Scopolamine, also known as L-asparagine, is a kind of alkaloid in Solanaceae. In 1892, e. Schmidt was first isolated from it. The effect is similar to atropine. Its mydriasis and inhibition of gland secretion are stronger than atropine. It has a stimulating effect on the respiratory center but has an apparent inhibitory effect on the cerebral cortex. In addition, it also has the effects of dilating capillaries, improving microcirculation, and anti seasickness. It has the development of a muscarinic receptor antagonist.it exerts its impact by acting as a competitive antagonist in muscarinic acetylcholine receptors; Therefore, it is classified as anticholinergic and antimuscarinic. It is a drug of anisodamine alkaloids artificially manufactured under the action of a muscarinic receptor antichemical agent. The primary sources of drugs are Solanaceae plants, tianxianzi, Datura, etc. Although the drug is highly toxic, it has even been used as a crime; There is even the nickname "devil's breath," but because of its nature as an acetylcholine inhibitor, it can be used as a legal, medical application in tiny doses; For example, postauricular patches for the treatment of carsickness, postoperative nausea, irritable bowel syndrome, gastrointestinal spasm, renal or biliary spasm, and preoperative administration to reduce respiratory secretions.
it is an alkaloid with the most potent pharmacological effect in belladonna. It can be used to block the parasympathetic nerve and as an inhibitor of the central nervous system. Its product is similar to belladonna, but its impact is solid and short-lived. Its hydrobromate is generally used clinically. It can be used for anesthesia, analgesia, cough, and asthma. It is effective for motion sickness. It can also control the stiffness and tremor of Parkinson's disease.
This product is a tertiary amine antimuscarinic drug. Its effect is generally similar to atropine and impacts the center and surroundings. It has a more substantial inhibitory effect on saliva secretion than atropine and usually slows rather than accelerates the heart rate, especially in small doses. Its impact on the center is different from that of atropine. It can inhibit the cerebral cortex and produce drowsiness and forgetfulness. The inhibitory effect on ocular smooth muscle and gland secretion was stronger than atropine. This product is a peripheral anticholinergic drug, which has an antispasmodic effect on smooth muscle, blocks ganglion and nerve-muscle junction, and has a weak impact on the center. The eye function is similar to atropine. Its mydriasis, regulating paralysis, and inhibiting secretion are twice as strong as atropine, but the duration is short. In contrast to atropine stimulating the brain, this product shows a significant sedative effect.it is prohibited in patients with glaucoma, prostatic hypertrophy, myasthenia gravis, severe heart disease, organic pyloric stenosis, gastrointestinal obstruction, reflux esophagitis, and ulcerative colitis toxic megacolon. The poisoned can be rescued with cholinergic drugs and treated symptomatically.
Clinically, according to the observation of the curative effect, the effect of the finished product is similar to that of atropine. Its mydriasis and gland inhibition effect is more potent than that of atropine. It has a stimulating effect on the respiratory center but has an apparent inhibitory effect on the cerebral cortex. In addition, Scopolamine also has the impact of expanding capillaries, improving microcirculation, and anti seasickness. it is an alkaloid extracted from Solanaceae honeysuckle, belladonna, and other plants. When used in Ophthalmology, it has a higher incidence of toxic reactions than other anticholinergic drugs, so it should not be used as the first choice. The action mechanism of which is similar to atropine. It has obvious bronchiectasis, can reduce the secretion of respiratory tract mucus, reduce obstruction, and is conducive to the patency of the respiratory tract. it has various effects, can significantly improve microcirculation, relieve vasospasm, and is conducive to enhancing and recovering respiratory tract inflammation.