The main component of lidocaine hydrochloride injection is lidocaine hydrochloride, used as its local anesthetic and antiarrhythmic drug and mainly used for infiltration anesthesia, epidural anesthesia, topical anesthesia and nerve conduction block. Lidocaine hydrochloride can also be used for ventricular premature beats and ventricular tachycardia after acute myocardial infarction. It can also be used for ventricular arrhythmias caused by digitalis poisoning, cardiac surgery and cardiac catheterization. But it is usually ineffective for supraventricular arrhythmias. The indications of lidocaine hydrochloride injection are local anesthesia and antiarrhythmic. It is the most commonly used local anesthesia drug in clinical practice. It is mainly used for infiltration, epidural, surface, and nerve conduction block. It can also be used for ventricular premature beats and ventricular tachycardia after acute myocardial infarction. It can also be used for ventricular arrhythmias caused by digitalis poisoning, cardiac surgery and cardiac catheterization.
However, because lidocaine hydrochloride injection is often used for epidural block and sacral block in clinical practice, this route of administration has high risks to the human body. If the liquid is not isotonic, it will increase the risk of clinical drug use.
Severe cases may even lead to irreversible injury and even death of the patient. However, the current version of the Chinese Pharmacopoeia standard for lidocaine hydrochloride injection does not require the osmotic pressure of the drug, and the risk caused by the product isotonic cannot be avoided. At the same time, the pH standard of lidocaine hydrochloride injection in the current version of the Chinese Pharmacopoeia is pH 3.5 to 5.5. Still, patients with lower pH values often experience irritation during the medication process. Lidocaine hydrochloride under the condition of lower pH value The anesthetic effect of caine injection is not apparent, so medical staff often adjust the pH of lidocaine hydrochloride injection to 5.0 to 7.0 before clinical use.
There are also works of literature showing that after the pH is more significant than 6.0, the stability of the solution is relatively poor, and particles are precipitated, so it needs to be used for clinical preparation—the risk of medication. Based on the clinical drug safety and effectiveness of lidocaine hydrochloride injection, the Chinese Pharmacopoeia 2015 draft for comments revised the quality standards of lidocaine hydrochloride, mainly reflected in the osmolarity and pH indicators, The pH value was adjusted to pH 4.0-6.0, and the standard osmolarity was 285-310 mOsm/Kg.