Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of vermox injection in China. Welcome to wholesale bulk high quality vermox injection for sale here from our factory. Good service and reasonable price are available.
Mebendazole(Vermox injection) is a broad-spectrum anthelmintic that has significant effects in killing larvae and inhibiting the development of insect eggs. Both in vivo and in vitro experiments have shown that it can directly inhibit the uptake of glucose by nematodes, leading to glycogen depletion and reducing the formation of adenosine triphosphate in the parasite, making it unable to survive, but it does not affect the blood glucose levels in the human body. Observation of ultrastructure shows that microtubules in the cytoplasm of the insect's membrane cells and intestinal cells undergo degeneration, causing the aggregation of secretory granules in the Golgi apparatus, resulting in transport blockage, cytoplasmic dissolution and absorption, complete cell degeneration, and insect death.
Basic information
1. Drug composition and chemical structure
The chemical name of benzimidazole is (5-benzoyl-1H-benzimidazol-2-yl) methyl formate, with a molecular formula of C16H13N3O3 and a molecular weight of 295.30. As a benzimidazole compound, benzimidazole inhibits the parasite's uptake of glucose, leading to glycogen depletion in the parasite and subsequently inhibiting its growth and reproduction, ultimately achieving the goal of killing the parasite.
2. Pharmacokinetic characteristics
Methylimidazole is rapidly absorbed after oral administration, but its bioavailability is low because most drugs are metabolized into inactive metabolites in the intestine. However, its active metabolites maintain high concentrations in the intestine, effectively killing parasites. For injectable formulations, it can be expected that they will bypass the barriers of oral absorption and enter the bloodstream directly, which may improve the bioavailability and efficacy of the drug, especially in the treatment of systemic parasitic infections.
Our product
Additional information of chemical compound:
| Product Name | Vermox Injection | Vermox Chewable Tablets | Vermox Syrup | Vermox Cream |
| Product Type | Injection | Tablet | Syrup | Cream |
| Product Purity | ≥99% | ≥99% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable | Customizable |
Our Product
Toltrazuril +. COA
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Certificate of Analysis |
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Compound name |
Mebendazole(Vermox) | |
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CAS No. |
31431-39-7 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.17% |
| Loss on drying |
≤1.0% |
0.23% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.7% |
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Single impurity |
<0.8% |
0.52% |
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Residue on ignition |
<0.20% |
0.07% |
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Total microbial count |
≤750cfu/g |
90 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
500ppm |
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Storage |
Store in a sealed, dark and dry place at 2-8°C |
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Vermox injection (commonly known as metronidazole) is a broad-spectrum antiparasitic drug, and its oral dosage form has been widely used in clinical practice, mainly for the treatment of infections caused by intestinal parasites such as roundworms, hookworms, and pinworms.
According to different application fields, bendazole products can be divided into two categories: human use and animal use. In the field of medicine, it is a well-known antiparasitic drug mainly used to treat infections caused by intestinal parasites such as roundworms, hookworms, and pinworms.
Pharmacological basis of metronidazole
Xylimidazole belongs to the benzimidazole class of compounds, and its anti parasitic mechanism mainly involves inhibiting the parasite's uptake of glucose, leading to glycogen depletion in the parasite and interfering with its survival and reproductive ability. Specifically, metronidazole can inhibit the aggregation of microtubule proteins in parasites, block the absorption and transport of glucose by the parasite, deplete endogenous glycogen in the parasite, and inhibit the mitochondrial malate reductase system, reducing ATP production and ultimately leading to parasite death. This mechanism enables benzimidazole to have a broad-spectrum killing effect on various intestinal parasites.
Potential indications
Vermox's injection form may have potential application value in the following situations:
Severe intestinal parasitic infection:
For patients with difficulty in oral administration or poor gastrointestinal absorption (such as coma, intractable vomiting, or patients after gastrointestinal surgery who cannot take oral drugs), intravenous administration of Vermox injection can be directly introduced into the bloodstream. This bypasses the gastrointestinal absorption process, avoiding the influence of gastrointestinal function on drug absorption and ensuring effective delivery of the drug to the intestinal infection site.
In cases of severe parasitic infection with obvious clinical symptoms, insufficient oral dosage, or poor therapeutic effect, the injection form can provide higher and more stable concentrations of drugs in the body, thereby enhancing insecticidal efficacy and shortening the treatment cycle.
