Tetracaine HCL powder can be used to make a 2% tetracaine hydrochloride solution. Clinically, 2% tetracaine hydrochloride solution is directly dripped, smeared, and sprayed on the mucosal surface of the oral cavity, nose, pharynx, larynx, etc. to paralyze the sensory nerve endings under the mucosa, thereby reducing nausea caused by the patient's examination and treatment. , vomiting and pain, improve the patient's compliance and realize the "people-oriented" treatment concept.
1 Prescription and preparation of 2% tetracaine hydrochloride solution
1.1 Prescription
Tetracaine hydrochloride 20g, purified water added to 1000ml.
1.2 Preparation
Dissolve tetracaine hydrochloride in about 800ml of purified water, add purified water to 1000ml, stir evenly, filter, pack, sterilize and sterilize.
2 Quality Control
2.1 Properties
This product is a colorless and transparent liquid.
2.2 Identification
(1) Take 1ml of the solution, add 1 drop of 5% sodium acetate solution and a few drops of 25% ammonium thiocyanate solution, and white crystalline precipitation will occur.
(2) Take a little of this product, add a few drops of nitric acid, and it turns yellow after shaking.
(3) This product shows the identification reaction of chloride.
2.3 Content determination
Precisely measure 5ml of 2% tetracaine hydrochloride solution, put it in a 100ml measuring bottle, add water to the mark, shake well; then precisely measure 2ml of diluent, put it in a 100ml measuring bottle, add water to the mark, and shake well. According to ultraviolet-visible spectrophotometry, at 310nm wavelength, measure the absorbance with water as blank, and calculate its content according to the regression equation.
Tetracaine hydrochloride solution is an effective topical anesthetic, used in electronic laryngoscopy, applications such as electronic nasopharyngoscopy can play a better role in surface anesthesia, thereby reducing pain during examination or treatment of mild patients, as well as discomforts such as nausea and vomiting.
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