Bisoprolol Powder (Bisoprolol Fumarate Powder) is a highly selective long-acting β 1 receptor blocker used clinically to treat diseases such as hypertension, angina pectoris, and arrhythmia. The appearance is white to off white powder, odorless, bitter in taste, easily soluble in water, soluble in ethanol, slightly soluble in acetone, insoluble in ether, requires light shielding, sealed storage, and some products need to be stored at 2-8 ℃. It is a highly selective beta 1 receptor blocker, with an affinity for the beta 1 receptor that is 100 times stronger than that for the beta 2 receptor. It can effectively block the cardiac beta 1 receptor, reduce heart rate and blood pressure. As a first-line long-acting antihypertensive drug, bisoprolol fumarate can steadily control blood pressure and reduce the damage of hypertension to important target organs such as the heart, brain, and kidneys. By reducing myocardial oxygen consumption, improving myocardial ischemia, reducing the frequency and severity of angina attacks, and improving patients' quality of life. In the treatment of chronic stable heart failure, bisoprolol fumarate is often used in combination with ACEI inhibitors, diuretics, and cardiac stimulants to improve heart function and delay disease progression.
Bisoprolol Powder CAS 66722-44-9
Product Code: BM-2-5-053
English Name: bisoprolol
CAS No.: 66722-44-9
Molecular formula: c18h31no4
Molecular weight: 325.44
EINECS No.: 613-980-5
Quality items: HPLC>99.5%, LC-MS
HS code: Need confirm
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Yinchuan Factory
Technology service: R&D Dept.-6
We provide Bisoprolol Powder CAS 66722-44-9, please refer to the following website for detailed specifications and product information.
What is the purpose of bisoprolol powder?
Bisoprolol Powder(https://en.wikipedia.org/wiki/Bisoprolol) is a highly selective long-acting β 1 receptor blocker with a wide range of clinical applications. The following will elaborate on its uses, including the treatment of various cardiovascular diseases, improvement of heart function, and combination with other drugs:
Treating hypertension
Bisoprolol Powder lowers blood pressure by blocking the cardiac β 1 receptor, inhibiting the renin-angiotensin system, reducing cardiac output and peripheral vascular resistance. Its highly selective β 1 receptor blockade reduces the impact on β 2 receptors in bronchial and vascular smooth muscle, lowers respiratory resistance, and reduces metabolic side effects. Multiple studies have confirmed that bisoprolol fumarate has significant antihypertensive effects in patients with mild to moderate hypertension. Its long-lasting properties allow for once daily administration, improving patients' treatment compliance. When used in combination with calcium channel blockers, angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor antagonists (ARBs), it can enhance blood pressure lowering effects and reduce side effects. Bisoprolol fumarate has shown good safety and tolerability in antihypertensive treatment. Its β 1 receptor selectivity reduces the occurrence of side effects such as bradycardia and hypotension. Long term treatment has no adverse effect on blood sugar and lipid metabolism, and is suitable for hypertensive patients with diabetes or dyslipidemia.
Treatment of coronary heart disease and angina pectoris
Bisoprolol fumarate reduces myocardial oxygen consumption by slowing down heart rate, lowering myocardial contractility and blood pressure. At the same time, it improves myocardial microcirculation, increases coronary artery blood flow, and alleviates symptoms of myocardial ischemia. Its antioxidant effect can alleviate myocardial damage and protect heart function. Bisoprolol fumarate is a first-line medication for the treatment of angina pectoris in coronary heart disease. In patients with stable angina, it can reduce the frequency and severity of angina attacks and improve exercise tolerance. Early use can stabilize the condition and reduce the risk of cardiovascular events in patients with unstable angina and acute coronary syndrome (ACS). Bisoprolol fumarate is often used in combination with nitrate esters, calcium channel blockers, and other drugs to enhance its anti angina effect. Combined use with aspirin, statins, and other medications can comprehensively control the risk factors of coronary heart disease and improve prognosis.
Treating heart failure
Bisoprolol fumarate inhibits sympathetic overactivation, reduces myocardial injury and remodeling by blocking cardiac β 1 receptors. It lowers heart rate and blood pressure, reduces heart load, and improves heart function. Long term use can reverse ventricular hypertrophy and delay the progression of heart failure. Bisoprolol fumarate is one of the cornerstone drugs for the treatment of chronic heart failure (CHF). In patients with NYHA grades II-IV and left ventricular ejection fraction (LVEF) ≤ 40%, it can significantly reduce mortality, hospitalization, and heart failure deterioration rates. It is necessary to start with a small dose and gradually titrate to the target dose to ensure safety and tolerability. Bisoprolol fumarate is often used in combination with ACEI/ARB, aldosterone receptor antagonists (MRA), and other drugs to form the "golden triangle" or "quadruple therapy" for the treatment of heart failure. These drugs work synergistically to comprehensively improve the prognosis of heart failure patients.
Treat arrhythmia
Bisoprolol fumarate inhibits supraventricular tachycardia and other arrhythmias by blocking the cardiac β 1 receptor, prolonging the effective refractory period of the atrioventricular node, slowing down the atrioventricular conduction velocity. Its negative frequency effect can reduce sinus tachycardia and stabilize heart rhythm. Bisoprolol fumarate is commonly used to treat arrhythmias such as sinus tachycardia, supraventricular tachycardia, and atrial fibrillation. In patients with atrial fibrillation, it can control ventricular rate and reduce symptom onset. For patients with arrhythmia accompanied by heart failure, their cardioprotective effect is particularly significant. Bisoprolol fumarate can be used in combination with antiarrhythmic drugs such as amiodarone and propafenone to enhance therapeutic efficacy. In the treatment of atrial fibrillation, anticoagulants such as warfarin are often used in combination to prevent thromboembolic events.
Treatment for other cardiovascular diseases
Bisoprolol Powder can reduce the mortality rate, re infarction rate, and incidence of heart failure in patients with myocardial infarction. Its antioxidant and anti-inflammatory effects can alleviate myocardial injury and promote myocardial repair. Bisoprolol fumarate can improve symptoms in patients with hypertrophic cardiomyopathy and reduce the risk of fainting and sudden death. It reduces myocardial contractility, alleviates outflow tract obstruction, and improves ventricular diastolic function. Bisoprolol fumarate can lower blood pressure and heart rate in patients with aortic dissection, reduce aortic wall shear stress, and lower the risk of dissection rupture. It is often used in combination with drugs such as nitroprusside and beta blockers to control the condition.
Conclusion
Bisoprolol Powder, as a highly selective long-acting β 1 receptor blocker, has broad application prospects in the treatment of cardiovascular diseases. Its various pharmacological effects, such as lowering blood pressure, anti angina, improving heart failure, and anti arrhythmia, make it one of the important drugs for the treatment of cardiovascular diseases. During use, attention should be paid to dosage adjustment, monitoring indicators, patient specific groups, and contraindications to ensure the safety and effectiveness of treatment. With the in-depth study of the pharmacological mechanism of action of bisoprolol fumarate and the development of new formulations, its application prospects in the treatment of cardiovascular diseases will be even broader.