Parasitic infection within the organization:
Some parasites, such as trichinella and cysticercus, not only parasitize the intestine, but can also invade deep tissues such as muscles and brain, causing serious complications and endangering the patient's health. Vermox injection can distribute to various tissues and organs throughout the body through blood circulation, exerting a direct killing effect on parasites hidden within the tissues.
For severe tissue infections such as cerebral cysticercosis, which is difficult to treat, the injection form can effectively penetrate the blood-brain barrier, reach an effective therapeutic concentration in the brain tissue, and targeted eliminate the parasites to alleviate neurological symptoms.
Mixed parasitic infections:
In clinical practice, patients are sometimes simultaneously infected with multiple parasites such as roundworms, hookworms, whipworms, etc. The broad-spectrum antiparasitic effect of Vermox injection can cover multiple types of parasites, simplifying the treatment plan significantly. This avoids the complexity of taking multiple oral drugs and reduces the potential drug-drug interactions caused by combined medication, improving treatment compliance and safety.
Special population infections:
For special populations such as pregnant women, infants and young children, and the elderly with weak physical functions, oral administration may pose difficulties in dose adjustment or potential safety risks due to differences in absorption and metabolism. Vermox injection can be precisely adjusted in dosage according to the patient's age, weight, and physical condition, maximizing treatment safety while ensuring efficacy.
In addition, in the event of a parasitic infection outbreak or public health event, the injection form can be quickly and massively applied to infected populations, enabling rapid drug delivery and effectively controlling the spread of the epidemic.
Metronidazole, as a broad-spectrum antiparasitic drug, plays an important role in the clinical treatment of parasitic diseases due to its unique pharmacological mechanism and good safety.
Case 1: Treatment of mixed infection of childhood pinworm disease
A 5-year-old male patient sought medical attention due to nocturnal perianal itching and restless sleep. The child resides in rural areas with poor hygiene conditions and a history of pet contact. Laboratory tests showed positive pinworm eggs in feces, while serological testing suggested the possibility of hookworm infection.
Administer Vermox Injection 200mg (10ml) intravenously once daily for 3 consecutive days. The infusion rate should be controlled at 1-2ml per minute to avoid rapid infusion causing hypotension. During treatment, oral iron supplements (100mg/day ferrous sulfate) were used to correct anemia caused by hookworm infection.
Egg turning negative rate: On the 7th day of treatment, fecal re examination showed that pinworm eggs disappeared and hookworm eggs decreased by 80%; On the 14th day, the hookworm eggs were re examined and completely turned negative.
Symptom relief: Perianal itching significantly reduced and sleep quality improved within 24 hours after medication.
Safety: During the treatment period, only mild nausea occurred (twice a day), which did not affect eating and had no other adverse reactions.
4. Case analysis
In this case, effective blood drug concentration was rapidly achieved through intravenous route, while covering dual infections of pinworms and hookworms. Its nanoscale particle dispersion technology improves the bioavailability of drugs in children's bodies, avoiding insufficient dosage caused by swallowing difficulties in oral tablets. The combination of iron supplementation therapy effectively corrected anemia related to hookworm infection, demonstrating the importance of comprehensive treatment.
Case 2: Treatment of adult hookworm disease combined with liver dysfunction
A 42 year old male farmer sought medical attention for recurrent abdominal pain and fatigue. The patient has a long history of working barefoot on the ground and a positive fecal occult blood test. Laboratory tests showed positive hookworm eggs (20-30/HPF), abnormal liver function (ALT 120U/L, AST 95U/L), and mild elevation of total bilirubin (28 μ mol/L).
Administer Injection 150mg (7.5ml) intravenously once daily for 5 consecutive days. Extend the infusion time to 90 minutes to reduce the metabolic burden of the drug on the liver. Simultaneously combining liver protective drugs (diammonium glycyrrhizinate 150mg/day) to treat liver dysfunction.
Egg turning negative rate: On the 10th day of treatment, the disappearance of hookworm eggs and relief of abdominal pain symptoms were observed in the fecal recheck.
Liver function improvement: On the 14th day of treatment, ALT decreased to 50U/L, AST decreased to 40U/L, and total bilirubin returned to normal (18 μ mol/L).
Safety: During the treatment period, there were no gastrointestinal reactions such as nausea and vomiting, and liver function indicators continued to improve.
