Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of folic acid powder cas 59-30-3 in China. Welcome to wholesale bulk high quality folic acid powder cas 59-30-3 for sale here from our factory. Good service and reasonable price are available.
Folic acid powder is a water-soluble vitamin with the molecular formula C19H19N7O6,CAS 59-30-3. It is also called pteroylglutamic acid because of its rich content in green leaves. There are several forms in nature, and the parent compound is composed of pteridine, p-aminobenzoic acid and glutamic acid. Folic acid contains one or more glutamyl groups. Most naturally occurring folic acid is in the form of polyglutamic acid. The bioactive form of folic acid is tetrahydrofolate. Folic acid is yellow crystal, slightly soluble in water, but its sodium salt is very soluble in water. Insoluble in ethanol. It is easy to be destroyed in acid solution, unstable to heat, easy to lose in room temperature, and easy to be destroyed in light.
| Chemical Formula | C19H19N7O6 |
| Exact Mass | 441 |
| Molecular Weight | 441 |
| m/z | 441 (100.0%), 442 (20.5%), 442 (2.6%), 443 (2.0%), 443 (1.2%) |
| Elemental Analysis | C, 51.70; H, 4.34; N, 22.21; O, 21.75 |
|
|
|
Folic acid has active absorption and diffusion passive absorption in vivo, and the absorption site is mainly in the upper part of the small intestine. The absorption rate of reduced folic acid is higher, and the more glutamyl groups, the lower the absorption rate. Glucose and vitamin C can promote absorption. After absorption, folic acid is stored in intestinal wall, liver, bone marrow and other tissues in the body. With the participation of NADPH, it is reduced by folic acid reductase to tetrahydrofolate (THFA or FH4) with physiological activity, which is involved in the synthesis of purine and pyrimidine. Therefore, folic acid plays an important role in protein synthesis, cell division and growth, and promotes the formation of normal red blood cells. When lacking, it can reduce the production of hemoglobin in red blood cells, block the maturation of cells, and lead to megaloblastic anemia.
Animal applications
(1) Application of folic acid in pigs
The results showed that 2.5 mg/kg folic acid could significantly increase the whole period daily gain of piglets compared with the basal diet group. The concentration of protein in serum, DNA, RNA and protein in liver increased significantly, and the concentration of urea nitrogen in serum decreased significantly. At the same time, it was also concluded that the higher level of folic acid addition decreased the growth performance of piglets.
Some scholars found that folic acid powder supplementation had no significant effect on the reproductive performance of primiparous sows, but significantly increased the serum folic acid content of primiparous sows and newborn piglets. As an important cofactor of one carbon unit metabolism, folic acid can reduce the content of plasma homocysteine, thereby improving lipid peroxidation. Proteomic analysis showed that folic acid significantly affected the expression and activity of antioxidant enzymes in rat liver.
(2) Application of Folic Acid in Dairy Cattle
There is little research on folic acid in ruminants. It is generally believed that ruminant rumen microorganisms can synthesize folic acid and make good use of it. However, Girard et al. believe that the demand for folic acid in lactating dairy cattle during pregnancy is large, and it still needs to be added from the diet. In the tissue metabolism of high-yield dairy cattle, folic acid and choline can provide a carbon group for the body tissues of dairy cattle for energy and protein metabolism, purine and DNA synthesis, thus improving the production performance of dairy cattle.
(3) Application of Folic Acid in Chicken Breeding
Some scholars added 1.64, 2.14 and 2.64 mg/kg folic acid to the diets of broilers. The results showed that 1.64 mg/kg folic acid significantly increased the feed intake and average daily gain of broilers, and significantly increased the content of fructosamine in their serum, while 2.64 mg/kg water significantly increased the content of serum uric acid in broilers; The addition of folic acid can significantly increase the content of serum protein in 21 day old broilers. The addition of 3.0mg/kg level can significantly increase the feed intake and average daily gain of broilers, and can significantly reduce the feed to weight ratio.
It was found that the combination of folic acid and niacin can significantly increase the average daily gain of broilers; Other studies show that the combination of niacin and folic acid can significantly reduce the abdominal fat weight and abdominal fat rate of broilers, significantly increase the chest muscle weight, leg muscle weight and leg muscle rate, and significantly increase the thymus index, spleen index and bursa index of broilers. It can also, to a certain extent, increase the content of immunoglobulin in serum, significantly reduce the content of cholesterol in serum, and increase dry matter, crude protein, crude fat, crude fiber Apparent digestibility of organic matter and nitrogen free extracts.
Medical applications
Existing research reports indicate that folic acid plays an extremely important role in human health. Folic acid deficiency can lead to the risk of neurological malformations in newborns, thrombotic occlusive cardiovascular and cerebrovascular diseases, anorexia and anorexia nervosa, megaloblastic anemia, senile vascular dementia, depression, and other diseases.
(1). Investigation on the effect of folic acid on neonatal neural tube defects
Some scholars' research on Americans' supplementation of folic acid from diet and nutritional health care products in 2003-2006 shows that the folic acid intake of women of childbearing age must be improved.
In areas with high incidence of NTDs, the daily amount of folic acid provided to pregnant women is only 100 μ g, far below the daily requirement of pregnant women.
In a study investigating the impact of dietary folate intake on blood folate levels in lactating women in Canada, it was found that the recommended daily folate intake for lactating women is 400 μ g. Folic acid plays an important role in regulating neurogenesis and programmed cell death.
The fortified supplementation of folic acid in American food has reduced the birth rate of infants with neurological deficits by 19%, but other factors cannot be ruled out as contributing to this decrease.
