Epithalon injection, also known as Epitalone Peptide AEDG, It is an artificially synthesized tetrapeptide, with the chemical name (4S) -4- [[[(2S) -2-aminopropanoyl] amino] -5- [[(2S) -3-carboxy-1- (carboxymethyl amino) -1-oxopropan-2-yl] amino] -5-oxovaleric acid, molecular formula C ₁ H ₂ N ₄ O ₉, molecular weight 390.35. Originally discovered from bovine pineal gland extract, it was extensively studied by Russian scientist Professor Vladimir Khavinson and his team over the next 35 years. Due to its unique biological activity, it has demonstrated potential application value in multiple fields such as anti-aging, tumor suppression, and neuroprotection. It is considered a telomerase activator that can extend telomere length by activating telomerase, potentially prolonging cell lifespan and the overall lifespan of the organism.
Additional information of chemical compound:
| Product Name | Epithalon Powder | Epithalon Injection |
| Product Type | Powder | Injection |
| Product Purity | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable |
| Product Package | Customizable | Customizable |
Epithalon +. COA
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Certificate of Analysis |
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Compound name |
Epithalon | |
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CAS No. |
307297-39-8 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Epithalon injection, also known as AEDG, is an artificially synthesized tetrapeptide originally discovered from bovine pineal gland extract. With the deepening of research, Epitaron injection has shown potential application value in multiple medical fields, and its indications have gradually expanded to anti-aging, tumor adjuvant therapy, neuroprotection, endocrine regulation, reproductive health improvement and other aspects.
Extend cell lifespan:
One of its core mechanisms of action is to activate telomerase and prolong telomere length. Telomeres are protective structures at the ends of chromosomes, and their shortening is closely related to cellular aging. By activating telomerase, telomere shortening can be delayed, thereby prolonging cell division and lifespan. Animal experiments have shown that it can significantly prolong the lifespan of fruit flies and mice, improve the secretion rhythm of cortisol and melatonin in elderly rhesus monkeys, and restore circadian rhythm function. These findings provide a scientific basis for the application of Epitaron in the field of anti-aging.
Improving aging related symptoms:
In human trials, it has been used to improve the sleep quality, cognitive function, and physical state of the elderly population. For example, a study on elderly volunteers found that continuous use of Epitarone injection significantly improved sleep efficiency and reduced daytime sleepiness symptoms; At the same time, cognitive function test scores (such as memory and attention) have also improved. In addition, Epitaron can enhance the body's resistance to pathogens and reduce the risk of infection by regulating immune system function, further demonstrating its anti-aging value.
Inhibition of tumor growth:
It has a direct inhibitory effect on various tumor cells. In vitro experiments have shown that it can induce apoptosis and inhibit proliferation of solid tumor and hematological tumor cells. In animal models, it can slow down the growth rate of multiple myeloma and solid tumors, and prolong the survival of tumor bearing animals. The mechanism may be related to inhibiting tumor angiogenesis and regulating immune cell function in the tumor microenvironment.
Reduce chemotherapy side effects:
During tumor chemotherapy, patients often experience side effects such as bone marrow suppression and decreased immune function. By regulating immune system function, the body's tolerance to chemotherapy drugs can be enhanced and adverse reactions can be reduced.
For example, a study on breast cancer patients found that after combined use, the white blood cell count of patients decreased, the incidence of infection decreased, and the quality of life improved.
Preventing tumor recurrence:
Its telomerase activation may have potential value in preventing tumor recurrence. Tumor cells often maintain unlimited proliferation ability by activating telomerase, which may regulate telomerase activity, inhibit the growth of residual tumor cells, and reduce the risk of recurrence. At present, relevant research is underway, and the preliminary results are encouraging.
Improving symptoms of neurodegenerative diseases:
It has a protective effect on neurons and can increase neuronal activity through intranasal administration or injection. In animal models, it can delay the progression of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, improve cognitive function and motor coordination. The mechanism may be related to antioxidant stress and inhibition of neuroinflammation.
Treatment of retinitis pigmentosa:
Retinitis pigmentosa is a hereditary retinal degenerative disease that can lead to gradual loss of vision. Used to improve the visual function of patients with this disease.
Clinical studies have shown that it can prolong the functional integrity of the retina in Campbell rats with hereditary pigmentary retinitis, and improve the visual field and light sensitivity of some patients. At present, it has become one of the potential treatment methods for pigmentary retinitis.
Relieve neuropathic pain:
Its neuroprotective effect is also reflected in the relief of neuropathic pain. Animal experiments have shown that it can inhibit pain signal transduction caused by nerve damage and reduce pain behavior. This discovery provides new ideas for the treatment of neuropathic pain.
Regulating circadian clock genes:
It can act on the hypothalamic pituitary gonadal axis (HPG axis), regulate the expression of circadian clock genes, and restore circadian rhythm function. In the elderly rhesus monkey model, it can correct the diurnal imbalance of cortisol and melatonin secretion and improve sleep quality. This effect has potential value in treating diseases such as sleep disorders and seasonal affective disorders.
