Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of fluralaner tablet in China. Welcome to wholesale bulk high quality fluralaner tablet for sale here from our factory. Good service and reasonable price are available.
Fluralaner Tablet is an oral systemic insecticide and acaricide primarily used to treat and prevent flea and tick infections in pets such as dogs and cats. It works by inhibiting the nervous system of insects and ticks, specifically targeting gamma aminobutyric acid (GABA) receptors and glutamate receptors, blocking chloride ion channels, and causing parasitic nerve paralysis and death. After being absorbed by pets, drugs are distributed throughout the body. When fleas or ticks bite pets, they may ingest the drugs and die. It can effectively kill fleas and ticks on pets and prevent reinfection.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
Our products
| Product Name | Fluralaner Drops | Fluralaner Tablet | Fluralaner Injection |
| Product Type | liquid | Tablet | liquid |
| Product Purity | ≥99% | ≥99% | ≥99% |
| Product Specifications | For dogs: 112.5mg, 2-4.5kg/250mg, >4.5-10kg/500mg, >10-20kg/1000mg, >20-40kg/1400mg, >40-56kg For cats: 112.5mg, 1.2-2.8kg/250mg, >2.8-6.25kg/500mg, >6.25-12.5kg |
For a 3-month-old dog: 112.5mg, 2-4.5kg/250mg, 4.5-10kg/500mg, >10-20kg/1000mg, >20-40kg/1400mg, >40-56kg For a 1-month-old dog: 45mg, 2-4.5kg/100mg, >4.5-10kg/200mg, >10-20kg/400mg, >20-40kg/560mg, >40-56kg |
For dogs: 112.5mg, 2-4.5kg/250mg, >4.5-10kg/500mg, >10-20kg/1000mg, >20-40kg/1400mg, >40-56kg For cats: 112.5mg, 1.2-2.8kg/250mg, >2.8-6.25kg/500mg, >6.25-12.5kg |
| Product Form | External application | Take Orally | Organic synthesis |
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Fluralaner COA
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| Certificate of Analysis | ||
| Compound name | Fluralaner | |
| Grade | Pharmaceutical grade | |
| CAS No. | 864731-61-3 | |
| Quantity | 337.3kg | |
| Packaging standard | 25kg/drum | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090036 | |
| MFG | Jan 9th 2025 | |
| EXP | Jan 8th 2028 | |
| Structure |  |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.38% |
| Loss on drying | ≤1.0% | 0.28% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.45% |
| Total microbial count | ≤750cfu/g | 90 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 400ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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In the field of pet health, parasitic infections are a common and serious problem, especially flea and tick infections. They not only cause pet skin itching and allergic reactions, but also may spread various diseases, posing a serious threat to pet health. In order to effectively control and prevent these parasitic infections, pet owners need a safe, effective, and convenient medication. Fluralaner Tablet, as a novel oral systemic insecticide and acaricide, have been widely used in the field of pet healthcare in recent years.
Targeting dogs
Fluorouracil tablets achieve efficient killing by inhibiting key ion channels in the parasitic nervous system, and their mechanism is highly selective. Frellana binds to gamma aminobutyric acid (GABA) receptors on the membrane of insect/tick nerve cells, blocking the opening of chloride ion channels and causing neuronal overexcitation leading to paralysis and death; Simultaneously inhibiting glutamate regulated chloride ion channels, further enhancing neurotoxic effects; The GABA receptors of mammals (such as dogs) are located in the central nervous system, and the blood-brain barrier prevents drugs from entering, making Frellana extremely safe for dogs. The peak blood drug concentration is reached 2-4 hours after administration, and it is widely distributed throughout the body tissues (including skin and subcutaneous tissue).
Core use: Comprehensive coverage from prevention and treatment to treatment
For flea infections (Ctenocephalides felis), kill over 98% of fleas within 12 hours after administration and achieve 100% eradication within 48 hours; Prevent flea bites from spreading Dipylidium caninum and Bartonelosis in dogs; By reducing the flea load on dogs, the risk of contamination from flea larvae and eggs in the household environment can be lowered. At the same time, Frellana tablets have efficient killing effects on various ticks, including:
Ixodes scapularis: spreads Lyme disease and Anaplasmosis;
Dermacentor variabilis: spreads Rocky Mountain spotted fever;
Rhipiocephalus sanguineus: spreads Babesiosis in dogs;
Haemaphysalis longicornis: an emerging tick species that can transmit various zoonotic diseases.
Clinical data: Within 48 hours after administration, more than 99% of attached ticks were killed, significantly reducing the risk of tick borne diseases.
Ingesting medication when bitten by scabies mites, resulting in neurological paralysis and death; Therefore, the itching index decreased by 80% 2 weeks after a single administration, and the recovery rate reached 95% within 4 weeks; Its advantage is to replace traditional Ivermectin injections (which require multiple doses), especially suitable for dogs that are intolerant to injections. If it is Otodectes cynotis, it can be taken orally or directly mixed with mineral oil and dripped onto the ears; It can kill over 90% of ear mites within 72 hours and achieve a 100% cure rate within 14 days; Its advantages are relatively better than traditional ear mite drops (which require daily medication and are easy to fall off). It is suitable for local or systemic demodex disease; After 3 consecutive doses (once every 12 weeks), 90% of cases showed a decrease in mite count to negative; At the same time, it is necessary to combine immune support therapy (such as supplementing with Omega-3 fatty acids).
