Clomipramine Hydrochloride Tablets, also known as Anafenib or Chlorpromazine Tablets, are a type of tricyclic antidepressant. They typically appear as white to slightly yellow crystalline powder or light yellow sugar coated tablets, which change color easily when exposed to light and are soluble in water and ethanol. They need to be stored in a dark sealed container and have a shelf life of typically 3 years. It exerts antidepressant effects by inhibiting the reuptake of serotonin and norepinephrine by neural synapses, and has both anticholinergic and α 1-adrenergic activities. It has a stronger inhibitory effect on the reuptake of serotonin than other tricyclic antidepressants, and can enhance the pressor effects of adrenaline and norepinephrine, while also having sedative and anticholinergic effects.
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Clomipramine Hydrochloride Tablets
Clomipramine Hydrochloride Capsules
| Product Name | Clomipramine Hydrochloride Tablets | Clomipramine Hydrochloride Capsules |
| Product Type | Tablet | Capsules |
| Product Purity | ≥99% | ≥99% |
| Product Specifications | 10mg/25mg | 25mg/50mg/70mg |
| Product Form | Take Orally | Take Orally |
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Clomipramine Hydrochloride COA
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| Certificate of Analysis | ||
| Compound name | Clomipramine hydrochloride | |
| Grade | Pharmaceutical grade | |
| CAS No. | 17321-77-6 | |
| Quantity | 337.3kg | |
| Packaging standard | 25kg/drum | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090039 | |
| MFG | Jan 9th 2025 | |
| EXP | Jan 8th 2028 | |
| Structure |  |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.37% |
| Loss on drying | ≤1.0% | 0.28% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.48% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Clomipramine Hydrochloride Tablets are a tricyclic antidepressant drug, mainly used to treat various mental and psychological disorders as well as some physical illnesses accompanied by mental symptoms. The following analysis is conducted from the perspectives of core indications, special population applications, combination therapy scenarios, and mechanisms of action：
Chlorpromazine hydrochloride tablets are widely used to treat various causes and symptoms of depression, with indications covering endogenous, reactive, neurotic, organic, occult, and menopausal depression, forming a comprehensive coverage of depression spectrum diseases.
Endogenous depression: including unipolar and bipolar depression, patients often exhibit core symptoms such as low mood, loss of interest, and decreased energy. Chlorpromazine hydrochloride effectively alleviates depression by inhibiting the reuptake of serotonin and norepinephrine, regulating the balance of neurotransmitters in the brain.
Reactive depression: a depressive state caused by external stress events such as unemployment, divorce, or the death of a loved one. Medication can help patients adjust their emotional responses and enhance their ability to cope with stress.
Core indication: Full spectrum coverage of depressive states
Neurotic depression: a depressive state accompanied by neurotic symptoms such as anxiety, obsessive-compulsive disorder, and fear. The anti anxiety effect of clomipramine hydrochloride can simultaneously improve comorbid symptoms.
Organic depression: Secondary depression caused by chronic physical diseases such as Parkinson's disease, cancer, stroke, etc. Medication can alleviate the psychological burden of physical diseases and improve quality of life.
Hidden depression: a depressive state characterized by physical symptoms (such as headache, stomach pain, insomnia) and a lack of typical emotional depression. Chlorpromazine hydrochloride can improve psychological state through physical symptoms.
Menopausal depression: Depressive emotions related to fluctuations in hormone levels. Medications can regulate the interaction between neurotransmitters and hormones, alleviating menopausal psychological symptoms.
In addition to depression, clomipramine hydrochloride tablets also play an important role in the treatment of anxiety related disorders, with indications including obsessive-compulsive disorder (OCD), phobias, and panic attacks, forming an effective intervention for anxiety spectrum disorders.
The core symptoms of Obsessive Compulsive Syndrome (OCD) are recurrent compulsive thinking (such as worrying about pollution, suspecting not locking the door) and compulsive behavior (such as repeatedly washing hands, checking items), which the patient knows is unreasonable but cannot control.
Treatment mechanism: Chlormipramine hydrochloride enhances serotonergic nerve conduction, regulates the function of the prefrontal cortex basal ganglia circuit, and improves obsessive-compulsive symptoms. Its efficacy has been validated in multiple randomized controlled trials (RCTs), with an effective rate of up to 60% to 80%.
Special indication: Targeted treatment for anxiety related disorders
Horror disorder: Excessive fear of specific objects (such as animals, blood) or scenes (such as high places, enclosed spaces), medication can lower anxiety thresholds and alleviate fear reactions.
Panic attack: a sudden and intense feeling of fear or discomfort accompanied by symptoms such as palpitations, sweating, and tremors. Chlorpromazine hydrochloride can reduce the frequency and severity of attacks.
