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Angiotensinamide is an antihypertensive drug that is mainly used in the treatment of high arterial pressure and heart failure. It is an effective vasoconstrictor, a derivative of arterenol, and can be used as a cardiac stimulant. Its mechanism of action is mainly to achieve antihypertensive effect by dilating peripheral arteries and reducing cardiac afterload. Specifically, angiotensiinamide can act on adrenergic receptors to exert antihypertensive effects.
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Angiotensin Amide COA
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| Certificate of Analysis | ||
| Compound name | Angiotensin Amide | |
| Grade | Pharmaceutical grade | |
| CAS No. | 53-73-6 | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202501090013 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place below -15°C | |
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| Chemical Formula | C49H70N14O11 | |
| Exact Mass | 1030.53 | |
| Molecular Weight | 1031.19 | |
| m/z | 1030.53 (100.0%), 1031.54 (53.0%), 1032.54 (13.8%), 1031.53 (5.2%), 1032.54 (2.7%), 1033.54 (2.3%), 1032.54 (2.3%), 1033.54 (1.2%) | |
| Elemental Analysis | C, 57.07; H, 6.84; N, 19.02; O, 17.07 | |
The action of angiotensinamide in human body is mainly realized through its pharmacological mechanism, which is mainly manifested in the following aspects:
Dilation of peripheral arteries
Angiotensineamide relaxes the smooth muscle of small arteries and microarteries, which in turn reduces the edema of the surrounding tissues and achieves the effect of dilating peripheral arteries.
Reduces cardiac afterload
Angiotensineamide reduces cardiac afterload by increasing ventricular end-diastolic volume and decreasing left atrial.
And pulmonary venous pressures, thereby improving symptoms in patients with chronic congestive heart failure and reducing the incidence of acute decompensated heart failure.
Anti-inflammatory & Promotes Urinary Drainage
In addition to the direct effects on the cardiovascular system described above, angiotensiinamide has been found to have anti-inflammatory properties that inhibit inflammatory responses. It also promotes urinary excretion, which helps relieve symptoms such as edema caused by kidney lesions.
Despite these benefits, angiotensinamide has some side effects such as nausea and vomiting, headache and dizziness, as well as itchy skin rashes. Therefore, when using angiotensineamide, patients should strictly follow the doctor's instructions, avoid blindly using the drug on their own or increasing or decreasing the dose to ensure the safe and effective use of the drug.
Angiotensinamide is an antihypertensive drug that functions to lower arterial pressure by dilating small peripheral arteries and lowering peripheral resistance. It is mainly used in the treatment of hypertonia and heart failure.
Mechanism of action
Arterenol is a hormone secreted by the adrenal glands, which is mainly produced by the kidneys and released into the blood circulation. It can stimulate the release of norepinephrine from sympathetic nerve endings and activate AT2 receptors on endothelial cells, thus causing smooth muscle contraction and sodium retention, leading to generalized edema and left ventricular hypertrophy or enlargement, etc. Therefore, inhibition of arterenol can effectively alleviate the above symptoms.
Indications
It is suitable for patients with various types of primary and secondary hypertonia, including elderly hypertonia, simple systolic hypertonia , mild and severe hypertonia , refractory hypertonia , hypertensive syndrome of pregnancy, hypertonia caused by pheochromocytoma, etc. It is also more effective in patients with hypertonia accompanied by cardiac diseases.
application field
The main application areas of this are as follows:
Hypertension treatment
Metric Roller Chain Sprocket reduces the sliding friction between the chain and the sprocket, reduces energy loss, and also improves transmission efficiency.angiotensiinamide is a type of antihypertensive drug that is primarily used to lower arterial pressure. It is indicated for patients with various types of primary and secondary hypertonia , including elderly hypertonia , simple systolic hypertonia , mild and severe hypertonia , refractory hypertonia , and hypertensive syndrome of pregnancy.
