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4-Ethylphenol is an organic compound with CAS 123-07-9 and molecular formula C8H10O. It is a colorless to light yellow solid or crystal. Its pure product is usually colorless or light yellow crystals, but commercially available products may appear dark due to impurities. It can be soluble in organic solvents such as alcohols, ethers, esters, etc., but not in water.
In addition, it has a certain degree of stability towards acidity and alkalinity. It is a compound composed of phenol and ethyl, where ethyl replaces the hydrogen atom adjacent to the hydroxyl group of phenol. In its molecular structure, there is a covalent bond between oxygen atoms and hydrogen atoms, forming hydroxyl groups; There are also covalent bonds between carbon atoms and hydrogen atoms, forming ethyl groups.

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Chemical Formula |
C8H10O |
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Exact Mass |
122 |
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Molecular Weight |
122 |
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m/z |
122 (100.0%), 123 (8.7%) |
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Elemental Analysis |
C, 78.65; H, 8.25; O, 13.10 |
It is a common phenolic compound and therefore has the properties of phenolic compounds. It can react with many compounds, such as condensation reaction with aldehydes, neutralization reaction with alkali metal hydroxides or acids, etc. In addition, due to its hydroxyl group, it can also undergo esterification and etherification reactions.
In the pesticide industry, it can be used as a key raw material for synthesizing pesticides such as insecticides, herbicides, and fungicides. By reacting with different chemical reagents, various pesticide compounds with specific insecticidal or herbicidal activities can be synthesized. In some specific liquid crystal materials, it can be used as a structural regulator. By adjusting the molecular structure of liquid crystal materials, the physical properties such as phase transition temperature and phase transition rate can be controlled.

4-Ethylphenol has demonstrated significant application value in the field of cocktails due to its unique woody, smoky, and sweet aroma characteristics. From enhancing the smoky flavor of whiskey to adjusting the complex flavor of seafood cocktails, its applications cover multiple dimensions from improving classic wines to developing innovative special blends.
The core use in cocktails
Whiskey and Rum
4-Ethylphenol is one of the important aroma components in whiskey and rum. During the distillation and aging process of whiskey, the decomposition of lignin in wooden barrels (such as oak barrels) produces 4-ethylphenol, giving whiskey a unique smoky, leathery, and barn flavor.

In the production process of rum, a small amount of 4-ethylphenol is also generated during the fermentation and distillation of molasses, enhancing its complex aroma of tropical fruit and smoke.
Smoked flavor blending
When preparing smoked cocktails (such as "smoked Manhattan"), the bartender may add a trace of 4-ethylphenol essence to simulate the flavor of smoked whiskey or peat, so as to make the wine more layered.
Flavor regulator
Coffee and Chocolate Flavors
The sweet and woody characteristics of 4-ethylphenol can enhance the flavor complexity of cocktails containing coffee or chocolate elements (such as "mocha Martini"), making their taste more mellow.
Meat and seafood flavors
In seafood cocktails (such as oyster cocktails) or meat flavored cocktails (such as bacon bourbon).
4-Ethylphenol can simulate the aroma of smoked meat or seafood, enhancing the flavor reduction of the drink.
Application of food grade spices:
According to GB 2760-1996 "Hygienic Standards for the Use of Food Additives", 4-ethylphenol is allowed as a food flavoring agent, with a concentration of approximately 0.2mg/kg in the final flavored food. This regulation provides a basis for its legal use in cocktails.
Techniques for using cocktails
liquid flavor
Liquid essence containing 4-ethylphenol can be purchased on the market, usually with ethanol as the solvent. When using, the dosage should be strictly controlled (usually adding 0.01-0.05ml per liter of wine), as excessive amounts can cause the aroma to be too abrupt.
Solid spice
Some high-end cocktail sets offer powdered or granular spices containing trace amounts of 4-ethylphenol. It can be dissolved in the wine by shaking or stirring to achieve sustained release of aroma.
Safety operation standards
Usage control
Excessive addition (exceeding 0.5mg/L) may cause medicinal and irritating odors in the liquor, affecting the drinking experience. It is recommended to use a step-by-step addition method when using for the first time, gradually adjusting to the optimal concentration.
Dissolving treatment
It can be dissolved in a small amount of high alcohol (such as vodka) first, and then slowly added to the liquor to avoid excessive local concentration.
Storage conditions
The essence containing 4-ethylphenol should be kept away from light and sealed to prevent oxidation from causing aroma decay.
Matching suggestions
| Alcohol base | 4-Ethylphenol Dosage | Combined With Ingredient | Flavor Effect |
| Whiskey | 0.02ml/L | Peat water, caramel syrup | Enhance smoky flavor and balance sweetness |
| Rum | 0.03ml/L | Pineapple juice, cloves | Tropical fruit aroma intertwined with smoky flavor |
| Gin | 0.01ml/L | Cucumber and mint | Fresh plant fragrance with woody aroma |
| Vodka | 0.01ml/L | Grapefruit juice, absinthe | Bitter and sweet intertwined, with a smoky finish at the end |

