Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 4-benzyloxyphenol cas 103-16-2 in China. Welcome to wholesale bulk high quality 4-benzyloxyphenol cas 103-16-2 for sale here from our factory. Good service and reasonable price are available.
4-Benzyloxyphenol is an organic aromatic compound with the chemical formula C₁₃H₁₂O₂. It is formed by replacing the hydroxyl group (-OH) of phenol with a benzyl oxygen group (-OCH₂C₆H₅) at the ortho position. It is a white to light yellow crystalline or powder substance, slightly soluble in water, but easily soluble in organic solvents such as ethanol and ether.
This compound possesses both phenolic hydroxyl groups and benzyl ether structures, endowing it with the weak acidity of phenolic compounds and the stability of ethers. The phenolic hydroxyl groups can participate in hydrogen bonding, undergo oxidation reactions, or act as nucleophilic sites, while the benzyl oxygen group can be deprotected under acidic or hydrogenation conditions, re-creating phenol, making it commonly used as a protecting group or intermediate in organic synthesis. Additionally, its structure is similar to certain natural antioxidants (such as tyrosol derivatives), possibly exhibiting antioxidant or antibacterial activities, and can be used in pharmaceutical or materials chemistry research.
When storing, it should be protected from light and moisture. Because the phenolic hydroxyl groups may be oxidized, and the benzyl group may break under strong acids/strong oxidants. In terms of safety, attention should be paid to skin and eye irritation. Protective equipment should be worn during operation.
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Chemical Formula |
C13H12O2 |
|
Exact Mass |
349 |
|
Molecular Weight |
349 |
|
m/z |
200 (100.0%), 201 (14.1%) |
|
Elemental Analysis |
C, 77.98; H, 6.04; O, 15.98 |
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Synthetic 4-benzyloxyphenol: in our laboratory, p-methoxyphenol, a cheap and easily available industrial raw material, is used as raw material. In the presence of potassium carbonate, anhydrous DMF is used as solvent to react with benzyl chloride to produce p-benzyloxyanisole, and human tetrabutylammonium bromide is added to catalyze the reaction. Then, under the catalysis of ethanethiol, p-benzyloxyanisole is demethylated to produce p-benzyloxyphenol. The raw material of this method is p-methoxyphenol, which is cheap and easy to obtain. At the same time, ethanethiol is used as a catalyst, with less dosage and low cost. The operation steps of this experiment are simple, with less by-products, and p-benzyloxyphenol is easy to separate and extract.
The main uses of 4-Benzyloxyphenol include the following aspects:
Monobenzoneis a locally used decolorizer, which is used to treat hyperpigmentation, such as various stains, age spots, melanoma and so on. It can decompose melanin in the skin, prevent the generation of melanin in the skin, and restore the healthy color of the skin without damaging melanocytes. It is very toxic. It is usually made into ointment or liniment, which has been included in the United States Pharmacopoeia. It can decompose the black in the skin, prevent the generation of melanin in the skin, and restore the healthy color of the skin without damaging the melanocytes, thus playing the role of decolorization. Clinically, it is mainly used to treat hyperpigmentation, such as various stains, senile plaques, vitiligo, melanoma, etc.
Skin depigmenter
Monobenzone is a locally used decolorizer, which is used to treat hyperpigmentation, such as various stains, senile plaques, melanoma, etc., with obvious effect. It can decompose the melanin in the skin, prevent the generation of melanin in the skin, and restore the healthy color of the skin without damaging the melanocytes. It is very toxic. It is usually made into ointment or liniment, which has been included in the United States Pharmacopoeia, but has not been produced in China. At present, China has no drugs for the treatment of color spots, and the cosmetics used for the treatment of color spots have little effect, and some cosmetics add a large amount of hydroquinone, metallic mercury and other harmful substances to achieve the effect of freckle removal and whitening. The development of monobenzone into freckle removing drugs or cosmetics has good effect and low toxicity, which can meet the urgent needs of a large number of yellow people with macular, and will be welcomed by the domestic and foreign markets.
This compound is mainly used as a pharmaceutical intermediate in the field of medicine. Pharmaceutical intermediates are key raw materials or intermediate products in the process of drug synthesis, which participate in the construction and modification of drug molecular structures. Due to their specific chemical structures and properties, they play an important role in drug synthesis.
Specifically, it can be converted into other biologically active compounds through a series of chemical reactions, which are further used to synthesize drugs for treating specific diseases or symptoms. For example, it may participate in the synthesis of certain drug molecules with anti-inflammatory, antibacterial, anti-tumor and other activities. However, due to the complexity and diversity of drug synthesis, the specific application of this substance in pharmaceutical intermediates may vary depending on the type of drug and synthesis pathway.