Auxiliary treatment for skin diseases
For flea allergic dermatitis (FAD), it can quickly kill fleas and block the continuous stimulation of allergens (flea saliva); The itching score decreased by 70% within 72 hours after administration, and the skin injury healing rate reached 85% within 2 weeks. It can also reduce the attachment time of ticks and decrease the release of local inflammatory factors such as IL-6 and TNF - α; Combined use with antibiotics can shorten the treatment cycle of tick borne diseases by 30%. Targeting dogs that frequently come into contact with the natural environment, such as hunting dogs, guide dogs, and search and rescue dogs, in specific environments; 12 week long-term protection reduces frequent medication interference and improves work efficiency. There are also multi pet families where treating a single dog can reduce the risk of infection for other pets in the family, such as cats.
Common medication specifications
| Month Dogs | Specification (mg) | BApplicable weight range (kg) |
| March | 112.5mg | 2-4.5kg |
| 250mg | >4.5-10kg | |
| 500mg | >10-20kg | |
| 1000mg | >20-40kg | |
| 1400mg | >40-56kg | |
| January | 45mg | 2-4.5kg |
| 100mg | >4.5-10kg | |
| 200mg | >10-20kg | |
| 400mg | >20-40kg | |
| 560mg | >40-56kg |
Regarding cats
Within 12 hours after administration of Ctenocephalides felis, more than 98% of fleas are killed, and 100% is achieved within 48 hours; Can prevent flea bites from spreading Bartonelosis and Cat Scratch Disease; By reducing the flea load on cats, the risk of contamination from flea larvae and eggs in the home environment can be lowered. Fluorouracil tablets have a highly effective killing effect on various ticks, including:
Rhipiocephalus sanguineus: spreads Babesiosis in cats;
Dermacetor variant tick: spreads Rocky Mountain spotted fever;
Haemaphysalis longicornis: an emerging tick species that can transmit various zoonotic diseases.
Clinical data: Within 48 hours after administration, more than 99% of attached ticks were killed, significantly reducing the risk of tick borne diseases.
Mite infection treatment&skin disease adjuvant therapy
Flea allergic dermatitis (FAD) quickly kills fleas and blocks the continuous stimulation of allergens (flea saliva); The itching score decreased by 70% within 72 hours after administration, and the skin injury healing rate reached 85% within 2 weeks. Inflammation after tick bites should be controlled to reduce tick attachment time and decrease the release of local inflammatory factors such as IL-6 and TNF - α; Combined use with antibiotics can shorten the treatment cycle of tick borne diseases by 30%. It is also suitable for cats that frequently come into contact with natural environments, such as stray cat rescue and outdoor adventure cats; 12 week long-term protection reduces frequent medication interference and improves quality of life. For multi pet families, treating a single cat can reduce the risk of infection for other pets (such as dogs) in the family.
Common adverse reactions and treatment
| Types of adverse reactions | Incidence rate | Typical manifestation | Handling measures |
| Gastrointestinal reactions | 3%-5% | Vomiting, diarrhea, loss of appetite | Administer with meals and use antiemetic if necessary |
| Neurological response | 0.1%-1% | Tremor, ataxia, epilepsy | Stop taking the medication immediately and use benzodiazepines for sedation |
| Skin reactions | 1%-2% | Itching, erythema, hair loss | Localized use of corticosteroid ointment |
Fluralaner Tablet belongs to the class of isoxazolines, and research on this type of compound began in the 1990s. Scientists have discovered that certain nitrogen-containing heterocyclic compounds, such as isoxazolines, have significant insecticidal activity, particularly exhibiting highly selective toxicity to the nervous system of arthropods, such as insects and mites.
Early isoxazoline compounds were mainly used as agricultural insecticides, but their potential toxicity to mammals limited their application in veterinary and human medicine. Until the early 21st century, scientists successfully developed isoxazoline derivatives with higher safety for mammals through structural optimization, laying the foundation for the discovery of Fluralaner.
In the study of isoxazoline compounds, the screening of lead compounds is a key step. Researchers have found through structure-activity relationship (SAR) analysis of thousands of compounds that certain specific substituents (such as trifluoromethyl and halogen substitution on the benzene ring) can significantly enhance the insecticidal activity and safety of the compounds.
In 2008, a research team from German pharmaceutical company Merck (later known as MSD Animal Health) discovered a precursor compound of Fluralaner, an isoxazoline derivative with potent insecticidal activity, during the screening process. Further optimization has reduced its toxicity to mammals while maintaining high insecticidal activity.
The chemical name of Fluralaner is 4- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2-methyl-N - [2-oxo-2- (2,2,2-trifluoroethylamino) ethyl] benzamide. The isoxazoline ring and trifluoromethyl group in its molecular structure are the key to its insecticidal activity.
Researchers have improved the bioavailability and safety of Fluralaner through the following optimization strategies:
Enhance selectivity towards insect GABA receptors: Fluralaner can specifically bind to gamma aminobutyric acid (GABA) receptors in insects and mites, with little effect on GABA receptors in mammals.
Improving metabolic stability: Through structural modification, Fluralaner has a longer half-life in animals, achieving long-lasting protection.
Improving oral absorption: The optimized molecular structure enables it to have good absorption in the gastrointestinal tract, making it suitable for making oral preparations.
From 2010 to 2013,Fluralaner Tablet conducted multiple clinical trials to evaluate its effectiveness in preventing and controlling fleas and ticks in dogs and cats. The key research results include: a killing rate of>90% within 24 hours after a single oral administration, a protection period of up to 12 weeks (much higher than the 4 weeks of traditional insecticides such as fipronil), and continued effectiveness against multiple drug-resistant strains of insects.
In 2014, Fluralaner made its debut in the European Union under the trade name Bravecto ®) Approved for marketing in the United States (FDA approved) for flea and tick control in dogs. Subsequently, its indications were extended to cats and other animals, and topical preparations such as Bravecto were introduced ® Spot-on)
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