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Ethylhexanoic acid, CAS 149-57-5, Molecular formula C8H16O2. colorless liquid, slightly odor, slightly soluble in cold water, soluble in hot water and ether, slightly soluble in ethanol. It is a kind of chemical substance that is harmful to health and irritating to skin and mucous membrane. After being heated and decomposed, it gives off irritating acid mist. Used in the synthesis of many dyes and spices. It is mainly used to prepare various metal salts as drying agents for coatings and paints, and its esters can be used as plasticizers and raw materials for carboxybenzylpenicillin.

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Chemical Formula |
C8H16O2 |
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Exact Mass |
144 |
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Molecular Weight |
144 |
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m/z |
144 (100.0%), 145 (8.7%) |
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Elemental Analysis |
C, 66.63; H, 11.18; O, 22.19 |
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2-ethylhexanoi acid (also known as isooctanoic acid) is an organic chemical product with wide applications. At present, it is mainly used in coating, plastics, leather making, medicine, wood, chemical fiber, pesticide, transportation and national defense, but most of it is used to produce metal salts of isooctanoic acid. This salt is widely used in the coating industry because it has more obvious drying effect than naphthenic acid salt to meet the needs of people for high-grade light color coatings. In medicine, isooctanoic acid is mainly used as a salt forming reagent for the synthesis of Cyanotoxin sodium salt by solvent method. In addition, it is also used in cosmetics and spices Its glyceride is an excellent plasticizer. With the development of industry and agriculture, the demand of isooctanoic acid is increasing year by year, and its economic status is also very important.

2-Ethylhexanoi acid, also known as isooctanoic acid, is an artificially synthesized branched fatty acid with a colorless, transparent, slightly odorous oily liquid form, and an aromatic odor at room temperature. Its chemical structural formula is CH ∝ (CH ₂) ∝ CH (C ₂ H ₅) COOH, and its unique molecular structure endows it with a wide range of reactivity and application value. The following will provide a detailed description of its uses from multiple dimensions, including the coatings and paint industry, plastic and synthetic resin industry, pharmaceutical and pesticide industry, ink and dye industry, metal processing and lubricants, fragrance and cosmetics industry, and agricultural pest control.
Coatings and Paint Industry
1. Application of drying agent
In the coatings and paint industry, it is mainly used as a core component of drying agents. Its metal salts such as cobalt, manganese, lead, and zinc can significantly reduce the viscosity of coatings and promote the drying process of coatings. Especially in light colored paints and varnishes, the application of 2-ethylhexanoate desiccants is particularly widespread. This is because these salts not only keep the coating colorless and transparent, but also effectively prevent the coating from yellowing.
Thus meeting the strict requirements of high-end coatings for color and stability.
2. Drying effect and advantages
The mechanism of action of 2-ethylhexanoate salt desiccants is that they can accelerate the rate of oxidative polymerization reaction in coatings, allowing the coating to reach the ideal drying state in a shorter time. Compared with traditional drying agents, 2-ethylhexanoate salts have higher drying efficiency and better stability, which can shorten the production cycle and improve production efficiency while ensuring coating quality.
Plastic and synthetic resin industry
1. The role of plasticizers
In the plastic and synthetic resin industry, 2-ethylhexanoic acid and its ester compounds are important plasticizers. They can increase the flexibility and processability of plastic, making plastic products have better elasticity and durability while maintaining strength. Especially in plastics such as polyvinyl chloride (PVC), the application of 2-ethylhexanoate plasticizers is particularly widespread.
2. Improvement of thermal stability
In addition to being used as a plasticizer, the metal salt of this substance is also used as a heat stabilizer for polyvinyl chloride plastics. These salts can absorb the heat generated during the processing of plastics, preventing them from decomposing or discoloring due to overheating. Meanwhile, they can also react with harmful substances in plastics, reducing their harm to the environment and human health.

Pharmaceutical and pesticide fields
1. Application of pharmaceutical raw materials
In the pharmaceutical industry, it is the main raw material for synthesizing the antibiotic ampicillin. Ampicillin is a widely used antibiotic that has a powerful bactericidal effect on various bacteria. Sodium 2-ethylhexanoate, as a key intermediate in its synthesis process, is of great significance for ensuring the quality and yield of ampicillin. In addition, the aluminum salt of this substance can also be used as a refrigerant for local surgical procedures and as an adjuvant for manufacturing antibiotics.
Providing strong support for the development of the pharmaceutical industry.
2. Contribution of pesticide components
In terms of pesticides, they also play an important role. It is used to prepare various ester fungicides, which have efficient inhibitory effects on various plant pathogens. At the same time, 2-ethylhexanoi acid can also be used as a solvent for pesticides, helping them to better disperse and adhere to plant surfaces, improving pesticide utilization and control effectiveness.
Ink and dye industry
1. The function of ink thickener
In the ink industry, it is used as a thickener. It can increase the viscosity and fluidity of ink, making the ink more evenly distributed on the printing plate during the printing process, thereby improving the quality and clarity of printed products. At the same time, it can also improve the drying performance of ink and prevent printed materials from sticking or blurring due to ink not drying.
2. Participation in dye synthesis
In the dye industry, it also plays an important role. It can be used as a starting material or intermediate to derive a series of spice components and dye molecules through chemical conversion. These dye molecules have bright colors and good stability, and are widely used in various fields such as textiles, leather, and papermaking.

