Tetrahydropyran-4-Methano CAS 14774-37-9

Tetrahydropyran-4-Methanol is a kind of API. Its molecular formula is C6H12O2, CAS 14774-37-9. Its finished product is a drug that can be used to treat the oral hepatitis virus. What we provide is a front-end chemical product. The product is the main source of cannabinoid CB2 and can be used to treat type 7 agonist paclitaxel receptor. Our company was founded in 2008. So far, we have 13 years of experience in organic chemicals. First, our main field is organic synthesis. After years of training, we have good resources, a mature scientific research team, many products with mature technology, good raw materials, exquisite synthesis technology and scientific quality control. Secondly, we are local manufacturers in China. We are very familiar with the whole Chinese market. We are committed to sharing China's high-quality resources with people in need all over the world, so we have developed international trade. Hope to serve more colleagues in the chemical industry. Of course, if your target compound does not exist or you have new products to be developed, we can design the route and carry out research and development. With a scientific and rigorous attitude combined with your needs, we can develop the reasonable and legal chemical products you need.

Tetrahydropyran-4-Methanol,Also known as 4-hydroxymethyltetrahydropyran, (tetrahydro-2H-pyran-4-yl) methanol, etc., CAS number 14774-37-9, molecular formula C ₆ H ₁ ₂ O ₂, it is an important organic compound with a wide range of applications in multiple fields. The following will elaborate on its purpose:

It can be used to synthesize some spices and essence with special fragrance. In the spice industry, different types of spice compounds can be synthesized by modifying and adjusting their molecular structures. These perfume compounds can be used alone or mixed with other spices to prepare essence for various perfume, cosmetics, food, etc. For example, some fragrances with floral, fruity or woody fragrance can be synthesized through the derivative reaction of Tetrahydropyran-4-Methanol, providing a rich selection of raw materials for the fragrance and essence industry. Tetrahydropyran-4-Methanol can be used as an additive in coatings and adhesives.

It can improve the performance of coatings and adhesives, such as increasing the adhesion, glossiness, water resistance, etc. of coatings, enhancing the bonding strength, heat resistance, chemical corrosion resistance, etc. of adhesives. By adding an appropriate amount of Tetrahydropyran-4-Methanol or its derivatives, the formulation of coatings and adhesives can be optimized to meet the needs of different application scenarios. It can also be used for modifying plastics and rubber, for example, adding Tetrahydropyran-4-Methanol derivatives to plastics can improve their toughness, heat resistance, and aging resistance; Adding relevant compounds to rubber can improve its vulcanization performance, strength, and wear resistance. Through modification treatment, the application range of plastics and rubber can be expanded, and their added value can be increased.

Can be used as a chromatographic analysis reagent in analytical methods such as gas chromatography (GC) and liquid chromatography (LC). In chromatographic analysis, the purity and stability of reagents are crucial for the accuracy and reliability of the analysis results. Tetrahydropyran-4-Methanol can be used as an internal standard, derivatization reagent, etc. As an internal standard, it can correct errors in the sample analysis process and improve the accuracy of quantitative analysis; As a derivatization reagent, it can react with target compounds in the sample to generate derivatives with better chromatographic separation performance, thereby improving separation efficiency and enhancing detection sensitivity.

It can also be used as a standard substance for the establishment, validation, and quality monitoring of analytical methods. In analytical chemistry laboratories, standard substances are an important basis for ensuring the accuracy and comparability of analytical results. By using high-purity Tetrahydropyran-4-Methanol standard substance, analytical instruments can be calibrated, and the accuracy and precision of analytical methods can be evaluated to ensure the reliability of analysis results. In addition, in fields such as environmental monitoring and food safety testing, Tetrahydropyran-4-Methanol reference materials can also be used for quantitative analysis of relevant compounds in actual samples.

We are the supplier of Tetrahydropyran-4-Methanol.

Remark: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us.

Method 1: To 250 ml LiAlH4 (2.3M THF solution, 0.575 mol) THF (200 ml) solution, drop 130 ml (0.974 mol) THF (900 ml) solution (note: high exothermic reaction). Use an ice bath to maintain the temperature at 40-45 ° C. After complete addition, stir at room temperature for 1.5 hours. The reaction was cooled in an ice bath and quenched with water (22 mL), 15% NaOH aqueous solution (21 mL) and water (66 mL). Through Celite ® Filter to remove the generated sediment and rinse with THF (300 mL). The filtrate is concentrated under reduced pressure to obtain (tetrahydro-2H-pyran-4-yl) methanol. Yield: 91%; 102.5g colorless oil. 1H NMR (400MHz, chloroform - d) δ Ppm is 1.20-1.39 (2h, m), 1.56-1.83 (3h, m), 2.03 (1H, br. s.), 3.29-3.52 (4h, m) and 3.89-4.05 (2h, m).

