Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of syn ake peptide in China. Welcome to wholesale bulk high quality syn ake peptide for sale here from our factory. Good service and reasonable price are available.
Syn Ake Peptide, also known as acetyl dipeptide diaminobutyroyl benzylamide diacetate, is a biomimetic cosmetic peptide synthesized via solid-phase peptide synthesis. Designed to gently modulate neuromuscular signal transmission for smoothing dynamic expression lines, this water-soluble raw material is widely used in anti-wrinkle serums, eye creams and facial masks. As the original manufacturer, Bloomtechz maintains strict production control, full batch COA documentation and professional technical support, offering reliable Syn Ake Peptide with customizable concentrations, samples and bulk supply for global cosmetic formulators.
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Dipeptide diaminobutyroyl benzylamide diacetate COA
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| Certificate of Analysis | ||
| Compound name | Dipeptide diaminobutyroyl benzylamide diacetate | |
| Grade | Pharmaceutical grade | |
| CAS No. | 823202-99-9 | |
| Quantity | 18g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090085 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.85% |
| Loss on drying | ≤1.0% | 0.32% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.63% |
| Single impurity | <0.8% | 0.57% |
| Total microbial count | ≤750cfu/g | 533 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 577ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Product Introduction
Syn Ake Peptide, commonly known as snake peptide, is a synthetic bionic small-molecule peptide with the chemical name Acetyl Dipeptide Diaminobutyroyl Benzylamide Diacetate.
It is artificially synthesized through solid-phase peptide synthesis and designed to mimic the active fragment of Waglerin-1 found in snake venom. Instead of being directly extracted from natural venom, this optimized biomimetic peptide gently and reversibly regulates neuromuscular signal transmission, reducing excessive muscle contraction and relieving dynamic expression lines. It is one of the most mature, safe, and widely used anti-wrinkle cosmetic active ingredients in the global skincare raw material industry.
In terms of physicochemical properties, Syn Ake Peptide appears as a clear to pale yellow aqueous solution with excellent water solubility and broad compatibility with common cosmetic formula systems.
Its low molecular weight enables favorable skin penetration, targeting the epidermis and superficial dermis with mild mechanism. Different from botulinum toxin with strong nerve-blocking effects, Syn Ake Peptide works gently and safely for topical use only. It is strictly prohibited for injection, medical treatment, or internal use. The standard commercial specification is 1000 ppm aqueous solution, while customized concentrations are available to support diverse formulation development.As a high-tech enterprise focusing on R&D and original manufacturing of cosmetic peptides, Bloomtechz takes Syn Ake Peptide as one of its core mass-produced raw materials.Supported by in-house peptide laboratories and GMP-standard clean workshops, Bloomtechz provides stably supplied, high-purity Syn Ake Peptide with customizable specifications.
Every batch is delivered with complete COA quality reports, strictly controlling peptide content, heavy metals, microbial limits, and residual solvents to fully comply with global cosmetic regulatory standards, delivering reliable raw material procurement solutions for international cosmetic brands and ODM/OEM manufacturers.
Syn Ake Peptide features outstanding formula compatibility and can be perfectly compounded with hyaluronic acid, pro-xylane, vitamin series, and other functional peptides such as palmitoyl tripeptide-1 and copper peptides to build synergistic anti-aging systems.During product development, the professional technical team of Bloomtechz provides targeted compounding guidance and compatibility evaluation to avoid common formula problems including stratification, discoloration, and activity attenuation, effectively reducing customers' R&D trial costs and improving formula stability.
Pre-Production Raw Material State
The production of Syn Ake Peptide adopts strictly screened high-purity raw materials, including Fmoc-protected amino acid monomers, specialized solid-phase resin carriers, coupling reagents, deprotection reagents, and chromatographic mobile phase solvents.
Before warehousing, all auxiliary materials undergo strict sampling inspection by Bloomtechz quality laboratory. The QC team verifies supplier qualifications, raw material purity, moisture content, and impurity indicators, rejecting unqualified materials entirely to eliminate hidden quality risks from the source.
