Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of vitamin d2 powder cas 50-14-6 in China. Welcome to wholesale bulk high quality vitamin d2 powder cas 50-14-6 for sale here from our factory. Good service and reasonable price are available.
Vitamin D2 powder, chemical name is 9,10-cycloergoste-5,7,10 (19), 22-tetraene-3 β- Alcohol, chemical formula C28H44O, is colorless acicular crystal or white crystalline powder, odorless and tasteless, and is easy to deteriorate when exposed to light or air. Vitamin D2(Arthin), a steroid derivative, is an active substance related to the metabolism of calcium and phosphorus, and plays an important role in the prevention and treatment of rickets in children and osteoporosis in the elderly. At present, there are 96 kinds of pharmaceutical preparations mainly composed of arthin.Arthin is also an indispensable and important additive in feed, which can significantly improve the egg production rate and lean meat production rate of poultry and livestock.
|
Chemical Formula |
C28H44O |
|
Exact Mass |
396 |
|
Molecular Weight |
397 |
|
m/z |
396 (100.0%), 397 (30.3%), 398 (2.7%), 398 (1.7%) |
|
Elemental Analysis |
C, 84.79; H, 11.18; O, 4.03 |
|
|
|
Vitamin D2, as an important fat soluble vitamin, plays an indispensable role in human health. It not only participates in regulating the balance of calcium and phosphorus in the body, maintaining bone health, but also has an impact on multiple aspects such as thyroid function and immune system.
Regulating the balance of calcium and phosphorus in the body
The main function is to promote the absorption of calcium and phosphorus by the body, thereby maintaining the balance of calcium and phosphorus in the body. This function is crucial for the growth and development of bones and the reconstruction of bone tissue.
Promote calcium absorption: After entering the human body, it can enhance the intestinal absorption capacity of calcium, allowing more calcium ions to enter the bloodstream and provide sufficient calcium source for bones.
Promote phosphorus absorption: Phosphorus is one of the important components that make up bones, and vitamin D2 powder can also promote phosphorus absorption to ensure the smooth mineralization process of bones.
Maintaining bone density: By promoting the absorption of calcium and phosphorus, it helps to maintain bone density and strength, reducing the risk of osteoporosis.
Promoting bone tissue reconstruction: When bones are damaged or aged, it can promote the repair and reconstruction of bone tissue, maintaining the integrity and stability of bones.
Regulating thyroid function
The regulation of thyroid function is also of great significance.
Promote thyroid hormone synthesis: It can affect the proliferation and differentiation of thyroid cells, thereby promoting the synthesis and secretion of thyroid hormones.
Regulating thyroid hormone levels: Thyroid hormones play a crucial role in human metabolism and growth and development. Arthin maintains the normal metabolic state of the human body by regulating thyroid hormone levels.
Preventing thyroid diseases: Moderate supplementation of vitamin D2 can help reduce the risk of thyroid diseases, such as hyperthyroidism and hypothyroidism.
Treating osteoporosis and rickets
Plays an important role in the treatment of osteoporosis and rickets.
Promote bone calcification: It can promote calcium deposition at the site of new bone formation, allowing citrate to deposit in the bone, thereby promoting bone calcification.
Enhance bone cell function: It can promote the function and maturation of bone cells, and improve the regenerative ability of bones.
Treatment of osteoporosis: Osteoporosis is a common bone disease characterized by decreased bone density and fragile bones. Supplementing can help slow down bone density loss and reduce the risk of fractures.
Prevention and treatment of rickets: Rickets is a bone disease caused by vitamin D deficiency, mainly manifested as skeletal deformities and softening. Supplementing with vitamin D2 can prevent and treat rickets and promote normal bone development.
Treating Vitamin D Deficiency
Vitamin D2 powder is also used to treat vitamin D deficiency, which is particularly important for specific populations.
Vegetarians: Due to the lack of animal based foods in their diet, vegetarians are prone to vitamin D deficiency. Supplementing can help meet the vitamin D needs of vegetarians.
Supporters of parenteral nutrition: Supporters of parenteral nutrition are unable to absorb vitamin D through the intestines and therefore require additional supplementation of arthin.
Patients with pancreatic insufficiency: Patients with pancreatic insufficiency may not be able to synthesize activated forms of vitamin D (such as vitamin D3) normally, so supplementation is also necessary.
Enhance immune system function
It also plays a certain role in the normal function of the immune system.
Enhance immune cell activity: It can enhance the activity of immune cells and improve the body's ability to resist infections and diseases.
