Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of cefpodoxime proxetil tablets in China. Welcome to wholesale bulk high quality cefpodoxime proxetil tablets for sale here from our factory. Good service and reasonable price are available.
Cefpodoxime proxetil tablets are a third-generation cephalosporin antibiotic that is orally administered and belongs to the prodrug class. It is hydrolyzed by non-specific esterase in the body and converted into cefuroxime, which has strong antibacterial activity, thereby exerting bactericidal effects. From the perspective of antibacterial spectrum, it shows excellent performance and broad-spectrum antibacterial activity against both Gram positive and Gram negative bacteria. Gram positive bacteria such as common streptococcus and pneumococcus, as well as Gram negative bacteria such as Escherichia coli, Klebsiella pneumoniae, and Haemophilus influenzae, are all within its "attack range". Moreover, it is stable against β - lactase, which allows it to maintain efficient antibacterial ability and effectively break through the bacterial resistance line when facing many resistant strains that produce the enzyme.
In clinical applications, cefpodoxime axetil tablets have a wide range of uses. It can treat various respiratory infections, such as acute otitis media, sinusitis, tonsillitis, community-acquired pneumonia, etc., and alleviate symptoms such as coughing, sputum production, and ear pain in patients; For urinary system infections such as cystitis, urethritis, pyelonephritis, etc., it can effectively eliminate pathogens and alleviate discomfort such as frequent urination, urgency, and pain; In the field of skin and soft tissue infections, it has good therapeutic effects on diseases such as folliculitis, boils, abscesses, and erysipelas, promoting inflammation resolution and wound healing. In addition, it can also be used for the treatment of various diseases caused by sensitive bacteria, such as otolaryngological infections and gynecological infections.
Additional information of chemical compound:
| Product Name | Cefpodoxime Proxetil Powder | Cefpodoxime Proxetil Tablets | Cefpodoxime Proxetil Liquid | Cefpodoxime Proxetil Capsules |
| Product Type | Powder | Tablets | Liquid | Capsules |
| Product Purity | ≥99% | ≥99% | ≥99% | ≥99% |
| Product Specifications | Customizable | Customizable | Customizable | Customizable |
| Product Package | Customizable | Customizable | Customizable | Customizable |
Our product form
Cefpodoxime Proxetil +. COA
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Certificate of Analysis |
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Compound name |
Cefpodoxime Proxetil | |
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CAS No. |
87239-81-4 | |
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Grade |
Pharmaceutical grade | |
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Quantity |
Customized | |
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Packaging standard |
Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
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Lot No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Structure |
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| TEST STANDARD | GB/T24768-2009 Industry. Stnndard | |
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Item |
Enterprise standard |
Analysis result |
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Appearance |
White or almost white powder |
Conformed |
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Water content |
≤4.5% |
0.30% |
| Loss on drying |
≤1.0% |
0.15% |
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Heavy Metals |
Pb≤0.5ppm |
N.D. |
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As≤0.5ppm |
N.D. | |
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Hg≤0.5ppm |
N.D. | |
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Cd≤0.5ppm |
N.D. | |
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Purity (HPLC) |
≥99.0% |
99.5% |
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Single impurity |
<0.8% |
0.48% |
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Residue on ignition |
<0.20% |
0.064% |
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Total microbial count |
≤750cfu/g |
80 |
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E. Coli |
≤2MPN/g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (by GC) |
≤5000ppm |
400ppm |
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Storage |
Store in a sealed, dark and dry place at-20 degrees |
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Cefpodoxime proxetil tablets are a third-generation oral cephalosporin antibiotic, belonging to the prodrug class. After entering the body, they are hydrolyzed by non-specific esterases to form the active ingredient Cefpodoxime, which exerts broad-spectrum antibacterial effects by inhibiting the biosynthesis of bacterial cell walls. Its indications cover multiple systems of infectious diseases, and the following six categories are described in detail: respiratory tract infection, urogenital system infection, skin and soft tissue infection, otorhinolaryngology infection, mastitis and other special infections.
Respiratory infection
1. Upper respiratory tract infection
(1) Acute otitis media
Caused by sensitive bacteria such as Streptococcus pneumoniae and Haemophilus influenzae, it manifests as symptoms such as ear pain, hearing loss, and ear discharge. Cefpodoxime axetil tablets rapidly alleviate inflammation and shorten the course of disease by inhibiting bacterial cell wall synthesis.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-10 days; Children should take 10mg/kg/day of body weight in 1-2 doses, with a maximum dose not exceeding 200mg/day.
(2) Sinusitis
Including acute sinusitis and acute exacerbation of chronic sinusitis, common pathogens include Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Symptoms include nasal congestion, purulent discharge, headache, etc.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-10 days; Children should take 10mg/kg/day of body weight in two doses, with a maximum dose not exceeding 200mg/day.
(3) Tonsillitis and pharyngitis
Tonsillitis: caused by group A beta hemolytic streptococcus, staphylococcus, etc., manifested as sore throat, fever, and swollen tonsils. Cefpodoxime axetil tablets can effectively penetrate tonsil tissue and inhibit bacterial growth.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-10 days; Children should take 10mg/kg/day of body weight in two doses, with a maximum dose not exceeding 200mg/day.