Before production initiation, solid-phase resin exists as white granular solid, while amino acid monomers are white crystalline powders requiring low-temperature sealed and light-proof storage. Coupling and deprotection reagents are special liquid chemicals stored in independently partitioned, explosion-proof, ventilated, and leak-proof storage areas.
All raw materials are managed strictly in accordance with MSDS specifications, with real-time temperature and humidity monitoring in the warehouse to prevent moisture absorption, oxidation, and raw material degradation.
Before batch feeding, the production workshop completes cleanliness inspection, equipment cleaning, passivation, and cross-contamination risk elimination. QC staff recheck all raw materials, and technical personnel verify production process parameters. Production can only start after the production supervisor issues official production instructions. Bloomtechz implements a full-chain traceability system, enabling every batch of Syn Ake Peptide to be traced back to the original raw material batch information, ensuring precise positioning of abnormal indicators and full production controllability.
Application Fields
Syn Ake Peptide is a topical cosmetic raw material only for external skincare use, prohibited for injection, medicine, or medical device application. It is widely applied in anti-aging and anti-wrinkle skincare products targeting dynamic expression lines, compatible with diverse formula types.
1. Essence and toner. As the most mainstream application scenario, simple and mild essence matrices facilitate peptide skin penetration. The recommended addition ratio of 1000 ppm stock solution is 0.5%–10%, widely used in anti-wrinkle and repair essences to improve forehead lines, glabellar lines, and dynamic crow's feet.
2. Facial cream and lotion. Compatible with both oil-in-water and water-in-oil emulsification systems. It can be compounded with moisturizing and anti-aging active ingredients to develop daily anti-wrinkle moisturizing skincare lotions and creams.
3. Eye care products. Eye skin is thin and features frequent muscle movement, making it the classic applicable scenario for Syn Ake Peptide. It is commonly compounded with caffeine and hyaluronic acid for eye creams and eye masks to relieve eye dynamic wrinkles.
4. Mask products. Added in mask essence liquid as an anti-wrinkle functional component, cooperating with moisturizing ingredients to achieve synergistic anti-aging effects for patch masks and smear-on masks.
5. Other skincare products. Suitable for anti-wrinkle sprays, stock solutions, and single-dose ampoule products. Single-dose packaging effectively avoids activity loss caused by repeated air contact and is a popular lightweight anti-aging formula solution in recent years.
As a cosmetic functional additive, the actual skincare effect of Syn Ake Peptide varies with individual skin condition, usage cycle, formula system, and usage habits, without absolute wrinkle-eliminating effect. Bloomtechz professional sales and technical teams provide targeted addition ratio reference and compatibility testing support according to customer product positioning and regional regulatory requirements, assisting clients in efficient formula development and product iteration.
Mechanism of Action
Syn Ake Peptide (Acetyl Dipeptide Diaminobutyroyl Benzylamide Diacetate) exerts its anti-rhytogenic efficacy through a reversible, competitive postsynaptic neuromuscular modulation mechanism at the superficial cutaneous neuromuscular junction, functioning as a structure-optimized biomimetic pharmacophore derived from the truncated active domain of natural Waglerin-1 polypeptide.
At the molecular level, the peptide's engineered low-molecular-weight conformational architecture enables stratum corneum transdermal permeation via passive intercellular lipid pathway diffusion, accumulating stably within the dermoepidermal junction and superficial papillary dermis without penetrating deep into muscular or systemic circulatory compartments. Upon cutaneous deposition, the peptide ligand selectively competes with endogenous acetylcholine for postsynaptic nicotinic acetylcholine receptor (nAChR) binding sites on cutaneous striated muscle endplates.Through reversible occupancy of receptor extracellular ligand-binding domains, Syn Ake Peptide attenuates acetylcholine-triggered ion channel gating, inhibits transmembrane cation influx, and diminishes postsynaptic membrane depolarization amplitude.
