Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of acriflavine cream in China. Welcome to wholesale bulk high quality acriflavine cream for sale here from our factory. Good service and reasonable price are available.
Acriflavine Cream is an external preparation containing the component of acridine yellow. As a compound with multiple biological activities, it has a long history of application in the medical field. From the perspective of compositional characteristics, it can be used as a fluorescent dye for labeling high molecular weight RNA and has certain application value in scientific research. Meanwhile, it is also a local preservative, indicating that it may have a certain inhibitory effect on microorganisms and help prevent skin infections. The cream may be used for the treatment of some skin infectious diseases, such as skin inflammation and ulcer caused by bacteria or fungi. Through its antibacterial effect, it inhibits the growth and reproduction of pathogens, promoting the healing of skin wounds.
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Additional information of chemical compound:
| Product Name | Acriflavine Cream | Acriflavine Powder | Acriflavine Tablets |
| Product Type | Cream | Powder | Tablets |
| Product Purity | ≥99% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable |
Our Product
Acriflavine+. COA
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Certificate of Analysis |
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Compound name |
Acriflavine | |
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CAS No. |
590-63-6 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Acriflavine cream, as a compound with a long history, exhibits various mechanisms of action in the fields of biology and medicine, including antibacterial, anti-tumor, antiviral, and photodynamic therapy.
(1) Embedding DNA interferes with replication and transcription
Acriflavine directly interferes with DNA replication and transcription by embedding double stranded bacterial DNA, disrupting the helical structure of DNA. In the process of bacterial proliferation, DNA replication and transcription are key steps. The embedding effect of Acriflavine prevents DNA polymerase and RNA polymerase from binding properly, leading to replication and transcription errors or termination, thereby inhibiting bacterial growth and reproduction. This mechanism of action is effective against various Gram positive and Gram negative bacteria, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, etc.
(2) Inhibit bacterial protein synthesis
Acriflavine can also bind to bacterial ribosomes, interfering with protein synthesis processes. Ribosomes are the site of bacterial protein synthesis, and the binding of Acriflavine changes the conformation of ribosomes, affecting the transport of amino acids and the extension of peptide chains, resulting in bacteria being unable to synthesize proteins with normal functions.
Proteins are the foundation of bacterial life activities, and their synthesis obstruction can seriously affect bacterial metabolism and function, ultimately leading to bacterial death.
(3) Disruption of bacterial cell membrane function
Acriflavine has a destructive effect on bacterial cell membranes. The bacterial cell membrane is an important barrier for maintaining the stability of the intracellular and extracellular environment. Acriflavine can alter the permeability of the cell membrane, causing the leakage of ions and small molecules from the cell, leading to an imbalance in the intracellular environment. At the same time, it may also interfere with enzyme activity on the cell membrane, affecting cell energy metabolism and material transport, further exacerbating bacterial damage.
(1) Inhibition of HIF-1 α activity
Acriflavine is an effective HIF-1 α (hypoxia inducible factor-1 α) inhibitor. HIF-1 α plays a crucial role in the occurrence, development, and metastasis of tumors, as it can regulate the metabolism, angiogenesis, invasion, and metastasis of tumor cells. Under hypoxic conditions, HIF-1 α is activated, promoting the expression of a series of genes related to tumor growth and metastasis. Acriflavine inhibits the activity of HIF-1 α by blocking its dimerization with the HIF-1 β subunit, thereby suppressing the transcriptional activity of HIF-1 and reducing the expression of downstream target genes such as VEGF (vascular endothelial growth factor) and PGK1 (phosphoglycerate kinase 1), thereby inhibiting tumor angiogenesis and growth and inducing tumor cell apoptosis.
(2) Inhibition of DNA replication and transcription in tumor cells
Similar to its antibacterial effect, Acriflavine can also embed into the double stranded DNA of tumor cells, interfering with DNA replication and transcription. Tumor cells have the characteristic of rapid proliferation and frequent DNA replication and transcription activities. The embedding effect of Acriflavine can lead to DNA replication errors and transcriptional abnormalities in tumor cells, affecting normal cell division and proliferation, ultimately resulting in tumor cell death.
(3) Inducing apoptosis of tumor cells
Acriflavine cream can induce tumor cell apoptosis through various pathways. On the one hand, it may activate apoptotic signaling pathways within cells, such as the mitochondrial pathway and death receptor pathway, leading to the release of cytochrome c and activation of caspase cascade reactions, ultimately triggering cell apoptosis. On the other hand, after inhibiting HIF-1 α activity, Acriflavine changes the metabolic environment of tumor cells, putting them in an oxidative stress state and inducing cell apoptosis.
(4) Photodynamic therapy effect
Acriflavine has the potential for photodynamic therapy. Under specific wavelength light irradiation, Acriflavine can absorb light energy and be excited to an excited state, then undergo energy transfer with surrounding oxygen to produce reactive oxygen species such as singlet oxygen. These reactive oxygen species have strong oxidizing properties and can damage the cell membrane, proteins, and DNA of tumor cells, leading to tumor cell death. Photodynamic therapy has the characteristic of selectively killing tumor cells and causing minimal damage to surrounding normal tissues.
