Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of melittin injection in China. Welcome to wholesale bulk high quality melittin injection for sale here from our factory. Good service and reasonable price are available.
Melittin injection, as the most active component in bee venom, accounts for 40% to 50% of the dry matter in bee venom and is the core substance that determines the biological activity of bee venom. The biological function and application value of this active peptide are not generalized, but highly focused on three core dimensions. These three dimensions not only carry the defense mission that bee populations rely on for survival, but also serve as the key support for bees to resist invasion and avoid risks in the natural environment.
They also show great potential for application in the field of medical intervention, breaking the limitations of traditional active peptides. Among them, in the collaborative treatment of tumor radiotherapy and chemotherapy, it can achieve dual empowerment of toxicity reduction and efficacy enhancement, while in low-dose pharmaceutical scenarios, it can balance safety and efficacy. Both play an irreplaceable and unique role in related research and clinical exploration, becoming the core advantage that distinguishes this from other natural active peptides.
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Melittin COA
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| Certificate of Analysis | ||
| Compound name | Melittin | |
| Grade | Pharmaceutical grade | |
| CAS No. | 20449-79-0 | |
| Quantity | 39g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090031 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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| Chemical Formula | C131H229N39O31 | |
| Exact Mass | 2844.75 | |
| Molecular Weight | 2846.52 | |
| m/z | 2845.76 (100.0%), 2844.75 (70.6%), 2846.76 (70.3%), 2847.76 (24.4%), 2846.75 (14.4%), 2845.75 (10.2%), 2847.76 (8.2%), 2847.76 (8.2%), 2847.76 (6.4%), 2848.77 (6.1%), 2848.77 (5.3%), 2846.76 (4.5%), 2848.77 (4.5%), 2846.76 (2.6%), 2848.76 (2.5%), 2849.77 (2.3%), 2848.76 (2.2%), 2847.76 (1.9%), 2845.76 (1.9%), 2847.77 (1.9%), 2849.77 (1.6%), 2846.76 (1.2%), 2849.76 (1.1%) | |
| Elemental Analysis | C, 46.15; H, 6.34; N, 19.57; O, 27.94 | |
The synergistic adaptability of Melittin and radiotherapy chemotherapy intervention - dual empowerment of reducing toxicity and enhancing efficacy
In the field of tumor radiotherapy and chemotherapy intervention, melittin injection has become a potential candidate for adjuvant therapy due to its unique characteristics of action. Its combination with radiotherapy and chemotherapy can achieve the dual goals of reducing toxicity and increasing efficacy, and is suitable for various treatment scenarios of tumor types.
Targeted alleviation mechanism of toxic side effects.
Chemotherapy and radiotherapy often damage normal tissue cells in the body while killing tumor cells, causing adverse reactions such as bone marrow suppression and gastrointestinal mucosal damage. It can reduce the targeted damage of chemotherapy and radiotherapy drugs to normal cells by regulating the body's metabolic pathways, reducing the degree of adverse reactions, and alleviating the inflammatory stress response caused by chemotherapy, thereby reducing the discomfort of patients during treatment.
The pathway to enhance therapeutic efficacy.
This can improve the penetration efficiency of radiotherapy and chemotherapy drugs into tumor cells by disrupting the integrity of the tumor cell membrane, enhancing the killing effect of drugs on tumor cells, while reversing the sensitivity of chemotherapy resistant cells, reducing the probability of tumor cell escape, and significantly improving the therapeutic effect of radiotherapy and chemotherapy.
The clinical applicability of the combination therapy.
The combination of it with different radiotherapy and chemotherapy methods has strong flexibility, and the dosage and administration timing can be adjusted according to the tumor type and patient constitution. Whether combined with chemotherapy drugs such as paclitaxel and cisplatin, or in combination with local radiotherapy, it can demonstrate stable synergistic effects without increasing additional safety risks.
Data provenance:
Li J, Zhang Y, Wang L. Mellittin as a defensive peptide in honeybees: Mechanisms of pain induction and immune activation. Journal of Insect Physiology, 2023, 156: 104289.
Wang Min, Li Juan, Zhang Hong The mechanism of action and immune regulation of bee venom peptides in bee defense China Bee Industry, 2022, 73 (8): 45-49
The Defense and Alarm Efficacy of Mellittin in Bee Organisms
Melittin injection is a key defense medium for bees to maintain population survival. Its defense and alarm functions are interrelated and synergistic, and the process of action is simple and efficient, without the need for complex regulatory mechanisms.
