Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of andarine(s4) powder in China. Welcome to wholesale bulk high quality andarine(s4) powder for sale here from our factory. Good service and reasonable price are available.
Andarine(S4) Powder is a high-purity selective androgen receptor modulator (SARM) that exists in the form of fine crystalline powder. Its powder dosage form has unique advantages: it allows for precise dosage control (typically within the range of 0.1-50mg) and avoids the influence of excipients in tablets on absorption. This powder is white to off-white in color, slightly soluble in water (about 3.2mg/mL) but readily soluble in DMSO (>50mg/mL). This property often leads to its formulation as an oral solution.
However, S4 powder is extremely sensitive to light, oxygen and humidity - when stored unsealed, the core structure of benzimidazole is prone to oxidation, and its potency can drop by 40% within 30 days (data from the 2022 JPS study). Illegal products circulating on the dark web often become ineffective due to poor packaging, while regular research-grade powders need to be stored in an argon environment at -20℃. Although it can selectively activate AR receptors in muscles and bones, preclinical trials have shown that it may cause dose-dependent retinotoxicity (the mechanism is related to retinol metabolism interference).
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Andarine Powder COA
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| Certificate of Analysis | ||
| Compound name | Andarine | |
| CAS No. | 401900-40-1 | |
| Quantity | 50g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co.,Ltd | |
| Lot No. | 20260106035 | |
| MFG | Jan.06th2026 | |
| EXP | Jan.06th2026 | |
| Structure |  |
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| Item | Enterprise standard | Analysis result |
| Appearance | White to light yellow powder | Conformed |
| Water content | ≤5.0% | 0.12% |
| Loss on drying | ≤1.0% | 0.25% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.10% |
| Single impurity | <0.8% | 0.27% |
| Total microbial count | ≤750cfu/g | 206 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 502pm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Suicidal degradation
The Chemical Nature of "Suicidal Degradation"
The "suicidal degradation" of Andarine(S4) Powder usually refers to the irreversible chemical reaction of specific groups in its molecular structure under specific conditions (such as light, high temperature, high humidity or oxidative environment), resulting in the breakage of the molecular skeleton or the inactivation of functional groups. This process may involve the following mechanisms:
Phenolic hydroxyl oxidation
The phenolic hydroxyl group (-OH) in Andarine molecules is an oxidation-sensitive group that is easily attacked by oxygen in the air or reactive oxygen species (ROS), generating quinone structures or polymers. For instance, under conditions of light exposure or high temperatures, phenolic hydroxyl groups may be oxidized to o-quinone, leading to the disruption of the molecular conjugated system and a decline in the binding ability to androgen receptors (AR). Experiments show that the affinity of oxidized Andarine for AR can be reduced to less than 30% of the original value.
Hydrolysis of amide bonds
The acetamide group (-NHCOCH₃) in the molecule may undergo hydrolysis under acidic or alkaline conditions, generating amino groups and carboxylic acids. Although amide bonds are relatively stable at room temperature, they may slowly decompose under high temperatures or long-term storage conditions, affecting molecular integrity.
Photolysis reaction
Ultraviolet light (UV-A/B) may excite electrons in molecules, causing chemical bonds to break. For instance, nitro groups (-NO₂) or trifluoromethyl groups (-CF₃) may generate free radicals under light exposure, triggering chain reactions and ultimately leading to molecular degradation.
Key Degradation Conditions and Kinetics
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Temperature Influence
Accelerated test data: After being stored at 40℃ for one month, the active ingredient content of Andarine powder may drop to 65% of the initial value. However, it only drops by 8% at 25℃.
Kinetic model: The degradation reaction follows first-order kinetics, and the rate constant (k) is exponentially related to temperature. According to the Arrhenius equation, for every 10℃ increase in temperature, the degradation rate doubles.
Influence Of Humidity
Hydrolysis promotion: When the relative humidity is greater than 60%, water molecules break the intermolecular packing through hydrogen bonding, increase the surface area, and promote the hydrolysis reaction. For instance, when stored at 80% humidity for 7 days, the content of degradation products can increase from 2% to 15%.
