FMOC-L-4-Fluorophe CAS 169243-86-1

FMOC-L-4-Fluorophe, also known as N-(9-fluorenylmethoxycarbonyl)-L-4-fluorophenylalanine or Fmoc Phe (4-F) - OH, is an important organic compound with wide applications in the fields of medicine and scientific research. Molecular formula C24H20FNO4, CAS 169243-86-1, appears as a white to gray solid powder at room temperature and pressure. Its color may vary slightly due to differences in purity and storage conditions, but overall it remains relatively bright white or grayish white. As an important chemical reagent, it has wide application value in scientific research and pharmaceutical fields. Its unique chemical structure and properties make it play important roles in various fields such as molecular biology, proteomics, and cell biology. At the same time, great potential has been demonstrated in fields such as drug development, targeted therapy, drug screening, and evaluation.

Regarding FMOC-L-4-Fluorophe, due to its main applications in scientific research and pharmaceutical fields, especially as an intermediate in chemical reagents and drug development, its direct non scientific or pharmaceutical uses are relatively limited. However, based on its chemical properties and importance in synthetic chemistry, it may also have the following potential uses:

Multifunctional reagents in organic synthesis

 

Synthesis of complex molecules: can serve as a building block with special functional groups, used for synthesizing organic molecules with complex structures and specific properties. These molecules may play a role in materials science, catalyst design, or fine chemical production.

Chiral source: Due to its chiral center (the alpha carbon of amino acids), it can be used as a starting material for chiral synthesis to prepare compounds with optical activity, which have important applications in fields such as pharmaceuticals, pesticides, and fragrances.

Catalysts and catalyst precursors

 

Metal complexes: can coordinate with metal ions to form metal complexes with specific catalytic activity. These complexes may play a role in organic synthesis, asymmetric catalysis, or biocatalysis.

Phase transfer catalyst: In some cases, FMOC groups may act as part of the phase transfer catalyst, promoting reactions between different phases (such as organic and aqueous phases).

Education and teaching

 

Teaching example: In chemistry education, it can serve as a teaching example to demonstrate to students the FMOC protection, deprotection, and application of amino acids in peptide synthesis.

Laboratory exercises: In the organic chemistry laboratory course, students can use this substance for experimental exercises such as peptide synthesis and amino acid derivatization to deepen their understanding of the principles of organic synthesis and biochemistry.

Biology and Biomedical Research

 

Biomarkers: Although this is not their primary use, the substance or its derivatives may be used as part of biomarkers for diagnosis or monitoring in biomedical research.

Drug delivery system: In some drug delivery systems, it or its analogues may serve as carriers or linkers for targeted delivery of drug molecules to specific cells or tissues.

Potential environmental applications

 

Environmental remediation: Although there are few specific application cases, based on its chemical properties, it or its derivatives may have certain potential applications in the field of environmental remediation, such as as as chelating agents for heavy metal ions or degradation agents for pollutants.

Regarding the substitute of this compound, as it is mainly used as a reagent for structural modification research and preparation of peptide biomolecules in the field of biochemistry, its substitute may need to have similar chemical properties and functions. However, it should be noted that due to its specific chemical structure and properties, identical alternatives may not exist. The following are some suggestions that may serve as alternatives, but the specific selection needs to be comprehensively considered based on factors such as experimental requirements, cost-effectiveness, and safety:

The price of this compound varies due to various factors such as brand, purity, specifications, suppliers, and market supply and demand relationships. Here are some price information provided based on the current market situation:

• Brand and Purity: Some brands, such as Kramar, offer this compound with a purity of 98%, and the price varies depending on the specifications. For example, the price for a 1-gram specification may be 511.5 yuan, while the unit price for a 25 gram specification is relatively lower. Other brands such as Amresco may also offer this compound, but the price may vary due to brand premium and market competition.
• Specifications and packaging: This compound is usually sold in grams, with specifications including 1 gram, 5 grams, 25 grams, 100 grams, etc. The packaging method may vary depending on the supplier, but typically moisture-proof and light proof packaging is provided to ensure the stability and long-term storage of the compound.
• Market price fluctuations: Due to changes in market supply and demand, the price of this compound may fluctuate. In some cases, suppliers may offer discounts or promotional activities to reduce purchasing costs.
• Supplier selection: The selection of suppliers has a significant impact on prices. Different suppliers may offer different prices and services. It is recommended to consider factors such as reputation, product quality, delivery speed, and after-sales service when selecting suppliers.