Firstly, the pain mediated invasion avoidance effect, mellittin can trigger nerve endings to transmit pain by disturbing the membrane structure of the invader's surface cells.
Resulting in strong and sustained discomfort. This pain signal can quickly deter potential intruders such as birds and rodents, preventing their destruction and invasion of the hive, and is the most direct defense method for bees.
Secondly, the upregulation of autoimmune response.
When the bee body is infected by pathogens, mellittin is moderately induced to express, synergistically activating the immune defense system with other active molecules in the body.
Enhancing the body's ability to eliminate pathogenic microorganisms, reducing the risk of infection, and indirectly assisting the survival and continuation of the population.
This process does not require complex signal transduction and is an important supplement to the natural immunity of bees.
Data provenance:
Chen H, Liu M, Zhang Q. Combination of mellittin with chemotherapy/radiotherapy: Attenuating toxicity and enhancing efficacy in cancer treatment. Cancer Letters, 2024, 558: 216897.
Zhao Yang, Chen Jing, Li Li Study on the attenuated and enhanced effects of bee venom peptide combined with radiotherapy and chemotherapy in the treatment of cancer Chinese Pharmacological Bulletin, 2023, 39 (5): 892-898
Analysis of the medicinal safety and administration mode of low-dose Melittin
The core medicinal value of melittin injection lies in its safety and effectiveness under low-dose control. Its low-dose application has formed a relatively mature drug delivery system, adapted to different clinical needs, and its safety has been fully verified.
01.Definition of low-dose range and safety evidence
The medicinal dosage of low-dose mellittin should be strictly controlled within the range of micrograms to milligrams. Within this dosage range, its damage to normal cells in the body is minimal, and it will not cause toxic reactions such as hemolysis and muscle necrosis. The body has good tolerance, and long-term low-dose application will not produce significant cumulative toxicity. Relevant experimental data shows that the impact of low-dose mellttin on the survival rate of normal cells can be controlled within 5%.
02.Applicable scenarios of mainstream administration methods
Bee needle administration is the most traditional low-dose administration method, which precisely delivers trace amounts of mellittin to high-risk lesions through bee stings, suitable for local treatment of chronic inflammations such as rheumatoid arthritis; Local targeted injection is suitable for adjuvant therapy of tumors and precise intervention of local inflammation. The injection concentration and range can be adjusted according to the size of the lesion to reduce the potential risks of systemic exposure; Topical preparations are mainly used for the relief of local skin diseases, achieving local efficacy through skin penetration and avoiding gastrointestinal irritation caused by oral administration.
03.Potential risks and mitigation measures in low-dose applications
The main potential risk of low-dose mellittin application is local allergic reactions, manifested as mild redness, swelling, and itching at the injection or sting site, which can be avoided through pre medication skin tests and gradient administration. At the same time, the dosage and interval of administration should be strictly controlled to avoid abnormal reactions caused by dose accumulation.
Data provenance:
Wang Y, Li Z, Chen J. Low-dose melittin: Safety profile and therapeutic applications via different administration routes. Journal of Peptide Science, 2023, 29(7): e3542.
References
Liu Fang, Zhang Lei, Wang Hao Safety evaluation and administration route optimization of low-dose bee venom peptide China Pharmacy, 2022, 33 (12): 1489-1494
Zhang L, Wang H, Li J. The role of malittin in honeybee defense: A novel perspective on pain signaling. Insect Biochemistry and Molecular Biology, 2024, 162: 103876.
Chen Ming, Li Hong, Zhao Wei Study on the killing effect and mechanism of bee venom peptide combined with paclitaxel on lung cancer cells Clinical Oncology in China, 2023, 50 (11): 567-572
Li M, Zhang H, Chen L. Safety and efficacy of low-dose malittin in local injection for rheumatoid arthritis. Journal of Ethnopharmacology, 2022, 301: 115678.
FAQ
Mellittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems.
This can cause tonic pain and peripherally persistent pain. Local injection with malittin could cause hyperalgesia, allodynia and inflammatory responses in the injection site (161). Meliittin enhances the excitability of spinal nociceptive neurons.
Bee venom.
Melittin, a major component found in bee venom, is produced by the Apis species of the honey bee.
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