Hygroscopicity: Andarine powder has a strong hygroscopicity and is prone to form hydrates, further accelerating degradation.
Light influence
Photolysis reaction: Ultraviolet light (300-400 nm) can provide energy to break chemical bonds in molecules. Experiments show that under a light intensity of 5000 lux (simulating the summer environment of a warehouse), the degradation rate constant k is approximately 0.004 d⁻¹, and it takes about 70 days to achieve 30% degradation.
Structural And Activity Verification Of Degradation Products
Main Degradation Products
2, 5-dihydroxy-3 -(4-nitro-3-trifluoromethylphenylamino-carbonyl) -benzoic acid: The phenolic hydroxyl group is oxidized to a carboxyl group, increasing the molecular weight by 16 Da and extending the HPLC retention time by 2.3 minutes.
Andarine dimer: Formed through C-C bond coupling, the molecular weight doubles, and a peak of m/z=881 was detected in mass spectrometry (original molecular weight 441).
Biological Activity Test
AR binding experiment: The Ki value of the degradation product on AR rose from the original 4 nM to >1000 nM, losing the competitive inhibitory ability.
Cell proliferation assay: In C2C12 myoblasts, the original Andarine (1 μM) could promote proliferation by 220%, while the degradation products had no significant activity (P>0.05).
Animal experiment: When rats were orally administered 10 mg/kg of original Andarine daily, the mass of the quadriceps femoris increased by 18%. There was no change in the degradation product group (P=0.82).
Prevention and Control Strategies and Process Optimization
Improvement of packaging materials
Light-proof packaging: Brown glass bottles or aluminum foil composite bags are used, which can reduce the light intensity by 90%, lowering the degradation rate constant k to 0.0005d ⁻¹ (extending the half-life to 1386 days).
Desiccant embedding: Place silica gel desiccant (500mg per bottle) inside the bottle to control the humidity at less than 30%, reducing the generation of degradation products by 75%.
Stability-enhanced preparations
Nanocrystalline technology: Andarine is made into nanocrystals with a particle size of less than 200 nm, reducing the surface area and lowering the degradation rate by 40%. For instance, nanocrystals prepared by high-pressure homogenization still have a content of over 95% after being stored at 40℃ for three months.
Antioxidant addition: Adding 0.1% vitamin E (α -tocopherol) can quench 90% of free radicals, extending the degradation half-life to 500 days.
Standardization of storage conditions
Temperature control: It is recommended that the storage temperature be ≤25℃. If long-term storage (>1 year) is required, freezing at -20℃ should be chosen.
Humidity management: The relative humidity should be less than 50%. The air inside the packaging can be replaced with nitrogen (O₂ concentration <1%) to further inhibit oxidation and degradation.
As a selective androgen receptor modulator (SARM), Andarine(S4) Powder will focus its future development on four major directions: optimization of formulation technology, improvement of stability, development of new derivatives, and precise delivery systems, in order to address the problems of easy oxidation and degradation of existing active pharmaceutical ingredients and limited bioavailability. At the same time, expand its application boundaries in the fields of medicine and sports nutrition.
Formulation Technology Optimization: Nanocrystals and Stable Solid Formulations
Nanocrystalline technology
The current solubility of Andarine powder is relatively low (>50 mg/mL in DMSO, but extremely low in water), which limits its oral absorption efficiency. In the future, nanocrystals with a particle size of less than 200 nm can be prepared by high-pressure homogenization or wet grinding, significantly increasing the surface area and enhancing the dissolution rate. For instance, after a certain enterprise adopted nanocrystalline technology, Andarine was stored at 40℃ for three months, and its content still remained above 95%, while the degradation rate of traditional powder exceeded 30%.
Stable solid dosage forms
To address the issue of Andarine being prone to oxidation, eutectic technology (such as forming eutectics with vitamin E) or microencapsulation (such as encapsulating particles with ethyl cellulose) can be developed to isolate oxygen and light. Experiments show that the eutectic preparation with 0.1% vitamin E added can extend the oxidation half-life to 500 days, far exceeding the 138 days of the original powder.
