DL Mandelic Acid Powder, also known as DL Mandelic Acid Powder, is a white crystalline powder that is easily soluble in ether, isopropanol, ethanol, and water, with a water solubility of 150 g/L (20 ℃).It is prone to discoloration and decomposition when exposed to light, so it needs to be stored away from light.
Due to its strong antibacterial effect, it can be directly taken orally for the treatment of urinary tract infections. As an important chiral drug intermediate and fine chemical product, it can be used to synthesize various drugs, such as vasodilator cyclohexanel ester, urinary tract infection anti-inflammatory drug DL mandelic acid urotropine, and antispasmodic drug DL mandelic acid benzyl ester. It has a dual function of killing sperm and trichomonas; It may also have therapeutic effects on rheumatoid arthritis, for example, D - (-) - Mandelic acid (related to DL mandelic acid) has anti arthritis effects in arthritis rats; It has a certain inhibitory or bactericidal effect on Escherichia coli, Toxoplasma gondii, and other bacteria. It can also be used as pharmaceutical raw materials and intermediates, dye intermediates, etc. For example, in the pharmaceutical industry, it can be used as an intermediate for cephalosporins, vasodilators such as cyclomandelic acid esters, eye drops such as hydroxybenzylazole, and pimolin. It can also be embedded into Zn Al layered double hydroxides (LDHs) through anion exchange reactions to construct novel antibacterial layered materials.
At the same time, our company not only provides pure powders, but also tablets and injections. If needed, please feel free to contact us at any time.
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Additional information of chemical compound:
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Product Name |
DL Mandelic Acid Powder |
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Product Type |
Powder |
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Product Purity |
100g/1kg/etc. |
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Product Form |
Organic synthesis |
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DL Mandelic Acid Powder COA
DL Mandelic Acid Powder,It is an important organic compound with a wide range of applications in multiple fields. The following will elaborate on its applications in medicine, chemical engineering, and other fields:
Application in the pharmaceutical field
DL mandelic acid is an important intermediate for the synthesis of vasodilator cyclohexyl ester. Cyclodextrin has various clinical applications and can be used to treat cerebral arteriosclerosis. Cerebral arteriosclerosis is a common neurological disease that can cause narrowing of blood vessels and poor blood flow in the brain, leading to symptoms such as dizziness, headache, and memory loss. Cyclodextrin can alleviate these symptoms by dilating brain blood vessels and improving blood circulation in the brain. It can also be used to treat post-stroke sequelae. After a stroke, patients may experience sequelae such as limb movement disorders and language disorders. Cyclomandelic acid can promote blood supply to the damaged areas of the brain, which helps with the recovery of neurological function. In addition, for the sequelae of traumatic brain injury and limb artery spasms, cyclohexyl esters can also play a certain therapeutic role, reducing patients' pain and improving their quality of life.
As a drug intermediate, synthesizing multiple drugs
DL mandelic acid is a key raw material for the synthesis of the anti-inflammatory drug DL mandelic acid urotropin for urinary tract infections. Urinary tract infection is a common urinary system disease, mainly caused by pathogens such as bacteria. Patients may experience symptoms such as frequent urination, urgency, and pain during urination, which seriously affects their quality of life. DL Mandelic acid Urotropin has antibacterial properties and can effectively kill bacteria that cause urinary tract infections. Its antibacterial mechanism may be achieved by interfering with bacterial cell wall synthesis, affecting bacterial metabolic processes, and other pathways. By inhibiting the growth and reproduction of bacteria, DL mandelic acid Urotropin can alleviate urinary tract inflammation, alleviate patients' symptoms, and promote the recovery of the urinary system.
DL mandelic acid can be used to synthesize the antispasmodic drug DL mandelic acid benzyl ester. Antispasmodic drugs are commonly used in clinical practice to alleviate symptoms such as muscle spasms and neuropathic pain. Muscle spasms can be caused by various reasons, such as overwork, calcium deficiency, neurological disorders, etc., which can lead to sudden and involuntary muscle contractions, causing pain and restricted movement. Neuropathic pain is pain caused by damage or dysfunction of the nervous system, such as trigeminal neuralgia, postherpetic neuralgia, etc. The degree of pain is severe and seriously affects the patient's life. DL Mandelic acid benzyl ester achieves antispasmodic effects by regulating the function of the nervous system, reducing excessive muscle contractions, blocking the transmission of pain signals, and relieving pain for patients.
Synthesize other drugs
In the pharmaceutical industry, DL mandelic acid is also an important intermediate for various drugs. For example, it is one of the raw materials for synthesizing methyl benzoate, which plays an important role in the synthesis of certain drugs. Meanwhile, DL mandelic acid is also used to synthesize cefoperazone, an antibiotic that can be used to treat bacterial infections. Cefotaxime can exert good antibacterial effects on respiratory, urinary tract, skin and soft tissue infections caused by sensitive bacteria. In addition, DL mandelic acid is also involved in the synthesis of eye drops such as hydroxybenzoxazole, pimolin, and other antispasmodic agents. Hydroxybenzimidazole eye drops are used to treat eye diseases such as viral conjunctivitis; Pimoline can be used to treat children with ADHD and improve symptoms such as inattention and hyperactivity; Tuo type antispasmodic agents are mainly used to relieve pain caused by smooth muscle spasms in the gastrointestinal tract, urinary tract, and other areas.
