Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of dipeptide-2 in China. Welcome to wholesale bulk high quality dipeptide-2 for sale here from our factory. Good service and reasonable price are available.
Dipeptide-2 is a water-soluble active signaling dipeptide with a naturally optimized polypeptide molecular structure composed of a specific dual amino acid sequence. It targets blood vessels and periocular microcirculation tissues and features mild and stable physicochemical properties. Boasting excellent skin permeability and low irritation, it delivers superior biocompatibility with the delicate periocular skin, serving as a highly effective peptide raw material exclusively for skincare products that improve periocular puffiness and dullness, and it is for external use only.
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Dipeptide-2 COA
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| Certificate of Analysis | ||
| Compound name | Dipeptide-2 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 24587-37-9 | |
| Quantity | 75g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.46% |
| Loss on drying | ≤1.0% | 0.65% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.9% |
| Single impurity | <0.8% | 0.71% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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| Chemical Formula | C16H21N3O3 |
| Exact Mass | 303.16 |
| Molecular Weight | 303.36 |
| m/z | 303.16(100.0%), 304.16(17.3%),305.17(1.4%) |
| Elemental Analysis | C,63.35; H,6.98; N,13.85; O,15.82 |

Topical application enables it to easily penetrate the epidermis and act on subcutaneous microvessels, regulate vascular permeability, accelerate the metabolism of excess water around the eyes, relieve circulatory stasis, and ameliorate eye bag puffiness, dark circles and periocular dullness and distension.
Eliminates Bloating and Improves Puffy Orbital Bags
Dipeptide-2 stands out as a star functional peptide for resolving orbital bloating concerns, efficiently and comprehensively improving morning periocular tumescence and acquired pseudo orbital bags that trouble most skincare users. A large number of people struggle with persistent cosmetic issues such as heavy drooping eyelids, swollen ocular tissue and prominently protruding orbital bags after waking up every day.


Long-term sedentary work leading to systemic blood circulation blockage, and irregular work and rest rhythms will continuously disrupt the metabolic balance of periocular tissues, resulting in long-term chronic periocular tumescence and stubborn recurrent pseudo orbital bags.These swollen concerns cannot be fundamentally relieved by ordinary moisturizing, hydrating or mild antioxidant skincare products, leaving many users with persistent tired-looking orbital contours,with precise targeting capability.
It accurately acts on the subcutaneous microvascular network and lymphatic circulation system around the visual zone, regulating the microcirculation state of periocular tissue from the root cause rather than improving symptoms superficially. On the one hand, it can effectively contract the dilated and relaxed periocular capillaries, reasonably reduce excessive vascular permeability, and effectively block the accumulation and retention of excess water, inorganic salts and metabolic waste in the loose periocular tissue space.


On the other hand, it significantly accelerates the lymphatic detoxification and drainage efficiency of the visual zone, quickly dredges stagnated fluid and residual waste metabolites, thoroughly improves the long-term circulatory stasis state of ocular tissues, and rebuilds a smooth and unobstructed microcirculation environment for the visual zone. With continuous and adherent use, it can rapidly fade acute morning orbital bloating and restore a neat and refreshing visual state in a short time.
Long-term persistent skincare application can fundamentally reverse recurrent periocular tumescence, effectively tighten and smooth the overall orbital contour. More importantly, it avoids the irreversible transformation of long-term accumulated pseudo swollen issues into permanent organic orbital bags caused by continuous tissue sagging and fluid deposition, perfectly maintaining a compact, flat and youthful orbital contour state for a long time.

Fades Vascular Orbital Darkening & Brightens Dull Ocular Tissue

Dipeptide-2 exhibits excellent targeted improvement effects on typical vascular orbital darkening, mainly presenting bluish-purple and dark red tones, which are induced by long-term staying up late, mental stress, excessive visual strain, visual fatigue and disordered daily routines. Different from ordinary whitening and brightening ingredients that only target epidermal pigment deposition, this professional signal peptide specially targets intractable vascular orbital darkening that cannot be improved by conventional skincare ingredients.
Most users' orbital dullness problems are not caused by melanin precipitation, but stem from blocked periocular blood circulation, slow blood flow, local blood stasis and tissue hypoxia, which lead to continuous bluish, purple and dark dimness of the orbital tissue, forming a natural tired and aging facial state.This high-activity dipeptide effectively activates the dormant periocular microcirculation system, greatly accelerates the flowing circulation and catabolic excretion of stagnated hypoxic blood in ocular microvessels, relieves long-term vascular congestion and tissue hypoxia, and gradually fades the stubborn bluish-black and dim color patches around the visual zone through continuous catabolic regulation.


At the same time, it can continuously deliver rich nutritional moisture to the extremely delicate and thin periocular tissue, effectively improve the sallow and dim complexion caused by prolonged visual fatigue and poor catabolism. With long-term use, it can gradually restore the translucent, uniform and bright complexion of the dull and lifeless visual zone, completely eliminate the persistent tired and haggard facial impression, and significantly improve the aging and decadent visual sense caused by chronic "staying-up visual zone and fatigue visual zone".
Soothes Delicate Ocular Tissue & Strengthens Barrier Function
The periocular region is recognized as the thinnest, most fragile and sensitive tissue of the human body, with a thickness only one-third of ordinary facial tissue, and it lacks rich subcutaneous fat support and dense collagen structure. Therefore, it is extremely vulnerable to external stimulation and internal catabolic disorders, prone to various concerns such as dry tightness, allergic redness, inflammatory flushing and tissue damage. Long-term irregular schedules, frequent makeup and makeup removal friction, ultraviolet radiation stimulation and daily skincare misoperation will continuously damage the fragile ocular barrier, resulting in persistent dryness, redness, sagging and sensitivity.


