Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of pure fenbendazole powder in China. Welcome to wholesale bulk high quality pure fenbendazole powder for sale here from our factory. Good service and reasonable price are available.
Pure fenbendazole powder is a white or off-white powder-like chemical substance, odorless and tasteless. Common purity specifications include 99%, 99.99%, etc. It is soluble in dimethyl sulfoxide, slightly soluble in methanol, insoluble in water, and soluble in glacial acetic acid. It should be stored in a light-proof, sealed container in a dry place to ensure its stability.
Fenbendazole is a benimidazole antworm. Its mechanism of action is to combine with the microtubule proteins of nematodes to exert an anthelmintic effect. By inhibiting the synthesis of microtubule proteins in parasites, it causes energy metabolism disorders in parasites and leads to their death. It not only has a high deworming activity against adult and larval nematodes in the animal gastrointestinal tract, but also has a good effect on nematodes nematodes, Trematodes caudatum, Trematodes procellatum and tapeworms.
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Additional information of chemical compound:
Fenbendazole Powder COA
Pure fenbendazole powder is a broad-spectrum, highly effective and low-toxicity benzimidazole antworm drug, which has multiple functions in veterinary clinical practice and animal husbandry, as follows:
Insect repellent function
Broad-spectrum insect repellent
Nematodes: This product has a highly efficient killing effect on various nematodes, including adult and larval Echinodes, adult and larval Echinodes, and viviparous nematodes.Bovine nematodes such as Nematode nematodes, Osternematode nematodes, and Nematode trichoderma, etc. Sheep's nematodes, Osternematodes, Trichodonodes, etc. Adult and larval red roundworms, ascaris roundworms and esophageal orifice nematodes of pigs; And hookworms, roundworms, hair-headed nematodes, etc. of dogs and cats.
Tapeworms: It has a good effect in eliminating various tapeworms such as the extended Monitz tapeworm and the Bergii Monitz tapeworm.
Trematodes: A higher dose is required for trematodes, such as 20mg/kg for 5 consecutive days, achieving a 100% effective rate against spear-shaped double-cavity trematodes. Continuous use at a dose of 15mg/kg for 6 days is highly effective against liver fluke.
Inhibiting the development of parasite eggs: This product can not only kill adult and larval insects, but also inhibit the development of parasite eggs and reduce the number of parasite eggs in the environment.
Pharmacokinetic characteristics
Absorption: Pure fenbendazole powder has a relatively low solubility and is absorbed very little after oral administration. Ruminants absorb slowly, while monogastric animals absorb slightly faster. The peak time of blood drug in dogs after oral administration is 24 hours, and in sheep it is 2 to 3 days.
Distribution: After absorption, fenbendazole is widely distributed in animals and can reach the sites where parasites parasitize.
Metabolism: It is metabolized into sulfoxides (active ofendazole) and sulfones in the animal body.
Excretion: In cattle, sheep and pigs, 44% to 50% of fenbendazole is excreted in its original form through feces, and less than 1% is excreted through urine. If a single dose is ineffective for dogs and cats, they must be treated for 3 days.
Clinical Application
This product is an effective drug for treating nematode disease and tapeworm disease in livestock and poultry.
Preventive medication: It can be used as a preventive medication to reduce the occurrence of parasitic diseases in livestock and poultry and improve the efficiency of breeding.
Safety and Precautions
Adverse reactions
Generally, no adverse reactions will occur when used at the recommended dosage. However, due to the release of antigens by dead parasites, secondary allergic reactions can occur, especially at high doses. Vomiting is occasionally observed in dogs or cats when taken orally. There has been a report of various types of leukopenia in dogs after taking the medicine.
Taboo
Prohibited for use on horses for food. Not applicable to lactating dairy cows and animals within the first 45 days of pregnancy; The use of fenbendazole in the early stage of pregnancy in sheep and rabbits may be accompanied by teratogenic and embryotoxic effects.
Drug interactions
When used in combination with the fluke killer bromide, it can cause the death of sheep and miscarriage of cattle. When using fenbendazole in equine animals, dichlorvos should not be used in combination; otherwise, the toxicity will be greatly enhanced.
Withdrawal period
14 days for cattle and sheep, 3 days for pigs, and 28 days for poultry. The milk abandonment period is 120 hours and the egg abandonment period is 7 days.
Molecular Structure
The molecular formula of fenbendazole is C₁₅H₁₃N₃O₂S, and its molecular weight is 299.348. Its chemical structure contains benzimidazole rings and sulfide groups. The benzimidazole ring is a common structural feature of many antihelmintic drugs, which can bind to tubulin in parasites and exert anthelmintic effects. The sulfide group has an important influence on its biological activity and chemical properties.
Physical Properties
Appearance: Pure fenbendazole powder is a white to light yellow or off-white crystalline powder, odorless and tasteless.
Density: Approximately 1.4 g/cm³. This density value indicates that fenbendazole has a certain bulk density, which is convenient for storage and transportation.
Melting point: The melting point is 233°C (decomposition), which means that fenbendazole will undergo decomposition reactions at higher temperatures. Therefore, high-temperature environments should be avoided during storage and use.
