Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of palmitoyl pentapeptide-4 peptide in China. Welcome to wholesale bulk high quality palmitoyl pentapeptide-4 peptide for sale here from our factory. Good service and reasonable price are available.
Palmitoyl pentapeptide-4 peptide is a biologically active lipopeptide compound created through fatty acid grafting on specific polypeptide chains, delivering accurate dermis-targeted efficacy and robust molecular structural stability. It possesses exceptional cutaneous penetration capacity, gentle usability and optimal biological safety, with excellent dermal tissue compatibility that causes no irritation or cutaneous stress. For this reason, it is widely utilized as a high-grade anti-aging active ingredient in cosmetic applications dedicated to dermal tightening, wrinkle reduction and cutaneous barrier restoration. This raw material is strictly formulated for external dermal use only.
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palmitoyl pentapeptide-4 COA
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| Certificate of Analysis | ||
| Compound name | palmitoyl pentapeptide-4 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 214047-00-4 | |
| Quantity | 56g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.42% |
| Loss on drying | ≤1.0% | 0.76% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.8% |
| Single impurity | <0.8% | 0.64% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | 2-8°C(protect from light) | |
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| Chemical Formula | C39H75N7O10 |
| Exact Mass | 801.56 |
| Molecular Weight | 802.07 |
| m/z | 801.56(100.0%), 802.56(42.2%),803.56(8.7%) |
| Elemental Analysis | C,58.40; H,9.43; N,12.22; O,19.95 |

Upon topical administration, it can rapidly permeate the outer dermal layers and effectively trigger the dermis's inherent renewal mechanism, greatly boosting the endogenous production of dermal fibrillin, elastin and hyaluronic acid within the dermis, which alleviates dermal sagging and fades micro-lines and superficial wrinkles.
Endogenously Stimulate Collagen Synthesis to Fill Dermal Hollow Spaces
As a well-recognized premium signal-type anti-aging peptide widely praised across the global skincare industry, palmitoyl pentapeptide-4 peptide carries an irreplaceable core advantage: it awakens endogenous collagen regeneration starting from the deepest layer of the dermis, the foundational core of facial tissue. The majority of mass-market care commodities on the market only stay on the outermost epidermis, merely offering transient surface moisturization and fleeting instant brightening effects that vanish within hours after application, failing to touch the root of intrinsic aging.


In stark contrast, it initiates a full-cycle repairing and renewing reaction deep inside the cutis, delivering authentic anti-aging efficacy that works from inner layers outwards instead of superficial cover-up.Human cutis naturally loses structural collagen day by day as chronological aging advances, yet multiple external stimuli drastically accelerate this depletion rate. Staying up late frequently and maintaining irregular biological clocks disrupt the self-repair cycle of fibroblasts inside the dermis;long-term unprotected UV radiation breaks peptide bonds of fibrous proteins; persistent air pollutants, dry air and harsh chemical irritants further erode the complete supporting network of the epidermis and dermis simultaneously.
Continuous collagen loss will snap the three-dimensional supportive framework under the facial cutis, triggering a full spectrum of unsightly aging manifestations: flattened mid-face contours, sunken cheek areas, deflated and sagging malar fat pads, hollow under-eye zones and loose, drooping facial tissue. These visible defects are the primary reason why the human face looks collapsed, lifeless and chronically exhausted, which troubles countless anti-aging seekers of all age groups.It possesses precise biomolecular recognition capacity to capture aging signals transmitted by damaged dermal cells.


Once permeating through the layered epidermis and reaching active fibroblasts in the dermis, it transmits high-efficiency repair and regeneration instructions to these core functional cells, selectively activating the inherent collagen manufacturing mechanism of the cutis itself. The formulation prioritizes boosting the biosynthesis of Type I and Type III collagen, two pivotal fibrous substances that construct the firm base of youthful facial contours and maintain plump, elastic tissue fullness. Many brands add animal-derived or bioengineered exogenous collagen into their serums and creams, yet macromolecular collagen molecules cannot penetrate the dense barrier of the epidermis to reach the dermis, resulting in zero practical nourishment for inner tissue.
It avoids this fatal defect completely, as it guides the dermis to produce self-native collagen rather than relying on ineffective external protein supplements.Newly synthesized native collagen precisely fills hollow gaps left by degraded fibrous structures within the dermis, mends fractured elastic fiber networks and lifts collapsed, sagging cutis layer by layer from deep to shallow. After consistent long-term application, users will witness gradual improvement on hollowed cheek areas, flattened facial outlines and weak adhesion between epidermis and underlying soft tissue.