Method 2: To 250 ml LiAlH4 (2.3M THF solution, 0.575 mol) THF (200 ml) solution, drop 130 ml (0.974 mol) THF (900 ml) solution (note: high exothermic reaction). Use an ice bath to maintain the temperature at 40-45 ° C. After complete addition, stir at room temperature for 1.5 hours. The reaction was cooled in an ice bath and quenched with water (22 mL), 15% NaOH aqueous solution (21 mL) and water (66 mL). Through Celite ® Filter to remove the generated sediment and rinse with THF (300 mL). The filtrate is concentrated under reduced pressure to obtain (tetrahydro-2H-pyran-4-yl) methanol. Yield: 91%; 102.5g colorless oil. 1H NMR (400MHz, chloroform - d) δ Ppm is 1.20-1.39 (2h, m), 1.56-1.83 (3h, m), 2.03 (1H, br. s.), 3.29-3.52 (4h, m) and 3.89-4.05 (2h, m).

Method 3: Add LiAlH4 (1M THF solution) (100.0ml, mmol) to the solution with THF (500.0ml) as tetrahydropyran-4-carboxylic acid ethyl ester (25.0g, 173.6mmol) at 0 ℃. The reaction mixture was heated to room temperature and stirred under reflux for 5 hours. Cool the reaction mixture to room temperature, then add 5.0ml water, 5.0ml 5N NaOH and 20.0mL water, filter the precipitated salt through diatomite pad and wash it with 1:1 Et2O: MeOH. The filtrate was concentrated under reduced pressure to obtain the title product (tetrahydro-2H-pyran-4-yl) methanol.

To reduce the potential health hazards of Tetrahydropyran-4-Methanol, the following are some safety usage recommendations:

Personal protection

 

When using, appropriate personal protective equipment should be worn, such as protective gloves, goggles, masks, etc. Avoid prolonged exposure or inhalation of the compound to reduce skin irritation and respiratory damage.

Operating environment

 

The substance should be operated in a well ventilated environment to reduce the accumulation of steam or dust. Avoid using in high temperature or humid environments to prevent compound decomposition or the production of harmful substances.

Storage conditions

 

It should be stored in a dry, cool, well ventilated place.
Avoid contact with oxidants or other substances that may trigger chemical reactions.

Waste disposal

The waste of this substance after use should be properly disposed of in accordance with relevant regulations. Avoid littering or discharging into the environment to prevent pollution of water bodies and soil.

Health monitoring

 

Personnel who have been exposed to this compound for a long time should undergo regular health checks. If abnormal conditions such as skin irritation and respiratory symptoms occur, seek medical attention promptly and inform the doctor of one's contact history.

1. What is Tetrahydropyran-4-Methano?
Tetrahydropyran-4-Methano is a term used to describe a specific chemical structure. It usually refers to a group of synthetic building blocks or key intermediates based on the framework of tetrahydropyran-4-methylene. The core structure involves connecting a methylene bridge or related functional groups to the fourth carbon atom of the tetrahydropyran ring. It does not refer to a specific single compound, but rather a class of chemical substances with a common parent nucleus.
2. What are the uses of Tetrahydropyran-4-Methano?
This type of compound is a very important advanced intermediate in both medicine and organic synthesis. Its rigid tetrahydropyran ring can provide a stable three-dimensional structure, and is often used as a "framework" to be introduced into the target molecule to regulate its biological activity, solubility, or metabolic stability. It is widely used in the research and development of innovative small molecule drugs and is the core fragment for constructing certain drug active molecules.
3. Can it be used as a finished chemical product?
No. Tetrahydropyran-4-Methano is a typical non-directly applicable chemical intermediate or research chemical. Its main value lies in being combined through further chemical reactions to form more complex molecules. It has not undergone any drug or consumer product safety assessment and is not suitable for any other uses except professional chemical synthesis.
4. What should be noted during purchase and usage?
The purchaser must be a research institution with professional qualifications, a pharmaceutical company, or a chemical supplier. It is necessary to clearly specify that the use is limited to laboratory research and compliant production. During the purchase process, the supplier should be requested to provide detailed chemical safety data sheets (MSDS/SDS) to understand the physical and chemical properties, hazards, and safety operation guidelines of the chemicals, and ensure that all operations comply with the local chemical management regulations.

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