4-trifluoromethylaniline is an organic substance with the chemical formula of c7h6nf3. It is a colorless liquid, insoluble in water and soluble in organic solvents. It is an important intermediate of medicine and pesticides, and can be used to prepare pesticides such as cyhalothrin, fipronil, and fluorouracil. Use and store according to the specifications, without decomposition, and avoid contact with oxides. This product decomposes into toxic smoke when heated. Poisoning caused by inhalation, skin absorption and digestive tract entry. It needs to be sealed and stored in a ventilated and dry place to avoid contact with other oxides. The packing shall be made of padding material outside the glass bottle and inside the wooden box or iron bucket. Store in a cool and ventilated warehouse. Keep away from fire and heat sources and avoid direct sunlight; Store and transport separately from edible raw materials; Handle with care to prevent damage to the container.
After chlorination of p-trifluoromethylaniline, 2,6-dichloro-p-amino trifluoromethyl toluene can be obtained. It is an important intermediate. It is used in the pesticide industry to synthesize high-efficiency and low toxicity insecticides fipronil (Regent), cyhalothrin, fluorouracil, herbicides ibuprofen, ethyl chemicalbook butene flurane, etc., and in the pharmaceutical industry to synthesize a new immunosuppressant drug leflunomide, etc. With the continuous deepening of green chemical technology and new drug research, new uses have been developed continuously, and have become important and promising chemical products.
2,6-dichloro-4-trifluoromethylaniline is an important pesticide synthesis intermediate, which is mainly used to synthesize fluorofenitrile and other fluoro organic pesticides. The method is as follows: add 200g p-trifluoromethylaniline and 480g dichloroethane into 3L reactor, control the temperature to 10 ℃, stir and drop the solution mixed with 503chemicalbookg sulfonyl chloride and 190g dichloroethane within 3h. After dropping, continue the reaction at 50 ℃ for 2h. After the reaction is completed, reduce the temperature, wash with water, wash with saturated sodium carbonate aqueous solution, remove the inorganic salt, and concentrate the organic phase to remove the solvent, 144g of 2,6-dichloro-4-trifluoromethylaniline was obtained by rectification.
P-nitrotoluene as raw material method: p-nitrotoluene is brominated with bromine to produce p-dibromomethyl nitrobenzene, then brominated with sodium hypobromate to produce p-tribromomethyl nitrobenzene, then fluorinated with antimony trifluoride, and then reduced with tin dichloride to obtain p-trifluoromethyl phenylamine. This method is a classic method. The raw materials used are easy to obtain, but bromination requires more bromine, and it is only an intermediate transition. It also needs to be fluorinated with sbf3 and reduced with SnCl2. The process is complex and there are more three wastes, which is difficult to industrialize. If bromination can be replaced by chlorination, fluorination with HF and reduction by conventional reduction methods, it will have certain industrial significance.
P-chlorotrifluoromethylbenzene as raw material method: p-chlorotrifluoromethylbenzene reacts with ammonia under high pressure and high temperature (150 ~ 240 ℃) to produce p-trifluoromethylaniline. Although p-chlorotrifluoromethylbenzene has been an industrialized commodity, the conditions of ammonolysis are relatively harsh, and industrialization is difficult.
P-trichloromethylbenzene isocyanate as raw material method: p-trichloromethylbenzene isocyanate reacts with hydrogen fluoride to form p-trifluoromethylaniline hydrofluorate, and then reacts with base. This method is developed abroad in recent years, and p-trichloromethylbenzene isocyanate can use p-methylaniline as raw material, phosgene can generate p-trichloromethylchloroformylaniline, and further generate p-trichloromethylbenzene isocyanate.