephalin and Leu-enkephalin, which are derived from PENK, are composed of five aa residues; the amino acid sequence of the former is Tyr-Gly-Gly-Phe-Met and that of the latter is Tyr-Gly-Gly-Phe-Leu.
Hot Tags: met-enkephalin cas 58569-55-4, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, CAS 1799295 84 3, iptg powder, 3r 5r 7r 1 3 bromophenyl adamantane, Cosmetic, CAS 1936437 58 9, Organic Intermediate