4-ethylphenol is an organic compound with important physical and chemical properties, often used in the laboratory to synthesize other compounds and materials. The following are common laboratory synthesis methods for 4 ethylphenol:
Method 1: Phenol Ethylation Method
C6H5OH+ C2H5OH → C6H5OCH2CH3
C6H5OCH2CH3 + Zn + HCl → C6H5CH2OH + ZnCl2 + CH3CH2OH
Prepare the required reagents: phenol, ethanol, concentrated hydrochloric acid, glacial acetic acid, zinc powder, and water.
Mix phenol, ethanol, and concentrated hydrochloric acid together, stir well, and then heat until reflux occurs.
When the reaction mixture clarifies, add zinc powder and glacial acetic acid, and continue heating and reflux.
After a certain period of reflux reaction, use TLC to detect the reaction process. When the raw material point disappears, stop heating.
Add water, adjust the pH to neutral with a sodium bicarbonate solution, and then extract with ether.
The extraction solution is dried with anhydrous sodium sulfate, filtered, and the solvent is spun dry to obtain the crude product.
Purify using silica gel column chromatography to obtain the pure product.
Method 2: Ethylation of acetophenone
C6H5COCH3 + BrCH2CH3 → C6H5COCH2CH3 + NaBr + H2O
C6H5COCH2CH3 + H2O → C6H5CH2OH + CH3COOH
Prepare the required reagents: acetophenone, bromoethane, sodium hydroxide, and water.
Mix acetophenone and bromoethane together, add sodium hydroxide aqueous solution, and stir evenly.
Heat the mixture to reflux for a certain period of time, use TLC to detect the reaction process, and stop heating when the raw material point disappears.
Add water, adjust the pH to acidity with concentrated hydrochloric acid, and then extract with ether.
The extraction solution is dried with anhydrous sodium sulfate, filtered, and the solvent is spun dry to obtain the crude product.
Purify using silica gel column chromatography to obtain the pure product.

Method 3: Ethylation of o-nitrophenol
C6H4NO2(OH)CH3 + BrCH2CH3 → C6H4NO2(OH)CH2CH3 + NaBr + H2O
C6H4NO2(OH)CH2CH3 + H2O → C6H4CH2OH + CH3COOH + HNO3
Prepare the required reagents: o-nitrophenol, bromoethane, sodium hydroxide, and water.
Mix o-nitrophenol and bromoethane together, add sodium hydroxide aqueous solution, and stir evenly.
Heat the mixture to reflux for a certain period of time, use TLC to detect the reaction process, and stop heating when the raw material point disappears.
Add water, adjust the pH to acidity with concentrated hydrochloric acid, and then extract with ether.
The extraction solution is dried with anhydrous sodium sulfate, filtered, and the solvent is spun dry to obtain the crude product.
Purify using silica gel column chromatography to obtain the pure 4-Ethylphenol.
The reagents and reaction conditions used in these methods may vary depending on the experimental conditions and specific objectives. When conducting experiments, appropriate reagents and conditions should be selected based on the specific situation. At the same time, attention should be paid to experimental safety to ensure that experimental operations comply with regulations and standards.
FAQ
What is 4ep?
Ethylphenol (4-EP) is an organic compound with the formula C2H5C6H4OH. It is one of three isomeric ethylphenols. A white solid, it occurs as an impurity in xylenols and as such is used in the production of some commercial phenolic resins. It is also a precursor to 4-vinylphenol.
What is 4-Methylphenol used for?
4-Methylphenol (p-cresol) is a natural product present in many foods, crude oil, and coal tar, and is also detected in animal and human urine. In addition to its industrial uses, p-cresol is also used as an antiseptic and disinfectant because of its bactericidal and fungicidal properties.
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