Semax Powder CAS 80714-61-0

Semax powder is an artificially synthesized neuroactive peptide drug raw material. Chemically, it is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro). It was initially developed based on the fragment of adrenocorticotropic hormone. As a solvent-free freeze-dried powder, it has high stability, is convenient for storage and transportation, and is the core component for preparing nasal spray solution. Its mechanism of action involves regulating the neural transmitter system in the brain, enhancing the expression of brain-derived neurotrophic factor, thereby significantly improving cognitive function, attention, and memory abilities, and demonstrating neuroprotective properties. Clinical studies mainly focus on its use in treating cerebrovascular diseases, cognitive disorders, and enhancing psychological stress tolerance. 

Semax COA

Certificate of Analysis
Compound name	Semax
Grade	Pharmaceutical grade
CAS No.	80714-61-0
Quantity	43g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202512090051
MFG	Dec 9th 2025
EXP	Dec 8th 2028
Structure
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.43%
Loss on drying	≤1.0%	0.32%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.90%
Single impurity	<0.8%	0.42%
Total microbial count	≤750cfu/g	93
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	535ppm
Storage	Store in a sealed, dark, and dry place below-20°C

It can achieve the effects of daily anti-fatigue and improved stress tolerance when used in compound formulations, reducing the incidence of occupational burnout.

The usage of Semax Powder needs to be carefully analyzed in combination with its drug properties, clinical studies and safety considerations. Currently, Semax is mainly used as a neuropeptide cognitive enhancer in clinical practice in the form of nasal drops. The powder form may involve experimental research or special purposes. The following is an explanation from three aspects: conventional usage, precautions, and potential risks:

The following is a possible Semax Powder laboratory synthesis method with detailed steps and chemical reaction equations:

1. Prepare the required reagents and equipment. Requires alanine, serine, glycine, lysine, peptide synthesis kit, nuclear magnetic resonance spectrometer, etc. Peptide synthesis kits typically include condensation agents (such as DIC or HBTU), activators (such as HOBt), bases (such as NMM), etc.

2. Under anhydrous conditions, mix alanine, serine, glycine, and lysine in a certain proportion and add an appropriate amount of solvent (such as DMF or DCM). In this step, the molar ratio of amino acids to solvent is usually around 1:3.

3. Add an appropriate amount of condensation agent (such as DIC or HBTU) and activator (such as HOBt) to the mixture, adjust the pH value to the appropriate range (such as pH 7-8), so that amino acids can be interconnected through peptide bonds. This reaction usually takes several hours to several days, depending on the reaction conditions and the reagents used.

4. Under the action of a condensation agent, four amino acid molecules condense into a tetrapeptide molecule, forming a cyclic structure of Semax. The chemical reaction equation for this condensation reaction can be expressed as:

H₂N-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-R

Among them, R represents the side chain group of lysine.

5. Slowly add an appropriate amount of acetic acid solution, adjust the pH value to acidity (such as pH 4-5), and allow the tetrapeptide molecules to precipitate in the form of salts. The chemical reaction equation for this reaction can be expressed as:

H₂N-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-R + HC₂H₃O₂ → H₂N-CH (CH₃)-CO-NH-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-CH(CH₃)-CO-NH-R·HC₂H₃O₂

6. Filter, wash, and dry the precipitated salt to obtain the crude product. In this step, the generated solid can be separated from the solution through centrifugation, filtration, and other methods, then washed several times with solvents such as methanol, and finally dried.

7. Purify the crude product using high-performance liquid chromatography to obtain high-purity Semax. High performance liquid chromatography is a commonly used separation and analysis method that separates various components in crude products through a chromatographic column, and then detects the content of each component through a detector.

8. Use a nuclear magnetic resonance spectrometer to determine the molecular structure and purity of Semax, ensuring the correctness and quality of the synthesized product. Nuclear magnetic resonance spectrometer can determine the chemical environment of hydrogen and carbon atoms in molecules, thereby inferring the structure of molecules. By comparing the nuclear magnetic resonance spectra of the synthesized structure with the theoretically calculated structure, it can be confirmed whether the synthesis was successful.

9. Conduct quality testing on the obtained Semax Powder, such as melting point, UV absorption spectrum, etc., to ensure that it meets relevant standards and requirements. This step usually requires the use of conventional chemical experimental methods and instruments, such as melting point testers, UV visible spectrophotometers, etc.

It should be noted that laboratory synthesis methods require strict laboratory conditions and operational specifications to ensure the safety and controllability of the synthesis process. In practice, appropriate adjustments and optimizations should be made based on specific experimental conditions and requirements. In addition, to ensure product quality and stability, more complex peptide production processes and non-standard equipment are usually required for large-scale production.

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