The ingredient continuously consolidates the foundational supportive matrix of the dermis, replenishes lost structural substances and restores bouncy, youthful fullness to slackened, aged cutis. It fundamentally neutralizes all early and mature aging issues induced by sustained collagen degradation, establishing a stable long-term anti-aging defense system rooted deep in the dermis instead of temporary surface improvement.
Fade Static True Wrinkles & Reverse Dry, Aged Epidermal Texture
Static permanent wrinkles refer to obvious creases that remain prominent even when the facial musculature is fully relaxed without any smiling, frowning or squinting movements, and they pose far greater repair challenges than dynamic expression lines generated by repeated muscle contraction. Dermatologists regard static creases as the most intuitive evaluation standard of advanced cutis aging, a common blind spot for most conventional anti-aging raw materials available on the market, which only target muscle-induced dynamic folds and ignore deep-set static texture damage.


Palmitoyl pentapeptide-4 peptide specially targets shallow static fine lines, chronic dry creases and mild permanent true wrinkles, perfectly filling the functional gap of ordinary anti-wrinkle actives.Multiple internal and external negative factors jointly destroy the orderly texture of the epidermis and dermis, gradually carving stubborn visible lines on the facial cutis. Severe long-term dehydration weakens the water-locking capacity of the epidermal barrier; impaired barrier function allows irritants to invade inner layers and damage fibrous tissue; continuous collagen loss reduces the filling volume of the dermis; cumulative photoaging from sunlight degrades elastic fibers irreversibly.
All these destructive forces tear apart the neat texture structure of epidermis and dermis, forming dense fine lines surrounding the eye sockets, dry folds beside nasal wings, vertical creases around lip corners, shallow horizontal lines across the forehead and faint nasolabial folds extending from nose to jawline. Alongside these visible folds, users often suffer from coarse epidermal grain, disordered tissue arrangement and dull, sallow dry complexions, combining to create a prematurely weathered, aged visual impression lacking vitality and smoothness.


It can permeate the broken junctions of epidermal and dermal texture layers to reconstruct impaired fibrous frameworks, gently metabolize aged dead keratin accumulated on the outermost epidermis and steadily shrink both depth and width of various creases, reorganizing chaotic epidermal texture from the source of damage. Unlike high-concentration acid ingredients that forcibly strip off the superficial epidermis to mechanically flatten wrinkles with strong irritation, it adopts a mild reconstructive mechanism without triggering stinging, redness or peeling reactions.It naturally stretches out deep-set creases by rebuilding the supportive structure of the dermis, reversing the dry, aged unhealthy state of the cutis in a gentle, non-invasive way.
For users who maintain regular, uninterrupted use over two to three months, stubborn recurring dry lines and shallow static fine wrinkles will fade visibly day after day. Uneven, bumpy surfaces of the epidermis get fully smoothed out, refining the overall cutis into a silky, translucent and even finish. It efficiently improves the three major aging troubles: prominent textured wrinkles, coarse grain and dull yellowish dry tone, sustaining consistently soft, delicate and youthful epidermal texture in the long run.

Lift & Tighten Facial Contours to Relieve Dermal Sagging

Drooping cutis and blurred facial contour lines stand as the most striking visual sign of mature epidermal aging, exerting a stronger aging effect on overall appearance than scattered fine lines. Loose, out-of-shape facial outlines easily convey a haggard, worn-out and middle-aged impression, making contour tightening the top priority of anti-aging care for most consumers over 25 years old.As collagen and elastic fibers inside the dermis keep depleting year after year, the supportive force holding up facial tissue weakens drastically, breaking the tight adhesion between epidermis and subcutaneous soft tissue.
Separated tissue gradually drifts downwards under gravity, triggering a series of contour flaws: descended malar fat pads, flabby redundant tissue on both sides of cheeks, completely faded jawline edges, slack loose skin under the chin forming double chins, and an overall heavy, dragging facial silhouette full of aging fatigue. All these issues eliminate sharp facial layering and create a bloated, unrefined look.Palmitoyl pentapeptide-4 peptide delivers remarkable contour lifting and tissue repositioning effects, centering its action on loose, slackened epidermal tissue to compress sagging soft tissue and recover tight, firm attachment between cutis and underlying facial frameworks.


