Adrenaline powder is white or off-white crystalline powder; odorless, bitter in taste; chemically unstable, in contact with air or sunlight, in the presence of oxides, alkalis, light and heat, it is easily oxidized to pink, and then becomes pink. Brown and fail. This product is slightly soluble in water, insoluble in ethanol, chloroform, ether, fatty oil or volatile oil; easily soluble in mineral acid or sodium hydroxide solution, insoluble in ammonia solution or sodium carbonate solution. The melting point (Appendix VI C of the 2010 edition of the Pharmacopoeia) is 206 to 212 °C, and it decomposes simultaneously when melting. Take this product, accurately weigh it, add a hydrochloric acid solution (9→200) to dissolve and quantitatively dilute it to make a solution containing 20 mg per 1 mL, and measure it according to the law (Appendix VI E of 2010 Edition Pharmacopoeia), the specific rotation is -50.0° to -53.5°.
Adrenaline has a strong excitatory effect on both α and β receptors, mainly manifesting as increased myocardial contractility, increased heart rate, increased myocardial oxygen consumption, constriction of small blood vessels in the skin mucous membranes and viscera, but dilation of coronary and skeletal muscle vessels. Different doses of epinephrine can have other effects on cardiovascular receptors: small amounts (0.01-0.05ug/kg per minute) mainly stimulate β1 and β2 receptors, increase myocardial contractility and cardiac output, dilate peripheral blood vessels, while a The receptor effect is not apparent; when the dose is increased to 0.1ug/kg per minute, in addition to the impact, the a-effect is obvious. When the amount is 0.1ug/kg per minute, the a-receptor is significantly stimulated, and at the same time, it shows a strong effect of constricting peripheral blood vessels, which is easy to cause. Causes tachycardia and arrhythmias. The use of epinephrine powder may be considered in patients with septic shock in the following situations: ① norepinephrine is ineffective; ② hemodynamically manifested as low cardiac output, and low peripheral vascular resistance in patients with the severe low cardiac output after cardiac surgery can be used alone or in combination with other vasoactive drugs.If you need bulk pure adrenaline powder, please contact us.