Promote immune cell differentiation: can affect the differentiation and proliferation of immune cells, thereby regulating the function of the immune system.
Reduce the risk of infection: Appropriate supplementation can help reduce the risk of infectious diseases such as respiratory tract and digestive tract.
Improving mood and combating depression
It also has a positive impact on mental health.
Promote dopamine secretion: Dopamine is a neurotransmitter closely related to pleasure and happiness. Arthin can promote the secretion of dopamine, thereby improving one's mood.
Antidepressant effect: Studies have shown that it has a certain antidepressant effect. Moderate supplementation of vitamin D2 can help alleviate depressive symptoms and improve quality of life.
Preventing cardiovascular diseases
In recent years, research has also found potential roles in preventing cardiovascular disease.
Lowering blood pressure: It can lower blood pressure and reduce the damage of hypertension to the cardiovascular system.
Improve vascular function: it can improve the function and structure of blood vessels and reduce the risk of atherosclerosis.
Preventing cardiovascular disease: Moderate supplementation can help prevent the occurrence and development of cardiovascular disease.
Other functions
In addition to the above functions, it also has the following effects:
Promoting dental health: helps maintain the normal development and mineralization process of teeth, and prevents dental caries and periodontal disease.
Improving muscle function: can enhance muscle contraction and endurance, and improve athletic performance.
Promote skin health: It can maintain the barrier function and moisturizing ability of the skin, prevent skin dryness and itching.
Vitamin D2 powder production process:
Dissolve 20 grams of ergosterol in 250 ml of cyclohexane, add antioxidants, cool to 0 ℃, fill the reaction system with nitrogen, and the solution enters the first photochemical reactor at a proper flow rate.
The photochemical ring opening reaction takes place under the illumination of LED light with a wavelength of 275 nm. The reaction temperature is controlled at 0 ± 5 ° C. Through the adjustment of the flow rate, the conversion rate of raw ergosterol is guaranteed to reach more than 75%, then the solution after the ring opening reaction directly passes through the second photochemical reactor and undergoes photochemical closed-loop reaction under the illumination of LED light with wavelength of 335 nm, and the reaction temperature is controlled at 0 ± 5 ° C.
The total reaction time is about 4 hours. After the completion of the reaction, the material is discharged, the reaction solvent is recovered under reduced pressure, the ethyl acetate is added, heated and refluxed for 5 minutes, and then cooled to 0 ℃. 4.2g of unconverted ergosterol is recovered by suction filtration, and the recovery rate of ergosterol is about 21%.
Add isooctane into the filtered mother liquor, heat and reflux for about 0.5 hours, and then cool to 0 ℃ to precipitate most of vitamin D2. The first batch of vitamin D2 products are obtained by suction filtration. 6.8 grams of vitamin D2 are dried in a vacuum dryer, with a purity of more than 95%.
The remaining mother liquor is further heated for about 0.5 hour, and then cooled to 0 ℃ after partial solvent removal under reduced pressure. Arthin is separated out, and the second batch of vitamin D2 products are obtained by suction filtration.
The vacuum dryer dries 3.6 grams of arthin, with a purity of more than 97%. The remaining mother liquor is further heated for 20 minutes, then depressurized to remove part of the solvent, cooled to 0 ℃, and the third batch of vitamin D2 is separated out. The vacuum dryer dries 1.6 grams of arthin, with a purity of more than 97%. The total yield of the three products is 60%, and the purity is more than 96%.
extraction process:
A method for extracting high content arthin from hydrangea fruiting body includes the following steps:
S1. Mix 100 mesh of 100 g hydrangea fruiting body after grinding and screening with 5 µ g water-soluble nano-fluorescent material, and disperse it in distilled water with 20 KHz ultrasound to disperse the suspension;
S2. Place the dispersed suspension in a pulsed electric field with an electric field intensity of 30Kv/cm and a pulse width of 6 µ s, and irradiate the dispersed suspension under the excitation wavelength of the water-soluble nano-fluorescent material. The excitation wavelength of the water-soluble nano-fluorescent material is 200-380nm, and the emission wavelength of the water-soluble nano-fluorescent material is 280-400nm. After 2 hours of irradiation, filter the filter residue to obtain the first extracted solid, The water-soluble nano fluorescent material is a water-soluble CdSe/ZnS quantum dot;
S3. The first extracted solid is ultrasonically dispersed with alkaline solution with pH value of 9, and saponification reaction is carried out under the action of pulsed electric field with electric field intensity of 20Kv/cm and pulse width of 40 µ s. The saponification reaction temperature is 95 ℃, and the saponification time is 2h. After the reaction, the filter residue is taken to obtain the second extracted solid;
S4. Add 500 ml of 100% ethanol solution to the second extraction solid, stir it evenly, and filter the filtrate to obtain the extraction solution;
S5. The extract is dried by vacuum rotary evaporation at 30 ℃ to obtain arthin extract.