DL mandelic acid can be used as a urethral preservative, and its preservative effect is mainly based on its antibacterial properties. In the urethral environment, DL mandelic acid can inhibit the growth and reproduction of bacteria and other pathogens, preventing them from colonizing and infecting the urethral mucosa. It may exert its preservative effect by changing the acidity or alkalinity of the urethral environment and disrupting the living conditions of bacteria. The normal urethral environment has a certain degree of pH and microbial balance, and when disturbed by external factors, it can easily lead to the invasion of pathogens. The addition of DL mandelic acid can maintain a relatively stable urethral environment and reduce the risk of infection. It can reduce the incidence of urinary tract infections, alleviate the pain and complications caused by urinary tract infections in patients, such as fever and lower back pain. At the same time, it can also reduce the use of antibiotics and avoid problems caused by antibiotic abuse, such as increased bacterial resistance and adverse drug reactions.
Capable of killing sperm and trichomonas
DL Mandelic Acid Powder has a spermicidal effect, it has fixed activity on sperm and causes mild membrane damage. Its mechanism of killing sperm may be through binding to specific receptors on the surface of sperm, interfering with the normal metabolism and motility of sperm. Sperm needs to maintain vitality and normal morphological structure during fertilization. The action of DL mandelic acid can cause sperm to lose their activity and be unable to bind with the egg, thereby achieving contraceptive effects. It also has a killing effect on vaginal trichomonas. Vaginal trichomoniasis is a common sexually transmitted disease caused by Trichomonas vaginalis. Patients may experience symptoms such as increased vaginal discharge and itching of the external genitalia, which seriously affects their quality of life. Can destroy the cellular structure of vaginal trichomonas, inhibit its growth and reproduction. It has high sperm fixation activity and low vaginal irritation, which gives it certain advantages as a spermicide and trichocide. Compared with some traditional spermicides and trichomonads, DL mandelic acid may have less stimulation on the vaginal mucosa, reducing discomfort for patients after use, and also reducing interference with the normal vaginal flora, helping to maintain the microecological balance of the vagina.
DL mandelic acid has been widely studied for its potential applications in health products, such as photoaging, irregular pigmentation, and antibacterial properties. In terms of photoaging, long-term exposure of the skin to ultraviolet radiation can lead to skin aging, resulting in wrinkles, sagging, pigmentation, and other problems. DL mandelic acid may delay skin aging by acting as an antioxidant, clearing free radicals, and reducing UV damage to the skin. For irregular pigmentation such as melasma, freckles, etc., DL mandelic acid may regulate pigment metabolism in the skin, inhibit melanin synthesis and deposition, and improve skin color. In terms of antibacterial properties, in addition to the known bactericidal effects on some bacteria and trichomonas, it may also have inhibitory effects on other pathogens, providing ideas for the development of new antibacterial drugs.
Potential therapeutic effects on rheumatoid arthritis
DL Mandelic Acid Powder has anti arthritis effects in rats with arthritis. Rheumatoid arthritis is an autoimmune disease that can cause joint inflammation, pain, and deformities. DL mandelic acid may alleviate joint inflammation and damage, improve joint function and quality of life in patients by regulating the immune system, inhibiting inflammatory responses, and other mechanisms. Future research can further explore its mechanism of action and its effectiveness and safety in the treatment of human rheumatoid arthritis.
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DL-mannitol usually appears as a white or off-white crystalline powder, which is hygroscopic and has a sweet and slightly bitter taste. Its crystal structure contains two isomers, α and β. The α form has a melting point of approximately 133°C, while the β form has a melting point of approximately 132°C (decomposition point).
Water solubility: Easily soluble in water, with a solubility of up to 248g/100mL at 25°C, forming a transparent solution.
Solubility in organic solvents: Slightly soluble in ethanol (with a solubility of about 0.4%), almost insoluble in non-polar solvents such as ether and benzene.
Stability: Stable at room temperature in a dry state, but needs to be sealed to prevent moisture absorption and caking. Avoid contact with strong oxidants to prevent oxidation reactions.
Reductivity: Reductive, can reduce Fehling's solution (a brick-red precipitate is formed) when reducing; can be reduced to mannitol under the action of hydrogenation catalyst.
Rotatory optical activity: The α and β isomers can interconvert in water and reach a balanced state, with a specific rotation of +14.5° (in water solution).
Molecular formula and isomer relationship: The molecular formula is C₆H₁₂O₆, which is a C-2 diastereoisomer of glucose (only the direction of the hydroxyl group at C2 is different).
Ring structure: There are linear structures and ring structures (pyran ring), and the ring structure further divides into α and β configurations, whose proportions affect physical properties (such as melting point, solubility).
Density and Boiling Point: The density is approximately 1.539 - 1.732 g/cm³, and the predicted boiling point is relatively high (around 410.8℃ or 527.1℃, depending on the data source).
Hygroscopicity: It readily absorbs moisture from the air and should be stored in a dry environment.
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