This pharmacological intervention suppresses the propagation of excitatory action potentials along facial micro-muscle fibers, thereby mitigating repetitive tetanic contraction of superficial expressive musculature.
Distinct from botulinum toxin-mediated presynaptic SNARE complex cleavage and irreversible neurotransmitter vesicle exocytosis blockade, Syn Ake Peptide implements non-permanent, concentration-dependent functional inhibition. Its receptor-binding affinity is transient and metabolically reversible via gradual interstitial peptide dissociation and cutaneous microcirculation clearance, eliminating persistent neuromuscular paralysis risk and cytotoxic sequelae.
Long-term topical intervention biomechanically alleviates chronic micro-traction stress imposed by cyclic facial muscular movement on dermal collagen fibrils, elastin networks and extracellular matrix architecture. By downregulating repetitive mechanical strain stimuli, the peptide inhibits progressive fibril fragmentation, elastic fiber fatigue and dermal microstructural remodeling, effectively arresting the phenotypic transition of reversible dynamic expression lines into irreversible static rhytides.In vitro reconstructed epidermal models and cutaneous biomechanical assays further validate that Syn Ake Peptide modulates inflammatory mediator expression induced by muscular over-contraction, reducing secondary matrix-degrading metalloproteinase (MMP) upregulation, thereby achieving dual-regulation of neuromuscular kinetic inhibition and dermal extracellular matrix structural protection.
References
[1]Fiume, M. M. (2010). Safety assessment of acetyl dipeptide diaminobutyroyl benzylamide diacetate. International Journal of Toxicology, 29(3), 221–230.
[2]Hox, M., & Van de Kerckhove, P. (2002). Neuromuscular modulating activity of synthetic Waglerin-1 peptide mimetic. International Journal of Cosmetic Science, 24(6), 321–330.
[3]Kim, S. H., et al. (2018). Thermal and pH stability of cosmetic anti-wrinkle peptides. Journal of Cosmetic Dermatology, 17(4), 578–585.
[4]Torres, S., & Santos, A. (2021). Optimization of solid-phase peptide synthesis for cosmetic peptides. Journal of Industrial and Engineering Chemistry, 98, 189–201.
[5]Chaudhary, R., & Singh, A. (2023). Global regulatory and application trends of anti-aging cosmetic peptides. Cosmetics, 10(3), 74.
Frequently Asked Questions
Q: What is the difference between the self-produced Syn Ake Peptide from Bloomtechz and low-cost peptide aqueous solutions available on the market?
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A: Many low-priced alternatives on the market adopt crude peptide formulations with insufficient purification, containing abundant truncated peptide fragments, unremoved protecting groups and residual synthesis reagents. Such materials often display unstable bioactivity, fluctuating pH and high microbial risk.
Q: Can I get samples of Bloomtechz Syn Ake Peptide for formula development?
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A: Yes. We supply 10 mL and 50 mL samples for lab trials. Simply submit your requirements to our dedicated account manager. Once sample testing passes, we can quickly move to bulk production orders with flexible volume options.
Q: What documents will Bloomtechz provide to support registration and customs clearance?
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A: We supply batch-specific COA, MSDS, factory qualification documents and safety assessment data. These materials support raw material incoming inspection and cosmetic registration for major markets including China, the EU, USA and Indonesia.
Q: What formulation advice can Bloomtechz offer for Syn Ake Peptide?
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A: The recommended addition rate for 1000 ppm Syn Ake Peptide aqueous solution is 0.5%–10%. It can be combined with hyaluronic acid and other anti-ageing peptides.
Q: How does Bloomtechz protect Syn Ake Peptide stability during international shipment?
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A: Bloomtechz uses light-proof sealed containers for Syn Ake Peptide. Thermal insulation packaging is available for long sea freight to mitigate high-temperature degradation. Each batch undergoes full inspection before release. We track logistics status and guarantee that the raw material arrives with quality matching the COA specifications.
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