GABA pure powder, chemical name 4-aminobutyric acid, is a compound with the chemical formula of C4H9NO2, alias 4-aminobutyric acid（ γ- Aminobutyric acid is an amino acid, which widely exists in vertebrates, plants, and microorganisms. γ- Gamma-aminobutyric acid is an essential neurotransmitter in the central nervous system, with good water and thermal stability. Low molecular weight is a safe amino acid and can be used in beverages and other foods. Studies have shown that a certain amount of which improves the quality of sleep in the human body and lowers blood pressure.
The fast-paced life makes many modern people suffer from insomnia and anxiety in today's society. According to the 2020 sleep index report, more than 300 million people in China have sleep disorders. Modern neuro medical research has confirmed that the over intensification of neural information transmission (overexcitation of the nervous system) is one of the important reasons for many everyday people's physical and mental discomfort symptoms. Based on scientists' long-term research on it, it is found that as a neurotransmitter inhibitor, it exists in the human brain and other nervous systems and is involved in regulating a variety of physiological activities. So far, many studies have shown that it is a safe and peaceful neurodepressant in the brain. Its presence in the human body can relieve or inhibit excessive excitement and intense nerve signal transmission.
it combines with the corresponding ion channel receptor to cause the opening of chloride ion channel, make chloride ion influx and hyperpolarization of the cell membrane, inhibit the occurrence of the action potential, inhibit nerve conduction, and prevent overheating of neurons, to make people stable and calm down. Therefore, it can improve sleep, alleviate fatigue, relieve pressure, and stimulate brain vitality.
On the contrary, if the concentration of which is insufficient, it will produce anxiety, anxiety, fatigue, anxiety, and other emotions. However, with the increase of age, the content in the human body will show a downward trend. It is reported that the GABA content of the human body decreases by about 5% every 10 years, and that of women decreases faster. The decline of which content is the trigger point for reducing human cognitive ability and brain aging. In addition, it can inhibit neuronal activation and improve skin condition (Huaxi biological GABA anti-aging efficacy test). With its powerful anti-aging effect, it is used step by step in eye creams, facial masks, face creams, and other cosmetics.
As a bioactive substance, it widely exists in the nervous system of mammals and plants, which is of great benefit to human life. Therefore, we can consciously supplement this substance and eat some foods rich in this substance in life. Such as tomato, potato, grape, pumpkin, and tea. Fermented foods such as pickles and germinated brown rice are also rich in them.
There are mainly chemical methods for synthetic GABA: First, potassium is used as the raw material for phthaloylimine and ionogenic γ-chloroprene or butyrolactone. the final product obtained after clarification and hydrolysis reaction is the second most common use of pyrrolidone as the primary surface material. When it stops opening, it reacts with calcium hydroxide and carbohydrate ammonia—the ring to get it. The third is using butyric acid and ammonia as raw materials for GABA; The fourth method is to synthesize it with propylamine and formic acid by glow discharge; The fifth is to use methyl bromoacetate and ethylene as raw materials to prepare it. Methyl 4-bromobutyrate is obtained through polymerization. Finally, the product after ammonolysis and hydrolysis is GABA. The chemical synthesis methods of which have the disadvantages of difficult reaction control and high cost.
The physiological role of which: expression and function of plant GAD during bacterial infection γ- The transcriptional abundance of hydroxybutyric acid will increase, increasing it. The sensitivity of tobacco with a high GABA synthesis level to Agrobacterium tumefaciens C58 infection decreased. it can induce the expression of Agrobacterium attklm operon, reduce the concentration of N - (3-oxooctyl) homoserine lactone, and downregulate quorum-sensing signal (or hormone), which affects its toxicity to plants.it also plays a role in the signal communication between plants and bacteria. GABA can inhibit the expression of the HrpL gene in bacteria (the protein encoded by the HrpL gene sensitizes plants or causes their tissue diseases) and inhibit the face of the HRP gene in plants to prevent plants from allergic reactions (HRP: controlling the pathogenic ability of plant pathogens and causing allergic reactions).