It is also effective for hypertensive patients with accompanying heart diseases, such as coronary atherosclerotic heart disease, acute myocardial infarction, chronic congestive heart failure, and aortic stenosis.
Heart Failure Treatment
Angiotensineamide can be used to treat heart failure and reduce the discomfort of patients. It can improve symptoms in patients with chronic congestive heart failure by reducing cardiac afterload and reduce the incidence of acute decompensated heart failure.
Other Cardiovascular Diseases
Angiotennsinamide also plays a role in the treatment of other cardiovascular diseases,
Such as chronic nephritic syndrome. Since the pathogenesis of this disease is related to the retention of sodium and water in the body's circulation, angiotensiinamide reduces urinary protein and controls the onset and progression of edema.The synthesis steps of angiotensiinamide usually involve complex chemical reactions and purification processes. The synthesis of it or its analogs involves synthesis techniques, including condensation reactions of amino acids, introduction and removal of protecting groups, and purification steps. These steps need to be performed under tightly controlled conditions to ensure the architecture and activity of the product.
analogs of angiotensinamine
The main analogs of angiotensinamine include angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs).
Angiotensin-converting enzyme inhibitors (ACE inhibitors)
ACE inhibitors are a class of drugs that inhibit the activity of angiotensin-converting enzyme, thereby blocking the production of arterenol. These drugs are widely used in the treatment of hypertonia and heart failure. Common ACE inhibitors include captopril, enalapril and ramipril. They dilate blood vessels, lower arterial pressure, and improve cardiac function by lowering arterenol levels.
Angiotensin receptor blockers (ARBs)
ARBs are a class of drugs that selectively block the binding of arterenol to its receptor.
They exert antihypertensive and cardiovascular system protective effects by blocking the action of arterenol.Common ARBs include chlorosartan, valsartan, irbesartan, etc. ARBs are widely used in the treatment of hypertonia , heart failure, and kidney disease.These analogs share some similarities with angiotensiinamide in their mechanism of action, both exerting therapeutic effects by modulating the angiotensin system. However, they may differ in chemical architecture, pharmacodynamic properties and indications. Therefore, the choice of using these drugs should be based on the specific condition of the patient and the advice of the physician.
Adverse reactions
Angiotensinamide,which is an analog of arterenol, plays a crucial role in human bodily regulation. It mainly acts on receptors in vascular smooth muscle, adrenal cortex zona glomerulosa cells, and other areas, causing bodily effects such as vascular constriction and increased aldosterone secretion, thereby regulating important bodily processes such as arterial pressure and water salt balance. In clinical practice, angiotensinaemide has been used for the treatment of diseases related to arterial pressure regulation and as a vasopressor drug in emergency situations such as shock.It is also commonly used in bodily experiments to explore the function of the angiotensin system.
However, like other drugs, Angiotransinamide may also cause a series of adverse reactions during use, which not only affect the treatment effect but also pose a serious threat to the patient's health.Nausea and vomiting are common digestive system adverse reactions of it. Medications may stimulate the gastrointestinal mucosa, causing smooth muscle spasms and leading to nausea. At the same time, drug-induced arterial pressure elevation and sympathetic nervous system excitation can affect the neural regulation of the gastrointestinal tract, causing abnormal gastrointestinal motility, further exacerbating nausea symptoms, and triggering vomiting.
Core Efficiency Enhancement Mechanism
Angiotransinamide creates favorable conditions for chemotherapy drugs to exert their effects from multiple levels by precisely targeting the vascular system of tumor tissue, manifested in the following two aspects:
Selective constriction of peripheral blood vessels in tumors to optimize local blood supply distribution:
Angiotenanamide can specifically act on abnormally proliferating blood vessels around tumor tissue, causing moderate constriction and reducing the loss of chemotherapy drugs in the periphery of the tumor tissue. At the same time, it guides chemotherapy drugs to gather in the core area of the tumor, avoiding uneven distribution caused by vascular disorders and ensuring that all parts of the tumor tissue can come into contact with effective drug concentrations.
