Lactoferrin Injection

Lactoferrin (LF) is a non-heme iron-binding glycoprotein that is widely present in exocrine fluids such as milk, saliva and tears of mammals, with a molecular weight of approximately 80 kDa. Since red protein was first isolated from milk in 1939, scientists have gradually revealed that it has multiple functions such as antibacterial, antiviral, immune regulation, iron metabolism regulation, antioxidant and anti-inflammatory. Lactoferrin inhibits bacterial growth by binding to iron ions, blocks viral infection by binding to viral receptors, and can also stimulate lymphocyte proliferation, promote red blood cell maturation, and regulate the function of the immune system.

People with weakened immune systems: Groups such as cancer patients, AIDS patients, and premature infants are prone to infections due to impaired immune systems and urgently need new immunomodulatory drugs.

The treatment dilemma of iron deficiency anemia: Traditional oral iron supplements may cause gastrointestinal discomfort, and some patients are intolerant to iron supplements. It is necessary to develop safer and more effective ways to supplement iron.

Antibiotic resistance issue: With the increase of bacterial resistance, the efficacy of traditional antibiotics declines. Lactoferrin, due to its broad-spectrum antibacterial properties, has become a potential alternative.

Treatment needs for severe infections: Patients with sepsis, severe pneumonia, etc. need adjuvant treatment methods to shorten the course of the disease and reduce the mortality rate.

Genetic engineering and bioreactor technology: Producing recombinant human lactoferrin through transgenic bovine mammary gland bioreactors to achieve large-scale industrial production. For instance, by introducing the human lactoferrin gene into bovine fertilized eggs and allowing it to be expressed in milk, several grams of lactoferrin can be produced per liter of milk.

Preparation process optimization: Develop lactoferrin injection, and through processes such as dissolution, sterilization, and filtration, produce a sterile preparation to solve the problem of easy degradation of natural lactoferrin in the gastrointestinal tract and improve bioavailability.

Tumor patients: Lactoferrin can enhance the proliferation ability of lymphocytes, improve the phagocytic function of macrophages, promote the secretion of immunoglobulins, and assist in enhancing the body's immune defense capacity.

Premature infants and newborns: Supplementing lactoferrin can reduce the risk of sepsis and necrotizing enterocolitis, and shorten the length of hospital stay.

AIDS patients: By regulating immune function, the occurrence of opportunistic infections can be reduced.

Patients intolerant to oral iron supplements: Lactoferrin injection is administered by injection to directly supplement iron, avoiding gastrointestinal irritation and improving patient compliance.

Patients with iron malabsorption: Lactoferrin promotes iron absorption in the intestines, rapidly increases hemoglobin levels, and improves anemia symptoms.

Pregnant women: Effectively improve iron deficiency anemia during pregnancy and reduce the risk of complications for both mother and baby.

Sepsis: The antibacterial and antiviral effects of lactoferrin can inhibit the growth of pathogenic bacteria, alleviate inflammatory responses, and assist in antibiotic treatment.

Severe pneumonia: By regulating immune function, reducing pulmonary infection and improving the prognosis of patients.

Drug-resistant bacterial infection: It has an inhibitory effect on multi-drug resistant bacteria (such as MRSA), providing a new option for anti-infection treatment.

Perioperative patients: Enhance immune function, reduce the risk of postoperative infection, and promote wound healing.

Inflammatory diseases: Inhibit the release of inflammatory factors and alleviate the inflammatory response in diseases such as rheumatoid arthritis.

Adjuvant therapy for COVID-19: Studies have shown that lactoferrin can shorten the time for the virus to turn negative, reduce inflammatory parameters, and improve clinical symptoms.