In this case, the patient had concurrent liver dysfunction, and traditional oral antiparasitic drugs may exacerbate the condition due to increased metabolic burden on the liver. By bypassing the first pass effect through the intravenous route, liver metabolic pressure is reduced, and the infusion time is prolonged to further reduce the risk of adverse reactions. The combined liver protection treatment effectively protects liver function, reflecting the importance of individualized medication.
Case 3: Multidrug resistant treatment of refractory roundworm disease
An 8-year-old female child was diagnosed with recurrent abdominal pain and malnutrition. The child resides in an area with poor hygiene conditions and has a history of multiple deworming treatments (such as albendazole and praziquantel), but the symptoms are recurrent. Fecal examination showed positive roundworm eggs (50-60/HPF), and the sensitivity of the worm body to albendazole decreased (in vitro drug sensitivity test showed MIC>10 μ g/ml).
Administer Injection 200mg (10ml) intravenously once daily for 7 consecutive days. The infusion rate is controlled at 1ml per minute, and probiotics (Bifidobacterium triple active powder) are combined to regulate the gut microbiota and reduce the interference of drugs on the gut microbiota.
Egg turning negative rate: On the 14th day of treatment, the disappearance of roundworm eggs and complete relief of abdominal pain symptoms were observed in the fecal examination.
Nutritional status improvement: On the 30th day of treatment, the weight increased by 1.5kg and the hemoglobin level increased from 105g/L to 120g/L.
Safety: During the treatment period, there were no intestinal dysfunction such as diarrhea or constipation, and the combination of probiotics effectively maintained the balance of intestinal microbiota.
4. Case analysis
In this case, the child developed resistance to traditional deworming drugs and overcame the problem of multidrug resistance through its unique microtubule inhibition mechanism. Its nanoscale particle dispersion technology improves the permeability of drugs in the intestine, ensuring effective killing of drug-resistant parasites. The combination of probiotics treatment reduces the interference of drugs on the intestinal microbiota, reflecting the advantages of comprehensive treatment in refractory parasitic diseases.
Case 4: Prophylactic treatment of toxoplasmosis in immunosuppressed patients
A 35 year old male kidney transplant recipient sought treatment for postoperative immunosuppressive therapy (tacrolimus+mycophenolate mofetil). The patient has a history of contact with pet cats, and serological testing shows positive IgG and negative IgM for Toxoplasma gondii, indicating a previous infection. To prevent the recurrence of toxoplasmosis, preventive treatment is necessary.
Vermox Injection 100mg (5ml) was administered intravenously twice a week for 12 consecutive weeks. The infusion time should be controlled at 60 minutes, while monitoring the blood concentration of tacrolimus to avoid drug interactions.
Preventive effect: During the treatment period, there were no symptoms related to toxoplasmosis (such as fever, headache, lymph node enlargement), and the serological test remained negative for IgM.
Immune function monitoring: CD4+T cell count remained stable at 400-500/μ l during treatment and did not further decrease due to drug use.
Safety: During the treatment period, there were no adverse reactions such as liver dysfunction or bone marrow suppression, and the blood concentration of tacrolimus remained stable within the target range (5-10ng/ml).
In this case, immunosuppressed patients have a high risk of recurrence of toxoplasmosis, and traditional oral medications may affect efficacy due to unstable absorption. The stable absorption of the drug is ensured through intravenous route, and its characteristics of no bone marrow suppression and no nephrotoxicity are suitable for long-term use. Monitoring the blood concentration of tacrolimus avoids drug interactions and highlights the importance of preventive treatment in special populations.
FAQ
What is the use of mebendazole injection?
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Mebendazole acts as an anthelmintic agent, preventing the development of worms. Hence, it is used for deworming, periodic worming, and treating infections caused by various types of worms. To ensure its effectiveness, users should strictly follow the instructions provided by their doctors or pharmacists.
What is Vermox mebendazole used for?
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Mebendazole is a type of medicine for treating worms. It's used mainly for infections of the gut such as threadworms (sometimes known as pinworms) and other less common worm infections (whipworm, roundworm and hookworm).
How long does it take for Vermox to work?
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The medicine should start to work straight away but it may take several days to kill all the worms. It's important to take the medicine as a pharmacist or doctor tells you. Do not stop early if you have been told to take it for several days.
When is the best time to take mebendazole?
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For common roundworms, hookworms, and whipworms: Adults and children 2 years of age and older-100 milligrams (mg) two times a day, morning and evening, for 3 consecutive days. Treatment may need to be repeated in 3 weeks.
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