Pharyngitis: including throat abscess, common pathogens are streptococcus and staphylococcus. The symptoms are sore throat, difficulty swallowing, and fever.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-10 days; Severe cases can be increased to 200mg per dose, twice a day.
2. Lower respiratory tract infection
(1). Pneumonia
The common pathogens of community-acquired pneumonia are Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and atypical pathogens such as Mycoplasma and Chlamydia. Cefpodoxime axetil tablets are highly sensitive to the above-mentioned pathogens and can effectively reduce inflammatory indicators such as C-reactive protein and white blood cell count.
Usage and dosage: 200mg per dose for adults, twice a day, for a treatment period of 10-14 days; For critically ill patients, the dosage can be increased to 400mg twice a day.
Acute bronchitis and acute exacerbation of chronic bronchitis
Acute bronchitis: caused by viruses or bacteria such as Haemophilus influenzae and Streptococcus pneumoniae, characterized by coughing, sputum production, and fever.
Cefotaxime axetil tablets can shorten the course of the disease and reduce complications.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-7 days.
Acute exacerbation of chronic bronchitis: The pathogens are mainly Haemophilus influenzae and Moraxella catarrhalis, and the symptoms include worsening cough, increased sputum volume, and purulent sputum.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 10 days.
(3) Secondary infection in bronchiectasis
Patients with bronchiectasis are prone to recurrent infections such as Pseudomonas aeruginosa and Haemophilus influenzae due to the destruction of airway structure. Cefotaxime tablets can cover common pathogens and reduce the frequency of acute exacerbations.
Usage and dosage: 200mg per dose for adults, twice a day, for a treatment period of 10-14 days; For critically ill patients, the dosage can be increased to 400mg twice a day.
Urinary and reproductive system infections
1. Pyelonephritis
Caused by Gram negative bacteria such as Escherichia coli and Klebsiella, it manifests as fever, lower back pain, frequent urination, urgency, and pain during urination. Cefotaxime tablets have a high concentration in urine and can effectively eliminate pathogens.
Usage and dosage: 100mg per dose for adults, twice a day, for a course of 7-14 days; For critically ill patients, the dosage can be increased to 200mg per dose, twice a day.
2.Cystitis
The common pathogens are Escherichia coli and Enterococcus faecalis, with symptoms including frequent urination, urgency, pain during urination, and lower abdominal pain. Cefotaxime Axetil tablets can quickly alleviate symptoms and reduce recurrence.
Usage and dosage: 100mg per dose for adults, twice a day, for a course of 7 days; Simple cystitis can be shortened to 3 days.
3. Gonococcal urethritis
Caused by Neisseria gonorrhoeae, characterized by increased urethral discharge and painful urination. Cefpodoxime axetil tablets are highly sensitive to Neisseria gonorrhoeae and can be cured with a single dose of 200mg.
Usage and dosage: 200mg per oral dose for adults.
Vestibular gland inflammation and vestibular gland abscess
Caused by Staphylococcus, Streptococcus, etc., it manifests as swelling, pain, and fever in the external genitalia. Cefoxime axetil tablets can penetrate locally and control infections.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 7-10 days; The formation of abscess requires incision and drainage before continuing medication.
Skin and soft tissue infections
1. Folliculitis and furuncle
Folliculitis: caused by Staphylococcus aureus, characterized by redness, swelling, and pain around hair follicles. Cefpodoxime proxetil tablets can penetrate skin tissue and inhibit bacterial growth.
Usage and dosage: 100mg per dose for adults, twice a day, for a course of 7 days; Severe cases can be increased to 200mg per dose, twice a day.
Boil: It is a deep infection of the hair follicle, characterized by local redness, swelling, pain, and induration.
2. Puruncle and cellulitis
Puruncle: caused by Staphylococcus aureus, characterized by the infection and fusion of multiple hair follicles, forming a red, swollen, and painful hard mass. Cefotaxime tablets can cover common pathogens and reduce complications.
Usage and dosage: 400mg per dose for adults, twice a day, for a course of 14 days.
Cellulitis: caused by streptococcus and staphylococcus, characterized by redness, swelling, pain, and fever of the skin.
Usage and dosage: 400mg per dose for adults, twice a day, for a course of 14 days.
3. Lymphatic vasculitis and lymphadenitis
Caused by streptococcus and staphylococcus, it manifests as red lines along the lymphatic vessels, pain, and lymph node enlargement. Cefotaxime tablets can quickly control infections and prevent their spread.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 10 days.
4. Subcutaneous abscess and sweat gland inflammation
Subcutaneous abscess: caused by Staphylococcus aureus, characterized by local redness, swelling, pain, and wave sensation. Cefotaxime tablets can penetrate the walls of abscesses and inhibit bacterial growth.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 10 days; Continue medication after incision and drainage of the abscess.
Sweat gland inflammation: caused by Staphylococcus aureus, manifested as redness, swelling, pain, and rupture in the armpits, groin, and other areas.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 10 days.
