Sodium diethyldithiocarbamate, odorless white crystal, aqueous solution is alkaline and decomposes gradually. In case of acid, carbon disulfide can be separated and the solution is turbid. It has certain toxicity. On October 27, 2017, the list of carcinogens published by the international agency for research on cancer of the World Health Organization was preliminarily sorted for reference. Sodium diethyldithiocarbamate was included in the list of class 3 carcinogens.
In the aspect of biological application, sodium diethylthiocarbamate is a copper reagent, which reacts with Cu2 + solution to form a complex, which improves the copper displacement precipitation rate. Sodium diethyldithiocarbamate can reduce HIV infection.
There are three applications in the field of rebiology :
1、Cancer
Zinc chelation by diethyldithiocarbamate inhibits metalloproteinases, which in turn avoids degradation of extracellular matrix, which is the initial step in distant metastasis and angiogenesis. That is, it can inhibit the deterioration of cancer.
2、Antioxidants
Diethyldithiocarbamate could inhibit SOD that had both antioxidant and oxidative effects on cells, and the two effects varied with time.
3、Role in metabolism
Diethyldithiocarbamate is described as interfering with glucocorticoid metabolism, mainly by reducing the activity of a specific enzyme, which mainly converts hydrocortisone ( cortisol ) into hydrocortisone.
Preparation the method of sodium diethylthiocarbamate is to dissolve diethanolamine in methanol, add methanol solution of carbon disulphide, kill 40% sodium hydroxide methanol solution, filter out the trapped crystals, wash with methanol to 3 § 4 times, recruit with methanol and dry to obtain pure sodium diethylthiocarbamate.