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Palmitoyl Tripeptide-5 is a novel lipophilic synthetic signal peptide with the molecular formula C35H66F3N5O7 and CAS 623172-56-5. With excellent skin penetration and biological activity, it has become a core functional ingredient in the field of cosmetics anti-aging and repair. This substance can simulate the structure of platelet reactive protein, target and activate the TGF - β signaling pathway in the skin, and achieve multiple effects such as skin anti-aging, barrier repair, and skin quality improvement by promoting extracellular matrix synthesis, inhibiting matrix metalloproteinase expression, and regulating low-grade inflammation of the skin.
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Palmitoyl Tripeptide-5 COA
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| Certificate of Analysis | ||
| Compound name | Palmitoyl Tripeptide-5 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 623172-56-5 | |
| Quantity | 70g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.32% |
| Loss on drying | ≤1.0% | 0.28% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.26% |
| Total microbial count | ≤750cfu/g | 450 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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| Chemical Formula: | C35H66F3N5O7 |
| Exact Mass: | 725 |
| Molecular Weight: | 726 |
| m/z: | 725 (100.0%), 726 (37.9%), 727 (4.3%), 727 (2.7%), 726 (1.8%), 727 (1.4%) |
| Elemental Analysis: | C, 57.91; H, 9.16; F, 7.85; N, 9.65; O, 15.43 |

With the rapid development of the functional skincare industry, mild, efficient, and low stimulating bioactive ingredients have become the core direction of skincare research and development. Due to the advantages of strong targeting, high cytocompatibility and low sensitization rate, peptide raw materials have gradually replaced some irritating anti-aging ingredients and become the mainstream raw materials in the field of derma anti-aging and repair.
Facial anti-aging repair
Facial anti-aging is the most core and mature application scenario of palmitoyl tripeptide-5, which has significant improvement effects on various derma problems caused by natural aging and photoaging. In terms of improving fine lines, an 84 day human clinical trial showed that 2.5% concentration
SYN-COLL cream can reduce the depth of derma wrinkles by 12%, and has better improvement effects on nasolabial lines, static fine lines around the eyes, and dry lines on the forehead than traditional palmitoyl pentapeptide-3. In terms of derma tightening, 8-week human testing has confirmed that this ingredient can increase skin elasticity by 24%.
Effectively tighten sagging derma, optimize facial jawline contours, and improve facial collapse and sagging problems. At the same time, it can tighten the collagen support structure of pore walls, inhibit pore inflammation and keratinization, improve the problem of enlarged pores caused by abnormal oil secretion and collagen loss. After 28 days of use, it can significantly reduce derma roughness and shrink the visual pore size in the T-zone and nasal wing. At the level of derma improvement, it can increase the moisture content of the stratum corneum, reduce transdermal water loss, improve dry derma dryness, peeling, tightness, and powder sticking problems, and effectively repair aging and damaged derma.
Sensitive Skin Repair and Medical Post Art
Relying on excellent anti-inflammatory, soothing, and barrier repair abilities, it is widely used in the fields of sensitive muscle care and minimally invasive medical beauty repair. For sensitive derma with redness, a 28 day clinical trial showed that topical application can reduce the redness value of the derma by 21%, effectively alleviate sensitive symptoms such as derma pain, itching, and redness, and has no sensitization or irritation. In the post medical art scene, minimally invasive medical beauty projects such as photon rejuvenation, dot matrix laser, microneedle, acid brushing and so on will cause derma damage and dermal collagen damage.
This raw material can penetrate the epidermis to activate the dermal repair pathway, accelerate collagen regeneration and cuticle healing, shorten the recovery period of postoperative redness and crusting, and reduce the risk of anti blackening and imprinting. It is the core active raw material of medical beauty repair dressing and postoperative repair essence. At the same time, it can buffer the irritant effects of highly active ingredients such as retinol and fruit acid, and is commonly used in the stabilization and compounding of high-performance formulas.