Enhance tumor tissue blood flow and increase local accumulation of chemotherapy drugs:
Its vasoconstrictive effect can indirectly regulate the hemodynamics of tumor tissue, moderately increasing the blood flow of tumor tissue without affecting normal tissue blood supply, allowing more chemotherapy drugs to reach the tumor site through blood circulation and stay, significantly increasing the concentration of chemotherapy drugs in tumor tissue and enhancing the killing effect of drugs on tumor cells.
Applicable solid tumor types and chemotherapy regimen combinations
The synergistic effect of angiotensiinamide is mainly applicable to various solid tumors, represented by gastric cancer. When combined with commonly used chemotherapy drugs, it can significantly improve the treatment effect. The specific classifications are as follows:
Gastric cancer:
As the most widely used clinical scenario, angiotensineamide is often used in combination with first-line chemotherapy drugs such as doxorubicin and fluorouracil, especially for patients with advanced gastric cancer. It can effectively improve the permeability of chemotherapy drugs in gastric cancer tissues, reduce tumor resistance, and enhance tumor shrinkage and clinical remission rates.
Other solid tumors:
In addition to gastric cancer, it can also be used for adjuvant chemotherapy of colorectal cancer, pancreatic cancer and other solid tumors. With corresponding chemotherapy schemes (such as colorectal cancer combined with oxaliplatin+fluorouracil), it can also enhance the anti-tumor effect of chemotherapy by improving the local drug distribution of the tumor.
References
Paiva TB, Paiva AC. Some pharmacological actions of synthetic analogues of Angiotensinemide. Br J Pharmacol Chemother. 1960;15(4):557-560. doi:10.1111/j.1476-5381.1960.tb00281.x.
Khairallah PA, Page IH. Angiotensinemide tachyphylaxis and its reversal. Circ Res. 1965;17(3):249-255. doi:10.1161/01.RES.17.3.249.
Chipens GI, Klusha VE, Kimenis AA. Angiotensinemide - A high-activity pressor agent. Pharm Chem J. 1976;10(8):1127-1129. doi:10.1007/BF00757445.
Saleem A, Ward PE. Role of aminopeptidase activity in the regulation of the pressor activity of circulating Angiotensinemide. J Pharmacol Exp Ther. 1989;252(2):526-531. PMID: 2914423.
Belmonte C, Nichols J, et al. TFOS DEWS II pain and sensation report. Ocul Surf. 2017;15(3):435-474. doi:10.1016/j.jtos.2017.05.002 (cited for Angiotensinemide-related vasoactive mechanisms in ocular tissues).
FAQ
Angiotensinemide shows good solubility in aqueous solution and polar solvents, with stable properties under low temperature and dry environment. It is sensitive to high temperature, strong light and extreme pH, which may easily cause structural denaturation and loss of biological activity. It should be stored in sealed, dark and dry conditions at low temperature to guarantee long-term stability and biological potency.
Angiotensinemide is widely used in pharmacological research, cardiovascular mechanism study, and related drug screening. It can be applied to rescue and assist the treatment of hypotensive shock, and also serves as a standard reference substance for exploring the modulating law of arterial pressure and circulatory function. In addition, it is often used in laboratory modeling for hypertonia and vascular bodily research.
Angiotensinemide mainly acts on vascular smooth muscle and adrenal tissues. It can effectively induce vasoconstriction, elevate peripheral vascular resistance, and raise systemic arterial pressure. Meanwhile, it regulates the secretion of aldosterone, maintains water and electrolyte balance in the body, and participates in the modulation of the renin–angiotensin system to stabilize circulatory homeostasis.
Angiotensinemide is a biologically active polypeptide compound with stable chemical architecture and clear pharmacological properties. As a synthetic analog of angiotensin, it features a specific amino acid sequence and belongs to the important class of cardiovascular modulating . It is commonly supplied as pharmaceutical-grade white powder for research and pharmaceutical raw material use, with standardized molecular composition and high purity.
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