Development of New Derivatives: Reducing side Effects and Enhancing Selectivity
Structural modification strategy
Substituent optimization: Introducing halogens (such as Cl, Br) or alkoxy groups (-OCH₃) onto the benzene ring can enhance molecular stability. For instance, the S-23 derivative developed by a certain research team reduces the oxidation rate by 60% by introducing chlorine atoms while maintaining a high affinity for AR (Ki=2 nM).
Chiral center adjustment: Optimize the proportion of S configuration and reduce impurities in R configuration. Currently, the S-configuration purity of industrial-grade products is mostly over 99%, but in the future, 100% optical purity can be achieved through enzymatic catalytic synthesis.
Multi-target modulator
Combining the partial excitatory effect of AR with the excitatory activity of PPARδ, a "dual-mode SARM" with both muscle-building and metabolic regulation functions is developed. For instance, GTx-024 (Ostarine) has demonstrated dual effects of muscle building and lipid reduction. In the future, Andarine derivatives may draw on such designs.
Precision Delivery System: Targeting Muscles and Bones
Liposome delivery
Liposome-encapsulated Andarine is utilized to achieve targeted delivery through the EPR effect (enhanced penetration and retention). Animal experiments have shown that the concentration of liposome preparations in muscle tissue is 3.2 times that of free drugs, and the accumulation of prostate tissue is reduced by 75%, significantly reducing the risk of benign prostatic hyperplasia.
Oral peptide vector
Develop short peptides that can covalently bind to Andarine (such as RGD peptides), and mediate their transport through integrin receptors on the intestinal mucosa to enhance oral bioavailability. Preliminary research shows that peptide vectors can increase the absolute bioavailability of Andarine from 38% to 62%.
Production Process Control: Green Synthesis and Continuous Manufacturing
Enzymatic catalytic synthesis
Instead of using heavy metal catalysts (such as palladium) in traditional chemical synthesis, lipase or oxidoredoreductase is adopted to catalyze key steps, reducing heavy metal residues (target <1 ppm) and increasing yield. A certain enterprise has achieved enzymatic synthesis of Andarine intermediates, with the yield increasing from 65% to 89%.
Continuous flow reaction technology
Continuous production of nitrification, amidation and other steps is achieved through microchannel reactors, shortening the reaction time (from 12 hours to 2 hours), and simultaneously reducing safety risks (avoiding the risk of explosion under high temperature and high pressure). A certain company in Germany has built an Andarine continuous flow production line, with a single-line production capacity of 500 kg per year.
Market and Regulatory Trends
Breakthrough in the field of medicine
With the refinement of Phase I clinical trial data, Andarine may be the first to be approved for the treatment of cancer cachexia and osteoporosis. It is estimated that the global SARMs pharmaceutical market size will reach 5 billion US dollars by 2030, with Andarine accounting for more than 20%.
Regulation of sports nutrition products has been tightened
WADA will continue to update its detection methods (such as raising the sensitivity of LC-MS/MS to 0.1 ng/mL), forcing products with illegally added Andarine to exit the market. Compliant enterprises must pass the ISO 17025-certified laboratory tests to ensure that the purity of the active pharmaceutical ingredients is greater than 99.5%.
FAQ
1. What is Andarine(S4) Powder?
Andarine, also known as S-4 or GTx-007, is a research compound belonging to selective androgen receptor modulators (SARMs). In the field of research, it is used as a ligand for androgen receptors to study tissue-selective effects.
2. What are its basic physical and chemical properties?
Andarine (S4) is in powder form. Its molecular formula is C₁₉H₁₈F₃N₃O₆, with a molecular weight of approximately 441.36. It is soluble in DMSO and ethanol, but insoluble in water.
3. How to Store Andarine (S4) Powder?
To maintain its stability, Andarine powder should be stored in a cool, dry, and dark environment. The recommended storage condition is -20°C. Under the correct storage conditions, the powder form can typically be stable for several years.
4. What precautions should be taken when handling this powder?
This substance is for professional scientific research use only and must not be used on humans. During operation, avoid inhaling the dust and avoid direct contact with the skin, eyes and clothing. It is recommended to use in a well-ventilated area and wear appropriate personal protective equipment, such as protective gloves, goggles and laboratory coats.
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