Metal processing and lubricants
1. Preparation of metal lubricants
2-ethylhexanoi acid and its ester compounds are also widely used in the field of metal processing. They can be used as metal lubricants to reduce friction and wear during metal processing, improve machining accuracy and surface quality. At the same time, these lubricants can prevent rust and corrosion on metal surfaces, extending the service life of metal products.
2. Enhancement of anti-corrosion performance
In addition to serving as lubricants, certain metal salts also have excellent anti-corrosion properties. They can form a dense protective film on the metal surface, preventing moisture and oxygen from coming into contact with the metal, thus preventing metal corrosion. These salts are widely used in the anti-corrosion treatment of metal pipelines, storage tanks, ships and other equipment.


Spices and cosmetics industry
1. Sources of spice ingredients
In the field of spices, it also holds an important position. It can be used as a starting material or intermediate to derive a series of uniquely aromatic spice components through chemical transformation. These spice ingredients are widely used in perfume, cosmetics, detergents and other fields, adding rich fragrance experience to people's life.
2. Optimization of cosmetic formula
In the cosmetics industry, 2-ethylhexanoi acid and its ester compounds are also used as formulation ingredients. They can regulate the texture and stability of cosmetics, making them easier to apply and absorb. Meanwhile, these compounds can also synergistically interact with other ingredients in cosmetics, enhancing their efficacy and safety.
Agricultural pest control
1. Research and development of pest repellents
In recent years, research has found significant repellent effects on pests. Especially for pests such as beet armyworms, it can interfere with their normal physiological and behavioral activities, keeping them away from the treated plants. Based on this discovery, researchers have developed pest repellents primarily composed of this substance.
2. Evasion effect and advantages
These repellents have the advantages of high efficiency, environmental friendliness, and no residue. They can effectively control the population of pests without harming their natural enemies and beneficial organisms. Meanwhile, as they are natural secondary metabolites with complete degradation pathways in nature, the use of these repellents will not cause environmental pollution.

3. Preparation method and application
The preparation method of pest repellent includes the preparation of mother liquor A, the preparation of auxiliary liquid B, and the preparation steps. Specifically, it is to accurately weigh 2-ethylhexanoic acid and dissolve it in a solvent to prepare mother liquor A; prepare Tween-80 solution with deionized water to obtain auxiliary solution B; mix mother liquor A and auxiliary solution B, sonicate, and dilute to obtain the target pest repellent. In practical applications, these repellents can be applied to plant surfaces through spraying, smearing, and other methods, providing powerful pest control measures for agricultural production.

There are three main methods for the synthesis of 2-z-hexanoic acid:
① oxidation of 2-ethylhexanol;
② 2-ethylhexene aldehyde oxidation method;
③ 2-ethylhexanol by hydrogen esterification
2-ethylhexanol oxidation method:
It is mainly used to react 2-ethylhexanol with potassium permanganate in alkaline or acidic medium to produce potassium 2-ethylhexanoate, which is acidified with concentrated sulfuric acid after cooling to room temperature;
Dehydrogenation and esterification of 2-ethylhexanol:
2-ethylhexanol and sodium hydroxide are used for oxidative dehydrogenation to prepare sodium 2-ethylhexanoate, which is neutralized with sulfuric acid to obtain isooctanoic acid.
These two methods are both small-scale traditional process units, and the problem of "three wastes" is serious Firstly, 2-ethylhexenal (also known as isooctenal) is selectively hydrogenated to produce 2-ethylhexenal (also known as isooctenal). Then, 2-ethylhexenal is oxidized in liquid phase with air or oxygen under the action of coolate catalyst to produce isooctanoic acid. This process route is reasonable and is a hot spot in pre-h research.
Research overview of synthesis of isooctanoic acid by aldehyde oxidation:
The synthesis of 2-Ethylhexanoic acid by aldehyde oxidation is generally divided into two steps: hydrogenation of ISOOCTENE aldehyde and oxidation of isooctyl aldehyde. The synthesis of isooctanoic acid by aldehyde oxidation method has reasonable process route, low consumption, stable product quality and high yield. The intermediate products and products produced in the reaction process are low toxic organic compounds, which cause less pollution to the environment. The synthesis of isooctanoic acid by aldehyde oxidation method is a hot research topic at home and abroad before H.
FAQ
What is the common name for 2-ethylhexanoic acid?
2-Ethylhexanoic acid (2-EHA), commonly known as octoic acid, is the organic compound with the formula CH3(CH2)3CH(C2H5)CO2H. It is a carboxylic acid that is widely used to prepare lipophilic metal derivatives that are soluble in nonpolar organic solvents. 2-Ethylhexanoic acid is a colorless viscous oil.
What is ethylhexanoic acid?
Eastman™ 2-Ethylhexanoic Acid is a colorless, high boiling liquid having a mild odor. The metallic salts of Eastman™ 2-ethylhexanoic acid are used as driers for odorless paints, inks, varnishes, and enamels. Cobalt and manganese are the most important driers.
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