1. Strictly implement laboratory rules and regulations: ensure that all personnel receive necessary training and education, and master laboratory operating procedures.
2. Laboratory environment management: Keep the laboratory environment clean and dust-free, regularly clean and disinfect, especially strengthen the management of key areas such as the cultivation room and operating table.
3. Personnel training and operating standards: Laboratory personnel should receive professional training to understand and master relevant operating standards. Personal hygiene must be taken seriously, including correctly wearing lab coats, hats, gloves, and masks, and regularly washing hands and disinfecting.
4. Disinfection of experimental equipment and reagents: All experimental equipment such as centrifuges, pipettes, incubators, and reagent bottles must be thoroughly disinfected to avoid cross contamination.
5. Regular disinfection of laboratory equipment: Regularly disinfect incubators, sterile rooms, etc., using formaldehyde or PP powder.
6. Eliminate the source of infection: Wear isolation clothing when entering the laboratory to reduce frequent entry and exit. During the operation, move gently to avoid the production of microbial aerosols.
7. Sampling and testing: Sampling of suspected contaminated areas, such as workstations, incubators, etc. Take samples of suspicious culture reagents and cell culture media, and use PCR, colorimetric or fluorescent staining methods to detect specific contaminants such as mycoplasma.
8. Setting up control experiments: Setting up positive and negative controls and blank controls can verify the reliability of the experiment and assist in judging the credibility of the system.
9. Calibration of experimental instruments and equipment: It is necessary to calibrate experimental instruments correctly to ensure the accuracy of experimental data.
10. Sample disposal: When analyzing and testing the submitted samples, procedures for sample collection, sealing, transportation, handover and acceptance, and retention should be developed in accordance with national technical specifications or standards to avoid sample deterioration, damage, or cross contamination during storage or testing, ensuring the integrity of the tested samples and the validity of the test results.

Brand

• Peptides International: This is a company dedicated to researching peptides and peptide substrates, producing and selling a variety of high-purity bioactive peptides since 1983. The product it produces is highly trusted.
• Kramar: Kramar Reagent is an independent reagent brand of Shanghai Puzhen Biotechnology Co., Ltd., and its product also has high popularity and market share.
• Amresco: Amresco is a globally renowned manufacturer of biochemical reagents, with a complete range of products, stable quality, and good cost-effectiveness. Its production of FMOC-L-4-fluorophenylalanine has also received high praise.
• In addition, multiple brands such as Shanghai Huicheng Biotechnology Co., Ltd., Shanghai Kolaman Reagent Co., Ltd., Shanghai Chuangsai Technology Co., Ltd., and Shanghai Meiruier Biochemical Technology Co., Ltd. are also selling this product.

Purity

• The purity of this compound varies depending on the brand and production process. Generally speaking, high-purity FMOC-L-4-fluorophenylalanine has better chemical stability and biological activity, and therefore has broader application prospects in fields such as drug development, biomedical engineering, and biomaterials science.
• 98% purity: This is a common compound purity level in the market. Many brands and suppliers offer products with 98% purity, such as Cramer and other brands.
• Higher purity: In addition to 98% purity, some brands and suppliers offer higher purity FMOC-L-4-Fluorophe, such as 99% or higher. These products are typically used in research fields or applications that require higher purity.

FMOC-L-4-Fluorophenylalanine represents a promising building block in peptide synthesis and biomedical research. Its unique structural features, reactivity, and biological activities make it a valuable tool in the synthesis of complex peptides, the development of therapeutic agents, and the design of functional materials. By understanding its properties, synthesis methods, and applications, researchers can harness the potential of FMOC-L-4-Fluorophenylalanine to advance scientific knowledge and improve human health.

As the field of peptide chemistry and medicinal research continues to evolve, the demand for versatile and efficient building blocks like FMOC-L-4-Fluorophenylalanine is expected to grow. Future research in this area may lead to the discovery of new compounds with enhanced properties and applications, further solidifying the importance of FMOC-L-4-Fluorophenylalanine in contemporary scientific research. With its potential to contribute to advances in medicine, materials science, and sustainable chemistry, FMOC-L-4-Fluorophenylalanine remains a compound of great promise and potential.

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