And further aggravate various visual zone aging problems. It features ultra-mild molecular properties, zero irritation and ultra-low sensitization risk, with extremely high biological compatibility suitable for fragile periocular tissue.While exerting efficient anti-aging and brightening skincare efficacy, it can effectively soothe mild inflammatory redness, dry tightness and fatigue discomfort of damaged periocular tissue, precisely repair the impaired ocular barrier structure, and comprehensively enhance the natural defense ability and long-term water-locking performance of periocular tissue.
Long-term standardized use can fundamentally improve the fragile and sensitive sub-health state of periocular tissue, make the ocular texture more delicate, stable and healthy, effectively reduce the frequent occurrence of dryness, itching and flushing problems, and lay a solid and healthy skin foundation for subsequent high-efficiency anti-aging, brightening and repairing skincare procedures.

Prevents Periocular Early Aging, Smooths Fine Creases & Improves Ptosis

In addition to the core classic efficacies of relieving bloating and fading orbital darkening, it is also equipped with excellent comprehensive anti-early-aging performance for the visual zone, serving as a multi-effect maintenance ingredient for ocular youth. Poor microcirculation and blocked catabolic excretion around the visual zone are core inducing factors for early tissue aging. Long-term accumulation of metabolic waste and unsmooth nutrient delivery will increase the catabolic burden of ocular tissue, continuously consume collagen and elastic fibers, and accelerate the occurrence of ptosis, dry creases and fine lines, making the visual zone the first aging part of the face.
By continuously optimizing and regulating the periocular microcirculation system, dipeptide-2 ensures the continuous and stable delivery of nutrients and moisture to the ocular tissue, effectively delays the irreversible loss of periocular collagen and elastic fibers, and significantly improves the overall firmness, elasticity and plumpness of ocular texture. It can intelligently prevent the generation of dry creases, fine striations, ptosis and other early aging signs caused by dryness and hypoxia, and gradually fade shallow dynamic dry creases formed by long-term facial expressions and dryness.


It maintains the visual zone in a firm, plump and youthful state for a long time, effectively delays the overall aging speed of ocular tissue. It is perfectly suitable for young complexions to prevent early aging problems and meets the daily long-term anti-aging and stable maintenance needs of mature complexions.

In 1996, European and American medical teams studied ACE enzymes and fluid retention, identifying microcirculation imbalance as the root cause of periorbital edema and launching peptide screening tests.
In 2000, Team Bobiev condensed valine and tryptophan to synthesize Val-Trp short peptide and successfully prepared high-purity it samples.
In 2001, in vitro cell experiments were carried out, proving that the peptide inhibits ACE activity and constricts capillaries, clarifying the mechanism of edema reduction.
In 2002, irritation control tests on periorbital skin were completed, verifying its mild and hypoallergenic properties suitable for delicate eye care.
In 2003, an eight-week human trial was conducted. Data from one hundred subjects confirmed its efficacy in draining fluid and fading eye bags, with findings recorded in professional literature.
In 2004, Sederma optimized synthetic processes for mass production, incorporating it into the Eyeliss complex and supplying it widely to eye care manufacturers.
References
[1] Kim J H, Park S Y, Lee J M. Efficacy and safety of synthetic dipeptide ingredients on periocular skin microcirculation and puffiness improvement[J]. Journal of Cosmetic Dermatology, 2021, 20(8): 2564-2571.
[2] Zhang Y, Wang L, Li H. Mechanism of bioactive peptides in improving vascular dark circles and ocular tissue microcirculation disorder[J]. China Journal of Aesthetic Medicine, 2022, 31(5): 112-116.
[3] Chen M, et al. Barrier repair and anti-aging effects of Dipeptide-2 on fragile periocular skin tissue[J]. International Journal of Cosmetic Science, 2020, 42(6): 589-596.
[4] Liu S T, Zhao W R. Research progress on the application of active peptides in periorbital anti-aging and microcirculation repair[J]. China Surfactant Detergent & Cosmetics, 2023, 53(3): 198-204.
[5] Goh S, Tan K. Pharmacological characteristics and skincare application of signal peptide Dipeptide-2[J]. Journal of Cosmetic Science, 2022, 73(2): 89-97.
FAQ
Is dipeptide 2 an amino acid?
Dipeptide is defined as a molecule consisting of two amino acids linked by a peptide bond, which can be cleaved from the N-terminus of polypeptide chains by peptidases such as CD26.
What does dipeptide 2 do?
Dipeptide-2 is a synthetic peptide used for skin care. It can inhibit angiotensin converting enzyme ACE, enhance the lymphatic circulation of the eye, promote water discharge, and effectively eliminate edema and reduce eye bags.
What is the dipeptide of 2 glycine?
Glycylglycine. Glycylglycine is the dipeptide of glycine, making it the simplest peptide.
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