0.4 milligrams of folic acid powder is used to prevent fetal neural tube defects. The Slian Folic Acid Project has been validated through 250000 cases of Sino US cooperation in preventing neural tube defects nationwide. Expectant mothers who take 0.4 milligrams of folic acid during pregnancy can reduce the incidence of fetal neural tube defects by 85%. This result has been widely used in more than 50 countries worldwide. 5mg folic acid is used to treat female anemia, and consumers must carefully read the instructions when choosing to purchase, and choose according to different situations.
(2). Research on the Effects of Folic Acid on Other Human Diseases
Folic acid not only has an effect on preventing incomplete neural closure in infants, but also plays a certain role in the prevention of some common human diseases.
(3). Research on the Effects of Folic Acid on Other Diseases
The increase in plasma homocysteine concentration can lead to the occurrence of thrombotic occlusive cardiovascular and cerebrovascular diseases, anorexia and anorexia nervosa, senile vascular dementia, depression and other diseases. Folic acid is an important cofactor in the cyclic metabolism of homocysteine. When activated, folic acid can be converted into 5,10-methylenetetrahydrofolate, providing a methyl group for the conversion of homocysteine to methionine.
Folic acid deficiency leads to the accumulation of a large amount of homocysteine, which is excreted into the extracellular space and causes an increase in plasma homocysteine concentration, resulting in disease. Research has shown that the consumption of folate fortified foods is fundamentally related to the increase in serum folate levels in middle-aged and elderly people. Folic acid can reduce the risk of gout in people with a history of painless wind. Folic acid deficiency can cause damage to multiple systems in the body, mainly leading to colitis, chronic atrophic gastritis, and increased risk of colon and stomach cancer in the digestive system. Folic acid supplements can inhibit the recurrence rate of colorectal cancer.
Research has shown that a certain concentration of folic acid can inhibit the growth of ovarian cancer cells by affecting folate metabolism. Folic acid may enhance the cytotoxic effect of chemotherapy drugs on ovarian cancer cells, thereby increasing the sensitivity of ovarian cancer to chemotherapy.
Synthesis of folic acid: trichloroacetone as intermediate
In 1948, Hultquist et al. condensed 1,1,3-trichloroacetone with 2,4,5-triamino-6-hydroxypyrimidine to prepare 4-amino-4-hydroxy-6-chloromethylpteridine, as shown in Figure :
At present, folic acid is mainly synthesized from trichloroacetone, 2,4,5-triamino-6-hydroxypyrimidine sulfate and p-aminobenzoylglutamic acid in China. Trichloroacetone, L-N-p-aminobenzoylglutamic acid, 6-hydroxy-2,4,5-triaminopyrimidine sulfate were reacted for 5h at the reaction temperature of 40-45 ℃ in the presence of sodium metabisulfite and sodium carbonate at pH 3.0 ～ 3.5. The reaction equation is shown in Figure :
The operation process is simple, the reaction time is short, the conditions are easy to control, and the folic acid powder cost is low. However, there is a large amount of waste water and waste gas. In the process of producing trichloroacetone, there is also great pollution, mainly in the following two aspects.
Wastewater pollution is serious. The prepared chlorinated mixture requires a large amount of water for water extraction to obtain trichloroacetone water extract with concentration that can be used for production, resulting in a large amount of wastewater.
Waste gas pollution is serious. Trichloroacetone is generally prepared by the reaction of acetone and chlorine in plants, and a large amount of hydrogen chloride gas is generated at the same time. If the waste gas is not fully recycled, it will lead to serious waste gas pollution.
In addition to the pollution of waste water and waste gas in the preparation of trichloroacetone, such problems also exist in the process of folic acid synthesis. Due to the poor solubility of 2,4,5-triamino-6-hydroxypyrimidine sulfate, there was a large amount of water in the reaction process, and the trichloroacetone water extract dropped also brought a large amount of water into the reaction system. In addition, in the final purification operation, acid dissolution and water separation are required, which together lead to serious pollution of the overall reaction wastewater.
In organisms, the synthesis of protein, nucleotide, pantothenic acid and methylation of molecules all require the participation of one carbon unit. Folic acid is an extremely important cofactor mediating the transfer of one carbon unit. Folic acid is mainly involved in the de novo synthesis of purine and pyrimidine. Folic acid forms different forms of folic acid because there are different forms of substituents on the pyrazine ring and their ortho aminobenzoyl glutamate partially combine with different amounts of glutamate residues:
Pyrazine ring is partially reduced - dihydrofolate;
Pyrazine ring is completely reduced - tetrahydrofolate;
Pyrazine ring is oxidized by formic acid - 5-formyl tetrahydrofolate or 10-formyl tetrahydrofolate or 5,10-methylene tetrahydrofolate;
Pyrazine ring is oxidized by formaldehyde - 5,10 methylene tetrahydrofolate;
Pyrazine ring is oxidized by methanol - 5-methyl-tetrahydrofolate. Tetrahydrofolate (TFH) is the most active form in vivo, because it is the most suitable substrate for polyglutamylation.
FAQ
Who should not take folic acid?
Is vitamin B12 also called folic acid?
Is it good to take folic acid every day?
What is the benefit of taking folic acid?
Hot Tags: folic acid powder cas 59-30-3, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, agarose powder, Pure Erythritol Powder CAS 149 32 6, Cyclohexyldimethoxymethylsilane, s allyl l cysteine, Pamoic acid, Alpha Amylase Powder CAS 9000 90 2