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The chemical name of Nefiracetam Powder is N-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidine acetamide, a synthetic pyrrolidinone derivative classified as a potent cognitive enhancer, or nootropic agent. Structurally distinct from traditional racetam compounds, it is specifically designed to target central nervous system functions related to learning, memory, and cognitive processing. It typically presents as a white to off-white crystalline powder with good chemical stability, making it suitable for research and formulation development. Pharmacologically, Nefiracetam exerts its cognition-promoting effects through multiple complementary mechanisms. It primarily modulates central neurotransmitter systems, with a particularly notable effect on acetylcholine (ACh) transmission.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
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Additional information of chemical compound:
| Product Name | Nefiracetam Powder | Nefiracetam Capsules | Nefiracetam Liquid |
| Product Type | Powder | Capsules | liquid |
| Product Purity | ≥99% | ≥99% | ≥99% |
| Product Specifications | 100g/1kg/etc. | 50mg/bottle | 5mg/10mg/25mg |
| Product Form | Organic synthesis | Take Orally | Organic synthesis |
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Nefiracetam COA
Nefiracetam interacts with GABA receptors, helping to balance the neurotransmitter environment by positively affecting excitatory and inhibitory neurotransmitters, improving attention and overall cognitive performance. It may also affect the levels of monoamine neurotransmitters such as dopamine and norepinephrine, further regulating cognitive function. It improves memory retention by promoting communication between neurons, increasing synaptic plasticity. It may also affect the function of L/N-type calcium channels and plasma channels, thereby regulating neuronal excitability.
It is mainly used to improve memory and cognitive impairments, such as Alzheimer's disease, vascular dementia, etc. However, current research on its clinical efficacy is inconsistent, with some studies showing limited or controversial efficacy. It also has a certain anticonvulsant effect and can be used to treat certain types of epilepsy or seizures.
Nefiracetam Powder is a pyrrolidone compound that belongs to cognitive enhancers and has certain application value in the fields of medicine and cognitive science. The following will elaborate on its purpose from multiple aspects:
Treating cognitive impairment related diseases
Vascular dementia is a cognitive impairment caused by cerebrovascular disease. Nefiracetam may benefit patients with vascular dementia by improving cerebral blood circulation, regulating the neurotransmitter system, and other mechanisms.
It can activate L/N-type calcium channels, cholinergic, monoaminergic, and GABAergic systems, enhance neuronal communication and promote neural plasticity, improve synaptic plasticity, and enhance memory formation. Some small-scale clinical trials have shown that Nefiracetam can improve cognitive function and quality of life in patients with vascular dementia. For example, after taking Nefiracetam, patients may have some improvement in memory, attention, language ability, etc., which enables them to better engage in daily activities such as dressing, eating, and washing. But larger and more rigorous clinical studies are also needed to confirm its efficacy.
Application in the treatment of vascular dementia
Nefiracetam may improve cerebral blood circulation, increase blood supply to brain tissue, and reduce neuronal damage. For example, it may improve blood perfusion in the brain by dilating cerebral blood vessels and reducing blood viscosity. Meanwhile, it can also regulate the neurotransmitter system and maintain the normal function of neurons. For patients with vascular dementia, interventions targeting cerebrovascular lesions are crucial. The dual mechanism of action of Nefiracetam gives it certain advantages in the treatment of vascular dementia. In the future, with the development of more clinical studies, Nefiracetam is expected to become one of the important drugs for the treatment of vascular dementia.
Nefiracetam Powder is a novel racetam class intelligent drug (nootropy), belonging to the pyrrolidone derivative, with potential cognitive enhancement, neuroprotective, and anti anxiety effects. Its discovery stems from research on the structural modification of piracetam, aimed at developing more efficient and selective neuroactive compounds. The research on Nefiracetam began with the exploration of racetam drugs. In 1964, Romanian chemist Corneliu E. Giurgea first synthesized piracetam and discovered its effects on enhancing memory and learning abilities, but the mechanism is still unclear.
Piracetam is considered the first truly "nootropy" drug, defined as:
Enhance cognitive function (such as memory, learning)
Protect the brain from physical or chemical damage
Low toxicity and minimal side effects
The success of Piracetam has driven scientists to study compounds with similar structures, attempting to develop more effective derivatives. The core structure of Piracetam is 2-oxo-1-pyrrolidinoacetamide.
Scientists have developed a series of derivatives by modifying its side chain, including:
- Aniracetam - Higher lipid solubility and stronger action
- Oxiracetam - enhances cholinergic transmission
- Pramiracetam - stronger memory enhancing effect
Early research found that Nefiracetam has multiple neuroregulatory effects:
- Enhance cholinergic system: increase acetylcholine release, improve memory (associated with Alzheimer's disease).
- Regulating glutamate receptors (NMDA/AMPA): promoting long-term potentiation (LTP) and enhancing synaptic plasticity.
Neuroprotective effect:
- Reduces neuronal death after ischemic brain injury.
