Noradrenaline acid tartrate,Chinese aliases include heavy tartaric acid norepinephrine, norepinephrine, levonorepinephrine, etc., which belong to anti shock drugs. The appearance is usually white crystalline powder, easily soluble in water, and can be formulated for injection use. It acts as a beta selective adrenergic receptor agonist (with an EC ₅₀ value of 5.37 μ M) and also exhibits direct activity against beta ₂ receptors at higher concentrations. By stimulating the beta and alpha receptors in the sympathetic nervous system, physiological responses such as vasoconstriction, elevated blood pressure, increased myocardial contractility, and decreased heart rate are triggered. It is mainly used to treat critical conditions such as severe hypotension, including anesthesia shock, toxic shock, and cardiogenic shock. Intravenous infusion of medication requires dilution with 5% glucose solution or physiological saline, and precise control of infusion rate with the aid of an infusion pump. The initial dose is usually 8-12 μ g/minute, followed by titration based on blood pressure response, with a maintenance dose of 2-4 μ g/minute.
Noradrenaline Acid Tartrate CAS 69815-49-2
Product Code: BM-2-5-060
English Name: L-4 - (2-amino-1-hydroxy) - 1,2-benzenediol bitartrate
CAS No.: 69815-49-2
Molecular formula: c12h19no10
Molecular weight: 337.28
EINECS No.: 211-268-5
Enterprise standard: HPLC>99.5%, HNMR
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Manufacturer: BLOOM TECH Changzhou Factory
Technology service: R&D Dept.-4
Usage: Pure API(Active pharmaceutical ingredient) for science researching only Shipping: Shipping as another no sensitive chemical compound name.
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What is noradrenaline acid tartrate used for?
Noradrenaline acid tartrate(https://en.wikipedia.org/wiki/Norepinephrine_(medication)) is an important drug with a wide range of clinical applications. The following will provide a detailed introduction to its uses from multiple perspectives:
Noradrenaline acid tartrate has a vasoconstrictive effect and can increase blood pressure by increasing peripheral resistance in cases of hypotension. Therefore, it is commonly used to treat hypotension caused by various reasons, such as reduced cardiac output, orthostatic hypotension, etc. For example, when a patient's cardiac output decreases due to heart disease, there is insufficient blood circulation and blood pressure drops. The use of norepinephrine bitartrate can contract blood vessels, increase blood pressure, and ensure blood supply to various organs in the body. For patients with orthostatic hypotension, when standing suddenly from a lying or sitting position, blood will accumulate in the lower limbs due to gravity, resulting in a decrease in the amount of blood returning and a drop in blood pressure. Norepinephrine bitartrate can improve this condition by constricting blood vessels and increasing peripheral resistance, leading to a rise in blood pressure. In clinical treatment, certain drugs may cause adverse reactions such as severe hypotension. Norepinephrine bitartrate can be used to combat severe hypotension caused by these drugs, such as antihypertensive drugs. When patients experience hypotension caused by medication, timely use of norepinephrine bitartrate can rapidly increase blood pressure and maintain stable vital signs.
Treating shock
Noradrenaline acid tartrate is a commonly used rescue drug in clinical practice, widely used in critically ill patients with hypovolemic shock, septic shock, and other conditions. Intravenous infusion of norepinephrine tartrate can be used for the treatment of various types of shock to increase blood pressure and ensure blood supply to important organs such as the brain. In septic shock, pathogens and their toxins can trigger systemic inflammatory response syndrome, leading to vasodilation, relatively insufficient blood volume, and decreased blood pressure. Tartrate norepinephrine increases peripheral resistance by constricting blood vessels, leading to an increase in both systolic and diastolic blood pressure, thereby improving tissue blood perfusion and enhancing patient survival rates. Meanwhile, for cardiogenic shock, it is usually caused by severe impairment of cardiac function, leading to a sharp decrease in cardiac output.
Tartrate norepinephrine can enhance myocardial contractility, increase cardiac output, contract blood vessels, raise blood pressure, and effectively improve shock state. It can also contract internal organs and skin blood vessels, reduce visceral blood flow, and increase cardiovascular and cerebrovascular blood supply, helping to maintain blood supply to important organs such as the brain and heart. For shock, hypotension caused by insufficient blood volume or hypotension after pheochromocytoma resection, norepinephrine bitartrate can be used as an adjuvant therapy to supplement blood volume during emergency treatment, in order to raise blood pressure and temporarily maintain cerebral and coronary artery perfusion until the blood volume supplement therapy takes effect. After the resection of pheochromocytoma, patients may experience hypotension due to a sharp decrease in catecholamine levels in the body. At this time, the use of norepinephrine bitartrate can help stabilize blood pressure and buy time for the patient's recovery.
Improve cardiac arrest
When a patient experiences cardiac arrest, norepinephrine bitartrate injection can promote vasoconstriction, increase blood flow, and maintain blood circulation. Cardiac arrest can lead to a disruption of blood circulation throughout the body, depriving vital organs of blood supply. If not rescued in a timely manner, the patient will quickly die. Norepinephrine bitartrate contracts blood vessels, increases blood pressure, and allows blood to continue flowing, providing oxygen and nutrients to important organs. This drug can also ensure the blood supply to important organs by raising blood pressure, thereby saving lives. Maintaining blood perfusion to important organs such as the brain and heart is crucial during cardiac arrest resuscitation. Norepinephrine bitartrate can rapidly raise blood pressure, increase blood flow in coronary and cerebral arteries, and improve the success rate of cardiopulmonary resuscitation.
The injection of noradrenaline acid tartrate can stimulate the contraction of respiratory smooth muscles, thereby relieving spasms. During an attack of bronchial asthma, smooth muscle spasms in the respiratory tract can cause airway narrowing, leading to symptoms such as difficulty breathing and wheezing in patients. The use of norepinephrine tartrate can relax respiratory smooth muscles, alleviate airway spasms, and improve ventilation function. In addition to dilating the bronchi, it also has the function of dilating the bronchi. By dilating the bronchi and increasing airway patency, patients can breathe more smoothly. This plays an important role in alleviating respiratory distress symptoms in patients with bronchial asthma. It can dilate the bronchi, increase myocardial contractility and cardiac output, thereby increasing blood and oxygen supply to the heart, reducing cardiac load, and effectively relieving angina. Angina pectoris is a clinical syndrome caused by insufficient blood supply to the coronary arteries, sudden temporary ischemia and hypoxia of the myocardium. Norepinephrine bitartrate improves the blood supply and metabolism of the heart, reduces the degree of myocardial ischemia, and alleviates symptoms of angina.