It continuously reinforces the cross-linked supportive matrix distributed throughout the dermis, gradually pulls drooping, outward-spread subcutaneous tissue back to its original youthful position, sharpens vague jawline boundaries and mitigates the heavy dragging sagging sensation across the whole face for a streamlined, neat silhouette.Numerous temporary firming serums rely on film-forming polymers to create an instant tight sensation on the epidermis, yet such superficial effects disappear completely once the epidermis secretes sweat or sebum, offering zero long-term structural improvement.
Differing fundamentally from these short-lived surface care products, it generates persistent lifting efficacy through sustained native collagen synthesis and comprehensive dermal structural reinforcement, tackling sagging tissue from its root cause rather than creating temporary optical illusions. After persistent regular application, users can observe distinctly sharpened, well-defined facial outlines, smooth and sleek jawlines, plus lifted, full malar pads with restored three-dimensional volume. It effectively fades the tired, aged dull impression brought by sagging tissue and reshapes delicate, compact youthful contour definition for the whole face.


Chemical Bonds and Hydrolysis Behaviors
It owns stable peptide bonds and palmitoyl amide bonds stronger than ester bonds. Hydrolysis only happens under harsh conditions like high temperature and proteases. Fatty chain shedding weakens penetration, and broken peptide chains lose the ability to trigger collagen synthesis in dermal fibroblasts.
Ionic Charge and Isoelectric Point
This amphiprotic lipopeptide has an isoelectric point at approximately 9.2. In common weakly acidic cosmetic formulas, it carries slight positive charges to bind negatively charged epidermal keratin via static electricity, extending surface residence time and greatly boosting its percutaneous penetration efficiency.
Antioxidation, Compatibility and Chelation Properties
Free of unsaturated bonds, it hardly oxidizes alone but needs EDTA to avoid yellowing from heavy metals. It mixes well with hyaluronic acid and retinol derivatives, yet conflicts with high-concentration acids. It has no bacteriostasis and requires matching preservatives.
Photochemical Stability
It is moderately sensitive to UVA and UVB rays. Long-term light exposure accelerates peptide oxidation, discoloration and activity attenuation. Both raw materials and finished skincare goods must be kept in fully sealed, lightproof containers for storage.
References
Palmitoyl pentapeptide-4(https://en.wikipedia.org/wiki/Palmitoyl_pentapeptide-4)
Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. Journal of Biological Chemistry, 1993, 268(14): 9941–9944.
Choi Y L, Park E J, Kim E, Na D H, Shin Y H. Dermal stability and in vitro skin permeation of collagen pentapeptides (KTTKS and palmitoyl-KTTKS). Biomolecules and Therapeutics, 2014, 22(4): 321-327.
Lintner K. Promoting production in the extracellular matrix. Journal of Cosmetic Science, 2000, 51(3): 209-215.
Gorouhi F, Maibach H I. Role of topical peptides in preventing or treating aged skin. Dermatologic Therapy, 2009, 22(1): 55-61.
FAQ
What does palmitoyl pentapeptide-4 do for skin?
Palmitoyl Pentapeptide-4 is a synthetic peptide that has skin-repairing and anti-aging properties. It stimulates collagen production and improves skin elasticity, in turn, reducing wrinkles and giving the skin a youthful glow. It is also great for moisturizing and healing the skin.
What is the mechanism of action of palmitoyl pentapeptide 4?
It promotes extracellular matrix synthesis, inhibits collagenase, activates TGF-β signaling, and contributes to skin repair by improving texture, reducing wrinkles, and supporting wound healing.
What is the amino acid sequence of palmitoyl pentapeptide 4?
Pentapeptide-4 is a synthetic peptide comprised of the amino acids, lysine, serine, and threonine, which are linked in the 5 amino acid sequence: lysine-threonine-threonine-lysine-serine (also represented as Lys-Thr-Thr-Lys-Ser or KTTKS; Figure 1).
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