- Anti anxiety and antidepressant effects: may regulate emotions through GABAergic or 5-HT systems.
Nefiracetam was developed in this context, characterized by the introduction of a diphenylmethyl group on the pyrrolidone ring, giving it unique pharmacological properties. It was developed by Japanese pharmaceutical company Daiichi Sankyo in the late 1980s, initially codenamed DM-9384. Its chemical name is N - (2,6-dimethylphenyl) -2- (2-oxo-1-pyrrolidine) acetamide, which is structurally more lipophilic than piracetam and may enhance blood-brain barrier penetration ability.
In the 1990s, multiple animal experiments showed that Nefiracetam was superior to traditional racetam drugs in improving learning disabilities, anti hypoxia injury, and anti epilepsy.
In the 1990s, Nefiracetam entered the clinical trial stage, mainly studying its potential therapeutic effects on cerebrovascular diseases (such as cognitive impairment after stroke) and Alzheimer's disease.
Improving vascular dementia: Some studies have shown that it can increase cognitive test scores (such as MMSE).
Antiepileptic effect: reduces epileptic seizures in animal models, but human data is limited.
Anti anxiety and anti depression: may be used as adjuvant therapy drugs.
However, due to inconsistent efficacy and commercial strategy adjustments, Nefiracetam has not been widely marketed globally and is only used as a prescription drug in some Asian countries, such as Japan.
At the beginning of the 21st century, scientists further explored the molecular mechanism of Nefiracetam:
- Enhance hippocampal synaptic plasticity (regulated by Ca ² ⁺ signaling)
- Regulating nicotinic acetylcholine receptors (nAChRs) may be helpful for nicotine withdrawal
- Promote BDNF (brain-derived neurotrophic factor) release to support neuronal survival
- These findings make it still of research value in the fields of neurodegenerative diseases and cognitive impairments.
side effect
Nefiracetam Powder is a pyrrolidine ketone compound with cognitive enhancing effects. Although it has shown potential to improve cognitive function in clinical applications, it also has a series of side effects, as follows:
Allergic reactions
(I)Skin rash:
Mechanism of occurrence
Some patients may be allergic to certain components of Nefiracetam. When the drug enters the body, the immune system recognizes it as a foreign object, causing an allergic reaction and resulting in a rash on the skin.
Clinical manifestations
The rash can manifest as erythema, papules, wheals, etc., mostly distributed in the trunk, limbs, and other areas. Rash is usually accompanied by itching, and in severe cases, symptoms such as blisters and erosions may appear.
Influencing factors
Patients with allergic constitution are more prone to allergic reactions such as rash. In addition, factors such as drug purity and formulation process may also affect the occurrence of allergic reactions.
Response measures
Once allergic symptoms such as rash appear, the medication should be stopped immediately and anti allergic treatment should be carried out under the guidance of a doctor. Patients should avoid scratching the rash area to prevent infection.
(II)Itching:
Mechanism of occurrence:
Inflammatory mediators such as histamine released by allergic reactions can stimulate skin nerve endings, causing itching symptoms. The degree of itching varies from person to person, and in severe cases, it can affect the patient's sleep and quality of life.
Clinical manifestations:
Patients may experience self perceived skin itching, which can be limited to the rash area or spread throughout the body. Itching sensation may worsen at night, affecting the patient's rest.
Response measures
Patients can use some topical anti itch drugs, such as calamine lotion, to alleviate itching symptoms. At the same time, the skin should be kept clean and irritating bathing products should be avoided. If the itching symptoms are severe, oral anti allergic drugs such as loratadine can be taken under the guidance of a doctor.
(III)Other severe allergic reactions:
Mechanism of occurrence
In rare cases, patients may experience severe allergic reactions, such as anaphylactic shock. This is due to allergic reactions causing systemic vasodilation and a sharp drop in blood pressure.
Clinical manifestations
Allergic shock has a sudden onset, and patients may experience symptoms such as difficulty breathing, pale complexion, cold sweats, and loss of consciousness. In severe cases, it can be life-threatening.
Response measures
Allergic shock is a serious medical emergency, and once it occurs, immediate rescue treatment should be carried out.
It significantly increases the release of acetylcholine in the cerebral cortex and hippocampus-brain regions critical for memory formation and learning. Nefiracetam may also enhance the activity of voltage-dependent Ca²⁺ channels via cAMP-dependent protein kinases, further promoting calcium influx and facilitating the synaptic release of ACh. As acetylcholine is a key neurotransmitter directly involved in memory encoding, information processing, and attention maintenance, the enhancement of cholinergic function supports overall cognitive performance.
Beyond cholinergic modulation, Nefiracetam also supports synaptic plasticity, improves neuronal metabolism, and helps maintain normal neural signal transmission under conditions of mild cognitive stress. These combined effects make it a valuable candidate for research aimed at supporting cognitive function, with potential applications in studies related to age-related cognitive changes, learning efficiency, and neurological function recovery.
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