Polygonatum Peptide

1. Immune regulation: building the first line of defense for the human body
One of the most essential functions is immune regulation. Research has shown that berberine can stimulate T lymphocyte proliferation and activation, promote lymphocyte maturation, and enhance the antibody response ability of B cells. It can significantly enhance the phagocytic ability of macrophages, improve the non-specific immune function of the body, and have a clear improvement effect on immune dysfunction symptoms such as recurrent respiratory infections and chronic fatigue syndrome.

The synergistic effect of steroidal saponins (such as Siberian Polygonatum sibiricum glycoside A and B) in Huangjing with oligopeptides can further activate NK cell activity and enhance overall immune surveillance function.

2. Anti fatigue: Injecting long-lasting endurance energy into the body
Its anti fatigue effect has been confirmed by multiple studies. The mechanism includes: ① increasing the content of muscle glycogen and liver glycogen in fatigued bodies, enhancing exercise endurance; ② Eliminate the accumulation of fatigue substances such as blood lactate and blood urea nitrogen;

③ Eliminate oxygen free radicals generated during exercise and alleviate muscle fatigue. Athletes and high-intensity workers can significantly improve their endurance performance after taking it, and sub-health individuals can accelerate their physical recovery after using it. In the oligopeptide products of Polygonatum sibiricum, corn oligopeptide works synergistically with Polygonatum sibiricum peptide and is rich in branched chain amino acids (leucine, isoleucine, valine), which can effectively repair skeletal muscle injuries and further alleviate exercise fatigue.

3. Antioxidant and anti-aging: the youthful code that protects cells
Rich in antioxidant active ingredients, polygonatum peptide can effectively scavenge free radicals such as DPPH and ABTS, and also has iron chelation activity and reduction activity. Research has shown that continuous feeding of Huangjing decoction can significantly increase the activity of superoxide dismutase (SOD) in mouse liver and reduce the content of myocardial lipofuscin. By activating antioxidant enzymes in the body, inhibiting oxidase activity, and chelating metal ions, multiple pathways can be used to block peroxidation reactions and delay the process of cellular aging.

In the field of cosmetics, its antioxidant capacity provides scientific support for anti-aging skincare.

4. Regulating blood sugar: good news for people with diabetes
Both Polygonatum sibiricum polysaccharides and Polygonatum sibiricum oligopeptides exhibit significant hypoglycemic potential.The experiment confirmed that Huangjing water extract could enhance the expression of GLUT gene in insulin resistant rats with type II diabetes mellitus, thereby reducing blood sugar.

Huangjing oligopeptide has a strong inhibitory effect on alpha glucosidase (active peptide segments such as RVPSLM and TPSPR), which can delay postprandial blood glucose elevation. In addition, polygonatum polysaccharide can improve the symptoms of diabetes nephropathy, protect the kidney, and reduce the levels of urinary microalbumin, blood creatinine and urea nitrogen. Polygonatum sibiricum oligopeptide exerts hypoglycemic effects by improving insulin resistance, promoting glycogen synthesis, and other multiple processes.

5. Regulating blood lipids: the cleaner of the cardiovascular system
It can significantly reduce the levels of total cholesterol (TC) and triglycerides (TG). Huangjing water decoction and ethanol extract mixed with feed can significantly reduce the serum TC and TG of hyperlipidemia rats. Huangjing polysaccharide can down regulate the high expression of VCAM-1 in experimental atherosclerosis vascular intima, inhibit the adhesion of inflammatory cells to endothelial cells, and prevent vascular endothelial inflammatory reaction. Hydrophobic peptide segments have functions such as reducing cholesterol.

Promoting cholesterol metabolism in the body, and increasing fecal sterol excretion, making them a core component of lipid-lowering functional foods.

6. Detoxification and Liver Protection: The Loyal Defender of the Liver
This is one of the most sought after uses of polygonatum peptide in the market in recent years. In compound products such as Polygonatum sibiricum oligopeptides, Polygonatum sibiricum peptides work synergistically with corn oligopeptides and rice bran fatty alcohols to relieve alcohol intoxication and protect the liver. The mechanism includes:

① Drinking before drinking can form a protective film on the surface of the gastric mucosa, while increasing the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver, accelerating alcohol metabolism; ② Drinking alcohol after drinking can accelerate the elimination of alcohol metabolites, reduce the concentration of ethanol and acetaldehyde in the body, and alleviate hangover symptoms such as headache and nausea; ③ Long term use has an auxiliary repairing effect on mild fatty liver and mild alcoholic liver injury. Symptoms such as reduced fatigue and improved appetite can be observed after 3 months of use, and liver function indicators (ALT, AST, bilirubin) can be improved after 6 months of use.

7. Strengthening the spleen and nourishing the stomach: the golden regulator of the digestive system
Huangjing belongs to the spleen, lung, and kidney meridians, and has the traditional effects of "tonifying qi and nourishing yin, strengthening the spleen and moistening the lungs, and benefiting the kidneys". The 2015 edition of the Chinese Pharmacopoeia clearly records that Huangjing is used for "spleen and stomach qi deficiency, fatigue and weakness, insufficient stomach yin, dry mouth, and insufficient food intake".

Low molecular weight, can be directly absorbed by the body, reducing the burden on the gastrointestinal tract, while repairing spleen and stomach cells and regulating spleen and stomach activity. It contains a variety of digestive enzymes and rich dietary fiber, which helps to break down and absorb food, promote gastrointestinal peristalsis, and effectively alleviate discomfort such as indigestion, loss of appetite, and bloating.

8. Tonifying Kidney and Nourishing Essence: A Good Nourishing Product Suitable for Both Men and Women

Inheriting the core medicinal effects of Huangjing, which nourish the kidneys and lungs, nourish the kidneys and nourish essence, it has a good regulating effect on symptoms such as kidney deficiency and essence deficiency, soreness and weakness of the waist and knees, and early white hair. In the low molecular weight peptide products of Polygonatum sibiricum oyster, Polygonatum sibiricum peptide and oyster peptide (rich in zinc element) work together to enhance the kidney tonifying effect. For men, it can improve sperm motility; For women, it helps improve endocrine function and delay menopausal discomfort. In addition, tryptophan can regulate the brain nerves, improve sleep quality, and alleviate insomnia and dreams.

9. Biomedical Materials: New Directions in Frontier Research
In 2026, the latest patent disclosed a kind of polygonatum oligopeptide nanocellulose composite hydrogel, which combines polygonatum peptide (PSP), tannic acid (TA) and nanocellulose (CNC) to produce multifunctional hydrogel through UV curing polymerization. This material has excellent mechanical properties, swelling properties, antibacterial properties, and antioxidant properties, showing broad prospects in the research of antibacterial and antioxidant composite materials in the biomedical field.

This marks the expansion of its application from food nutrition to the forefront of biomedical materials.

10. Beauty and skincare: the way to rejuvenate from the inside out
Polygonatum sibiricum oligopeptide promotes collagen synthesis, inhibits its degradation, maintains skin elasticity and radiance, and reduces the formation of wrinkles and pigmentation. Its antioxidant capacity clears free radicals and delays skin oxidative aging. In the field of cosmetics, polygonatum oligopeptides can be added to anti-aging essence, facial mask and other products as active ingredients, with models covering food level and cosmetics level