Medication plan: The dosage for phobias and panic attacks is 75-150mg/day, divided into 2-3 oral doses. The initial dose is 10mg/day, and treatment should be continued for at least 6 months as tolerance gradually increases. During this period, the maintenance dose can be gradually reduced.
Chlorpromazine hydrochloride tablets also have application value in the adjuvant treatment of symptoms related to physical diseases. Its indications include cataplexy accompanied by episodic sleep disorders, chronic pain states, and nocturnal enuresis, forming a comprehensive intervention for the intersection of physical and psychological diseases.
The core symptom of cataplexy accompanied by narcolepsy is the sudden loss of muscle tone in narcolepsy patients, leading to falls or drooping of the head, often triggered by strong emotions such as laughter and anger.
Therapeutic mechanism: Chlorpromazine hydrochloride regulates monoamine neurotransmitters, enhances muscle tone, and reduces sudden onset.
Medication plan: The dosage is 25-75mg/day, adjusted according to the frequency and severity of attacks.
Special indication: Adjuvant treatment for symptoms related to physical diseases
The core symptoms of chronic pain state: pain lasting for more than 3 months, which may be caused by nerve damage, inflammation, or psychological factors. Medication can alleviate pain perception and improve quality of life.
Therapeutic mechanism: Chlorpromazine hydrochloride enhances the function of the endogenous pain suppression system by inhibiting the reuptake of serotonin and norepinephrine, while regulating the impact of emotions on pain.
Medication plan: The dosage should be individualized, ranging from 10 to 150mg/day. Patients may need to consider the possibility of concomitant use of painkillers, and adverse reactions should be monitored when drugs are used in combination.
The core symptoms of nocturnal enuresis (limited to children aged 5 and above) are involuntary urination during sleep in children aged 5 and above. After excluding organic causes such as urinary tract infections and spina bifida, it may be related to psychological factors or delayed bladder function maturation.
Treatment mechanism: Chlorpromazine hydrochloride may reduce enuresis by regulating the secretion of antidiuretic hormone or enhancing bladder control ability.
Medication plan: The initial dose for children aged 5-8 is 10mg/day (2-3 tablets), for children aged 9-12 it is 25mg/day (1-2 tablets), and for children aged 12 and above it is 25mg/day (1-3 tablets). If there is no sufficient therapeutic effect within one week of medication, the dosage can be increased. Generally, the medication should be administered once after dinner, but for children who experience bedwetting shortly after falling asleep, a partial dose should be given in advance (at 4 pm). After achieving the expected therapeutic effect, the maintenance dose should be gradually reduced and treatment should be continued for 1-3 months.
Mechanism of action: Multi target regulation of neurotransmitter balance
Inhibition of 5-hydroxytryptamine reuptake: Chlorpromazine hydrochloride has a significantly stronger inhibitory effect on 5-hydroxytryptamine reuptake than other tricyclic antidepressants, and can effectively regulate mood, sleep, and appetite, improving core symptoms of depression.
Inhibition of norepinephrine reuptake: By enhancing noradrenergic nerve conduction, regulating attention, alertness, and motivation, alleviating fatigue and loss of interest associated with depression.
Anticholinergic effect: The drug has mild anticholinergic activity and can cause adverse reactions such as dry mouth, constipation, and blurred vision, but it also helps alleviate anxiety and tension.
Alpha 1 adrenergic blockade: may lead to orthostatic hypotension, and blood pressure changes need to be monitored during the early stages of medication.
Histamine H1 receptor blockade: produces sedative effects and helps improve insomnia and anxiety symptoms.
FAQ
1. Besides treating obsessive-compulsive disorder, what other rare applications does it have?
Under the strict assessment by professional doctors, it may be used for the treatment of refractory depression, panic disorder, specific chronic pain (such as neuropathic pain) and premature ejaculation, which is related to its potent inhibition of the reuptake of serotonin and norepinephrine.
2. What are the main characteristics of its side effects?
Compared with other antidepressants, its anticholinergic side effects (dry mouth, constipation, blurred vision, difficulty urinating) and sedative effects are more prominent. Additionally, it has certain effects on the cardiac conduction system (such as QT interval prolongation), and electrocardiogram monitoring is often required before and during the medication.
3. What are the most important precautions to be aware of when using it?
Do not stop the medication suddenly. Otherwise, it may cause severe withdrawal reactions (such as dizziness, nausea, and abnormal sensations). The dosage must be reduced slowly and gradually under the guidance of a doctor. Additionally, it may interact with multiple drugs. When visiting the doctor, inform them of all the medications you are currently taking.
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