(1) Interference with viral DNA replication
For certain DNA viruses, Acriflavine can embed double stranded viral DNA, interfering with the virus's replication process. When viruses replicate in host cells, they need to utilize the host cell's enzymes and raw materials for DNA synthesis. The embedding effect of Acriflavine can disrupt the structure of viral DNA, prevent the normal binding and extension of viral DNA polymerase, and thus inhibit viral replication.
(2) Inhibition of viral protein synthesis
Acriflavine may also affect the synthesis of viral proteins. The synthesis of viral proteins depends on the ribosome and translation system of the host cell.
The mechanism by which Acriflavine binds to bacterial ribosomes and interferes with protein synthesis may also be applicable to viral protein synthesis. It can inhibit viral protein synthesis by altering the function of ribosomes or interfering with the translation of viral mRNA, thereby affecting virus assembly and release.
(3) Destroy the viral envelope
For some enveloped viruses, Acriflavine may disrupt the structure of the viral envelope. The viral envelope is an important component of viral particles, which protects the viral nucleic acid and participates in the adsorption and fusion process between the virus and host cells. Acriflavine may alter the permeability and stability of the viral envelope by interacting with lipids or proteins on the envelope, leading to the rupture of the viral envelope and rendering the virus unable to infect.
(1) Interference with parasite metabolism
Acriflavine has inhibitory effects on parasitic insects such as pear shaped worms, red blood cell bodies, horse Babesia, cowpea Babesia, bovine Babesia, and sheep Babesia. It may interfere with the energy metabolism pathways of parasites, such as inhibiting the activity of key enzymes such as glycolysis, tricarboxylic acid cycle, or electron transport chain, leading to insufficient energy supply for parasites and affecting their growth and reproduction.
(2) Destruction of parasitic cell structure
Acriflavine may also damage the cellular structure of parasites, such as cell membranes and organelles. It can alter the permeability of parasite cell membranes, causing the leakage of ions and small molecules from the cell, leading to an imbalance in the intracellular environment. At the same time, it may interfere with the function of organelles such as mitochondria and endoplasmic reticulum, affecting the normal physiological activities of parasites and ultimately leading to parasite death.
Other biological mechanisms of action
(1) Inhibit the production of inflammatory factors
Acriflavine can inhibit the production and release of various inflammatory factors, such as tumor necrosis factor - α (TNF - α), interleukin-1 β (IL-1 β), etc. Inflammatory factors play an important role in the inflammatory response, and their excessive production can lead to tissue damage and exacerbation of the inflammatory response. Acriflavine has potential therapeutic value for inflammatory diseases by inhibiting the production of inflammatory factors and reducing inflammatory responses.
(2) Antioxidant effect
Acriflavine has the ability to scavenge free radicals and protect cells from oxidative stress damage. Free radicals are highly active molecules produced during cellular metabolism, which can attack biomolecules such as DNA, proteins, and lipids inside cells, leading to cell damage and aging. The antioxidant effect of Acriflavine can neutralize free radicals, reduce cellular damage caused by oxidative stress, and have a positive effect on delaying aging and preventing diseases.
(1) Concentration dependence
The biological effects of Acriflavine are concentration dependent. The mechanism and effect of its action may vary at different concentrations. For example, at low concentrations, it may primarily exert antibacterial or antiviral effects, inhibiting microbial growth by interfering with DNA replication or protein synthesis; At high concentrations, it may also have a certain toxic effect on host cells, while enhancing its anti-tumor or photodynamic therapy efficacy.
(2) Lighting conditions
For the photodynamic therapy effect of Acriflavine, lighting conditions are the key factor. The wavelength, intensity, and duration of light exposure can affect the photosensitization efficiency of Acriflavine and the production of reactive oxygen species.
The excitation ability of Acriflavine varies with different wavelengths of light, and an appropriate wavelength can enable it to more effectively absorb light energy and produce reactive oxygen species. The intensity and duration of light also need to be precisely controlled to ensure minimal damage to surrounding normal tissues while killing tumor cells.
(3) Cell type and state
The sensitivity of different types of cells to Acriflavine may vary. Tumor cells may be more sensitive to Acriflavine due to their rapid proliferation and metabolic characteristics. In addition, the state of cells can also affect the effectiveness of Acriflavine, such as tumor cells in a hypoxic state that may be more sensitive to Acriflavine's inhibition of HIF-1 α activity.
Acriflavine cream has shown potential application value in antibacterial, anti-tumor, antiviral, and antiparasitic fields through various biological mechanisms of action. The mechanisms underlying its antibacterial activity include interference with DNA replication and transcription, inhibition of protein synthesis, and disruption of cell membrane function; The mechanisms of inhibiting HIF-1 α activity, inducing tumor cell apoptosis, and photodynamic therapy give it unique advantages in the field of anti-tumor treatment; The mechanisms of interfering with viral DNA replication, inhibiting viral protein synthesis, and damaging viral envelope provide theoretical basis for its antiviral effect; The mechanisms of interfering with parasite metabolism and disrupting parasite cell structure explain its inhibitory effect on parasites. However, the mechanism of action of Acriflavine is also influenced by factors such as concentration, lighting conditions, and cell type. Future research needs to further explore the details of its mechanism of action, optimize its application conditions, improve its efficacy and safety, and provide new strategies and methods for the treatment of related diseases.
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