Special care for local skin
In the field of segmented area care, it is suitable for derma care around the eyes, lips, neck, body and other multiple areas. The derma around the eyes is thin and tender, with a fast rate of collagen loss. Low concentrations can safely penetrate the derma around the eyes. Continuous use for 12 weeks can significantly reduce crow's feet, improve sagging derma under the eyes, and will not induce fat particles. It is widely used in firming eye cream and eye mask products. In lip care, palmitoyl tripeptide-5 can repair dry and cracked lip barriers, fade vertical lip lines, and enhance lip plumpness.
In neck and body care, it can improve transverse neck lines, postpartum abdominal relaxation, rough dry lines of limbs and other problems, and is suitable for neck cream, body firming milk, postpartum repair lotion and other products. In addition, in recent years, emerging research has applied it to scalp care, which can thicken scalp collagen, stabilize hair follicle base, alleviate scalp sensitivity, dryness, and fine and soft hair problems after perming, and belongs to a niche application scenario with great development potential.

Skin care, makeup and daily chemical care
In the field of color makeup, it breaks the limitation that traditional base makeup only covers physically, and is added to liquid foundation, air cushion, concealer and other products as a maintenance active ingredient. Low concentration addition can continuously repair pores and fine lines during the makeup process, reduce makeup residue and discoloration.
Long term use can improve rough derma texture, reduce derma inflammation caused by makeup blockage, and achieve a dual effect of "makeup application+skin care". In the field of daily chemical care, it can be applied to hand cream, foot repair cream, fade joint lines on the hands, and repair dry, cracked, and aged derma on the heels; The weakly acidic low concentration formula can also be used for intimate skin care, soothing dry derma and enhancing derma elasticity.

Research and Experimental Industry
In addition to the civilian skincare field, it is a core standardized reagent for derma pharmacology research and cosmetic raw material development. Firstly, it can serve as a positive control reagent for fibroblast model experiments and be used for comparative screening of the efficacy of new anti-aging active substances; Secondly, it is commonly used for the validation of the effectiveness of nano transdermal delivery systems and is the core model material for the development of peptide delivery technology; Thirdly, it can be used to construct in vitro cell models of skin photoaging and low-grade inflammation, providing support for the mechanism research of anti-inflammatory and antioxidant materials; Fourthly, it can be used as a safety assessment reference substance for the sensitization and irritation testing of new cosmetic raw materials.

Based on molecular characteristics and regulatory standards, palmitoyl tripeptide-5 has clear prohibited and ineffective application scenarios, which is a core principle that must be followed in industrial applications.
Firstly, it is prohibited to use it in medical injection and medical beauty filling scenarios. This raw material is safe for external use, but subcutaneous injection will continue to activate the TGF - β pathway, posing risks of skin fibrosis and scar hyperplasia, and does not have any injection safety compliance qualifications.
Secondly, oral administration is prohibited as its molecular structure cannot tolerate the degradation of gastric acid in the digestive tract. After oral administration, it completely loses its biological activity and there is no oral safety assessment data available. Therefore, it cannot be used in the fields of food and health products.
Thirdly, it is not suitable for rinse type care products. The raw material needs to stay on the skin for more than 4 hours to activate the collagen repair pathway, and short-term rinse products such as shampoo, shower gel, and facial cleanser cannot be effective.
Fourthly, it is prohibited to use it in non skincare fields such as industrial materials and food additives, without relevant compliance assessment and application value.
FAQ
What does palmitoyl tripeptide-5 do for skin?
Skin Perfection Syn-Coll Serum Booster or Palmitoyl Tripeptide-5 is a natural collagen-boosting peptide that you can mix into lotions, serums, moisturizers, and eye creams to promote collagen production.
What is another name for palmitoyl tripeptide-5?
Palmitoyl Tripeptide-5 (Syn-Coll) Peptide and Collagen Production. Syn-Coll, also known as Palmitoyl Tripeptide-5 or Tripeptide-5, is a peptide that researchers suggest may act to increase the production of Type I and Type III collagen while possibly also inhibiting its degradation.
What is palmitoyl Tripeptide-5 used for?
Palmitoyl tripeptide-5 is also used in anti-aging cosmetic products, due to its ability to reduce MMP'S and promote the synthesis of type I and type II collagen from extracellular matrix, as well as for inhibiting melanin production by reducing tyrosinase activity.
Is palmitoyl Tripeptide-5 natural?
Palmitoyl Tripeptide-5 is produced synthetically using solid-phase peptide synthesis. The tripeptide (Lys-Val-Lys) is assembled and then conjugated with palmitic acid. This biomimetic peptide is designed to mimic natural signaling molecules in the skin for improved efficacy and penetration.
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