Boiling point: The boiling point is 541.4±42.0°C (at 760 mmHg). A higher boiling point indicates that fenbendazole is not volatile at normal temperature and pressure.
Flash point: approximately 281.2±27.9°C, further demonstrating its non-flammable property.
Vapor pressure: At 25°C, it is 0.0±1.5 mmHg, indicating that its vapor pressure is relatively low and it is not easy to volatilize into the air at normal temperature.
Refractive index: 1.679. Refractive index is one of the optical properties of substances and can be used for the identification and analysis of substances.
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Solubility
Water solubility: This product is insoluble in water. This property limits its application in some water-based preparations, but it can be prepared into dosage forms suitable for animal administration through other methods such as suspensions or emulsions.
Organic solvent solubility
Dimethyl sulfoxide: Readily soluble in dimethyl sulfoxide, a commonly used organic solvent that can be employed to dissolve many insoluble substances.
Methanol: It is slightly soluble in methanol. The slightly soluble property makes it necessary to control the amount and conditions of the solvent when preparing certain preparations.
Glacial acetic acid: It also has a certain solubility in glacial acetic acid. Glacial acetic acid can be used in some special chemical reactions or the preparation of preparations.
Stability
Conventional stability
Pure fenbendazole powder is stable under normal storage conditions (sealed, cool and dry), and will not decompose or deteriorate.
Thermal stability
Due to its melting point of 233°C (decomposition), it will undergo decomposition reactions at high temperatures. Therefore, high-temperature environments should be avoided during storage and use.
Light stability
Sensitive to light, prolonged exposure to light may cause drug degradation. Therefore, light-blocking measures should be taken during storage and transportation.
Chemical Reactivity
Binding to tubulin: The main mechanism of action of fenbendazole is to bind to tubulin in parasites, interfering with the normal function of the microtubule system and thereby exerting an anthelmintic effect. This binding effect has a high degree of specificity and affinity, enabling fenbendazole to effectively kill parasites.
Metabolic reaction: In the animal body, fenbendazole is metabolized into metabolites such as sulfoxide (active ofendazole) and sulfone. These metabolites still have certain deworming activity and can be excreted from the body through urine and feces.
Interactions with other drugs:
When fenbendazole is used in combination with the fluticide bromide, it can cause adverse reactions, such as leading to the death of sheep and miscarriage of cattle.
When using fenbendazole in equine animals, dichlorvos should not be used in combination; otherwise, the toxicity will be greatly enhanced.
Calculate chemical data
Reference values for hydrophobic parameter calculation (XlogP) : No relevant data.
The number of hydrogen bond donors: 2. The number of hydrogen bond donors affects the solubility of molecules in aqueous solutions and their interactions with other molecules.
The number of hydrogen bond receptors: 4. The number of hydrogen bond receptors also affects the solubility and interaction of molecules.
The number of rotatable chemical bonds: 4. The number of rotatable chemical bonds affects the flexibility and conformation of a molecule.
Number of tautomers: 5. Tautomers refer to compounds with the same molecular formula but different structures, which can be transformed into each other.
Topological molecular polar surface area (TPSA) : 92.3. Topological molecular polar surface area can be used to predict the solubility, permeability and biological activity of molecules, etc.
Number of heavy atoms: 21. The number of heavy atoms refers to the number of atoms in a molecule other than hydrogen atoms.
Surface charge: 0. Surface charge affects the interaction between molecules and other charged particles.
Complexity: 363. Complexity reflects the degree of complexity of the molecular structure.
The number of isotope atoms is 0, indicating that the fenbendazole molecule does not contain isotope atoms.
Determine the number of atomic steric centers: 0. Steric centers refer to atoms in a molecule that have different configurations due to chirality.
Uncertain number of atomic steric centers: 0.
Determine the number of constitutive centers of chemical bonds: 0.
Uncertain number of chemical bond establishment centers: 0.
The number of covalent bond units is 1, indicating that the fenbendazole molecule is an independent covalent bond unit.
Safety and Toxicity
Acute toxicity: The oral LD50 of rats is above 10,000 mg/kg, indicating that the acute toxicity of fenbendazole is relatively low. However, during the usage process, it is still necessary to follow the doctor's advice and the recommended dosage on the instructions to avoid adverse reactions caused by excessive use.
Chronic toxicity: Long-term and excessive use may cause certain chronic toxic effects on animals. Therefore, it is necessary to regularly monitor the health status of the animals and adjust the dosage or discontinue the drug as needed.
Taboos for special groups and animals:
Prohibited for use on horses for food.
It should not be used on lactating dairy cows and animals within the first 45 days of pregnancy.
The use of fenbendazole in the early stage of pregnancy in sheep and rabbits may be accompanied by teratogenic and embryotoxic effects.
Storage and Transportation
Storage conditions
It should be stored in a sealed container, in a cool and dry place, away from high temperatures and light. Light-blocking packaging materials can be used to store the medicine in a cool warehouse.
Transportation requirements
During transportation, the packaging must be kept intact to prevent moisture and light exposure. Transportation can be carried out in sealed containers and necessary protective measures should be taken.
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