The above synthesis methods need to be selected and used based on one's own actual situation. A more convenient way is to send us an inquiry. We are arthin supplier and we will provide you with the highest quality vitamin d2 v d3.
|
|
|
|
|
Solubility
Insoluble in water but readily soluble in organic solvents:
Very soluble in chloroform, chloroform
Soluble in ethanol, acetone, diethyl ether
Slightly soluble in vegetable oils
Does not precipitate in digitalis saponin solution (negative digitalis saponin test).
Stability and Reactivity
Sensitive to light and air: Degrades upon exposure to light or air; store in light-protected, sealed containers.
Good thermal stability: Melting point 115-118°C; relatively stable at elevated temperatures, though prolonged heat may accelerate decomposition.
Decomposition accelerated by inorganic salts: Stability decreases and decomposition rate increases in environments containing inorganic salts.
Chemical color reactions:
Reaction with acetic anhydride-sulfuric acid: Solution color sequentially changes to yellow → red → purple → green.
UV Absorption Characteristics: Exhibits a significant absorption peak at 265 nm, suitable for quantitative analysis.
Spectroscopic Properties
Infrared Spectrum: Matches standard patterns with characteristic absorption peaks.
UV Spectrum: Absorption coefficient at 265 nm ranges from 460 to 490, applicable for content determination.
Purity and Impurity Control
Food-grade/pharmaceutical-grade products typically require ≥97.0% purity, with impurity levels meeting standards:
Area of any single impurity peak ≤ 0.5% of the main peak area in the reference solution
Total impurity peak area ≤ 1.0% of the main peak area in the reference solution
Residual precursor substances such as precursor vitamin D2 must be controlled.
I. Correlation with Diseases and Preliminary Exploration
From the late 19th century to the early 20th century, rickets was prevalent among children in Europe and America. Medical researchers found that sunlight exposure and certain foods could alleviate the disease. In early studies, this fat-soluble nutrient was classified as a component related to vitamin A and not categorized independently. In 1919, scientists confirmed that ultraviolet rays in sunlight could stimulate the human body to produce anti-rickets substances. This finding identified the active ingredient and kicked off dedicated research on vitamin D.
II. Isolation and Nomenclature
After 1920, scholars purified active ingredients from cod liver oil, fungi and grains. In 1927, research teams irradiated ergosterol with ultraviolet rays, successfully converting and isolating arthin, and clarified its chemical precursor and structural characteristics. This substance was officially named ergocalciferol, to distinguish it from vitamin D₃ of animal origin. Both compounds exert anti-rickets effects.
III. Advanced Research and Widespread Application
In the 1930s, the chemical structure of arthin was fully elucidated, and its artificial synthesis technology gradually matured. With well-established production processes, it has been widely added to foods and dietary supplements. Subsequent studies further revealed its physiological functions. Besides preventing and treating rickets, it regulates calcium and phosphorus metabolism. To this day, it remains a commonly used vitamin raw material for food fortification and health products.
FAQ
Why do doctors prescribe vitamin D2 instead of D3?
+
-
Doctors often prescribe vitamin D2 (ergocalciferol) instead of D3 (cholecalciferol) because high-dose D2 is the most readily available FDA-approved prescription option for treating severe deficiencies. While vitamin D3 is generally superior at raising blood levels, prescription D2 allows for massive, standardized weekly or monthly doses.
What are the symptoms of a vitamin D2 deficiency?
+
-
Vitamin D2 deficiency symptoms can be subtle and primarily revolve around bone and muscle pain, fatigue, a depressed mood, and frequent illnesses. Low levels can severely impact how your body absorbs calcium, causing systemic discomfort.
Hot Tags: vitamin d2 powder cas 50-14-6, suppliers, manufacturers, factory, wholesale, buy, price, bulk, for sale, epinephrine powder, Best Phenibut powder, Ethacridine Lactate Monohydrate CAS 6402 23 9, Norepinephrine Powder CAS 51 41 2, Methylergonovine Maleate Salt CAS 57432 61 8, Atropine Sulfate Monohydrate CAS 5908 99 6