Other potential applications
This compound can be used as a raw material for synthesizing other organic compounds in the field of chemical synthesis. Due to its specific chemical structure and reactivity, it can participate in various chemical reactions such as substitution reactions, oxidation reactions, etc., thereby generating organic compounds with different structures and properties. These compounds may have specific application value, such as being used as raw materials or intermediates for dyes, fragrances, pesticides, etc. In the field of materials science, it may be used to prepare materials with special properties. For example, it can be used as an additive or modifier for polymers or composite materials to improve their physical properties, chemical stability, or biocompatibility. In addition, due to its certain antioxidant properties, it may also be used to prepare antioxidant materials to extend their service life. In the field of biochemistry, it may serve as a research tool or probe for studying certain biochemical processes or enzyme activities within living organisms. By binding to specific molecules or enzymes within the organism, the function of these molecules or the activity of enzymes can be influenced or regulated, thereby revealing certain biochemical mechanisms or signaling pathways within the organism.
Melting point 119-120 ° C (lit.), Boiling point 297.96 ° C (rough estimate), Density 1,26 g/cm3, Refractive index 1.5906 (estimate), Storage condition store below +30 ° C, Solubility chloroform (slightly), DMSO (slightly), methanol (slightly), Morphology powder, crystals, and/or chunks, Acidity coefficient (PKA) 10.29 ± 0.15 (predicted), Color off white to beige to brown, Water soluble, BRN 1958305, InChIKeyVYQNWZOUAUKGHI-UHFFFAOYSA-N, Dangerous goods sign Xi, Hazard category code 36-43, Safety instructions 24/25-26-37, WGK Germany 2, RTECS No. sj7700000, Hazard Note Irritant, TSCA Yes, Toxicity LD50 i.p. in mice: >600 mg/kg (Takahashi).
What are the side effects of this compound?
4-Benzyloxyphenol, also known as Monobenzone, is primarily used as a topical depigmenting agent that can break down melanin in the skin and prevent its formation, thereby restoring a healthy color to the skin. However, it also has some potential side effects. Here is a detailed summary of its side effects:
Skin irritation and allergic reactions
Skin irritation: Monobenzone may have a stimulating effect on the skin, causing discomfort such as redness, swelling, itching, or pain.
Allergic reactions: Individual populations may experience allergic reactions to Monobenzone, manifested as skin inflammation such as contact dermatitis. The symptoms of allergic reactions may include rash, itching, redness, and swelling.
Pigmentation loss and risk of vitiligo
Pigmentation loss: As a decolorizing agent, Monobenzone may cause skin pigmentation loss, resulting in lighter skin color or white patches.
Vitiligo risk: Studies have shown that long-term use of Monobenzone may increase the risk of developing vitiligo. Vitiligo is a skin depigmentation disease characterized by the appearance of white patches on the skin, either locally or throughout the body.
Other potential risks
Eye irritation: Monobenzone may have a stimulating effect on the eyes, causing discomfort such as redness, pain, or tears. Therefore, contact with the eyes should be avoided during use.
Inhalation risk: Long term inhalation of Monobenzone may have adverse effects on the respiratory system, leading to respiratory irritation or inflammation. Therefore, good ventilation should be ensured during use to avoid prolonged inhalation.
Potential toxicity: Although the toxicity of Monobenzone is relatively mild, long-term extensive use may still pose potential risks to physical health. Therefore, the recommended dosage should be followed according to medical advice or product instructions when using.
Precautions for use
When using Monobenzone, a skin test should be conducted first to ensure no allergic reactions to the product.
Avoid touching sensitive areas such as eyes, mouth, and nose with the product.
If any discomfort occurs during use, stop using immediately and seek medical assistance.
Pregnant women, breastfeeding women, and special populations such as children should consult a doctor's opinion before use.
When storing, it should be placed in a cool and ventilated warehouse, away from dangerous sources such as fire and heat.
What is the price range of this compound?
The price of 4-benzyloxyphenol is influenced by various factors, including brand, purity, packaging specifications, market supply and demand, etc. Here is a summary and analysis of its price:
1.Price Range
The price of this compound varies greatly depending on different brands and specifications in the market. Generally speaking, its price range ranges from several hundred yuan to several thousand yuan, and the specific price needs to be determined based on the supplier and product details.
2.Price influencing factors
Brand: The price of this substance may vary among different brands. Famous brands usually have higher quality assurance and after-sales service, so prices may be relatively high.
Purity: Its purity is also an important factor affecting the price. High purity products usually have better usability and safety, so the price may be higher.
Packaging specifications: The price of different packaging specifications may also vary. Generally speaking, products with large packaging may have higher cost-effectiveness, but the specific price still needs to be determined based on the supplier and product details.
Market supply and demand: The supply and demand relationship in the market can also affect its price. If there is a tight supply in the market, prices may rise; On the contrary, if there is sufficient supply, prices may decrease.
3. Purchase advice
When purchasing, it is recommended to first understand the brand, purity, packaging specifications, and other information of the product, and choose the appropriate product according to your own needs.
You can choose products with higher cost-effectiveness by comparing the prices and service quality of different suppliers.
Pay attention to choosing legitimate channels for purchase to ensure the quality and safety of the product.
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