Ear, nose and throat infections
1. Otitis media
Including acute otitis media and acute exacerbation of chronic otitis media, common pathogens are Streptococcus pneumoniae and Haemophilus influenzae. Cefotaxime tablets can penetrate the tympanic membrane and enter the middle ear cavity, inhibiting bacterial growth.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-10 days; Children should take 10mg/kg/day of body weight in 1-2 doses, with a maximum dose not exceeding 200mg/day.
2. Sinusitis
Caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, it presents as nasal congestion, purulent discharge, and headache. Cefotaxime tablets can cover common pathogens and reduce complications.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 5-10 days.
Mastitis
Caused by Staphylococcus aureus and Streptococcus, it manifests as breast redness, swelling, pain, and fever. Cefotaxime tablets can penetrate breast tissue, inhibit bacterial growth, and promote milk secretion.
Usage and dosage: 100mg per dose for adults, twice a day, with a treatment course of 7-10 days; For critically ill patients, the dosage can be increased to 200mg per dose, twice a day.
Other special infections
1. Periodontitis and crown periodontitis
Caused by a mixed infection of anaerobic bacteria (such as Streptococcus pyogenes) and aerobic bacteria, it manifests as swollen, painful, and bleeding gums. Cefpodoxime axetil tablets have antibacterial activity against both anaerobic and aerobic bacteria, and can quickly alleviate symptoms.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 7 days.
Caused by Staphylococcus and Streptococcus, it manifests as submandibular swelling, pain, and fever. Cefotaxime tablets can cover common pathogens and reduce complications.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 10 days.
2. Perianal abscess
Caused by Staphylococcus aureus and Escherichia coli, it presents as redness, swelling, pain, and wave sensation around the anus. Cefpodoxime proxetil tablets can penetrate the walls of abscesses and inhibit bacterial growth.
Usage and dosage: 200mg per dose for adults, twice a day, for a course of 10 days; Continue medication after incision and drainage of the abscess.
Cefpodoxime proxetil tablets are oral third-generation cephalosporin antibiotics, whose manufacturing process strictly complies with GMP standards to ensure safety, efficacy and stability.
1. Core Raw Materials and Excipients
The active pharmaceutical ingredient (API) is cefpodoxime proxetil, with a purity requirement not less than 98.5% to guarantee antibacterial activity. Common excipients include microcrystalline cellulose (filler), croscarmellose sodium (disintegrant), magnesium stearate (lubricant), and hypromellose (film-coating material). All raw materials and excipients must pass strict incoming inspection, excluding impurities and harmful substances, and comply with the national pharmaceutical standards.
2. Key Production Process
The production adopts the dry granulation or wet granulation process. Firstly, API and excipients are accurately weighed and mixed uniformly according to the prescription ratio. For wet granulation, an appropriate amount of binder is added to make soft materials, which are then granulated, dried and sized. After that, the granules are mixed with lubricants, and pressed into plain tablets by a tablet press. Finally, film coating is carried out to improve stability and mask the bitter taste, with the coating thickness controlled at 5-10μm.
3. Quality Control Standards
Quality inspection runs through the whole manufacturing process. In-process inspection includes granule fluidity, tablet hardness (3-5 kg), friability (≤1.0%) and disintegration time (≤30 minutes). Finished product inspection covers appearance (white film-coated tablets), API content (90.0%-110.0%), dissolution rate (≥75% in 30 minutes), and microbial limit (no pathogenic bacteria detected), ensuring each batch meets the standard before leaving the factory.
4. Production Environment and Specifications
The production workshop is a Class D clean area, with temperature controlled at 18-26℃ and relative humidity at 45%-65% to avoid contamination. Production equipment is regularly cleaned, sterilized and verified. The whole process is recorded in detail, including raw material weighing, granulation, tableting and coating, to realize full traceability. The product is packaged in aluminum-plastic blisters, and the shelf life is 24 months when stored in a cool and dry place away from light.
FAQ
What is the use of cefpodoxime proxetil tablets?
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Cefpodoxime is used to treat certain infections caused by bacteria such as bronchitis (infection of the airway tubes leading to the lungs); pneumonia; gonorrhea (a sexually transmitted disease); and infections of the skin, ear, sinuses, throat, tonsils, and urinary tract.
Is cefpodoxime 200 mg a strong antibiotic?
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Cefpodoxime is quite effective in treating bacterial infections. However, the drug is not very strong or severe and is well tolerated by a majority of people.
What to avoid when taking cefpodoxime?
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What may interact with this medication?
Antacids.
Diuretics.
Medications for stomach acid or ulcer, such as cimetidine, famotidine, lansoprazole, nizatidine, omeprazole, ranitidine.
Probenecid.
Sodium bicarbonate.
What are the common side effects of cefpodoxime?
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Common Side Effects
Diaper rash or fungal skin rash in children (up to 9%)
Diarrhea (up to 7% in adults; up to 13% in children under 2 years old)
Nausea (3%)
Vomiting (2%)
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