Improving reproductive function:
It has a regulatory effect on the reproductive system. Animal experiments have shown that it can increase testosterone levels in the blood of male rats, restore the estrus cycle of female rats, and improve the quality of oocytes.
These findings provide a basis for its application in the field of reproductive medicine, such as assisting in the treatment of infertility and improving menopausal symptoms.
Regulating thyroid function:
Preliminary research suggests that it may have a regulatory effect on thyroid function. In animal models of hypothyroidism, epitarone can promote the synthesis and release of thyroid hormones, improving metabolic function. However, further research is needed on the relevant mechanisms.
Improving the quality of oocytes:
Epithalon injection has been shown to maintain mitochondrial function and reduce oxidative stress damage during in vitro aging of oocytes after ovulation, thereby improving the quality of oocytes. This discovery has significant implications for assisted reproductive technologies such as in vitro fertilization, which may improve embryo implantation rates and pregnancy success rates.
Improving male reproductive function:
Epitaron can increase testosterone levels in male animals, promote sperm production and maturation. In male infertility patients, Epitarone injection may improve the testicular microenvironment, regulate hormone levels, and increase sperm count and vitality.
Other potential indications
Antioxidant and tissue repair:
Has strong antioxidant properties, can eliminate free radicals, and alleviate tissue damage caused by oxidative stress. In animal models, Epitarone can promote wound healing and accelerate tissue repair. This effect may have potential value in treating burns, injuries, ulcers, and other conditions.
Immune regulation:
It can regulate the function of the immune system and enhance the body's resistance to pathogens. Epitalon may be used as an immune enhancer in patients with immunodeficiency diseases (such as AIDS) or immunosuppression (such as after chemotherapy).
Sports Medicine and Physical Fitness Enhancement:
Its anti fatigue and physical fitness enhancement effects have been validated in animal experiments. In the field of sports medicine, Epitarone injection may be used to improve athletes' endurance and reduce the recovery time from sports injuries. However, the relevant applications must strictly comply with anti doping regulations.
Pharmacological action
The anti-aging effect of Epitaron is one of its most striking features. Research has shown that Epitaron can inhibit the development of spontaneous tumors in mice and has a protective effect against aging. Adding eptaglutide to telomerase negative human fetal fibroblast cultures can lead to the expression of catalytic subunits, telomerase enzyme activity, and telomere elongation, indicating that telomerase genes may be reactivated in somatic cells and may result in prolonged lifespan of cell populations and the entire organism. In addition, Epitaron can help elderly rhesus monkeys restore the circadian rhythm of cortisol and melatonin production, further confirming its anti-aging effect.
Epitaron has inhibitory effects on various tumor cells. For example, in vitro experiments, epithalon injection showed anti proliferative and apoptotic activity against solid tumor and hematological tumor cells. Animal experiments have also shown that Epitaron can inhibit protease activity in blood and tissue, and delay tumor growth in hematological and solid tumor models of multiple myeloma. These findings provide scientific evidence for the potential application of Epitaron in cancer treatment.
Epitaron has a protective effect on the nervous system. By intranasal administration, Epitarone can increase neuronal activity, which may be related to its improved cognitive function and delayed progression of neurodegenerative diseases. In addition, Epitaron can enhance the visual function of patients with pigmentary retinitis and prolong the functional integrity of the retina in Campbell rats with inherited pigmentary retinitis, further confirming its potential in neuroprotection.
In addition to the aforementioned effects, Epitaron may also have various biological activities such as regulating immune function and improving sleep quality. These effects together form a multi-target and multi pathway biological regulatory network of Epitaron, providing possibilities for its application in the treatment of complex diseases.
Frequently Asked Questions
Is Epithalon FDA approved?
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Epithalon is not FDA-approved as a pharmaceutical treatment for any indication. However, it may be available through compounding pharmacies for research purposes or off-label use under physician supervision.
Does epitalon increase testosterone?
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Epitalon. Hormone Replacement Therapy (HRT) involves restoring declining levels of estrogen, progesterone, or testosterone to alleviate symptoms of aging. While HRT can improve energy, libido, and bone health, it carries risks such as cancer, cardiovascular disease, and blood clots Rossouw et al., JAMA, 2002.
How long does it take for Epithalon to work?
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How soon does Epithalon begin working? Clients often report improvements in sleep quality within 2–3 weeks. Longevity and cellular benefits, such as improved energy and resilience, may take several months of consistent therapy to appear.
Does Epitalon really work?
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Epitalon can induce the expression of telomerase enzyme components and increase telomerase activity. In some studies, telomere length rose by an average of 33.3%, though results varied between individuals, likely due to differences in baseline telomerase activity, cellular age, and other metabolic factors.
Where to inject epithalon?
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Epithalon is typically administered via subcutaneous injection, allowing the peptide to bypass digestion and enter the bloodstream directly for maximum efficacy.
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